3,310 research outputs found
Athletic Policy, Passive Well-Being: Defending Freedom in the Capability Approach
G.A. Cohen has criticized the capability approach for focusing on individualsâ freedom â their capability to control their lives â and ignoring benefits achieved passively. He argues that this view of well-being is excessively âathleticâ. However, if the capability approach is employed to guide egalitarian public policy, capabilities are the appropriate goal of just distributive policies, not just components of individual well-being. When understood as a policy-guide, I argue that the capability approach's focus on âathleticâ individual freedom and control is justified: in the public domain, it is important not just that individuals receive benefits, but that they participate in their achievement
What are Adaptive Preferences? Exclusion and Disability in the Capability Approach
It is a longstanding problem for theorists of justice that many victims of injustice seem to prefer mistreatment, and perpetuate their own oppression. One possible response is to simply ignore such preferences as unreliable âadaptive preferencesâ. Capability theorists have taken this approach, arguing that individuals should be entitled to certain capabilities regardless of their satisfaction without them. Although this initially seems plausible, worries have been raised that undermining the reliability of individuals' stronglyâheld preferences impugns their rationality, and further excludes already marginalised groups. I argue that such criticisms trade on an ambiguity between two uses of the term âadaptive preferenceâ. An adaptive preference is often assumed to be irrational, and an unreliable guide to its possessor's best interests. However, I suggest a preference may also be adaptive in the sense that it is an unreliable guide to our distributive entitlements, and that this does not require an assessment of individuals' rationality. I consider this distinction in relation to disability, arguing that this clarification allows us to justifiably ignore some disabled individuals' preferences, in the context of theorising about distributive justice, without disrespecting or undermining their rationality or culture
Mechanisms responsible for ERBB2 gene overexpression in human breast and non-breast cancer cells. The role of AP-2 transcription factors
The vicious circle and infection intensity: The case of Trypanosoma microti in field vole populations
Objective: In natural populations, infection and condition may act synergistically to trigger a vicious circle: poor condition predisposes to host infections, which further reduce condition, and so on. If this vicious circle originates from a reduced resistance to infection, it will not only result in greater proneness to becoming infected of those that are in poorer condition, but it may also cause infections of higher intensity. Here, we investigate the temporal relationship between host condition and intensity of infection by a specific pathogen using as a system the dynamics of the protozoan Trypanosoma microti in field vole (Microtus agrestis) populations. Methods and results: With two years of longitudinal data from three monthly-sampled populations, we evaluated if individuals acquiring a high intensity of infection previously had lower haematological indicators of condition (red blood cells [RBCs] and lymphocyte counts) than those that acquired lower infection intensities. Also, the association of these indicators with past and present trypanosome blood levels was investigated. The individuals that developed high levels of parasitaemia were those that previously had low lymphocyte counts. Greater intensity of infection corresponded with lower RBCs only in low to moderate weight females, and no effect of intensity of infection on lymphocyte counts was observed. However, delayed effects of high trypanosome intensity were seen on both RBCs and lymphocytes. Conclusions: The vicious circle may also result in high infection intensity: individuals in poor condition are not only more likely to become infected by one pathogen; they may also be the most important source of infection for that and for other pathogens, and thus key protagonists for parasite dynamics.Fil: Beldomenico, Pablo MartĂn. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Telfer, Sandra. University of Liverpool; Reino UnidoFil: Gebert, Stephanie. University of Liverpool; Reino UnidoFil: Lukomski, Lukasz. University of Liverpool; Reino UnidoFil: Bennett, Malcolm. University of Liverpool; Reino UnidoFil: Begon, Michael. University of Liverpool; Reino Unid
Transcriptome-wide analysis reveals different categories of response to a standardised immune challenge in a wild rodent
Individuals vary in their immune response and, as a result, some are more susceptible to infectious disease than others. Little is known about the nature of this individual variation in natural populations, or which components of immune pathways are most responsible, but defining this underlying landscape of variation is an essential first step to understanding the drivers of this variation and, ultimately, predicting the outcome of infection. We describe transcriptome-wide variation in response to a standardised immune challenge in wild field voles. We find that markers can be categorised into a limited number of types. For the majority of markers, the response of an individual is dependent on its baseline expression level, with significant enrichment in this category for conventional immune pathways. Another, moderately sized, category contains markers for which the responses of different individuals are also variable but independent of their baseline expression levels. This category lacks any enrichment for conventional immune pathways. We further identify markers which display particularly high individual variability in response, and could be used as markers of immune response in larger studies. Our work shows how a standardised challenge performed on a natural population can reveal the patterns of natural variation in immune response
Una crĂtica avant la lettre a la raĂł moderna. Montaigne i el problema de la interculturalitat
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