New accurate measurement of 36ArH+ and 38ArH+ ro-vibrational transitions by high resolution IR absorption spectroscopy

The protonated Argon ion, $^{36}$ArH$^{+}$, has been identified recently in the Crab Nebula (Barlow et al. 2013) from Herschel spectra. Given the atmospheric opacity at the frequency of its $J$=1-0 and $J$=2-1 rotational transitions (617.5 and 1234.6 GHz, respectively), and the current lack of appropriate space observatories after the recent end of the Herschel mission, future studies on this molecule will rely on mid-infrared observations. We report on accurate wavenumber measurements of $^{36}$ArH$^{+}$ and $^{38}$ArH$^{+}$ rotation-vibration transitions in the $v$=1-0 band in the range 4.1-3.7 $\mu$m (2450-2715 cm$^{-1}$). The wavenumbers of the $R$(0) transitions of the $v$=1-0 band are 2612.50135$\pm$0.00033 and 2610.70177$\pm$0.00042 cm$^{-1}$ ($\pm3\sigma$) for $^{36}$ArH$^{+}$ and $^{38}$ArH$^{+}$, respectively. The calculated opacity for a gas thermalized at a temperature of 100 K and a linewidth of 1 km.s$^{-1}$ of the $R$(0) line is $1.6\times10^{-15}\times N$($^{36}$ArH$^+$). For column densities of $^{36}$ArH$^+$ larger than $1\times 10^{13}$ cm$^{-2}$, significant absorption by the $R$(0) line can be expected against bright mid-IR sources

Atomic and molecular interstellar absorption lines toward the high galactic latitude stars HD~141569 and HD~157841 at ultra-high resolution

We present ultra-high resolution (0.32 km/s) spectra obtained with the 3.9m Anglo-Australian Telescope (AAT) and Ultra-High-Resolution Facility (UHRF), of interstellar NaI D1, D2, Ca II K, K I and CH absorption toward two high galactic latitude stars HD141569 and HD157841. We have compared our data with 21-cm observations obtained from the Leiden/Dwingeloo HI survey. We derive the velocity structure, column densities of the clouds represented by the various components and identify the clouds with ISM structures seen in the region at other wavelengths. We further derive abundances, linear depletions and H2 fractional abundances for these clouds, wherever possible. Toward HD141569, we detect two components in our UHRF spectra : a weak, broad component at - 15 km/s, seen only in CaII K absorption and another component at 0 km/s, seen in NaI D1, D2, Ca II K, KI and CH absorption. In the case of the HD157841 sightline, a total of 6 components are seen on our UHRF spectra in NaI D1, D2 Ca II K, K I and CH absorption. 2 of these 6 components are seen only in a single species.Comment: 16 pages, Latex, 4 figures, ps files Astrophysical Journal (in press

Acceleration and Substructure Constraints in a Quasar Outflow

We present observations of probable line-of-sight acceleration of a broad absorption trough of C IV in the quasar SDSS J024221.87+004912.6. We also discuss how the velocity overlap of two other outflowing systems in the same object constrains the properties of the outflows. The Si IV doublet in each system has one unblended transition and one transition which overlaps with absorption from the other system. The residual flux in the overlapping trough is well fit by the product of the residual fluxes in the unblended troughs. For these optically thick systems to yield such a result, at least one of them must consist of individual subunits rather than being a single structure with velocity-dependent coverage of the source. If these subunits are identical, opaque, spherical clouds, we estimate the cloud radius to be r = 3.9 10^15 cm. If they are identical, opaque, linear filaments, we estimate their width to be w = 6.5 10^14 cm. These subunits are observed to cover the Mg II broad emission line region of the quasar, at which distance from the black hole the above filament width is equal to the predicted scale height of the outer atmosphere of a thin accretion disk. Insofar as that scale height is a natural size scale for structures originating in an accretion disk, these observations are evidence that the accretion disk can be a source of quasar absorption systems. Based on data from ESO program 075.B-0190(A).Comment: 14 emulateapj pages, 7 figures, ApJ in pres

Topiramate improves neurovascular function, epidermal nerve fiber morphology, and metabolism in patients with type 2 diabetes mellitus

Amanda L Boyd, Patricia M Barlow, Gary L Pittenger, Kathryn F Simmons, Aaron I VinikDepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USAPurpose: To assess the effects of topiramate on C-fiber function, nerve fiber morphology, and metabolism (including insulin sensitivity, obesity, and dyslipidemia) in type 2 diabetes.Patients and methods: We conducted an 18-week, open-label trial treating patients with topiramate. Twenty subjects with type 2 diabetes and neuropathy (61.5 ± 1.29 years; 15 male, 5 female) were enrolled and completed the trial. Neuropathy was evaluated by total neuropathy scores, nerve conduction studies, quantitative sensory tests, laser Doppler skin blood flow, and intraepidermal nerve fibers in skin biopsies.Results: Topiramate treatment improved symptoms compatible with C-fiber dysfunction. Weight, blood pressure, and hemoglobin A1c also improved. Laser Doppler skin blood flow improved significantly after 12 weeks of treatment, but returned to baseline at 18 weeks. After 18 weeks of treatment there was a significant increase in intraepidermal nerve fiber length at the forearm, thigh, and proximal leg. Intraepidermal nerve fiber density was significantly increased by topiramate in the proximal leg.Conclusion: This study is the first to demonstrate that it is possible to induce skin intraepidermal nerve fiber regeneration accompanied by enhancement of neurovascular function, translating into improved symptoms as well as sensory nerve function. The simultaneous improvement of selective metabolic indices may play a role in this effect, but this remains to be determined.Keywords: diabetic neuropathy, skin blood flow, skin biopsy, diabete

Knowledge-based vision and simple visual machines

The vast majority of work in machine vision emphasizes the representation of perceived objects and events: it is these internal representations that incorporate the 'knowledge' in knowledge-based vision or form the 'models' in model-based vision. In this paper, we discuss simple machine vision systems developed by artificial evolution rather than traditional engineering design techniques, and note that the task of identifying internal representations within such systems is made difficult by the lack of an operational definition of representation at the causal mechanistic level. Consequently, we question the nature and indeed the existence of representations posited to be used within natural vision systems (i.e. animals). We conclude that representations argued for on a priori grounds by external observers of a particular vision system may well be illusory, and are at best place-holders for yet-to-be-identified causal mechanistic interactions. That is, applying the knowledge-based vision approach in the understanding of evolved systems (machines or animals) may well lead to theories and models that are internally consistent, computationally plausible, and entirely wrong

High-Resolution Observations of Interstellar Ca I Absorption -- Implications for Depletions and Electron Densities in Diffuse Clouds

We present high-resolution (FWHM ~ 0.3-1.5 km/s) spectra of interstellar Ca I absorption toward 30 Galactic stars. Comparisons of the column densities of Ca I, Ca II, K I, and other species -- for individual components identified in the line profiles and also when integrated over entire lines of sight -- yield information on relative electron densities and depletions. There is no obvious relationship between the ratio N(Ca I)/N(Ca II) [equal to n_e/(Gamma/alpha_r) for photoionization equilibrium] and the fraction of hydrogen in molecular form f(H2) (often taken to be indicative of the local density n_H). For a smaller sample of sightlines for which the thermal pressure (n_H T) and local density can be estimated via analysis of the C I fine-structure excitation, the average electron density inferred from C, Na, and K (assuming photoionization equilibrium) seems to be independent of n_H and n_H T. While the n_e obtained from the ratio N(Ca I)/N(Ca II) is often significantly higher than the values derived from other elements, the patterns of relative n_e derived from different elements show both similarities and differences for different lines of sight -- suggesting that additional processes besides photoionization and radiative recombination commonly and significantly affect the ionization balance of heavy elements in diffuse IS clouds. Such additional processes may also contribute to the (apparently) larger than expected fractional ionizations (n_e/n_H) found for some lines of sight with independent determinations of n_H. In general, inclusion of ``grain-assisted'' recombination does reduce the inferred n_e, but it does not reconcile the n_e estimated from different elements. The depletion of calcium may have a much weaker dependence on density than was suggested by earlier comparisons with CH and CN.Comment: aastex, 70 pages, accepted to ApJ

Properties of shocked dust grains in supernova remnants

Shockwaves driven by supernovae both destroy dust and reprocess the surviving grains, greatly affecting the resulting dust properties of the interstellar medium (ISM). While these processes have been extensively studied theoretically, observational constraints are limited. We use physically-motivated models of dust emission to fit the infrared (IR) spectral energy distributions of seven Galactic supernova remnants, allowing us to determine the distribution of dust mass between diffuse and dense gas phases, and between large and small grain sizes. We find that the dense ($\sim 10^3 \,{\rm cm}^{-3}$), relatively cool ($\sim 10^3 \, {\rm K}$) gas phase contains $>90\%$ of the dust mass, making the warm dust located in the X-ray emitting plasma ($\sim 1 \,{\rm cm}^{-3}$/$10^6 \, {\rm K}$) a negligible fraction of the total, despite dominating the mid-IR emission. The ratio of small ($\lesssim 10 \, {\rm nm}$) to large ($\gtrsim 0.1 \, {\rm \mu m}$) grains in the cold component is consistent with that in the ISM, and possibly even higher, whereas the hot phase is almost entirely devoid of small grains. This suggests that grain shattering, which processes large grains into smaller ones, is ineffective in the low-density gas, contrary to model predictions. Single-phase models of dust destruction in the ISM, which do not account for the existence of the cold swept-up material containing most of the dust mass, are likely to greatly overestimate the rate of dust destruction by supernovae.Comment: 13 pages, 12 figures. MNRAS accepte

Revisiting the dust destruction efficiency of supernovae

Dust destruction by supernovae is one of the main processes removing dust from the interstellar medium (ISM). Estimates of the efficiency of this process, both theoretical and observational, typically assume a shock propagating into a homogeneous medium, whereas the ISM possesses significant substructure in reality. We self-consistently model the dust and gas properties of the shocked ISM in three supernova remnants (SNRs), using X-ray and infrared (IR) data combined with corresponding emission models. Collisional heating by gas with properties derived from X-ray observations produces dust temperatures too high to fit the far-IR fluxes from each SNR. An additional colder dust component is required, which has a minimum mass several orders of magnitude larger than that of the warm dust heated by the X-ray emitting gas. Dust-to-gas mass ratios indicate that the majority of the dust in the X-ray emitting material has been destroyed, while the fraction of surviving dust in the cold component is plausibly close to unity. As the cold component makes up virtually all the total dust mass, destruction timescales based on homogeneous models, which cannot account for multiple phases of shocked gas and dust, may be significantly overestimating actual dust destruction efficiencies, and subsequently underestimating grain lifetimes

The dust mass in Cassiopeia A from a spatially resolved Herschel analysis

Theoretical models predict that core-collapse supernovae (CCSNe) can be efficient dust producers (0.1–1.0 M⊙), potentially accounting for most of the dust production in the early Universe. Observational evidence for this dust production efficiency is however currently limited to only a few CCSN remnants (e.g. SN 1987A, Crab nebula). In this paper, we revisit the dust mass produced in Cassiopeia A (Cas A), a ∼330-yr old O-rich Galactic supernova remnant (SNR) embedded in a dense interstellar foreground and background. We present the first spatially resolved analysis of Cas A based on Spitzer and Herschel infrared and submillimetre data at a common resolution of ∼0.6 arcmin for this 5 arcmin diameter remnant following a careful removal of contaminating line emission and synchrotron radiation. We fit the dust continuum from 17 to 500 μm with a four-component interstellar medium and supernova (SN) dust model. We find a concentration of cold dust in the unshocked ejecta of Cas A and derive a mass of 0.3–0.5 M⊙ of silicate grains freshly produced in the SNR, with a lower limit of ≥0.1–0.2 M⊙. For a mixture of 50 per cent of silicate-type grains and 50 per cent of carbonaceous grains, we derive a total SN dust mass between 0.4 and 0.6 M⊙. These dust mass estimates are higher than from most previous studies of Cas A and support the scenario of SN-dominated dust production at high redshifts. We furthermore derive an interstellar extinction map for the field around Cas A which towards Cas A gives average values of AV = 6–8 mag, up to a maximum of AV = 15 mag