Linear and nonlinear parameters of heart rate variability in ischemic stroke patients

Introduction Cardiovascular system presents cortical modulation. Post-stroke outcome can be highly influenced by autonomic nervous system disruption. Heart rate variability (HRV) analysis is a simple non-invasive method to assess sympatho-vagal balance. Objectives The purpose of this study was to investigate cardiac autonomic activity in ischemic stroke patients and to asses HRV nonlinear parameters beside linear ones. Methods We analyzed HRV parameters in 15 right and 15 left middle cerebral artery ischemic stroke patients, in rest condition and during challenge (standing and deep breathing). Data were compared with 15 age- and sex-matched healthy controls. Results There was an asymmetric response after autonomic stimulation tests depending on the cortical lateralization in ischemic stroke patients. In resting state, left hemisphere stroke patients presented enhanced parasympathetic control of the heart rate (higher values for RMSSD, pNN50 and HF in normalized units). Right hemisphere ischemic stroke patients displayed a reduced cardiac parasympathetic modulation during deep breathing test. Beside time and frequency domain, using short-term ECG monitoring, cardiac parasympathetic modulation can also be assessed by nonlinear parameter SD1, that presented strong positive correlation with time and frequency domain parameters RMSSD, pNN50, HFnu, while DFA α1 index presented negative correlation with the same indices and positive correlation with the LFnu and LF/HF ratio, indicating a positive association with the sympatho-vagal balance. Conclusions Cardiac monitoring in clinical routine using HRV analysis in order to identify autonomic imbalance may highlight cardiac dysfunctions, thus helping preventing potential cardiovascular complications, especially in right hemisphere ischemic stroke patients with sympathetic hyperactivation

Antimatter and Matter Production in Heavy Ion Collisions at CERN (The NEWMASS Experiment NA52)

Besides the dedicated search for strangelets NA52 measures light (anti)particle and (anti)nuclei production over a wide range of rapidity. Compared to previous runs the statistics has been increased in the 1998 run by more than one order of magnitude for negatively charged objects at different spectrometer rigidities. Together with previous data taking at a rigidity of -20 GeV/c we obtained 10^6 antiprotons 10^3 antideuterons and two antihelium3 without centrality requirements. We measured nuclei and antinuclei (p,d,antiprotons, antideuterons) near midrapidity covering an impact parameter range of b=2-12 fm. Our results strongly indicate that nuclei and antinuclei are mainly produced via the coalescence mechanism. However the centrality dependence of the antibaryon to baryon ratios show that antibaryons are diminished due to annihilation and breakup reactions in the hadron dense environment. The volume of the particle source extracted from coalescence models agrees with results from pion interferometry for an expanding source. The chemical and thermal freeze-out of nuclei and antinuclei appear to coincide with each other and with the thermal freeze-out of hadrons.Comment: 12 pages, 8 figures, to appear in the proceedings of the conference on 'Fundamental Issues in Elementary Matter' Bad Honnef, Germany, Sept. 25-29, 200

Violation of energy-per-hadron scaling in a resonance matter

Yields of hadrons, their average masses and energies per hadron at the stage of chemical freeze-out in (ultra)relativistic heavy-ion collisions are analyzed within the statistical model. The violation of the scaling / = 1 GeV observed in Au+Au collisions at $\sqrt{s}$ = 130 AGeV is linked to the formation of resonance-rich matter with a considerable fraction of baryons and antibaryons. The rise of the energy-per-hadron ratio in baryon-dominated matter is discussed. A violation of the scaling condition is predicted for a very central zone of heavy-ion collisions at energies around 40 AGeV.Comment: 5 pages incl. 3 figures and 2 tables, to be published in Phys. Rev.

Warm strange hadronic matter in an effective model with a weak Y-Y interaction

An effective model is used to study the equation of state of warm strange hadronic matter with nucleons, Lambda-hyperons, Xi-hyperons, sigmastar and phi. In the calculation, a newest weak Y-Y interaction deduced from the recent observation of a He double hypernucleus is adopted. Employing this effective model, the results with strong Y-Y interaction and weak Y-Y interaction are compared.Comment: 9 pages, 9 figure

Charged pion production in fixed target Pb + Pb collisions at 158 GeV per nucleon

Changes in pion production as a function of the impact parameter of the collision or the incident energy, may reveal characteristics of a possible first-order phase transition from nuclear to quark matter, as predicted by lattice quantum chromodynamics. In this paper we investigate charged pion production in Pb+Pb collisions at 158 GeV/nucleon near 0° production angle and at forward rapidity $(4.3\leq y \leq 6.3)$. The centrality dependence of pion production is shown in the impact parameter range ~ 2-12 fm at the rapidities y = 5.7 and 6.3. An enhancement in the pi-/pi+ ratio has been measured near beam rapidity, indicating Coulomb interaction of charged pions with the spectator protons. The charged pion yield per nucleon participating in the collision (N_p) at y = 5.7 increases faster than linearly with N_p, up to N_p~100 and then it saturates, while at y = 6.3 it does not exhibit any sudden change as a function of N_p

Centrality dependence of K+ produced in Pb+Pb collisions at 158 GeV per nucleon

The NA52 collaboration searches for a discontinuous behaviour of charged kaons produced in Pb+Pb collisions at 158 A GeV as a function of the impact parameter, which could reveal a hadron to quark-gluon plasma (QGP) phase transition. The K+ yield is found to grow proportional to the number of participating ('wounded') nucleons N, above N=100. Previous NA52 data agree with the above finding and show a discontinuous behaviour in the kaon centrality dependence near N=100, marking the onset of strangeness enhancement -over e.g. p+A data at the same \sqrt{s}- in a chemically equilibrated phase.Comment: 2 pages, 2 figures, submitted to the XXXth International Conference on High Energy Physics, 27 July - 2 August, 2000, Osaka, Japa

Intestinal Epithelial Serum Amyloid A Modulates Bacterial Growth In Vitro and Pro-Inflammatory Responses in Mouse Experimental Colitis

<p>Abstract</p> <p>Background</p> <p>Serum Amyloid A (SAA) is a major acute phase protein of unknown function. SAA is mostly expressed in the liver, but also in other tissues including the intestinal epithelium. SAA reportedly has anti-bacterial effects, and because inflammatory bowel diseases (IBD) result from a breakdown in homeostatic interactions between intestinal epithelia and bacteria, we hypothesized that SAA is protective during experimental colitis.</p> <p>Methods</p> <p>Intestinal SAA expression was measured in mouse and human samples. Dextran sodium sulfate (DSS) colitis was induced in SAA 1/2 double knockout (DKO) mice and in wildtype controls. Anti-bacterial effects of SAA1/2 were tested in intestinal epithelial cell lines transduced with adenoviral vectors encoding the CE/J SAA isoform or control vectors prior to exposure to live <it>Escherichia coli</it>.</p> <p>Results</p> <p>Significant levels of SAA1/SAA2 RNA and SAA protein were detected by in situ hybridization and immunohistochemistry in mouse colonic epithelium. SAA3 expression was weaker, but similarly distributed. SAA1/2 RNA was present in the ileum and colon of conventional mice and in the colon of germfree mice. Expression of SAA3 was strongly regulated by bacterial lipopolysaccharides in cultured epithelial cell lines, whereas SAA1/2 expression was constitutive and not LPS inducible. Overexpression of SAA1/2 in cultured epithelial cell lines reduced the viability of co-cultured <it>E. coli</it>. This might partially explain the observed increase in susceptibility of DKO mice to DSS colitis. SAA1/2 expression was increased in colon samples obtained from Crohn's Disease patients compared to controls.</p> <p>Conclusions</p> <p>Intestinal epithelial SAA displays bactericidal properties in vitro and could play a protective role in experimental mouse colitis. Altered expression of SAA in intestinal biopsies from Crohn's Disease patients suggests that SAA is involved in the disease process..</p

Pion yield from 450 GeV/c protons on beryllium

This paper reports on the charged pion production yields measured by the SPY/NA56 experiment for 450 GeV/c proton interactions on beryllium targets. The present data cover a secondary momentum range from 7 GeV/c to 135 GeV/c in the forward direction. An experimental accuracy ranging from 5 to 10\%, depending on the beam momentum, has been achieved, limited mainly by the knowledge of the beam acceptance. These results will be relevant in the calculation of neutrino fluxes in present and future neutrino beams

Accumulation of Polychlorinated Biphenyls in Adipocytes: Selective Targeting to Lipid Droplets and Role of Caveolin-1

Background : Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that preferentially accumulate in lipid-rich tissues of contaminated organisms. Although the adipose tissue constitutes a major intern reservoir of PCBs and recent epidemiological studies associate PCBs to the development of obesity and its related disorders, little is known about the mechanisms involved in their uptake by the adipose tissue and their intracellular localization in fat cells

Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice

Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin resistance in mice. Methodology/Principal Findings: Adult male C57BL/6J mice were fed control diet (C), a very high-fat diet without or with farmed Atlantic salmon fillet (VHF and VHF/S, respectively), and Western diet without or with farmed Atlantic salmon fillet (WD and WD/S, respectively). Other mice were fed VHF containing farmed salmon fillet with reduced concentrations of persistent organic pollutants (VHF/S-POPs). We assessed body weight gain, fat mass, insulin sensitivity, glucose tolerance, ex vivo muscle glucose uptake, performed histology and immunohistochemistry analysis, and investigated gene and protein expression. In comparison with animals fed VHF and WD, consumption of both VHF/S and WD/S exaggerated insulin resistance, visceral obesity, and glucose intolerance. In addition, the ability of insulin to stimulate Akt phosphorylation and muscle glucose uptake was impaired in mice fed farmed salmon. Relative to VHF/S-fed mice, animals fed VHF/S-POPs had less body burdens of POPs, accumulated less visceral fat, and had reduced mRNA levels of TNFa as well as macrophage infiltration in adipose tissue. VHF/S-POPs-fed mice further exhibited better insulin sensitivity and glucose tolerance than mice fed VHF/S. Conclusions/Significance: Our data indicate that intake of farmed salmon fillet contributes to several metabolic disorders linked to type 2 diabetes and obesity, and suggest a role of POPs in these deleterious effects. Overall, these findings may participate to improve nutritional strategies for the prevention and therapy of insulin resistance