Spectral analysis and parameter estimation in levitated optomechanics

Optical levitation of nanoscale particles has emerged as a platform for precision measurement. Extremely low damping, together with optical interferometric position detection, makes possible exquisite force measurement and promises low-energy tests of fundamental physics. Essential to such measurement is an understanding of the confidence with which parameters can be inferred from spectra estimated from the indirect measurement provided by interferometry. We present an apparatus optimized for sensitivity along one motional degree of freedom, a theoretical model of the spectrum, and maximum likelihood estimation. The treatment accounts for the sinusoidal dependence of interferometric signal on particle position, and we use the technique to extract thermodynamic quantities in a regime where simpler treatments are confounded

Research campaign: Macroscopic quantum resonators (MAQRO)

The objective of the proposed macroscopic quantum resonators (MAQRO) mission is to harness space for achieving long free-fall times, extreme vacuum, nano-gravity, and cryogenic temperatures to test the foundations of physics in macroscopic quantum experiments at the interface with gravity. Developing the necessary technologies, achieving the required sensitivities and providing the necessary isolation of macroscopic quantum systems from their environment will lay the path for developing novel quantum sensors. Earlier studies showed that the proposal is feasible but that several critical challenges remain, and key technologies need to be developed. Recent scientific and technological developments since the original proposal of MAQRO promise the potential for achieving additional science objectives. The proposed research campaign aims to advance the state of the art and to perform the first macroscopic quantum experiments in space. Experiments on the ground, in micro-gravity, and in space will drive the proposed research campaign during the current decade to enable the implementation of MAQRO within the subsequent decade

Effects of Newtonian gravitational self-interaction in harmonically trapped quantum systems

The Schr\"odinger-Newton equation has gained attention in the recent past as a nonlinear modification of the Schr\"odinger equation due to a gravitational self-interaction. Such a modification is expected from a fundamentally semi-classical theory of gravity, and can therefore be considered a test case for the necessity of the quantisation of the gravitational field. Here we provide a thorough study of the effects of the Schr\"odinger-Newton equation for a micron-sized sphere trapped in a harmonic oscillator potential. We discuss both the effect on the energy eigenstates and the dynamical behaviour of squeezed states, covering the experimentally relevant parameter regimes.Comment: 22 pages, 14 figure

On issues of equalization with the decorrelation algorithm : fast converging structures and finite-precision

To increase the rate of convergence of the blind, adaptive, decision feedback equalizer based on the decorrelation criterion, structures have been proposed which dramatically increase the complexity of the equalizer. The complexity of an algorithm has a direct bearing on the cost of implementing the algorithm in either hardware or software. In this thesis, more computationally efficient structures, based on the fast transversal filter and lattice algorithms, are proposed for the decorrelation algorithm which maintain the high rate of convergence of the more complex algorithms. Furthermore, the performance of the decorrelation algorithm in a finite-precision environment will be studied and compared to the widely used LMS algorithm

Actively stabilized wavelength-insensitive carrier elimination from an electro-optically modulated laser beam

We demonstrate a simple and robust technique for removal of the carrier wave from a phase-modulated laser beam, using a non-interferometric method that is insensitive to the modulation frequency and instead exploits the polarization-dependence of electro-optic modulation. An actively stabilized system using feedback via a liquid crystal cell yields long-term carrier suppression in excess of 28 dB at the expense of a 6.5 dB reduction in sideband power.Comment: 9 pages, 5 figure

Voltage transfer function as an optical method to characterize electrical properties of liquid crystal devices

The voltage transfer function is a rapid and visually effective method to determine the electrical response of liquid crystal (LC) systems using optical measurements. This method relies on cross-polarized intensity measurements as a function of the frequency and amplitude of the voltage applied to the device. Coupled with a mathematical model of the device it can be used to determine the device time constants and electrical properties. We validate the method using photorefractive LC cells and determine the main time constants and the voltage dropped across the layers using a simple nonlinear filter model

First impressions count: Almost double! : A study of the interaction of interviewer appearance and information effects in stated preference studies

A simple but novel experiment is described examining the impact of interviewer appearance upon stated willingness to pay (WTP) for an environmental good. This test consists of an interviewer wearing either formal or more casual clothing. This analysis is interacted with a cross cutting treatment examining the more familiar impact of adding information on certain of the less familiar attributes of the good in question. Face to face interviews are employed to collect a sample of respondents who are randomly allocated to one of the four treatment permutations described by our interviewer appearance and information change study design. Our analysis suggests that both altering the appearance of an interviewer and changing the degree of information provided can have significant impacts upon stated WTP. Furthermore this effect is heightened when both effects are running in parallel. We argue that such findings are to be expected given the highly interactive nature of face-to-face interviewing but note that this serves to provide a cautionary note regarding the complex array of influences at work when members of the public are asked to express preferences regarding goods for which they have not previous provided monetary values

Virtual patient design : exploring what works and why : a grounded theory study

Objectives: Virtual patients (VPs) are online representations of clinical cases used in medical education. Widely adopted, they are well placed to teach clinical reasoning skills. International technology standards mean VPs can be created, shared and repurposed between institutions. A systematic review has highlighted the lack of evidence to support which of the numerous VP designs may be effective, and why. We set out to research the influence of VP design on medical undergraduates. Methods: This is a grounded theory study into the influence of VP design on undergraduate medical students. Following a review of the literature and publicly available VP cases, we identified important design properties. We integrated them into two substantial VPs produced for this research. Using purposeful iterative sampling, 46 medical undergraduates were recruited to participate in six focus groups. Participants completed both VPs, an evaluation and a 1-hour focus group discussion. These were digitally recorded, transcribed and analysed using grounded theory, supported by computer-assisted analysis. Following open, axial and selective coding, we produced a theoretical model describing how students learn from VPs. Results: We identified a central core phenomenon designated ‘learning from the VP’. This had four categories: VP Construction; External Preconditions; Student–VP Interaction, and Consequences. From these, we constructed a three-layer model describing the interactions of students with VPs. The inner layer consists of the student's cognitive and behavioural preconditions prior to sitting a case. The middle layer considers the VP as an ‘encoded object’, an e-learning artefact and as a ‘constructed activity’, with associated pedagogic and organisational elements. The outer layer describes cognitive and behavioural change. Conclusions: This is the first grounded theory study to explore VP design. This original research has produced a model which enhances understanding of how and why the delivery and design of VPs influence learning. The model may be of practical use to authors, institutions and researchers

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

AIM: To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS: Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005 and 2011 at a single institution were reviewed. Triplet neoadjuvant chemotherapy consisting of platinum, fluoropyrimidine and anthracycline was considered for operable patients (World Health Organization performance status ? 2) with clinical stage T2-4 N0-1. Response to neoadjuvant chemotherapy (NAC) was assessed using TRG, as described by Mandard et al. In addition lymph node downstaging was also assessed. Lymph node downstaging was defined by cN1 at diagnosis: assessed radiologically (computed tomography, positron emission tomography, endoscopic ultrasonography), then pathologically recorded as N0 after surgery; ypN0 if NAC given prior to surgery, or pN0 if surgery alone. Patients were followed up for 5 years post surgery. Recurrence was defined radiologically, with or without pathological confirmation. An association was examined between t TRG and lymph node downstaging with disease free survival (DFS) and a comprehensive range of clinicopathological characteristics.RESULTS: Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years (median follow up: 2.552, 95%CI: 2.022-3.081). There was a 1.8% (n = 4) inpatient mortality rate. One hundred and thirty-six (62.4%) patients received NAC, with 74.3% (n = 101) of patients demonstrating some signs of pathological tumour regression (TRG 1-4) and 5.9% (n = 8) having a complete pathological response. Forty four point one percent (n = 60) had downstaging of their nodal disease (cN1 to ypN0), compared to only 15.9% (n = 13) that underwent surgery alone (pre-operatively overstaged: cN1 to pN0), (P < 0.0001). Response to NAC was associated with significantly increased DFS (mean DFS; TRG 1-2: 5.1 years, 95%CI: 4.6-5.6 vs TRG 3-5: 2.8 years, 95%CI: 2.2-3.3, P < 0.0001). Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC (median DFS; TRG 3-5 and nodal down-staging: 5.533 years, 95%CI: 3.558-7.531 vs TRG 3-5 and no nodal down-staging: 1.114 years, 95%CI: 0.961-1.267, P < 0.0001).CONCLUSION: Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS