Studies on Complex Formation by Di(2-pyridyl)amine & 2-Aminopyridine with Metal Ions in Aqueous Solution: Evaluation of Enthalpies & Entropies of Complex Formation with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) & Cd(II) & Ligand Field Stabilization Energies of the Metal Complexes

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A Study on the Selection Criteria of Different Hotels of Delhi NCR in Accordance to the Hr Policies and Market Trends

The hotel industry is one of the most booming industry contributing tremendous growth in the global economy. It has never got affected by any kind of recession or economic turmoil, and this happens because of the fact that individuals/ families would need services of hotel industry for various reasons of human activities like business, recreation, pilgrimage educational tour, historical tours, festivals, carnivals, medical assistance trip etc. and so on. The biggest apprehension about this industry is attrition/turnover rate of employees; and to trounce this matter, selection of the right candidate at the right profile for the right post is the way to success. Selection criteria include all the essential and desirable skills, attributes, experience, and education which an organization decides is necessary for a position. Selection criteria help to select the most capable, effective, suited, experienced, qualified, the person for the job. Applicants must demonstrate and prove the ways in which they will be of valued for the job and the organization. Job selection criteria are also known as key selection criteria or KSC. They are designed to help make the most accurate match between the requirements of a position and the skills of an applicant. For selecting the right candidate, perfect for a particular job, selection has to be well planned, tactically accurate and strategically correct, as there is a huge pressure of short listing, filtering and selecting the right candidate, which makes the whole exercise lengthy as well as painstaking

Empirical model for the electron-impact K-shell-ionization cross sections

The total cross sections of electron-impact single-K-shell ionization of 14 atomic targets ranging from H to U (1 \u3c= Z \u3c= 92) are calculated using a modified version of the BELI formula [Bell , J. Phys. Chem. Ref. Data 12, 891 (1983)] by incorporating both ionic and relativistic corrections in it. The proposed modified Bell model with a single set of parameters is found to provide an excellent description of the experimental data in the reduced energy range 1 \u3c= E/I-K \u3c= 10(6) (E and I-K are, respectively, the incident energy and ionization potential) with a performance level at least as good as any of the existing methods and models

A Novel Enediynyl Peptide Inhibitor of Furin That Blocks Processing of proPDGF-A, B and proVEGF-C

BACKGROUND: Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis. As a result it is considered a major target for intervention of these diseases. METHODOLOGY/PRINCIPAL FINDINGS: Herein, we report, for the first time, the synthesis and biological evaluation of a newly designed potent furin inhibitor that contains a highly reactive beta-turn inducing and radical generating "enediynyl amino acid" (Eda) moiety. "Eda" was inserted between P1 and P1' residues of hfurin(98-112) peptide, derived from the primary cleavage site of furin's own prodomain. The resulting hexadecapeptide derivative inhibited furin in vitro with IC(50) approximately 40 nM when measured against the fluorogenic substrate Boc-RVRR-MCA. It also inhibited furin-mediated cleavage of a fluorogenic peptide derived from hSARS-CoV spike protein with IC(50) approximately 193 nM. Additionally it also blocked furin-processing of growth factors proPDGF-A, B and VEGF-C that are linked to tumor genesis and cancer. Circular dichroism study showed that this inhibitor displayed a predominantly beta-turn structure while western blots confirmed its ability to protect furin protein from self degradation. CONCLUSION/SIGNIFICANCE: These findings imply its potential as a therapeutic agent for intervention of cancer and other furin-associated diseases

Constraints on compact dark matter from gravitational wave microlensing

If a significant fraction of dark matter is in the form of compact objects, they will cause microlensing effects in the gravitational wave (GW) signals observable by LIGO and Virgo. From the non-observation of microlensing signatures in the binary black hole events from the first two observing runs and the first half of the third observing run, we constrain the fraction of compact dark matter in the mass range $10^2-10^5~{M_\odot}$ to be less than $\simeq 50-80\%$ (details depend on the assumed source population properties and the Bayesian priors). These modest constraints will be significantly improved in the next few years with the expected detection of thousands of binary black hole events, providing a new avenue to probe the nature of dark matter