Frequency of Hyponatremia in Gastroentric Patients Treated with Intravenous Hypotonic Fluid

How to Cite This Article: Badeli HR, Golshekan K, Shahrdami M, Azizi Asl MR, Hassanzadeh Rad A. Frequency of Hyponatremia in Gastroentric Patients Treated with Intravenous Hypotonic Fluid. J Ped.  Nephrology 2013 July;1(1):23-27. Introduction: Acute gastroenteritis (AGE) is one of the most common infectious illnesses of childhood. While no treatment is needed for self-limited virus-induced AGE, dehydration caused by diarrhea and emesis is of great concern and should be treated vigorously. However, there is no consensus on the most appropriate electrolyte composition of intravenous fluids; therefore, according to basic protocols in our hospital which suggest hypotonic fluid therapy for AGE, investigators aimed to assess the frequency of hyponatremia in gastroenteritis patients treated with intravenous hypotonic fluid therapy.Materials and Methods: This descriptive observational study was conducted at 17 Shahrivar Pediatrics Hospital between September 2008 and January 2011. The patients’ medical records were assessed and children aged between 1 month and 14 years with a diagnosis of gastroenteritis and dehydration were enrolled in the study. According to sodium concentration at T0, patients were divided into three groups: hyponatremic, hypernatrmic and isonatremic. The blood samples were analyzed for the sodium concentration at T0 and during 24 hours. Statistical analyses were performed by T test and chi-square using SPSS18 and statistical significance was defined as a p-value less than 0.05.Results: The mean age of the participants was 16.43±11.1 months; 58 patients were male (67.4%) and 28 were female (32.6%). At T0, 35 patients (40.7%) were hyponatremic, 2 patients (2.3%) were hypernatremic and 49 patients were isonatremic. Sodium concentration in the hyponatremic and isonatrmic group were 137.25±1.9 and 138.29±2.04 mEq/L respectively which showed a significant difference (p=0.028).Conclusions: Our study showed that increased sodium intake could decrease acquired hyponatremia. It seems that hyponatremia could be prevented by administering high sodium concentration fluids. Keywords: Hyponatremia; Gastroenteritis; Hypotonic Solution; Intravenous Infusio

Identification of a novel mutation in ARSA gene in three patients of an Iranian family with metachromatic leukodystrophy disorder

<div><p>Abstract Metachromatic leukodystrophy disorder (MLD) is an autosomal recessive and lysosomal storage disease. The disease is caused by the deficiency of the enzyme arylsulfatase A (ARSA) which is encoded by the ARSA gene. Different mutations have been reported in different populations. The present study was aimed to detect the mutation type of the ARSA gene in three relative Iranian patients. We found a novel homozygous missense mutation c.1070 G > T (p.Gly357Val) in exon 6 of these patients. The mutation was found to be reported for the first time in MLD patients. The data can update the mutation profile and contribute toward improved clinical management and counseling of MLD patients.</p></div

Global Burden of Cardiovascular Diseases and Risks, 1990-2022

Age-standardized CVD mortality rates by regionranged from 73.6 per 100,000 in High-income Asia Pacific to432.3 per 100,000 in Eastern Europe in 2022. Global CVDmortality decreased by 34.9% from 1990 to 2022. Ischemicheart disease had the highest global age-standardized DALYsof all diseases at 2,275.9 per 100,000. Intracerebralhemorrhage and ischemic stroke were the next highest CVDcauses for age-standardized DALYs. Age-standardized CVDprevalence ranged from 5,881.0 per 100,000 in South Asia to11,342.6 per 100,000 in Central Asia. High systolic bloodpressure accounted for the largest number of attributableage-standardized CVD DALYs at 2,564.9 per 100,000globally. Of all risks, household air pollution from solid fuelshad the largest change in attributable age-standardizedDALYs from 1990 to 2022 with a 65.1% decrease