Researcher-led teaching:embodiment of academic practice

This paper explores the embodied practices of leading researchers(and/or leading scholars/practitioners), suggesting that distinctive‘researcher-led teaching’ depends on educators who are willing and able to be their research in the teaching setting. We advocate an approach to the development of higher education pedagogy which makes lead-researchers the objects of inquiry and we summarise case study analyses (in neuroscience and humanities) where the knowledge-making‘signatures’ of academic leaders are used to exhibit the otherwise hidden identities of research. We distinguish between learning readymade knowledge and the process of knowledge in the making and point towards the importance of inquiry in the flesh. We develop a view of higher education teaching that depends upon academic status a priori, but we argue that this stance is inclusive because it has the propensity to locate students as participants in academic culture

A Critical Examination of the Phonics and Structural Analysis Skill Development in the SRA Reading Laboratory IIIa

The study was made in an effort to tabulate all of the phonics and structural analysis skills presented in the SRA Reading Laboratory IIIa as to the various kinds offered; frequency of use; methods of presentation. Also, extensive research was attempted to ascertain leading reading authorities\u27 opinions on the use of these analyses for secondary students. The purpose of the study was to determine whether the SRA Reading Laboratory IIIa would be the best material to use for the retarded and disabled readers at the secondary level

Observaciones sobre la recepción de “Fineza contra fineza” de Calderón: representación y lectura

El significado de “Fineza contra fineza” de Calderón, cuya recepción comienza en 1671, varía para los que sólo la leyeron y para aquellos que la vieron representada. Este trabajo contrasta las diversas recepciones tomando como base las representaciones palaciegas de 1671 y 1717 y un ejemplo de 1672 del texto leído. Acciones que tienen importancia escénica son sólo incidentales en la intriga narrativa y, a su vez, en lo dramático no se destaca el mito, esencial para el texto poético narrativo. Mientras que la representación se orienta a exaltar a los monarcas, la obra leída sería una historia de actos de valor y de amor iniciada con una casualidad

Does ursodeoxycholic acid change the proliferation of the colorectal mucosa? A randomized, placebo-controlled study

Background: In animal models ursodeoxycholic acid (UDCA) showed a chemoprotective effect against colon cancer. To explain this, a reduced proliferation of the colorectal mucosal proliferation was suggested. We, therefore, examined the influence of UDCA on the proliferation of normal colorectal mucosa in humans. Methods: Following endoscopic polypectomy, 20 patients with colorectal adenomas were randomized to receive either UDCA (750 mg/day, n = 10, group A) or placebo (n = 10, group B) for 6 months in a double-blinded way. Colorectal biopsies were sampled before and at the end of the medication by total colonoscopy. Colorectal mucosal proliferation was measured by FACScan analysis of propidium iodine labeling. Serum was sampled, and serum bile acids were analyzed by gas chromatography. Results: The proliferation rates at the end of the study were similar in both groups (median 15.4%; range 12.0-20.9 in group A; median 16.0%, 14.0-20.2 in group B, p = 0.41). Serum lithocholic acid levels at the end of the study were significantly higher in group A (1.3 mumol/l, 0.9-1.8) than in group B (0.7 mumol/l, 0-1.7, p < 0.02), whereas serum deoxycholic acid levels were similar in both groups. Conclusions: In this study, UDCA treatment for 6 months does not seem to induce changes in the proliferative behavior of the colorectal mucosa in patients with adenomas. It seems likely that a putative chemopreventive effect of UDCA in humans is not exerted by a reduction of the colorectal proliferation. Copyright (C) 2003 S. Karger AG, Basel

Coral reefs in crisis: reversing the biotic death spiral

Coral reefs are disappearing due to global warming, overfishing, ocean acidification, pollution, and interactions of these and other stresses. Ecologically informed management of fishes that facilitate corals by suppressing seaweeds may be our best bet for bringing reefs back from the brink of extinction

Introduction: the politicisation of permanent crisis in Europe

Taking stock of the numerous crises that have confronted Europe in the last decade, this special issue investigates the relationship between crisis and the politicisation of the process of European integration. It draws attention in so doing to the epistemic construction of crises. In this conceptual overview, we discuss first, how crises are framed and reframed in relation to the constitutive elements of a political community. Second, we explore the extent to which, and how, the emergence of different understandings of crisis and the ensuing frame competition between them contribute to such politicisation. By elucidating the link between the politics of a now seemingly permanent crisis in Europe and the politicisation of European integration, this introduction sets the framework informing all of the articles in this special issue

The genetic architecture of petal number in Cardamine hirsuta

International audienceInvariant petal number is a characteristic of most flowers and is generally robust to genetic and environmental variation. We took advantage of the natural variation found in Cardamine hirsuta petal number to investigate the genetic basis of this trait in a case where robustness was lost during evolution. We used quantitative trait locus (QTL) analysis to characterize the genetic architecture of petal number. Αverage petal number showed transgressive variation from zero to four petals in five C. hirsuta mapping populations, and this variation was highly heritable. We detected 15 QTL at which allelic variation affected petal number. The effects of these QTL were relatively small in comparison with alleles induced by mutagenesis, suggesting that natural selection may act to maintain petal number within its variable range below four. Petal number showed a temporal trend during plant ageing, as did sepal trichome number, and multi-trait QTL analysis revealed that these age-dependent traits share a common genetic basis. Our results demonstrate that petal number is determined by many genes of small effect, some of which are age-dependent, and suggests a mechanism of trait evolution via the release of cryptic variation

Stochastic variation in Cardamine hirsuta petal number

Background and Aims Floral development is remarkably robust in terms of the identity and number of floral organs in each whorl, whereas vegetative development can be quite plastic. This canalization of flower development prevents the phenotypic expression of cryptic genetic variation, even in fluctuating environments. A cruciform perianth with four petals is a hallmark of the Brassicaceae family, typified in the model species Arabidopsis thaliana. However, variable petal loss is found in Cardamine hirsuta, a genetically tractable relative of A. thaliana. Cardamine hirsuta petal number varies in response to stochastic, genetic and environmental perturbations, which makes it an interesting model to study mechanisms of decanalization and the expression of cryptic variation. Methods Multitrait quantitative trait locus (QTL) analysis in recombinant inbred lines (RILs) was used to identify whether the stochastic variation found in C. hirsuta petal number had a genetic basis. Key Results Stochastic variation (standard error of the average petal number) was found to be a heritable phenotype, and four QTL that influenced this trait were identified. The sensitivity to detect these QTL effects was increased by accounting for the effect of ageing on petal number variation. All QTL had significant effects on both average petal number and its standard error, indicating that these two traits share a common genetic basis. However, for some QTL, a degree of independence was found between the age of the flowers where allelic effects were significant for each trait. Conclusions Stochastic variation in C. hirsuta petal number has a genetic basis, and common QTL influence both average petal number and its standard error. Allelic variation at these QTL can, therefore, modify petal number in an age-specific manner via effects on the phenotypic mean and stochastic variation. These results are discussed in the context of trait evolution via a loss of robustness

Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis

One strategy to control mosquito-borne diseases, such as malaria and dengue fever, on a regional scale is to use gene drive systems to spread disease-refractory genes into wild mosquito populations. The development of a synthetic Medea element that has been shown to drive population replacement in laboratory Drosophila populations has provided encouragement for this strategy but has also been greeted with caution over the concern that transgenes may spread into countries without their consent. Here, we propose a novel gene drive system, inverse Medea, which is strong enough to bring about local population replacement but is unable to establish itself beyond an isolated release site. The system consists of 2 genetic components—a zygotic toxin and maternal antidote—which render heterozygous offspring of wild-type mothers unviable. Through population genetic analysis, we show that inverse Medea will only spread when it represents a majority of the alleles in a population. The element is best located on an autosome and will spread to fixation provided any associated fitness costs are dominant and to very high frequency otherwise. We suggest molecular tools that could be used to build the inverse Medea system and discuss its utility for a confined release of transgenic mosquitoes