14,400 research outputs found
Local transient rheological behavior of concentrated suspensions
This paper reports experiments on the shear transient response of
concentrated non-Brownian suspensions. The shear viscosity of the suspensions
is measured using a wide-gap Couette rheometer equipped with a Particle Image
Velocimetry (PIV) device that allows measuring the velocity field. The
suspensions made of PMMA particles (31m in diameter) suspended in a
Newtonian index- and density-matched liquid are transparent enough to allow an
accurate measurement of the local velocity for particle concentrations as high
as 50%. In the wide-gap Couette cell, the shear induced particle migration is
evidenced by the measurement of the time evolution of the flow profile. A
peculiar radial zone in the gap is identified where the viscosity remains
constant. At this special location, the local particle volume fraction is taken
to be the mean particle concentration. The local shear transient response of
the suspensions when the shear flow is reversed is measured at this point where
the particle volume fraction is well defined. The local rheological
measurements presented here confirm the macroscopic measurements of
Gadala-Maria and Acrivos (1980). After shear reversal, the viscosity undergoes
a step-like reduction, decreases slower and passes through a minimum before
increasing again to reach a plateau. Upon varying the particle concentration,
we have been able to show that the minimum and the plateau viscosities do not
obey the same scaling law with respect to the particle volume fraction. These
experimental results are consistent with the scaling predicted by Mills and
Snabre (2009) and with the results of numerical simulation performed on random
suspensions [Sierou and Brady (2001)]. The minimum seems to be associated with
the viscosity of an isotropic suspension, or at least of a suspension whose
particles do not interact through non-hydrodynamic forces, while the plateau
value would correspond to the viscosity of a suspension structured by the shear
where the non-hydrodynamic forces play a crucial role
Recommended from our members
BaBar simulation production - A millennium of work in under a year
The BaBar experiment requires simulated events beyond the ability of a single computing site to provide. This paper describes the evolution of simulation and job management methods to meet the physics community requirements and how production became distributed to use resources beyond any one computing center. The evolution of BaBar simulation along with the development of the distribution of the computing effort is described. As the computing effort is distributed to more sites there is a need to simplify production so the effort does not multiply with number of production centers. Tools are created to be flexible in handling errors and failures that happen in the system and respond accordingly, this reduces failure rates and production effort. This paper will focus on one cycle of simulation production within BaBar as a description of a large scale computing effort which was fully performed, and provided new simulation data to the users on time
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination.
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis. Evidence suggests that the therapeutic benefit of FTY720 occurs by preventing the egress of lymphocytes from lymph nodes thereby inhibiting the infiltration of disease-causing lymphocytes into the central nervous system (CNS). We hypothesized that FTY720 treatment would affect lymphocyte migration to the CNS and influence disease severity in a mouse model of viral-induced neurologic disease.MethodsMice were infected intracranially with the neurotropic JHM strain of mouse hepatitis virus. Infected animals were treated with increasing doses (1, 3 and 10 mg/kg) of FTY720 and morbidity and mortality recorded. Infiltration of inflammatory virus-specific T cells (tetramer staining) into the CNS of FTY720-treated mice was determined using flow cytometry. The effects of FTY720 treatment on virus-specific T cell proliferation, cytokine production and cytolytic activity were also determined. The severity of neuroinflammation and demyelination in FTY720-treated mice was examined by flow cytometry and histopathologically, respectively, in the spinal cords of the mice.ResultsAdministration of FTY720 to JHMV-infected mice resulted in increased clinical disease severity and mortality. These results correlated with impaired ability to control viral replication (P < 0.05) within the CNS at days 7 and 14 post-infection, which was associated with diminished accumulation of virus-specific CD4+ and CD8+ T cells (P < 0.05) into the CNS. Reduced neuroinflammation in FTY720-treated mice correlated with increased retention of T lymphocytes within draining cervical lymph nodes (P < 0.05). Treatment with FTY720 did not affect virus-specific T cell proliferation, expression of IFN-γ, TNF-α or cytolytic activity. FTY720-treated mice exhibited a reduction in the severity of demyelination associated with dampened neuroinflammation.ConclusionThese findings indicate that FTY720 mutes effective anti-viral immune responses through impacting migration and accumulation of virus-specific T cells within the CNS during acute viral-induced encephalomyelitis. FTY720 treatment reduces the severity of neuroinflammatory-mediated demyelination by restricting the access of disease-causing lymphocytes into the CNS but is not associated with viral recrudescence in this model
Embeddings of SL(2,Z) into the Cremona group
Geometric and dynamic properties of embeddings of SL(2,Z) into the Cremona
group are studied. Infinitely many non-conjugate embeddings which preserve the
type (i.e. which send elliptic, parabolic and hyperbolic elements onto elements
of the same type) are provided. The existence of infinitely many non-conjugate
elliptic, parabolic and hyperbolic embeddings is also shown.
In particular, a group G of automorphisms of a smooth surface S obtained by
blowing-up 10 points of the complex projective plane is given. The group G is
isomorphic to SL(2,Z), preserves an elliptic curve and all its elements of
infinite order are hyperbolic.Comment: to appear in Transformation Group
Dependence of Nebular Heavy-Element Abundance on H I Content for Spiral Galaxies
We analyze the galactic H I content and nebular log(O/H) for 60 spiral
galaxies in the Moustakas et al. (2006) spectral catalog. After correcting for
the mass-metallicity relationship, we show that the spirals in cluster
environments show a positive correlation for log(O/H) on DEF, the galactic H I
deficiency parameter, extending the results of previous analyses of the Virgo
and Pegasus I clusters. Additionally, we show for the first time that galaxies
in the field obey a similar dependence. The observed relationship between H I
deficiency and galactic metallicity resembles similar trends shown by
cosmological simulations of galaxy formation including inflows and outflows.
These results indicate the previously observed metallicity-DEF correlation has
a more universal interpretation than simply a cluster's effects on its member
galaxies. Rather, we observe in all environments the stochastic effects of
metal-poor infall as minor mergers and accretion help to build giant spirals.Comment: Accepted for publication in Ap
Resistive Switching Assisted by Noise
We extend results by Stotland and Di Ventra on the phenomenon of resistive
switching aided by noise. We further the analysis of the mechanism underlying
the beneficial role of noise and study the EPIR (Electrical Pulse Induced
Resistance) ratio dependence with noise power. In the case of internal noise we
find an optimal range where the EPIR ratio is both maximized and independent of
the preceding resistive state. However, when external noise is considered no
beneficial effect is observed.Comment: To be published in "Theory and Applications of Nonlinear Dynamics:
Model and Design of Complex Systems", Proceedings of ICAND 2012 (Springer,
2013
Non-rationality of some fibrations associated to Klein surfaces
We study the polynomial fibration induced by the equation of the Klein
surfaces obtained as quotient of finite linear groups of automorphisms of the
plane; this surfaces are of type A, D, E, corresponding to their singularities.
The generic fibre of the polynomial fibration is a surface defined over the
function field of the line. We proved that it is not rational in cases D, E,
although it is obviously rational in the case A.
The group of automorphisms of the Klein surfaces is also described, and is
linear and of finite dimension in cases D, E; this result being obviously false
in case A.Comment: 18 page
- …