Assessment of naturally occurring radiation in lithofacies of oil field in Niger Delta region and its possible health implications

The accumulation and increase in radionuclide activities of NORMs beyond permissible levels, will lead to health hazards and environmental damages if proper measures are not taken to control their occurrence as well as protect the lives of drillers and the environment. Therefore, evaluations and risk assessments of subsurface lithofacies is inevitable in order to protect people and the environment. Lack of existing Federal environmental regulations to address the presence of NORMs in oil and gas exploration activities in Nigeria, gives credence to this study. However, before these regulations can be developed, adequate research knowledge is needed to better understand the occurrence and distribution of Norms in subsurface lithofacies, as well as quantify the hazards posed by these NORMs to the people in the environment. This study then investigates the occurrence of naturalradiation in lithofacies of an oil field region in Niger-Delta area using Hyper Germanium (HPGe) detector. Six (6) samples of different subsurface layers of lithofacies were collected during drilling, and analyzed. The results showed that the measured activity concentration of 238U decreased as the depth increased; the activity concentration of 232Th ranged between 11.8 9.29 Bq/kg and 23.1 8.43 Bq/kg, while the activity concentration of 4 K ranged from 161.8 Bq/kg to 245.4 Bq/kg. The estimated radiological risks such as absorbed dose rates, annual effective dose rates, radium equivalent index, external hazard index and internal hazard index were determined. The mean values for the estimated radiological parameters were 12.32 nGyh 1, 15.1049 Svy 1,44.7720 Bqkg 1 , 0.1209 and 0.1318 respectively. The gamma index estimated for the samples used were within the standard values recommended by Unscear, 2000. Significantly, this study reveals a distinctive decrease in 232Th activity with depth within the area under consideration. Based on the compared results, the measured radioactive concentrations and estimated radiological risks were below international reference valu

Assessment of naturally occurring radiation in lithofacies of oil field in Niger Delta region and its possible health implications

The accumulation and increase in radionuclide activities of NORMs beyond permissible levels, will lead to health hazards and environmental damages if proper measures are not taken to control their occurrence as well as protect the lives of drillers and the environment. Therefore, evaluations and risk assessments of subsurface lithofacies is inevitable in order to protect people and the environment. Lack of existing Federal environmental regulations to address the presence of NORMs in oil and gas exploration activities in Nigeria, gives credence to this study. However, before these regulations can be developed, adequate research knowledge is needed to better understand the occurrence and distribution of Norms in subsurface lithofacies, as well as quantify the hazards posed by these NORMs to the people in the environment. This study then investigates the occurrence of natural radiation in lithofacies of an oil field region in Niger-Delta area using Hyper Germanium (HPGe) detector. Six (6) samples of different subsurface layers of lithofacies were collected during drilling, and analyzed. The results showed that the measured activity concentration of 238U decreased as the depth increased; the activity concentration of 232Th ranged between 11.8 ± 9.29 Bq/kg and 23.1 ± 8.43 Bq/kg, while the activity concentration of 4 K ranged from 161.8 Bq/kg to 245.4 Bq/kg. The estimated radiological risks such as absorbed dose rates, annual effective dose rates, radium equivalent index, external hazard index and internal hazard index were determined. The mean values for the estimated radiological parameters were 12.32 nGyh−1, 15.1049 Svy−1, 44.7720 Bqkg−1, 0.1209 and 0.1318 respectively. The gamma index estimated for the samples used were within the standard values recommended by Unscear, 2000. Significantly, this study reveals a distinctive decrease in 232Th activity with depth within the area under consideration. Based on the compared results, the measured radioactive concentrations and estimated radiological risks were below international reference values

Inaccessibility and low maintenance of medical data archive in low-middle income countries: Mystery behind public health statistics and measures

Africa bears the largest burden of communicable and non-communicable diseases globally, yet it contributes only about 1 % of global research output, partly because of inaccessibility and low maintenance of medical data. Data is widely recognized as a crucial tool for improvement of population health. Despite the introduction of electronic health data systems in low-and middle-income countries (LMICs) to improve data quality, some LMICs still lack an efficient system to collect and archive data. This study aims to examine the underlying causes of data archive inaccessibility and poor maintenance in LMICS, and to highlight sustainable mitigation measures. Method Authors conducted a comprehensive search on PubMed, Google scholar, organization websites using the search string “data archive” or “medical data” or “public health statistics” AND “challenges” AND “maintenance” AND “Low Middle Income Countries” or “LMIC”. to Identify relevant studies and reports to be included in our review. All articles related data archive in low and middle income countries were considered without restrictions due to scarcity of data. Result Medical data archives in LMICs face challenges impacting data quality. Insufficient training, organizational constraints, and limited infrastructure hinder archive maintenance. To improve, support for public datasets, digital literacy, and technology infrastructure is needed. Standardization, cloud solutions, and advanced technologies can enhance data management, while capacity building and training programs are crucial. Conclusion The creation and maintenance of data archives to facilitate the storage of retrospective datasets is critical to create reliable and consistent data to better equip the development of resilient health systems and surveillance of diseases in LMICs

Concentrations of iodine and some environmental goitrogens in two selected water bodies - Adada and Akoru in Nsukka, Enugu State, Nigeria

This study was designed to investigate the distribution of iodine and goitrogens in two selected rivers: Adada and Akoru in Enugu Sate, Nigeria. Iodine concentrations were found to be 0.109±0.001 and 0.108±0.001 ppm, respectively in both water bodies. The evaluated environmental goitrogens were as follows in Adada and Akoru Rivers: Calcium 109.333±16.0 and 74.667±7.67 ppm; sulphate 33.400±7.40 and 65.000±2.60 ppm; chloride 183.000±13.20 and 257.7±14.30 ppm; potassium 0.733±0.02 and 0.733±0.02 ppm; nitrate 6.000±1.00 and 6.000±1.00 ppm; copper 3.455±0.46 and 2.792±1.35 ppm; phosphate 3.067±1.30 and 0.267±0.07 ppm; manganese 0.692±0.20 and 0.513±0.08 ppm; iron 0.476±0.05 and 0.181±0.01 ppm; magnesium 0.085±0.02 and 0.085±0.02 ppm, respectively. High values of these goitrogens in both rivers could be attributed to the high salt level of the two water bodies. Considering the iodine and goitrogen ratio in both Adada and Akoru rivers, the two water bodies would be a good source of iodine for the population and fresh water bodies that are dependent on them.Keywords: Adada River, Akoru River, iodine, goitrogens, hardness, acidity, pH.African Journal of Biotechnology, Vol 13(44) 4215-421

A novel formulation design based on hetero-templated solid lipid microparticles to improve the solubility of anti-inflammatory piroxicam for oral administration

The aim of the work was to formulate piroxicam-loaded solid lipid microparticles (SLMs) using natural biodegradable lipids and to evaluate the in vitro and in vivo properties of the formulations. The lipid matrix composition consisted of 1 : 2 ratios of dika wax from Irvingia gabonensis and goat fat or beeswax. Varying amounts of the drug (0.5, 0.25 and 0.1%) were loaded into the SLMs. The SLMs were formulated using a melt homogenization method and analysed using animal model standard methods. In vivo anti-inflammatory studies were performed using Wistar rats and showed stable formulations with spherical particles within the range of 35 +/- 0.577 to 50 +/- 1.527 mu m. The encapsulation efficiency (EE) ranged from 43.20% to 89.03% and was significantly affected by the amount of drug loaded (p < 0.05). The formulations also exhibited a stable pH from 24 h to 2 months, meaning that there was no degradation of the active pharmaceutical ingredient (API) and the excipients. The in vitro drug release increased with the amount of drug loaded with an approximately 86% release at 600 min for formulations containing 0.5% drug, and 24% for formulations with 0.1% drug. Absorption of the SLMs was enhanced compared with a market formulation and the SLMs had better anti-inflammatory properties, which attests to the effects of the lipids at improving the oral absorption of piroxicam. Hence, piroxicam-loaded SLMs are a possible alternative to the current market formulations

Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats

In the present study, in vitro, in vivo, and in silico models were used to evaluate the therapeutic potential of Pulmeria alba methanolic (PAm) extract, and we identified the major phytocompound, apigetrin. Our in vitro studies revealed dose-dependent increased glucose uptake and inhibition of α-amylase (50% inhibitory concentration (IC50)= 217.19 µg/mL), antioxidant (DPPH, ferric-reducing activity of plasma (FRAP), and lipid peroxidation (LPO) [IC50 = 103.23, 58.72, and 114.16 µg/mL respectively]), and anti-inflammatory potential (stabilizes human red blood cell (HRBC) membranes, and inhibits proteinase and protein denaturation [IC50 = 143.73, 131.63, and 198.57 µg/mL]) by the PAm extract. In an in vivo model, PAm treatment reversed hyperglycemia and attenuated insulin deficiency in rats with streptozotocin (STZ)-induced diabetes. A post-treatment tissue analysis revealed that PAm attenuated neuronal oxidative stress, neuronal inflammation, and neuro-cognitive deficiencies. This was evidenced by increased levels of antioxidants enzymes (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), and decreased malondialdehyde (MDA), proinflammatory markers (cyclooxygenase 2 (COX2), nuclear factor (NF)-κB and nitric oxide (NOx)), and acetylcholinesterase (AChE) activities in the brain of PAm-treated rats compared to the STZ-induced diabetic controls. However, no treatment-related changes were observed in levels of neurotransmitters, including serotonin and dopamine. Furthermore, STZ-induced dyslipidemia and alterations in serum biochemical markers of hepatorenal dysfunction were also reversed by PAm treatment. Extract characterization identified apigetrin (retention time: 21,227 s, 30.48%, m/z: 433.15) as the major bioactive compound in the PAm extract. Consequently, we provide in silico insights into the potential of apigetrin to target AChE/COX-2/NOX/NF-κB Altogether the present study provides preclinical evidence of the therapeutic potential of the apigetrin-enriched PAm extract for treating oxidative stress and neuro-inflammation associated with diabetes