411 research outputs found
PLASTICITY OF HUMAN TENDON’S MECHANICAL PROPERTIES: EFFECTS ON SPORT PERFORMANCE
INTRODUCTION: In the literature it is often mentioned, that the tendon is very relevant for the work producing capability of the muscle fibers and for the motion and the performance of the human body. During a given movement, strain energy can be stored in the tendon and this way the whole energy delivery of the muscle can be enhanced. Further, the higher elongation capability of the tendon with respect to the muscle fiber, allows a bigger change in length of the muscle-tendon unit. Therefore, the muscle fibers may work on a lower shortening velocity and as a consequence of the force-velocity relationship their force producing potential will be higher. Generally, the main functions of the tendon during locomotion are: (a) to transfer muscle forces to the skeleton (b) to store mechanical energy coming from the human body or/and from muscular work as strain energy and (c) to create favorable conditions for the muscle fibers to produce force as a result of the force-length-velocity relationship. A higher force potential of the muscle fibers due to the force-length-velocity relationship during submaximal contractions would decrease the volume of active muscle at a given force or a given rate of force generation and consequently would decrease the cost of force production. In the same manner during maximal muscle contractions (maximal activation level) the higher force potential of the muscle fibers will allow the muscles to exert higher forces. The reports about the influence of the non rigidity of the tendon on the effectivity of muscle force production reveal the expectation that sport performance during submaximal as well as maximal running intensities may be affected by the mechanical and morphological properties of the tendon. In a series of experiments we examined the mechanical properties of the lower extremities muscle-tendon units (MTU) from athletes displaying different running economy and sprint performance. The most economical runners showed a higher contractile strength and a higher tendon stiffness in the triceps surae MTU and a higher compliance of the quadriceps tendon and aponeurosis at low level tendon forces (Arampatzis et al., 2006). The faster sprinters exhibited a higher elongation of the vastus lateralis (VL) tendon and aponeurosis at a given tendon force and a higher maximal elongation of the VL tendon and aponeurosis during the MVC (Stafilidis and Arampatzis, 2007). Furthermore, the maximal elongation of the VL tendon and aponeurosis showed a significant correlation with the 100 m sprint times (r = -0.567, P = 0.003). It has been supposed that, the more compliant quadriceps tendon and aponeurosis will increase the energy storage and return as well as the force potential of the muscle due to the force-velocity relationship. These studies provide evidence that the mechanical properties of the tendons at the lower extremity at least partially explain the performance of the human musculoskeletal system during running activities. However, until now no study exist in reference to the potential for improving running performance by manipulating the tendon mechanical properties. Mechanical load induced as cyclic strain on connective soft tissues such as tendons is an important regulator of fibroblast metabolic activity as well as for the maintenance of tendon matrix (Chiquet et al., 2003). An increased loading typically stimulates cells for remodelling and, therefore, for increasing the mechanical properties of the tissue (Arnoczky et al., 2002). Whereas, a decreased loading leads to tissue destruction and weak mechanical properties of the tissue (Arnoczky et al., 2004). These reports demonstrate the highly plastic nature of tendons within the muscle-tendon unit of mammals and give evidence that tendon strain is an important mechanical factor regulating tendon properties. Generally, from a mechanobiological point of view strain magnitude, strain frequency, strain rate and strain duration of cells influence the cellular biochemical responses and the mechanical properties of collagen fascicles. Although it is known that mechanical loading induced as cyclic strain affects the mechanical properties of human tendons in vivo, the effect of a controlled modulation in cyclic strain magnitude, frequency, rate or duration applied to the tendon on the plasticity of human tendons in vivo is not well established. Understanding the details of tendon plasticity in response to mechanical loading applied to the tendon in vivo may help to improve tendon adaptation, reduce tendon injury risks and increases the performance potential of the human system. This paper aimed (a) to present the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties and (b) to investigate whether an exercise induced increase in tendon-aponeurosis stiffness and contractile strength at the triceps surae muscle-tendon unit affect running economy
Goal-oriented sensitivity analysis for lattice kinetic Monte Carlo simulations
In this paper we propose a new class of coupling methods for the sensitivity
analysis of high dimensional stochastic systems and in particular for lattice
Kinetic Monte Carlo. Sensitivity analysis for stochastic systems is typically
based on approximating continuous derivatives with respect to model parameters
by the mean value of samples from a finite difference scheme. Instead of using
independent samples the proposed algorithm reduces the variance of the
estimator by developing a strongly correlated-"coupled"- stochastic process for
both the perturbed and unperturbed stochastic processes, defined in a common
state space. The novelty of our construction is that the new coupled process
depends on the targeted observables, e.g. coverage, Hamiltonian, spatial
correlations, surface roughness, etc., hence we refer to the proposed method as
em goal-oriented sensitivity analysis. In particular, the rates of the coupled
Continuous Time Markov Chain are obtained as solutions to a goal-oriented
optimization problem, depending on the observable of interest, by considering
the minimization functional of the corresponding variance. We show that this
functional can be used as a diagnostic tool for the design and evaluation of
different classes of couplings. Furthermore the resulting KMC sensitivity
algorithm has an easy implementation that is based on the Bortz-Kalos-Lebowitz
algorithm's philosophy, where here events are divided in classes depending on
level sets of the observable of interest. Finally, we demonstrate in several
examples including adsorption, desorption and diffusion Kinetic Monte Carlo
that for the same confidence interval and observable, the proposed
goal-oriented algorithm can be two orders of magnitude faster than existing
coupling algorithms for spatial KMC such as the Common Random Number approach
Hierarchical fractional-step approximations and parallel kinetic Monte Carlo algorithms
We present a mathematical framework for constructing and analyzing parallel
algorithms for lattice Kinetic Monte Carlo (KMC) simulations. The resulting
algorithms have the capacity to simulate a wide range of spatio-temporal scales
in spatially distributed, non-equilibrium physiochemical processes with complex
chemistry and transport micro-mechanisms. The algorithms can be tailored to
specific hierarchical parallel architectures such as multi-core processors or
clusters of Graphical Processing Units (GPUs). The proposed parallel algorithms
are controlled-error approximations of kinetic Monte Carlo algorithms,
departing from the predominant paradigm of creating parallel KMC algorithms
with exactly the same master equation as the serial one.
Our methodology relies on a spatial decomposition of the Markov operator
underlying the KMC algorithm into a hierarchy of operators corresponding to the
processors' structure in the parallel architecture. Based on this operator
decomposition, we formulate Fractional Step Approximation schemes by employing
the Trotter Theorem and its random variants; these schemes, (a) determine the
communication schedule} between processors, and (b) are run independently on
each processor through a serial KMC simulation, called a kernel, on each
fractional step time-window.
Furthermore, the proposed mathematical framework allows us to rigorously
justify the numerical and statistical consistency of the proposed algorithms,
showing the convergence of our approximating schemes to the original serial
KMC. The approach also provides a systematic evaluation of different processor
communicating schedules.Comment: 34 pages, 9 figure
Evidence of different sensitivity of muscle and tendon to mechano-metabolic stimuli
This study aimed to examine the temporal dynamics of muscle-tendon adaptation and whether differences between their sensitivity to mechano-metabolic stimuli would lead to non-uniform changes within the triceps surae (TS) muscle-tendon unit (MTU). Twelve young adults completed a 12-week training intervention of unilateral isometric cyclic plantarflexion contractions at 80% of maximal voluntary contraction until failure to induce a high TS activity and hence metabolic stress. Each participant trained one limb at a short (plantarflexed position, 115°: PF) and the other at a long (dorsiflexed position, 85°: DF) MTU length to vary the mechanical load. MTU mechanical, morphological, and material properties were assessed biweekly via simultaneous ultrasonography-dynamometry and magnetic resonance imaging. Our hypothesis that tendon would be more sensitive to the operating magnitude of tendon strain but less to metabolic stress exercise was confirmed as tendon stiffness, Young's modulus, and tendon size were only increased in the DF condition following the intervention. The PF leg demonstrated a continuous increment in maximal AT strain (i.e., higher mechanical demand) over time along with lack of adaptation in its biomechanical properties. The premise that skeletal muscle adapts at a higher rate than tendon and does not require high mechanical load to hypertrophy or increase its force potential during exercise was verified as the adaptive changes in morphological and mechanical properties of the muscle did not differ between DF and PF. Such differences in muscle-tendon sensitivity to mechano-metabolic stimuli may temporarily increase MTU imbalances that could have implications for the risk of tendon overuse injury
Accelerated Sensitivity Analysis in High-Dimensional Stochastic Reaction Networks
In this paper, a two-step strategy for parametric sensitivity analysis for
such systems is proposed, exploiting advantages and synergies between two
recently proposed sensitivity analysis methodologies for stochastic dynamics.
The first method performs sensitivity analysis of the stochastic dynamics by
means of the Fisher Information Matrix on the underlying distribution of the
trajectories; the second method is a reduced-variance, finite-difference,
gradient-type sensitivity approach relying on stochastic coupling techniques
for variance reduction. Here we demonstrate that these two methods can be
combined and deployed together by means of a new sensitivity bound which
incorporates the variance of the quantity of interest as well as the Fisher
Information Matrix estimated from the first method. The first step of the
proposed strategy labels sensitivities using the bound and screens out the
insensitive parameters in a controlled manner based also on the new sensitivity
bound. In the second step of the proposed strategy, the finite-difference
method is applied only for the sensitivity estimation of the (potentially)
sensitive parameters that have not been screened out in the first step. Results
on an epidermal growth factor network with fifty parameters and on a protein
homeostasis with eighty parameters demonstrate that the proposed strategy is
able to quickly discover and discard the insensitive parameters and in the
remaining potentially sensitive parameters it accurately estimates the
sensitivities. The new sensitivity strategy can be several times faster than
current state-of-the-art approaches that test all parameters, especially in
"sloppy" systems. In particular, the computational acceleration is quantified
by the ratio between the total number of parameters over the number of the
sensitive parameters
Investigating the Behavior of Compact Composite Descriptors in Early Fusion, Late Fusion and Distributed Image Retrieval
In Content-Based Image Retrieval (CBIR) systems, the visual content of the images is mapped into a new space named the feature space. The features that are chosen must be discriminative and sufficient for the description of the objects. The key to attaining a successful retrieval system is to choose the right features that represent the images as unique as possible. A feature is a set of characteristics of the image, such as color, texture, and shape. In addition, a feature can be enriched with information about the spatial distribution of the characteristic that it describes. Evaluation of the performance of low-level features is usually done on homogenous benchmarking databases with a limited number of images. In real-world image retrieval systems, databases have a much larger scale and may be heterogeneous. This paper investigates the behavior of Compact Composite Descriptors (CCDs) on heterogeneous databases of a larger scale. Early and late fusion techniques are tested and their performance in distributed image retrieval is calculated. This study demonstrates that, even if it is not possible to overcome the semantic gap in image retrieval by feature similarity, it is still possible to increase the retrieval effectiveness
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