Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with I--adrenergic activity

Cognitive processes, such as learning and memory, are essential for our adaptation to environmental changes and consequently for survival. Numerous studies indicate that hormones secreted during stressful situations, such as glucocorticoids (GCs), adrenaline and noradrenaline, regulate memory functions, modulating aversive memory consolidation and retrieval, in an interactive and complementary way. Thus, the facilitatory effects of GCs on memory consolidation as well as their suppressive effects on retrieval are substantially explained by this interaction. On the other hand, low levels of GCs are also associated with negative effects on memory consolidation and retrieval and the mechanisms involved are not well understood. the present study sought to investigate the consequences of blocking the rise of GCs on fear memory retrieval in multiple tests, assessing the participation of (3-adrenergic signaling on this effect. Metyrapone (GCs synthesis inhibitor; 75 mg/kg), administered 90 min before the first test of contextual or tone fear conditioning (TFC), negatively affected animals' performances, but this effect did not persist on a subsequent test, when the conditioned response was again expressed. This result suggested that the treatment impaired fear memory retrieval during the first evaluation. the administration immediately after the first test did not affect the animals' performances in contextual fear conditioning (CFC), suggesting that the drug did not interfere with processes triggered by memory reactivation. Moreover, metyrapone effects were independent of beta-adrenergic signaling, since concurrent administration with propranolol (2 mg/kg), alpha,beta-adrenergic antagonist, did not modify the effects induced by metyrapone alone. These results demonstrate that pre-test metyrapone administration led to negative effects on fear memory retrieval and this action was independent of a beta-adrenergic signaling.Associacao Fund de Incentivo a Pesquisa (AFIP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao de Amparo Pesquisa do Estado de São PauloUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, BrazilUniv Fed ABC, Ctr Matemat Comp & Cognicao, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, BrazilFundacao de Amparo Pesquisa do Estado de São Paulo: FAPESP 2011/16977-8Web of Scienc

武蔵丘短大卒業生の本学入学目的と学生生活の満足度 : 卒業生のアンケート調査の中間報告

The purpose of this paper is to clarify our students needs to Musashigaoka College. And we sent our questionnaire, which has 27 items, to the graduates of Musashigaoka Junior College in 1999. In this survey we got the opinions of 466 graduates. The response rate was 30.5%. This paper is an interim report on the survey. We examined the results. 1 Many students want to learn the practical knowledge and practical training. 2 Many students want to get the license(teacher\u27s license and dietician license). 3 Many students are satisfied with their college lives and especially they enjoy their campus lives with their many friends

ゲンダイ キョウイク ニンゲンロン ニオケル カタリ : 「キョウイク ト ニンゲン」 タンキュウ ノ タビ

The main queries in the class Discussion on the Current Education and Humanity are ‘What is humanity?’ and ‘What is education?’ Definite answers to these questions are not expected from the onset. Accordingly, four lecturers explore these themes from different viewpoints, similar to the metaphor of four visually impaired people trying to identify an elephant. This paper presents the findings of the four lecturers ; the observations they compiled while ‘touching’ the elephant−like questions, guided by their own individual research interests and knowledge. The response to the class varied, from criticism that the goals of the lesson appeared too vague or confusing, to positive comments about the opportunity to explore concepts more deeply and the uniqueness of the class. In the lecture of the 2013 academic year, Chikamori talked about support from the anthropological viewpoint, quoting findings from several different research fields. Tanimura shed light on the contrasting difference in the way of looking at children between E.H. Erikson and E. Lévinas. Ota discussed the possibility of development under the adverse conditions which humans face referring to the deconstruction of J. Derrida. Then Hirose introduced the practice of “Steiner Education” and discussed the possibility of application of it in Japanese primary schools based on the views of humanity and education according to R. Steiner. This paper is like an itinerary describing not only the narratives during our journey to explore “Education and Humanity”, but also providing evidence of something tangible which emerged within the individual travelers. It is our hope that answers of one form or another to the questions ; ‘What is education?’ and ‘What is humanity?’ might begin to appear in the process of reading and reflecting on this itinerary

本学学生の体力水準と評価方法に関する研究 : 平成6年度 健康・栄養専攻 女子学生を対象として

The purpose of the present study is to clarify phyisical fitness level of Musashigaoka College female students. The subjects of the study were 129 female freshman students enrolled in general health and physical education classes. The subjects took fitness tests(grip strength, back strength, vertical jump, sidestep test, standing trunk flexion, trunk extension, and step test). The basic statistical analysis was examined. No significant difference was found between the results of the present study and standards of Japanese students

The Plasma Wave Experiment (PWE) on board the Arase (ERG) satellite

The Exploration of energization and Radiation in Geospace (ERG) project aims to study acceleration and loss mechanisms of relativistic electrons around the Earth. The Arase (ERG) satellite was launched on December 20, 2016, to explore in the heart of the Earth’s radiation belt. In the present paper, we introduce the specifications of the Plasma Wave Experiment (PWE) on board the Arase satellite. In the inner magnetosphere, plasma waves, such as the whistler-mode chorus, electromagnetic ion cyclotron wave, and magnetosonic wave, are expected to interact with particles over a wide energy range and contribute to high-energy particle loss and/or acceleration processes. Thermal plasma density is another key parameter because it controls the dispersion relation of plasma waves, which affects wave–particle interaction conditions and wave propagation characteristics. The DC electric field also plays an important role in controlling the global dynamics of the inner magnetosphere. The PWE, which consists of an orthogonal electric field sensor (WPT; wire probe antenna), a triaxial magnetic sensor (MSC; magnetic search coil), and receivers named electric field detector (EFD), waveform capture and onboard frequency analyzer (WFC/OFA), and high-frequency analyzer (HFA), was developed to measure the DC electric field and plasma waves in the inner magnetosphere. Using these sensors and receivers, the PWE covers a wide frequency range from DC to 10 MHz for electric fields and from a few Hz to 100 kHz for magnetic fields. We produce continuous ELF/VLF/HF range wave spectra and ELF range waveforms for 24 h each day. We also produce spectral matrices as continuous data for wave direction finding. In addition, we intermittently produce two types of waveform burst data, “chorus burst” and “EMIC burst.” We also input raw waveform data into the software-type wave–particle interaction analyzer (S-WPIA), which derives direct correlation between waves and particles. Finally, we introduce our PWE observation strategy and provide some initial results