4 research outputs found
An Exploration of Maximum Power Point Tracking Algorithms
This project investigated the performance of various solar maximum power point tracking algorithms on a single hardware platform. It also developed a low-cost hardware platform including a rudimentary solar cell emulator circuit and a maximum power point tracker circuit to test these algorithms. Additionally, the project covered the development of the two software algorithms that were tested in the project: the âSweepâ algorithm and the âPerturb and Observeâ algorithm
Sustainable Campus Buildings: A Case Study of Climate Control in Kaven Hall
This project analyzed the energy usage of Worcester Polytechnic Instituteâs Kaven Hall, and examined various improvements that would efficiently provide a comfortable climate for learning. These improvements were ranked based on various factors, such as energy efficiency, comfort, and cost. The methods used to determine improvements were described in detail, so that a similar process could be applied to other buildings in need of indoor climate improvements
Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability
International audienceAcetylation of the lysine residues in histones and other DNA-binding proteins plays a major role in regulation of eukaryotic gene expression. This process is controlled by histone acetyltransferases (HATs/KATs) found in multiprotein complexes that are recruited to chromatin by the scaffolding subunit transformation/transcription domain-associated protein (TRRAP). TRRAP is evolutionarily conserved and is among the top five genes intolerant to missense variation. Through an international collaboration, 17 distinct de novo or apparently de novo variants were identified in TRRAP in 24 individuals. A strong genotype-phenotype correlation was observed with two distinct clinical spectra. The first is a complex, multi-systemic syndrome associated with various malformations of the brain, heart, kidneys, and genitourinary system and characterized by a wide range of intellectual functioning; a number of affected individuals have intellectual disability (ID) and markedly impaired basic life functions. Individuals with this phenotype had missense variants clustering around the c.3127G>A p.(Ala1043Thr) variant identified in five individuals. The second spectrum manifested with autism spectrum disorder (ASD) and/or ID and epilepsy. Facial dysmorphism was seen in both groups and included upslanted palpebral fissures, epicanthus, telecanthus, a wide nasal bridge and ridge, a broad and smooth philtrum, and a thin upper lip. RNA sequencing analysis of skin fibroblasts derived from affected individuals skin fibroblasts showed significant changes in the expression of several genes implicated in neuronal function and ion transport. Thus, we describe here the clinical spectrum associated with TRRAP pathogenic missense variants, and we suggest a genotype-phenotype correlation useful for clinical evaluation of the pathogenicity of the variants