1,209 research outputs found
Pre-excitation of the right branch of the bundle of his
A patient with an ECG exhibiting a short P-R interval followed by a QRS resembling complete left bundle-branch block (CLBBB) is presented. The Wolff-Parkinson-White (WPW) syndrome complicated by left bundle-branch block was suspected. The vectorcardiogram (YCG) closely approximated that of CLBBB but the characteristic delta segment of WPW conduction was absent. Subsequently, typical delta vectors appeared, and upon abolition of pre-excitation with procainamide, no LBBB was found. Evidence is assembled that a James bundle-like bypass was responsible for the accelerated atrioventricular (AY) conduction in thefirst tracings with transmission directly into the right bundle system causing functional LBBB; later, the impulse was re-routed either directly or via Mahaim fibres into septal muscle, creating a typical WPW-QRS loop. Six other possible mechanisms for the short P-R-CLBBB pattern arediscussed.S. Afr. Med. J., 48, 1790 (1974
Sensitivity of Nuclear Transition Frequencies to Temporal Variation of the Fine Structure Constant or the Strong Interaction
There exist in nature a few nuclear isomers with very low (eV) excitation
energies, and the combination of low energy and narrow width makes them
possible candidates for laser-based investigations. The best candidate is the
lowest-energy excited state known in nuclear physics, the 7.6(5) eV isomer of
Th. A recent study suggests that a measurement of the temporal
variation of the excitation energy of this isomer would have 5-6 orders of
magnitude enhanced sensitivity to a variation of the fine structure constant
() or of a strong interaction parameter
(). We reexamine the physics involved in these arguments. By
invoking the Feynman-Hellmann Theorem we argue that there is no expectation of
significantly enhanced sensitivity to a variation in the fine structure
constant (beyond that obtained from experimental considerations such as the low
energy and narrow width of the isomer). A similar argument applies to the
strong interaction, but evaluating the shift due to temporal variations of the
underlying parameters of the strong interaction may be beyond current nuclear
structure techniques.Comment: 4 Pages, no figure
Comparative transcriptomics in three Methylophilaceae species uncover different strategies for environmental adaptation
We carried out whole transcriptome analysis of three species of Methylophilaceae, Methylotenera mobilis, Methylotenera versatilis and Methylovorus glucosotrophus, in order to determine which metabolic pathways are actively transcribed in cultures grown in laboratory on C1 substrates and how metabolism changes under semi-in situ conditions. Comparative analyses of the transcriptomes were used to probe the metabolic strategies utilized by each of the organisms in the environment. Our analysis of transcript abundance data focused on changes in expression of methylotrophy metabolic modules, as well as on identifying any functional modules with pronounced response to in situ conditions compared to a limited set of laboratory conditions, highlighting their potential role in environmental adaptation. We demonstrate that transcriptional responses to environmental conditions involved both methylotrophy and non-methylotrophy metabolic modules as well as modules responsible for functions not directly connected to central metabolism. Our results further highlight the importance of XoxF enzymes that were previously demonstrated to be highly expressed in situ and proposed to be involved in metabolism of methanol by Methylophilaceae. At the same time, it appears that different species employ different homologous Xox systems as major metabolic modules. This study also reinforces prior observations of the apparent importance of the methylcitric acid cycle in the Methylotenera species and its role in environmental adaptation. High transcription from the respective gene clusters and pronounced response to in situ conditions, along with the reverse expression pattern for the ribulose monophosphate pathway that is the major pathway for carbon assimilation in laboratory conditions suggest that a switch in central metabolism of Methylotenera takes place in response to in situ conditions. The nature of the metabolite(s) processed via this pathway still remains unknown. Of the functions not related to central metabolism, flagellum and fimbria synthesis functions appeared to be of significance for environmental adaptation, based on their high abundance and differential expression. Our data demonstrate that, besides shared strategies, the organisms employed in this study also utilize strategies unique to each species, suggesting that the genomic divergence plays a role in environmental adaptation
Gemini Observations of Disks and Jets in Young Stellar Objects and in Active Galaxies
We present first results from the Near-infrared Integral Field Spectrograph
(NIFS) located at Gemini North. For the active galaxies Cygnus A and Perseus A
we observe rotationally-supported accretion disks and adduce the existence of
massive central black holes and estimate their masses. In Cygnus A we also see
remarkable high-excitation ionization cones dominated by photoionization from
the central engine. In the T-Tauri stars HV Tau C and DG Tau we see
highly-collimated bipolar outflows in the [Fe II] 1.644 micron line, surrounded
by a slower molecular bipolar outflow seen in the H_2 lines, in accordance with
the model advocated by Pyo et al. (2002).Comment: Invited paper presented at the 5th Stromlo Symposium. 9 pages, 7
figures. Accepted for publication in Astrophysics & Space Scienc
Time--Distance Helioseismology Data Analysis Pipeline for Helioseismic and Magnetic Imager onboard Solar Dynamics Observatory (SDO/HMI) and Its Initial Results
The Helioseismic and Magnetic Imager onboard the Solar Dynamics Observatory
(SDO/HMI) provides continuous full-disk observations of solar oscillations. We
develop a data-analysis pipeline based on the time-distance helioseismology
method to measure acoustic travel times using HMI Doppler-shift observations,
and infer solar interior properties by inverting these measurements. The
pipeline is used for routine production of near-real-time full-disk maps of
subsurface wave-speed perturbations and horizontal flow velocities for depths
ranging from 0 to 20 Mm, every eight hours. In addition, Carrington synoptic
maps for the subsurface properties are made from these full-disk maps. The
pipeline can also be used for selected target areas and time periods. We
explain details of the pipeline organization and procedures, including
processing of the HMI Doppler observations, measurements of the travel times,
inversions, and constructions of the full-disk and synoptic maps. Some initial
results from the pipeline, including full-disk flow maps, sunspot subsurface
flow fields, and the interior rotation and meridional flow speeds, are
presented.Comment: Accepted by Solar Physics topical issue 'Solar Dynamics Observatory
Current Indications of Secondary Enucleation in Retinoblastoma Management: A Position Paper on Behalf of the European Retinoblastoma Group (EURbG).
Secondary enucleation (SE) puts an irreversible end to eye-preserving therapies, whenever their prolongation is expected to violate the presumed state of metastatic grace. At present, it must be acknowledged that clear criteria for SE are missing, leading to empiric and subjective indications commonly related to disease progression or relapse, disease persistence masking the optic nerve head or treatment-related complications obscuring the fundus view. This absence of evidence-based consensus regarding SE is explained by the continuously moving frontiers of the conservative management as a result of diagnostic and therapeutic advances, as well as by the lack of studies sufficiently powered to accurately stratify the risk of metastasis in conservatively treated patients. In this position paper of the European Retinoblastoma Group (EURbG), we give an overview of the progressive shift in the indications for SE over the past decades and propose guidelines to assist decision-making with respect to when SE becomes imperative or recommended, with corresponding absolute and relative SE indications. Further studies and validation of biologic markers correlated with the risk of metastasis are expected to set more precisely the frontiers of conservative management and thus consensual criteria for SE in the future
Implementation of an Optimal First-Order Method for Strongly Convex Total Variation Regularization
We present a practical implementation of an optimal first-order method, due
to Nesterov, for large-scale total variation regularization in tomographic
reconstruction, image deblurring, etc. The algorithm applies to -strongly
convex objective functions with -Lipschitz continuous gradient. In the
framework of Nesterov both and are assumed known -- an assumption
that is seldom satisfied in practice. We propose to incorporate mechanisms to
estimate locally sufficient and during the iterations. The mechanisms
also allow for the application to non-strongly convex functions. We discuss the
iteration complexity of several first-order methods, including the proposed
algorithm, and we use a 3D tomography problem to compare the performance of
these methods. The results show that for ill-conditioned problems solved to
high accuracy, the proposed method significantly outperforms state-of-the-art
first-order methods, as also suggested by theoretical results.Comment: 23 pages, 4 figure
Explosive events - swirling transition region jets
In this paper, we extend our earlier work to provide additional evidence for
an alternative scenario to explain the nature of so-called `explosive events'.
The bi-directed, fast Doppler motion of explosive events observed
spectroscopically in the transition region emission is classically interpreted
as a pair of bidirectional jets moving upward and downward from a reconnection
site. We discuss the problems of such a model. In our previous work, we focused
basically on the discrepancy of fast Doppler motion without detectable motion
in the image plane. We now suggest an alternative scenario for the explosive
events, based on our observations of spectral line tilts and bifurcated
structure in some events. Both features are indicative of rotational motion in
narrow structures. We explain the bifurcation as the result of rotation of
hollow cylindrical structures and demonstrate that such a sheath model can also
be applied to explain the nature of the puzzling `explosive events'. We find
that the spectral tilt, the lack of apparent motion, the bifurcation, and a
rapidly growing number of direct observations support an alternative scenario
of linear, spicular-sized jets with a strong spinning motion.Comment: 9 pages, 3 figures, accepted for publication in Solar Physic
Effective action approach and Carlson-Goldman mode in d-wave superconductors
We theoretically investigate the Carlson-Goldman (CG) mode in two-dimensional
clean d-wave superconductors using the effective ``phase only'' action
formalism. In conventional s-wave superconductors, it is known that the CG mode
is observed as a peak in the structure factor of the pair susceptibility
only just below the transition temperature T_c and only
in dirty systems. On the other hand, our analytical results support the
statement by Y.Ohashi and S.Takada, Phys.Rev.B {\bf 62}, 5971 (2000) that in
d-wave superconductors the CG mode can exist in clean systems down to the much
lower temperatures, . We also consider the manifestations of
the CG mode in the density-density and current-current correlators and discuss
the gauge independence of the obtained results.Comment: 23 pages, RevTeX4, 12 EPS figures; final version to appear in PR
The Physics of turbulent and dynamically unstable Herbig-Haro jets
The overall properties of the Herbig-Haro objects such as centerline
velocity, transversal profile of velocity, flow of mass and energy are
explained adopting two models for the turbulent jet. The complex shapes of the
Herbig-Haro objects, such as the arc in HH34 can be explained introducing the
combination of different kinematic effects such as velocity behavior along the
main direction of the jet and the velocity of the star in the interstellar
medium. The behavior of the intensity or brightness of the line of emission is
explored in three different cases : transversal 1D cut, longitudinal 1D cut and
2D map. An analytical explanation for the enhancement in intensity or
brightness such as usually modeled by the bow shock is given by a careful
analysis of the geometrical properties of the torus.Comment: 17 pages, 10 figures. Accepted for publication in Astrophysics &
Spac
- …