Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

El cuento muy fermoso del enperador Otas de Roma : espejo literario del c\uf3digo caballeresco

Contributo, su invito, in una miscellanea internazionale di studi; saggio di letteratura medievale, nel quale si analizza il ruolo socio-letterario dell\u2019abbigliamento in un testo in prosa castigliana del secolo XIV, attraverso lo studio del lessico dei tessuti, dei colori e dei capi di vestiario

Bodeg&#243;n: estudio de un t&#233;rmino art&#237;stico

This study, starting from the origins of the lemma bodeg\uf3n, sets out to analyse the reasons for its choice in the arts, the meanings it was attributed and its semantic evolution along the centuries. For this purpose, a series of Tratados art\uedsticos (artistic treaties) from the XVII century, the time of utmost flourishing of the genre, were taken into account. Starting from the XVIII century and until the end of the XIX century, its registry as an artistic term in general lexicographic works \u2013 both academic and non-academic \u2013 is studied. For the XX and XXI century, this study is focused solely on academic dictionaries and on seven dictionaries on artistic terms published between 1973 and 2001. Since the term naturaleza muerta (still life) enters the artistic terminology starting from the XIX century, and it is considered a synonym of bodeg\uf3n, its evolution is studied here as well