Multi-objective vehicle routing and loading with time window constraints:a real-life application

Motivated by a real-life application, this research considers the multi-objective vehicle routing and loading problem with time window constraints which is a variant of the Capacitated Vehicle Routing Problem with Time Windows with one/two-dimensional loading constraints. The problem consists of routing a number of vehicles to serve a set of customers and determining the best way of loading the goods ordered by the customers onto the vehicles used for transportation. The three objectives pertaining to minimisation of total travel distance, number of routes to use and total number of mixed orders in the same pallet are, more often than not, conflicting. To achieve a solution with no preferential information known in advance from the decision maker, the problem is formulated as a Mixed Integer Linear Programming (MILP) model with one objective—minimising the total cost, where the three original objectives are incorporated as parts of the total cost function. A Generalised Variable Neighbourhood Search (GVNS) algorithm is designed as the search engine to relieve the computational burden inherent to the application of the MILP model. To evaluate the effectiveness of the GVNS algorithm, a real instance case study is generated and solved by both the GVNS algorithm and the software provided by our industrial partner. The results show that the suggested approach provides solutions with better overall values than those found by the software provided by our industrial partner

Disability and therapeutic response in paediatric neuromyelitis optica spectrum disorder: A case series from Iran

                                                                                         ABSTRACT Objectives:The characteristics of paediatric neuromyelitis optica spectrum disorder (NMOSD) may indicate the degree of disability and identify factors that predict the response to treatment.Materials & MethodsAmong 114 NMOSD patients in an acquired demyelinating syndromes registry at the Sina Hospital, in Tehran, Iran, 10 paediatric NMOSD patients with longitudinal follow-up from 2005 to 2016 were retrospectively identified. The median time between disease onset and diagnosis was 18 months (range 1-108 months).ResultsAll patients had a relapsing course, which resulted in disability in six with severe visual impairment and functional blindness in one and impaired ambulation in five patients during follow-up. Azathioprine (AZA) was first drug of choice for prophylaxis, but in five patients new attacks occurred and therapy was switched to rituximab (RTX) with no further relapses after median two years (range 1-3 y) follow-up.Conclusion:Paediatric onset of NMOSD was associated with severe attacks and poor response in 50 % of cases to AZA, RTX seemed to decrease the relapse rate

Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome

Background A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). Objective To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features of a large cohort of MOG-IgG-positive patients with optic neuritis (ON) and/or myelitis (n = 50) as well as attack and long-term treatment outcomes. Methods Retrospective multicenter study. Results The sex ratio was 1:2.8 (m:f). Median age at onset was 31 years (range 6-70). The disease followed a multiphasic course in 80% (median time-to-first-relapse 5 months; annualized relapse rate 0.92) and resulted in significant disability in 40% (mean follow-up 75 ± 46.5 months), with severe visual impairment or functional blindness (36%) and markedly impaired ambulation due to paresis or ataxia (25%) as the most common long-term sequelae. Functional blindness in one or both eyes was noted during at least one ON attack in around 70%. Perioptic enhancement was present in several patients. Besides acute tetra-/paraparesis, dysesthesia and pain were common in acute myelitis (70%). Longitudinally extensive spinal cord lesions were frequent, but short lesions occurred at least once in 44%. Fourty-one percent had a history of simultaneous ON and myelitis. Clinical or radiological involvement of the brain, brainstem, or cerebellum was present in 50%; extra-opticospinal symptoms included intractable nausea and vomiting and respiratory insufficiency (fatal in one). CSF pleocytosis (partly neutrophilic) was present in 70%, oligoclonal bands in only 13%, and blood-CSF-barrier dysfunction in 32%. Intravenous methylprednisolone (IVMP) and long-term immunosuppression were often effective; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal. Full recovery was achieved by plasma exchange in some cases, including after IVMP failure. Breakthrough attacks under azathioprine were linked to the drug-specific latency period and a lack of cotreatment with oral steroids. Methotrexate was effective in 5/6 patients. Interferon-beta was associated with ongoing or increasing disease activity. Rituximab and ofatumumab were effective in some patients. However, treatment with rituximab was followed by early relapses in several cases; end-of-dose relapses occurred 9-12 months after the first infusion. Coexisting autoimmunity was rare (9%). Wingerchuk’s 2006 and 2015 criteria for NMO(SD) and Barkhof and McDonald criteria for multiple sclerosis (MS) were met by 28%, 32%, 15%, 33%, respectively; MS had been suspected in 36%. Disease onset or relapses were preceded by infection, vaccination, or pregnancy/delivery in several cases. Conclusion Our findings from a predominantly Caucasian cohort strongly argue against the concept of MOG-IgG denoting a mild and usually monophasic variant of NMOSD. The predominantly relapsing and often severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis

Fairness in hazmat routing-scheduling: a bi-objective Stackelberg game

We investigate a hazmat routing-scheduling problem. To minimize the overall expected risk, various vehicles may take different routes/schedules to avoid multiple accidents on the same link. Therefore, the company envisages two issues: (1) unfairly, a vehicle departing earlier from its origin may arrive earlier at its destination than the others leaving later; (2) focusing only on the minimization of risk may increase travel time/cost incurred by the company. We suggest a bi-objective game-theoretic formulation and solve it by a modified Adaptive Large Neighborhood Search and Simulated Annealing. We test the solution on a real-life case and extract practical insights

OR models in urban service facility location : a critical review of applications and future developments

[EN] Facility location models are well established in various application areas with more than a century of history in academia. Since the 1970s the trend has been shifting from manufacturing to service industries. Due to their nature, service industries are frequently located in or near urban areas that results in additional assumptions, objectives and constraints other than those in more traditional manufacturing location models. This survey focuses on the location of service facilities in urban areas. We studied 110 research papers across different journals and disciplines. We have analyzed these papers on two levels. On the first, we take an Operations Research perspective to investigate the papers in terms of types of decisions, location space, main assumptions, input parameters, objective functions and constraints. On the second level, we compare and contrast the papers in each of these applications categories: (a) Waste management systems (WMS), (b) Large-scale disaster (LSD), (c) Small-scale emergency (SSE), (d) General service and infrastructure (GSI), (e) Non-emergency healthcare systems (NEH) and (f) Transportation systems and their infrastructure (TSI). Each of these categories is critically analyzed in terms of application, assumptions, decision variables, input parameters, constraints, objective functions and solution techniques. Gaps, research opportunities and trends are identified within each category. Finally, some general lessons learned based on the practicality of the models is synthesized to suggest avenues of future research.Ruben Ruiz is partially supported by the Spanish Ministry of Economy and Competitiveness, under the project "SCHEYARD - Optimization of Scheduling Problems in Container Yards (No. DPI2015-65895-R) financed by FEDER funds.Farahani, RZ.; Fallah, S.; Ruiz García, R.; Hosseini, S.; Asgari, N. (2019). OR Models in Urban Service Facility Location: A Critical Review of Applications and Future Developments. European Journal of Operational Research. 276(1):1-27. https://doi.org/10.1016/j.ejor.2018.07.036S127276