CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Propuesta para la aplicación de reingeniería en la empresa Sincrón-diseño electrónico Ltda

Tesis (ingeniero industrial)-- Corporación Universitaria Autónoma de Occidente. División de Ingenierías, 1997PregradoIngeniero(a) Industria

Propuesta para la aplicación de reingeniería en la empresa Sincrón-diseño electrónico Ltda

Tesis (ingeniero industrial)-- Corporación Universitaria Autónoma de Occidente. División de Ingenierías, 199

Maskana. Revista Científica

Estudio cualitativo observacional que explora sobre los sentimientos y reacciones de los padres con hijos con Síndrome de Down (SD) a través de un grupo focal con 8 personas y de entrevistas semiestructuradas. Los niños participantes en la investigación pertenecieron a un Centro de Atención para personas con SD de la ciudad de Cuenca, Ecuador. La investigación identificó el significado cultural sobre las personas con SD, los sentimientos de los padres, el impacto en la familia y la comunicación de la noticia en el servicio de salud. El estudio reveló que las actitudes negativas con respecto a las personas con SD persisten. Adicionalmente, las entrevistas dieron luces sobre las respuestas de adaptación de los padres y de las familias. Por último, pero no menos importante, se reconoce la necesidad de mejorar la comunicación del personal de salud de acuerdo a los sentimientos y funcionamiento familiar para la aceptación y el cuidado de las personas con SD. Los resultados conducen a desarrollar programas de asesoramiento para las personas con SD, sus familias y para aumentar la conciencia y el apoyo social de la comunidad.The paper presents the results of a qualitative observational study mapping the emotional responses of a focus group of 8 persons with children with Down Syndrome. The respondents also completed a semi-structured questionnaire. The children of the focus group all belong to the DS daycare centre of the city of Cuenca, Ecuador. The group interview and questionnaire addressed respectively the crossculturally stigma and discrimination versus persons with DS, the parent’s feelings, the impact on the whole family, and the communication with the health care sector. The study revealed that in Cuenca city the negative attitude regarding DS persons still persists. Additionally, the survey shed light on the responses and adaption of parents and families. Last but not least it is recognized that improved communication with health care personnel, knowledgeable of the emotional attitude of parents and family functioning, will be beneficial for the acceptance and care-taking of DS persons. Findings leads to the necessity of developing counseling programs for children with DS and their families, and underscores the vital need to increase community awareness and social support.CuencaVol. 4; no. 2 (2013

Acute physiological responses in different recovery intervals between series of leg press 45º.

O objetivo do presente estudo foi comparar as respostas fisiológicas agudas da frequência cardíaca (FC), pressão arterial sistólica (PAS), duplo produto (DP), índice de perceção de esforço (IPE) e lactato sanguíneo (LA) no exercício resistido (ER) entre um e dois minutos de intervalo de recuperação entre séries de exercícios. A amostra foi composta por 12 homens universitários voluntários, aparentemente saudáveis, com idade entre 20 a 32 anos (24.6 ± 3.7 anos de idade; massa corporal 71.3 ± 8.7 kg; estatura 178 ± 5.6 cm; gordura corporal 11.5 ± 4.5%). Todos os participantes foram submetidos ao teste de uma repetição máxima (1-RM) no exercício leg press 45º. Foram realizadas três séries de dez repetições a 60% de 1-RM no leg press 45º. Apenas o LA e a FC não apresentaram diferenças significativas entre 1 e 2 minutos. Analisando o efeito das séries subsequentes, a FC, PAS, DP e IPE foram significativamente maiores (p ≤ .05) na 3ª, 2ª e 1ª séries, respetivamente. Menor intervalo de recuperação entre as séries (um minuto) proporciona maior sobrecarga cardiovascular aguda (PAS e DP) em relação a um intervalo maior (dois minutos) no ER de membro inferior em jovens universitários.The aim was to compare the acute physiological responses of cardiac frequency (CF), systolic blood pressure (SBP), double product (DP), perception of strain index (PSI) and blood lactate (BL) in resistance exercise (RE) between one and two minutes of recovery interval among exercise sets. The sample was composed by 12 voluntary male college students, apparently healthy, with ages between 20 and 32 years (24.6 ± 3.7 years of age; body mass 71.3 ± 8.7 kg; stature 178 ± 5.6 cm; body fat 11.5 ± 4.5%). All participants were submitted to the maximum repeat test (1-RM) on the leg press 45º exercise. Three sets of ten repetitions at 60% of 1-RM in the leg press 45º exercise were performed. Results indicated that only the BL and the CF did not show significant differences between one and two minutes. Analyzing the effect of subsequent sets, the CF, SBP, DP and PSI were significant superior (p ≤ .05) in the 3rd, 2nd and 1st sets, respectively. In conclusion, minor interval of recovery among the sets (one minute) provides greater acute cardiovascular overload (SBP and DP) in relation to a major interval (two minutes) on the RE of the inferior members of young college students

Maskana. Revista Científica

Estudio cualitativo observacional que explora sobre los sentimientos y reacciones de los padres con hijos con Síndrome de Down (SD) a través de un grupo focal con 8 personas y de entrevistas semiestructuradas. Los niños participantes en la investigación pertenecieron a un Centro de Atención para personas con SD de la ciudad de Cuenca, Ecuador. La investigación identificó el significado cultural sobre las personas con SD, los sentimientos de los padres, el impacto en la familia y la comunicación de la noticia en el servicio de salud. El estudio reveló que las actitudes negativas con respecto a las personas con SD persisten. Adicionalmente, las entrevistas dieron luces sobre las respuestas de adaptación de los padres y de las familias. Por último, pero no menos importante, se reconoce la necesidad de mejorar la comunicación del personal de salud de acuerdo a los sentimientos y funcionamiento familiar para la aceptación y el cuidado de las personas con SD. Los resultados conducen a desarrollar programas de asesoramiento para las personas con SD, sus familias y para aumentar la conciencia y el apoyo social de la comunidad.The paper presents the results of a qualitative observational study mapping the emotional responses of a focus group of 8 persons with children with Down Syndrome. The respondents also completed a semi-structured questionnaire. The children of the focus group all belong to the DS daycare centre of the city of Cuenca, Ecuador. The group interview and questionnaire addressed respectively the crossculturally stigma and discrimination versus persons with DS, the parent’s feelings, the impact on the whole family, and the communication with the health care sector. The study revealed that in Cuenca city the negative attitude regarding DS persons still persists. Additionally, the survey shed light on the responses and adaption of parents and families. Last but not least it is recognized that improved communication with health care personnel, knowledgeable of the emotional attitude of parents and family functioning, will be beneficial for the acceptance and care-taking of DS persons. Findings leads to the necessity of developing counseling programs for children with DS and their families, and underscores the vital need to increase community awareness and social support.Cuencavolumen 4, número 2 (2013

Maskana. Revista Científica

Estudio cualitativo observacional que explora sobre los sentimientos y reacciones de los padres con hijos con Síndrome de Down (SD) a través de un grupo focal con 8 personas y de entrevistas semiestructuradas. Los niños participantes en la investigación pertenecieron a un Centro de Atención para personas con SD de la ciudad de Cuenca, Ecuador. La investigación identificó el significado cultural sobre las personas con SD, los sentimientos de los padres, el impacto en la familia y la comunicación de la noticia en el servicio de salud. El estudio reveló que las actitudes negativas con respecto a las personas con SD persisten. Adicionalmente, las entrevistas dieron luces sobre las respuestas de adaptación de los padres y de las familias. Por último, pero no menos importante, se reconoce la necesidad de mejorar la comunicación del personal de salud de acuerdo a los sentimientos y funcionamiento familiar para la aceptación y el cuidado de las personas con SD. Los resultados conducen a desarrollar programas de asesoramiento para las personas con SD, sus familias y para aumentar la conciencia y el apoyo social de la comunidad.The paper presents the results of a qualitative observational study mapping the emotional responses of a focus group of 8 persons with children with Down Syndrome. The respondents also completed a semi-structured questionnaire. The children of the focus group all belong to the DS daycare centre of the city of Cuenca, Ecuador. The group interview and questionnaire addressed respectively the crossculturally stigma and discrimination versus persons with DS, the parent’s feelings, the impact on the whole family, and the communication with the health care sector. The study revealed that in Cuenca city the negative attitude regarding DS persons still persists. Additionally, the survey shed light on the responses and adaption of parents and families. Last but not least it is recognized that improved communication with health care personnel, knowledgeable of the emotional attitude of parents and family functioning, will be beneficial for the acceptance and care-taking of DS persons. Findings leads to the necessity of developing counseling programs for children with DS and their families, and underscores the vital need to increase community awareness and social support.CuencaVol. 4; no. 2 (2013

Actas del IV congreso sobre la enseñanza del español en Portugal : Universidade de Évora 2, 3 y 4 de junio de 2011

Resumen basado en el de la publicación.Se recogen las comunicaciones y talleres presentados durante el IV Congreso sobre la enseñanza del español en Portugal que se celebró en las instalaciones de la Universidade de Évora los días 2, 3 y 4 de junio de 2011. Se presentaron un total de once comunicaciones y catorce talleres a cargo de profesores de español de todos los niveles educativos y de representantes de editoriales españolas. Durante el congreso fue posible asistir tanto a ponencias de contenido académico como a talleres y presentaciones de experiencias de aula por lo que el evento generó bastante interés y contó con una asistencia de 200 profesionales.ES

International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module

We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2007-December 2012 in 503 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study using the Centers for Disease Control and Prevention's (CDC) U.S. National Healthcare Safety Network (NHSN) definitions for device-associated health care–associated infection (DA-HAI), we collected prospective data from 605,310 patients hospitalized in the INICC's ICUs for an aggregate of 3,338,396 days. Although device utilization in the INICC's ICUs was similar to that reported from ICUs in the U.S. in the CDC's NHSN, rates of device-associated nosocomial infection were higher in the ICUs of the INICC hospitals: the pooled rate of central line–associated bloodstream infection in the INICC's ICUs, 4.9 per 1,000 central line days, is nearly 5-fold higher than the 0.9 per 1,000 central line days reported from comparable U.S. ICUs. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days) as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days). Frequencies of resistance of Pseudomonas isolates to amikacin (42.8% vs 10%) and imipenem (42.4% vs 26.1%) and Klebsiella pneumoniae isolates to ceftazidime (71.2% vs 28.8%) and imipenem (19.6% vs 12.8%) were also higher in the INICC's ICUs compared with the ICUs of the CDC's NHSN