Detection of evolving injury to the brachial plexus during transaxillary robotic thyroidectomy.

OBJECTIVES/HYPOTHESIS: Continuous intraoperative neuromonitoring (IONM) of transcranial electric motor evoked potentials (tceMEPs) and somatosensory evoked potentials (SSEPs) has gained universal acceptance as an efficacious method for detecting emerging positional brachial plexopathy or peripheral nerve compression during spinal and shoulder surgery. This has implications for transaxillary thyroid surgery. STUDY DESIGN: Case report with literature review. METHODS: The patient underwent robotic transaxillary thyroid surgery with continuous tceMEP and SSEP monitoring of brachial plexus function. We present detailed IONM data depicting the emergence of positional brachial plexopathy. RESULTS: Significant amplitude loss of both IONM modalities were identified during an evolving positional plexopathy, which resolved upon upper extremity repositioning and conversion to an open procedure. No permanent nerve injury or deficit was noted following surgery. CONCLUSIONS: Given the potential for brachial plexus injury during robotic transaxillary thyroid surgery secondary to arm positioning, we recommend that continuous tceMEP and SSEP monitoring be considered during such procedures

Northern hemisphere tropical cyclones during the quasi-El Niño of late 2014

During the second half of 2014, the tropical Pacific was in a state marginally consistent with El Niño. While oceanic indicators were indicative of a weak El Niño event, a number of atmospheric indicators were not, and a number of forecast centers did not declare an El Niño. Nonetheless, the most active tropical cyclone basins of the northern hemisphere—those of the North Atlantic and Pacific—showed tropical cyclone statistics that in some respects were consistent with El Niño. In particular, the numbers of relatively intense storms in the four basins considered—major hurricanes in the Eastern North Pacific and North Atlantic, super typhoons in the Western North Pacific, and hurricanes in the Central North Pacific—formed a pattern strongly consistent with El Niño

Mobile phone use among commercial drivers in Ghana: An important threat to road safety

Background: Ghana passed a law in 2012 banning the use of mobile phones while driving. However, data on compliance to the law has been lacking.Objective: To examine factors associated with mobile phone use while driving among Ghanaian commercial drivers.Methods: A survey was conducted among 627 commercial drivers (98.0% response rate). Bivariate and multivariate logistic regressions were performed to determine how a priori covariates influenced commercial drivers’ use of phones while driving. The covariates included driver age, education, driving route distance, driving under the influence (DUI), and knowledge that phone use during driving causes distraction.Results: Respondents were aware of the law (94.7%) but compliance was low (38%). Drivers who did not believe that cell phone use contributed to crash risk were more likely to report distracted driving (AOR 2.02,95%CI 1.05-3.9). Drivers who had completed primary (AOR 4.49,95%CI 1.14-17.78) or at least senior high school (AOR 6.89,95%CI 1.5-31.59) had increased odds of using the phone while driving, compared to those having no formal education. Drivers with 6-10 years (AOR 2.00,95%CI 1.00-3.98) or >10 years driving experience (AOR 2.87,95%CI 1.24-6.62) were more likely to report distracted driving compared to those with ≤5 years’ experience. Drivers who travelled longer distances were more likely to report distracted driving (AOR 2.41,95%CI 1.23-4.71). Those who had never engaged in DUI were less likely to use the phone while driving (AOR 0.06,95%CI 0.01-0.43).Conclusion: Future prevention efforts for distracted driving in Ghana will require targeted distracted driving enforcement and education for commercial drivers and their passengers. Funding: This study was funded, in part, by a grant (D43-TW007267) from the Fogarty International Center, US National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Keywords: Mobile phone, commercial drivers, Ghana, road safety, distracted drivin

Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment

© 2020. Published by The Company of Biologists Ltd. Cellular polarization underlies many facets of cell behavior, including cell growth. The rod-shaped fission yeast Schizosaccharomyces pombe is a well-established, genetically tractable system for studying growth polarity regulation. S. pombe cells elongate at their two cell tips in a cell cycle-controlled manner, transitioning from monopolar to bipolar growth in interphase when new ends established by the most recent cell division begin to extend. We previously identified cytokinesis as a critical regulator of new end growth and demonstrated that Fic1, a cytokinetic factor, is required for normal polarized growth at new ends. Here, we report that Fic1 is phosphorylated on two C-terminal residues, which are each targeted by multiple protein kinases. Endogenously expressed Fic1 phosphomutants cannot support proper bipolar growth, and the resultant defects facilitate the switch into an invasive pseudohyphal state. Thus, phosphoregulation of Fic1 links the completion of cytokinesis to the re-establishment of polarized growth in the next cell cycle. These findings broaden the scope of signaling events that contribute to regulating S. pombe growth polarity, underscoring that cytokinetic factors constitute relevant targets of kinases affecting new end growth.This article has an associated First Person interview with Anthony M. Rossi, joint first author of the paper

Kinematics reconstruction in solenoidal spectrometers operated in active target mode

We discuss the reconstruction of low-energy nuclear reaction kinematics from charged-particle tracks in solenoidal spectrometers working in Active Target Time Projection Chamber mode. In this operation mode, reaction products are tracked within the active gas medium of the Active Target with a three dimensional space point cloud. We have inferred the reaction kinematics from the point cloud using an algorithm based on a linear quadratic estimator (Kalman filter). The performance of this algorithm has been evaluated using experimental data from nuclear reactions measured with the Active Target Time Projection Chamber (AT-TPC) detector

Effects of Fire Severity on Habitat Recovery in a Mixed Grass Prairie Ecosystem

We assessed the recovery and current status of three mixed grass prairie sites 5 yr post burn in the Wichita Mountains Wildlife Refuge, Indiahoma, Oklahoma. These sites represent three burn histories: moderate burn, severe burn, and unburned. We used a modified point-intercept method to sample 38 habitat variables at 280 points along three transects at each site. These data were subjected to principal components analysis to assess trends in habitat structure among the sites. The first three components explained 66.6% of the variation in the dataset. Component I represents a gradient from short forbs, lichen covered rocks, and minimal disturbance to areas of tall grasses and ungulate disturbance. Component II represents a gradient from tall forbs and water disturbance to areas with woody shrubs, short herbaceous litter, and graminoid and moss ground cover. Component III represents a gradient from areas with mid-level forbs, fecal matter and herbaceous litter ground cover to areas with tall grasses and bare ground. Projections of the burn treatment sites onto principal components I–III indicate that the moderate and unburned sites cluster closely on component I but are distinct along components II and III. We interpret our results as supporting a relationship between high severity fire and more complete nutrient cycling from accumulated litter, leading initially post fire to dense grass cover followed by increasing forb cover. This increase in forage density potentially alters the grazing patterns of large herbivores, which inflicts higher levels of disturbance. Conversely, the unburned and moderate burn sites had a greater diversity of herbaceous species at lower coverage densities, perhaps resulting from reestablshiment from surviving shoots and seeds

A Uniform Algorithm for All-Speed Shock-Capturing Schemes

There are many ideas for developing shock-capturing schemes and their extension for all-speed flow. The representatives of them are Roe, HLL and AUSM families. In this paper, a uniform algorithm is proposed, which expresses three families in the same framework. The algorithm has explicit physical meaning, provides a new angel of understanding and comparing the mechanism of schemes, and may play a great role in the further research. As an example of applying the uniform algorithm, the low-Mach number behaviour of the schemes is analyzed. Then, a very clear and simple explanation is given based on the wall boundary, and a concise rule is proposed to judge whether a scheme has satisfied low-Mach number behaviour

Test structure and measurement system for characterising the electrochemical performance of nanoelectrode structures

This paper presents a complete test structure and characterisation system for the evaluation of nanoelectrode technology. It integrates microfabricated nanoelectrodes for electrochemical measurements, 3D printing and surface tensionconfined microfluidics. This system exploits the inherent analytical advantages of nanoelectrodes that enables their operation with small volume samples, which has potential applications for onwafer measurements

Brangus cows have ovarian reserve parameters more like Brahman than Angus cows

Bos indicus females have more surface antral follicles than Bos taurus females; however, histological studies demonstrated no difference in total number of primordial follicles between these two biological types of cattle. Primordial follicle density in the ovary was less in Nelore ovaries compared to Angus ovaries, but no studies have examined the primordial follicle density in Bos indicus cross-bred females. It, therefore, was hypothesized that primordial follicle density in the ovary would decrease as percentage Bos indicus increased. Ovaries were collected from cross-bred Angus (n=32, no Bos indicus influence), Brangus (n=15), or Brahman (n=9) cows and prepared for histological evaluation. There was no difference in total number of primordial follicles per ovary between breeds (P \u3e 0.10). When numbers of primordial follicles were expressed on a per gram of ovarian tissue basis, there were fewer primordial follicles per gram of ovarian tissue in Brangus and Brahman cows than in Angus cows (P \u3c 0.05). Brangus cows did not differ from Brahman cows in primordial follicle density (P \u3e 0.10). Differences in primordial follicle density could indicate differences in capacity of ovarian stroma to produce factors necessary for oogonial proliferation and primordial follicle formation among breeds. Identifying these factors could improve the aprroach for culturing pre-antral follicles of cattle. Furthermore, these results explain why ultrasonographic antral follicle counts may need to be adjusted to a greater threshold to predict size of the ovarian reserve and determine ovarian reserve related reproductive traits in Bos indicus females