How German general practitioners justify their provision of complementary and alternative medicine

Background: Many German general practitioners (GPs) use complementary and alternative medicine (CAM) in their daily work although most CAM procedures are controversial from an academic point of view. Objective: We aimed to investigate how GPs justify their use of CAM. Methods: We performed semi-structured, individual face-to-face interviews with 20 purposively sampled, experienced GPs providing primary care within the framework of the German statutory health insurance system. A grounded theory approach was used for data analysis. Results: All GPs participating in this study used at least some CAM in their clinical practice. Participants did not have any major conflicts when justifying their use of CAM therapies. Important arguments justifying CAM provision were: using it as a supplementary tool to conventional medicine; the feeling that evidence and science leave many problems in primary care unanswered; a strong focus on helping the individual patient, justifying the use of procedures not based on science for therapeutic and communicative purposes; a strong belief in one’s own clinical experience; and appreciation of placebo effects. In general, participants preferred CAM therapies which seemed at least somewhat plausible to them and which they could provide in an authentic manner. Conclusions: Our results suggest that many German GPs integrate CAM treatments in their routine primary carework without perceiving any major internal conflicts with professional ideals

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

The ephrins, ligands of Eph receptor tyrosine kinases, have been shown to act as repulsive guidance molecules and to induce collapse of neuronal growth cones. For the first time, we show that the ephrin-A5 collapse is mediated by activation of the small GTPase Rho and its downstream effector Rho kinase. In ephrin-A5–treated retinal ganglion cell cultures, Rho was activated and Rac was downregulated. Pretreatment of ganglion cell axons with C3-transferase, a specific inhibitor of the Rho GTPase, or with Y-27632, a specific inhibitor of the Rho kinase, strongly reduced the collapse rate of retinal growth cones. These results suggest that activation of Rho and its downstream effector Rho kinase are important elements of the ephrin-A5 signal transduction pathway

Descriptive analysis of 179 German reports of melanoma reported to an adverse drug reaction database as a drug-related adverse effect, and comparison with melanoma cases contained in German cancer registries

Background: Malignant melanoma (MM) is one of the most aggressive forms of skin cancer. The occurrence of MM associated with drug therapy has been described in the literature. However, there is no analysis of a substantial number of validated reports of drug-associated MM. Aim: To analyse a substantial number of validated spontaneous reports of drug-associated MM with regard to the suspected drug and the reported characteristics, and to compare these analyses with those of MM cases occurring in the general population in Germany. Methods: Spontaneous reports of MM associated with drug therapy in Germany were identified in a large adverse drug reaction database (EudraVigilance). These results were then compared with analyses of MMs in the pooled data from a population-based German cancer registry. Results: The 10 most frequently suspected drugs in the MM reports all target the immune system, with 7 of these being immunosuppressants. The median time to onset to MM diagnosis was 2.0 years. Patients with drug-associated MM were 11 years (median) younger than patients with MM in the cancer registry, and this age difference was greater for female than for male patients. Conclusions: Our results emphasize the importance of regular dermatological examinations of patients being treated with immunosuppressants. Physicians should be aware that in these patients, MM might be detected at younger ages and even within 2 years after initiating therapy.Peer Reviewe

Discrepancies from registered protocols and spin occurred frequently in randomized psychotherapy trials:A meta-epidemiologic study

Objectives: This study aimed to investigate the relationship between trial registration, trial discrepancy from registered protocol, and spin in nonpharmacological trials. Study Design and Setting: Recent psychotherapy trials on depression (2015-2018) were analyzed regarding their registration status and its relationship to discrepancies between registered and published primary outcomes and to spin (discrepancy between the nonsignificant finding in a study and an overly beneficial interpretation of the effect of the treatment). Results: A total of 196 trials were identified, of which 78 (40%) had been registered prospectively and 56 (29%) had been registered retrospectively. In 102 (76%) of 134 registered trials, discrepancies between trial and protocol were present. Of 72 trials with a nonsignif-icant difference between treatments for the primary outcome, 68 trials (94%) showed spin. Discrepancies from protocol were less frequent in prospectively than in retrospectively registered trials (odds ratio5 0.19; 95% confidence interval [CI]: 0.07-0.52), but regarding the amount of spin, there was no difference between prospectively and retrospectively registered trials (rb=0.12; 95% CI: -0.41 to 0.19) or between registered and unregistered trials (rb=0.22, 95% CI -0.49 to 0.08). Conclusion: Protocol discrepancies and spin have a high prevalence in psychotherapy outcome research. The results show no relation between registration and spin, but prospective registration may prevent discrepancies from protocol

Eine bakterielle Inaktivierung des Steroidhormons Ecdysteron

Aus einer wäßrigen Lösung des Crustaceenäautungshormons Ecdysteron wurden Bakterien in Reinkultur isoliert, die das Hormon abzubauen vermögen. Die mögliche Bedeutung der bakteriellen Inaktivierung des Ecdysterons wird diskutiert. A bacterium which is able to degrade the crustacean malting hormone ecdysterone was isolated from an aqueous solution of the hormone. The possible significance of this inactivation by bacteria is discussed

Neubewertung des historischen Schadensbebens von 1735 im Westerwald = Re­-evaluation of the historical 1735 earthquake in the Westerwald/Germany

Am 22. August 1735 ereignete sich gegen halb drei Uhr morgens ein Erdbeben, welches laut den historischen Erdbebenkatalogen in einem seismisch wenig aktiven Gebiet bei Gießen/Mittelhessen lokalisiert war und eine Epizentralintensität I0 von V und eine Magnitude ML = 4,4 hatte. Nach Auswertung neuer historischer Quellen ereignete sich das Erdbeben etwa 50 km weiter westlich im südlichen bis zentralen Teil des Westerwalds und erzeugte leichte Gebäudeschäden entsprechend Maximalintensitäten von VI. Das Spürbarkeitsgebiet war NWSO ausgerichtet und hatte einen mittleren Radius von etwa 80 km. In Kombination mit der neu bestimmten Maximalintensität kann daraus eine Lokalmagnitude ML = 4,2 ± 0,4 und eine Herdtiefe im Bereich der Oberkruste von ungefähr 10 km abgeschätzt werden. Das Beben ereignete sich somit in einem Gebiet nahe der Epizentren der Erdbebenserie von Bad Marienberg im Jahr 1982 mit Magnituden bis ML = 4,2. Die örtliche Nähe lässt die Vermutung zu, dass auch das historische Erdbeben von 1735 auf der Bad Marienberger Bruchzone stattfand und somit einen Hinweis auf wiederholte Erdbebentätigkeit in der sonst als aseismisch betrachteten Region darstellt