268 research outputs found

    Utilizing dataset affinity prediction in object detection to assess training data

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    Data pooling offers various advantages, such as increasing the sample size, improving generalization, reducing sampling bias, and addressing data sparsity and quality, but it is not straightforward and may even be counterproductive. Assessing the effectiveness of pooling datasets in a principled manner is challenging due to the difficulty in estimating the overall information content of individual datasets. Towards this end, we propose incorporating a data source prediction module into standard object detection pipelines. The module runs with minimal overhead during inference time, providing additional information about the data source assigned to individual detections. We show the benefits of the so-called dataset affinity score by automatically selecting samples from a heterogeneous pool of vehicle datasets. The results show that object detectors can be trained on a significantly sparser set of training samples without losing detection accuracy.Comment: Accepted at the International Conference on Robotics, Computer Vision and Intelligent Systems (ROBOVIS) 202

    Predictors of Adherence Among Patients With Multiple Sclerosis Using the BETACONNECT® Autoinjector: A Prospective Observational Cohort Study

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    Background: In patients with multiple sclerosis (MS), non-adherence to disease-modifying drug therapy is associated with an increased rate of MS relapses. Early identification of patients at risk of non-adherence would allow provision of timely and individualized support. The aim of the BETAPREDICT study was to investigate potential predictors of adherence in patients with MS in Germany treated with interferon β-1b (IFNβ-1b) using the BETACONNECT® autoinjector. Methods: BETAPREDICT was a national, multi-center, prospective, non-interventional, single-arm, 24-month cohort study of patients with relapsing–remitting MS or clinically isolated syndrome receiving IFNβ-1b via the BETACONNECT® autoinjector (ClinicalTrials.gov: NCT02486640). Injection data were captured by the autoinjector. The primary objective was to determine baseline predictors of compliance, persistence, and adherence to IFNβ-1b treatment after 12- and 24 months using multivariable-adjusted regression. Secondary objectives included evaluation of satisfaction with the autoinjector, injection site pain, vitamin and nutrient supplementation, clinical course, and patient-related outcome measures. Results: Of 165 patients enrolled, 153 were available for analysis (120 with autoinjector data). Seventy-two patients left the study prematurely. Compliance (N = 120), persistence (N = 153), and adherence (N = 120) at 24 months were 89.1, 53.6, and 41.7%, respectively. Compliance at 12- and 24 months was predicted by intake of vitamin D supplements and absence of specific injection site reactions. Positive predictors of persistence included age (at 12- and 24 months) and previous duration of treatment (at 12 months), while intake of vitamins/nutrients other than vitamin D was a negative predictor (at 12 months). Positive predictors of adherence at 24 months were age and being experienced with IFNβ-1b. Higher scores in specific SF-36 subscales were positive predictors of medication-taking behavior at 24 months. Satisfaction with the autoinjector was high at baseline and 24 months (median score: 9 out of 10). Conclusions: Compliance with IFNβ-1b treatment among participants still under observation remained high over a 24-month period, while persistence and adherence continuously declined. Multiple factors affected medication-taking behavior, including patient characteristics, treatment history, injection site reactions, patients’ perception of their health and support programs. The importance of these factors may differ among patients according to their individual situation

    Precursor molecules for 1,2-diamidobenzene containing cobalt(ii), nickel(ii) and zinc(ii) complexes – synthesis and magnetic properties

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    Molecular magnetic materials based on 1,2-diamidobenzenes are well known and have been intensively studied both experimentally and computationally. They possess interesting magnetic properties as well as redox activity. In this work, we present the synthesis and investigation of potent synthons for constructing discrete metal–organic architectures featuring 1,2-diamidobenzene-coordinated metal centres. The synthons feature weakly bound dimethoxyethane (dme) ligands in addition to the 1,2-diamidobenzene. We characterize these complexes and investigate their magnetic properties by means of static and dynamic magnetometry and high-field electron paramagnetic resonance (HFEPR). Interestingly, the magnetic and magnetic resonance data strongly suggest a dimeric formulation of these complexes, viz. [MII(bmsab)(dme)]2 (bmsab = 1,2-bis(methanesulfonamido)benzene; dme = dimethoxyethane) with M = Co, Ni, Zn. A large negative D-value of −60 cm−1 was found for the Co(ii) synthon and an equally large negative D of −50 cm−1 for the Ni(ii) synthon. For Co(ii), the sign of the D-value is the same as that found for the known bis-diamidobenzene complexes of this ion. In contrast, the negative D-value for the Ni(ii) complex is unexpected, which we explain in terms of a change in coordination number. The heteroleptic Co(ii) complex presented here does not feature slow relaxation of the magnetization, in contrast to the homoleptic Co(ii) 1,2-diamidobenzene complex

    Living with Uncertainty

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    The last few years have seen a major rethinking of some of the hallowed assumptions of range ecology and range management practice. This book examines the management of policy implications of this new ecological thinking for pastoral development in dryland areas. With examples drawn from all over Africa, the contributors examine the consequences of living with uncertainty for pastoral development planning, range and fodder management, drought responses, livestock marketing, resource tenure, institutional development and pastoral administration

    Living with Uncertainty

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    The last few years have seen a major rethinking of some of the hallowed assumptions of range ecology and range management practice. This book examines the management of policy implications of this new ecological thinking for pastoral development in dryland areas. With examples drawn from all over Africa, the contributors examine the consequences of living with uncertainty for pastoral development planning, range and fodder management, drought responses, livestock marketing, resource tenure, institutional development and pastoral administration

    Microbial Cell Factories / Monitoring the Dynamics of Transcription and Translation Within the Time Course of Recombinant E. coli Cultivations

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    Oral presentation from The 4th Recombinant Protein Production Meeting: a comparative view on host physiology, Barcelona, Spain. 21\u201323 September 200
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