Effect of omega-3 polyunsaturated fatty acid supplementation on glycemic control and renal function in type 2 diabetic patients with chronic kidney disease

Introduction: The aim of this study was to evaluate the short-term effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on glycemic control and renal function in type 2 diabetic patients with chronic kidney disease. Materials and methods: Twenty-five diabetic patients received medication containing 2 g/day n-3 PUFA orally in addition to standard treatments. Their estimated glomerular filtration rates (eGFR) were <80 mL/min/1.73 m(2). Biochemical values were evaluated before and 3 months after treatment. Results: After three months of supplementation, the changes in serum creatinine, uric acid, eGFR and urinary albumin excretion levels did not reach statistical significance. There was no difference between serum glucose, HbAlC and lipid profile values before and after the n-3 PUFA.supplementation in patients. Only serum albumin significantly increased from 4.10 +/- 0.26 to 4.28 +/- 0.31 g/dL (p=0.016), and systolic blood pressure decreased from 121.4 +/- 14.5 to 116 .6 +/- 14.9 mmHg (p=0.001). Conclusion: Short-term n-3 PUFA supplementation did not affect renal function and glycemic control in patients with type 2 diabetes with chronic kidney disease

Sequential Application of Oxygen Therapy via High-flow Nasal Cannula and Non-invasive Ventilation in COVID-19 Patients with Acute Respiratory Failure in the Intensive Care Unit: A Prospective, Observational Study

Objective:Non-invasive mechanical ventilation (NIV) and high-flow nasal oxygen therapy (HFNO) are the most frequently used methods for treating hypoxemia in those diagnosed with coronavirus disease-2019 (COVID-19) in the intensive care unit (ICU). In this prospective study, we compared the effects of these two treatment modalities applied alternately in the same patient.Materials and Methods:Standard oxygen therapy (SOT) was administered for 1 hour to patients hospitalized in the ICU with a diagnosis of acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) due to COVID-19. HFNO and NIV were applied alternately to patients who met the inclusion criteria, and we evaluated the effects of HFNO and NIV applied to the same patient.Results:Thirty of forty-five patients admitted to the ICU for COVID-19 ARDS met the inclusion criteria for the study. According to the first and second arterial blood gas (ABG) values, the PaO2/FiO2 (P/F) ratio was significantly higher during NIV compared to both baseline and HFNO. In addition, the ROX index was significantly higher during NIV than HFNO, and SpO2 in NIV increased significantly compared with the baseline value. In both methods, patient satisfaction according to the visual analog scale was better than that of SOT. Eighty percent (24/30) of the patients were orotracheally intubated; 13 patients were transferred to the ward (43.3%), 2 patients were discharged home (6.7%), and 15 patients died (50%).Conclusion:Starting respiratory support with HFNO and/or NIV rather than SOT is more effective in improving oxygenation in patients with AHRF and ARDS due to COVID-19 and other causes. NIV is more effective than HFNO in increasing the SpO2 and P/F ratio

Bellek dönüştürme katmanı tasarım ve simulasyonu.

Flash Memories have been widely used as a storage media in electronic devices such as USB flash drives, mobile phones and cameras. Flash Memory offers a portable and non-volatile de- sign, which can be carried to everywhere without data loss. It is durable against temperature and humidity. With all these advantages, Flash Memory gets popular day by day. However, Flash Memory has also some disadvantages, such as erase-before restriction and erase limi- tation of each individual block. Erase-before restriction pushes every single writable unit to be erased before an update operation. Another limitation is that every block can be erased up to a fixed number. Flash Translation Layer - FTL is the solution for these disadvantages. Flash Translation Layer is a software module inside the Flash Memory working between the operating system and the memory. FTL tries to reduce these disadvantages of Flash Memory via implementing garbage collector, address mapping scheme, error correcting and many oth- ers. There are various Flash Translation Layer software. Some of them have been reviewed in terms of their advantages and disadvantages. The study aims at designing, implementing and simulating a NAND type FTL algorithm.M.S. - Master of Scienc

The Other Side of The Coin in Assisted Peritoneal Dialysis

&lt;p&gt;&lt;strong&gt;Background&lt;/strong&gt;: Assisted peritoneal dialysis (aPD) has long been used worldwide to treat elderly and frail patients with end-stage renal disease.&nbsp; In developed countries, aPD is provided by health professionals, while in developing countries it is provided by family members or caregivers. The main aim of this study was to examine the quality of life (QoL) of caregivers and to investigate its impact on PD.&lt;br&gt;&lt;strong&gt;Methods&lt;/strong&gt;: We included 31 patients on self-administered peritoneal dialysis and 40 patients on aPD. Patients were compared in terms of peritonitis, hospitalization, and catheter exit site infection. SF-36 questionnaire was administered to family members and caregivers assisting peritoneal dialysis and compared with the control group.&lt;br&gt;Results: When the SF-36 life scale sections of the assistants were evaluated separately, the median physical function score, median physical role difficulty score, median emotional role difficulty score, median social functioning score, median pain score, mean general health perception and total SF36 score were found to be statistically significantly lower compared to the control group ( 90 vs 57.5, 100 vs 0, 100 vs 16.7, 100 vs 50, 90 vs 55, 77.4 vs 47, 3020 vs 1575, p&lt;0.001, p&lt;0.001, p&lt;0.001, p&lt;0.001, p=0.001, p &lt;0.001, p&lt;0.001). There was no statistically significant difference between the groups in terms of clinical outcomes such as peritonitis, catheter exit site infection, and the need for hospitalization.&lt;br&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;: In developing countries, peritoneal dialysis supported by family members can be a convenient, safe, and cost-effective dialysis method. Nevertheless, it can be reasonable to establish measures and policies to enhance the quality of life of caregivers.&lt;/p&gt

An Enflammatory Marker in Chronic Renal Failure Patients: Visfatin

Aim: Visfatin is a cytokine released from adipose tissue, especially in enflammation. In our study, we tried to show the relationship of visfatin levels with chronic renal failure (CRF) as an enflammatory marker. Methods: We included 50 CRF patients (28 male, 22 female) who attended Uludağ University Nephrology Clinic and 31 healthy volunteers (13 male, 18 female). Visfatin levels and biochemical parameters, such as parathyroid hormone (PTH), lipid parameters, albumin, C-reactive protein (CRP), creatinine, urea, immunoglobulins, etc. were examined. Results: In CRF patients, visfatin levels were found to be significantly increased (p<0.001) and albumin, hemoglobin, body mass index (BMI) and high density lipoprotein (HDL) cholesterol levels were decreased (p<0.001). Triglycerides (p=0.003), CPR (p=0.005), procalcitonin (p<0.001), IgG3 (p=0.003), and ferritin (p<0.001) levels were significantly higher in patient group than in control group as an enflammatory marker. Conclusion: CRF is an independent enflammatory process. Visfatin levels in patients with chronic renal failure patients are determined to be high as an indicator of enflammation. (The Medical Bulletin of Haseki 2013; 53: 187-91

The Results of Upper Gastrointestinal Endoscopy Performed in Bayburt Province

Aim: We analyzed the results of upper gastrointestinal endoscopy performed between November 2011 and January 2013 in the endoscopy unit at Bayburt State Hospital. Methods: Endoscopic analyses were done with a PENTAX EPK 100P equipment. The results were assessed retrospectively. Results: A total of 1008 patients (664 women, 344 men) aged between 17 and 88 (mean: 50±18) years have undergone upper gastrointestinal endoscopy. 186 (18.4%) patients were diagnosed with pangastritis, 81 - with esophagitis (8%), 68 - with antral gastritis (6.7%), 67 - with duodenal ulcer (6.6%), 57 - with gastric ulcer (5.6%), 35 - with alkaline reflux gastritis (3.6%), 21 - with duodenitis (2.1%), 5 - with gastric cancer (0.5%), 4 - with esophagial cancer (0.4%), 4 - with gastric polyp (0.4%) and 3 patients were diagnosed with esophagial ulcer (0.3%). Conclusion: Lesions were most commonly observed in the stomach. Gastritis, esophagitis, duodenal and gastric ulcer were frequently observed in our city. (The Medical Bulletin of Haseki 2013; 51: 116-9

On A New Type of (k, mu)-Contact Metric Manifolds

International Conference on Advances in Natural and Applied Sciences (ICANAS) -- APR 18-21, 2017 -- Antalya, TURKEYWOS: 000405093100005n the present paper we introduce cyclic-parallel t-curvature tensor on (k, mu)-contact metric manifolds. We investigate some curvature properties of these type manifolds and we obtain that these type of manifolds have cyclic-parallel Ricci tensor under some conditions. Furthermore, we get these type of manifolds are K-contact under some special cases and we obtain that M is locally isometric to the product En+1 x S-n (4) under some algebraic conditions.Agri Ibrahim Cecen Univ, IC Fd

Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties

A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment

Antibacterial Effects of Methanol Extracts of Some Plant Species Belonging to Lamiaceae Family

Species belonging to Lamiaceae family are used as an antibacterial agent among medical plants. The aim of the present study was to determinate the antibacterial effects of the methanolic extracts of some plant species belonging Lamiaceae family which distributed to different ecological conditions in Amasya. The antibacterial effects of Stachys annua, Scutellaria salviifolia and Nepata nuda plant extracts were determined by disc diffusion and micro dilution methods. The antibacterial effects of plant extracts were tested against standard strains of Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Klebsiella pneumoniae ATCC 70600, Pseudomonas aeruginosa ATCC 27853 and Salmonella enteritidis ATCC 13076. We observed that plant extracts had antibacterial effect when they compared with control group antibiotics. According to the results of disc diffusion method, the highest antibacterial effect was identified in Scutellaria salviifolia, Stachys annua and Nepata nuda, respectively. The microdilution method was studied concentration range from 6.25 - to 50 mg/ml. MICs of the most effective Scutellaria salviifolia plant extract were 12.5 mg/ml for S. aureus, S. enteritidis and E. coli; 25 mg/ml for K. pneumoniae and P. aeruginosa. The MICs of Stachys annua extract were 12.5 mg/ml for P. aeruginosa, S. enteritidis and E. coli; 25 mg/ml for S. aureus and 50 mg/ml for K. pneumoniae. MICs of Nepata nuda were 12.5 mg/ml K. pneumonia; 25 mg/ml for S. aureus; 50 mg/ml for P. aeruginosa, S. enteritidis and E. coli. This study showed that Scutellaria salviifolia, Stachys annua and Nepata nuda species have in vitro antibacterial activities