Factors Associated With Unplanned Hospitalizations Among Patients With Nonmetastatic Colorectal Cancers Intended for Treatment in the Ambulatory Setting

Chemotherapy administration and supportive management for solid tumors is intended to take place in the ambulatory setting, but little is known about why some patients experience treatment-related, adverse events so severe as to require acute inpatient care

EDSN - Edison Demonstration for SmallSat Networks: EDSN Overview

The EDSN overview provides information on the project's objectives, particular technologies being demonstrated, an overview of the structural components of the satellites, and the concept of operations

The Grizzly, March 27, 1981

Parents Day Slated for Early April • Overwhelming Enthusiasm Welcomes Special Olympics • Bomberger Tower Under Construction • SPC Elects New Grizzly Editor-in-Chief • Shakespeare Opens • Departmental Focus: Math Department • Transplanted Texan: NY to Collegeville • Spectrum Tries New Ticket Sales • Values Next Forum Topic • TV Production in Communications • Language Clubs Host Dessert Festival • Final Exam Schedule • Baseball Team Carries Much Potential • Hoopsters Finish 3rd in Nation • Tennis Team Prepares for Tough Season • Women\u27s Lacrosse Start Season 1-1https://digitalcommons.ursinus.edu/grizzlynews/1056/thumbnail.jp

The Grizzly, April 30, 1982

Speakers Announced for Graduation • New Tuition Plan Announced • Letters to the Editor • Aims for 1982-86 Present Concern for Administration • Japanese Exchange Students Visit in August • President\u27s Corner • Women\u27s Club Continues to Support Campus • An Ursinus Friday Night • Students Direct One Act Plays • USGA Notes • Sports Profile: Jeff Grassie • Lacrosse Skids • UC Track and Field Heads to MAC • Tough Luck Bears Lose 4-1 • Women\u27s Tennis Eliminated From MAC • Penn State Dumps Women\u27s Lacrossehttps://digitalcommons.ursinus.edu/grizzlynews/1080/thumbnail.jp

Advantages and Challenges of Using Physics Curricula as a Model for Reforming an Undergraduate Biology Course

We report on the development of a life sciences curriculum, targeted to undergraduate students, which was modeled after a commercially available physics curriculum and based on aspects of how people learn. Our paper describes the collaborative development process and necessary modifications required to apply a physics pedagogical model in a life sciences context. While some approaches were easily adapted, others provided significant challenges. Among these challenges were: representations of energy, introducing definitions, the placement of Scientists’ Ideas, and the replicability of data. In modifying the curriculum to address these challenges, we have come to see them as speaking to deeper differences between the disciplines, namely that introductory physics—for example, Newton\u27s laws, magnetism, light—is a science of pairwise interaction, while introductory biology—for example, photosynthesis, evolution, cycling of matter in ecosystems—is a science of linked processes, and we suggest that this is how the two disciplines are presented in introductory classes. We illustrate this tension through an analysis of our adaptations of the physics curriculum for instruction on the cycling of matter and energy; we show that modifications of the physics curriculum to address the biological framework promotes strong gains in student understanding of these topics, as evidenced by analysis of student work

The Grizzly, February 20, 1981

SAC Approves Spring Term 1981 Allocations • SPC to Propose Journalism Seminar • USGA Announces New Officers • Grizzly Planning Satire Issue • Professional Credentials Committee Explored • Departmental Focus: Biology Department • USGA Notes • Astronomy Club Planning Open House • Music News Defends JDB • Lorelei Outcast • Alumni Office Sponsors Homecoming II • Sorority Pledging With Frats • Graterford Visit Provides New Insights • Classics Club Planning Another Trip • Special Olympics Slated for March • Athletic Department Announces Play-off Plans • Sports Profile: Greg Gifford • Basketball Team Clinches MAC Southern Division • Textile Downs Lady Hoopsters • Grapplers: 10-5-1https://digitalcommons.ursinus.edu/grizzlynews/1053/thumbnail.jp

Translation initiation from conserved non-AUG codons provides additional layers of regulation and coding capacity

Neurospora crassa cpc-1 and Saccharomyces cerevisiae GCN4 are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation. The cpc-1 mRNA contains two upstream open reading frames (uORFs) in its >700-nucleotide (nt) 5' leader, and its expression is controlled at the level of translation in response to amino acid starvation. We used N. crassa cell extracts and obtained data indicating that cpc-1 uORF1 and uORF2 are functionally analogous to GCN4 uORF1 and uORF4, respectively, in controlling translation. We also found that the 5' region upstream of the main coding sequence of the cpc-1 mRNA extends for more than 700 nucleotides without any in-frame stop codon. For 100 cpc-1 homologs from Pezizomycotina and from selected Basidiomycota, 5' conserved extensions of the CPC1 reading frame are also observed. Multiple non-AUG near-cognate codons (NCCs) in the CPC1 reading frame upstream of uORF2, some deeply conserved, could potentially initiate translation. At least four NCCs initiated translation in vitro. In vivo data were consistent with initiation at NCCs to produce N-terminally extended N. crassa CPC1 isoforms. The pivotal role played by CPC1, combined with its translational regulation by uORFs and NCC utilization, underscores the emerging significance of noncanonical initiation events in controlling gene expression. IMPORTANCE There is a deepening and widening appreciation of the diverse roles of translation in controlling gene expression. A central fungal transcription factor, the best-studied example of which is Saccharomyces cerevisiae GCN4, is crucial for the response to amino acid limitation. Two upstream open reading frames (uORFs) in the GCN4 mRNA are critical for controlling GCN4 synthesis. We observed that two uORFs in the corresponding Neurospora crassa cpc-1 mRNA appear functionally analogous to the GCN4 uORFs. We also discovered that, surprisingly, unlike GCN4, the CPC1 coding sequence extends far upstream from the presumed AUG start codon with no other in-frame AUG codons. Similar extensions were seen in homologs from many filamentous fungi. We observed that multiple non-AUG near-cognate codons (NCCs) in this extended reading frame, some conserved, initiated translation to produce longer forms of CPC1, underscoring the significance of noncanonical initiation in controlling gene expression