I beni comuni tra categorie romanistiche e dibattiti vecchi e nuovi

The article, after having reconstructed some lines of the international and Italian debate on commons and their legal discipline, examines in the light of the Roman sources the attempt to indicate in the Roman categories of goods removed from individual ownership possible models for the regulation of commons. Finally, two examples taken from medieval and modern history will be taken in consideration, which show how recourse to Roman categories of goods to model the discipline of current phenomena is an operation to be carried out with caution

Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study.

OBJECTIVE: Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported studies, successful real-life experiences with the approved dose for treating severe eosinophilic asthma (100 mg every 4 weeks) were observed. We undertook this study to assess the effectiveness and safety of mepolizumab 100 mg every 4 weeks and 300 mg every 4 weeks in a large European EGPA cohort. METHODS: We included all patients with EGPA treated with mepolizumab at the recruiting centers in 2015-2020. Treatment response was evaluated from 3 months to 24 months after initiation of mepolizumab. Complete response to treatment was defined as no disease activity (Birmingham Vasculitis Activity Score [BVAS] = 0) and a prednisolone or prednisone dose (or equivalent) of ≤4 mg/day. Respiratory outcomes included asthma and ear, nose, and throat (ENT) exacerbations. RESULTS: Two hundred three patients, of whom 191 received a stable dose of mepolizumab (158 received 100 mg every 4 weeks and 33 received 300 mg every 4 weeks) were included. Twenty-five patients (12.3%) had a complete response to treatment at 3 months. Complete response rates increased to 30.4% and 35.7% at 12 months and 24 months, respectively, and rates were comparable between mepolizumab 100 mg every 4 weeks and 300 mg every 4 weeks. Mepolizumab led to a significant reduction in BVAS score, prednisone dose, and eosinophil counts from 3 months to 24 months, with no significant differences observed between 100 mg every 4 weeks and 300 mg every 4 weeks. Eighty-two patients (40.4%) experienced asthma exacerbations (57 of 158 [36%] who received 100 mg every 4 weeks; 17 of 33 [52%] who received 300 mg every 4 weeks), and 31 patients (15.3%) experienced ENT exacerbations. Forty-four patients (21.7%) experienced adverse events (AEs), most of which were nonserious AEs (38 of 44). CONCLUSION: Mepolizumab at both 100 mg every 4 weeks and 300 mg every 4 weeks is effective for the treatment of EGPA. The 2 doses should be compared in the setting of a controlled trial

Acqua e diritto romano: "invenzione" di un modello?

Il paper affronta il problema delle condizioni di configurabilità dell'acqua come bene dotato di una disciplina autonoma, nelle fonti romane e nella tradizione romanistica

USUS PUBLICUS: tutela interdittale e classificazione delle cose

La presente indagine rappresenta il tentativo di mettere a fuoco la nozione di usus publicus emergente dalla lettura delle fonti romane in tema di tutela interdittale di taluni beni pubblici chiamati perciò nelle fonti,perlomeno a partire dall'età augustea, res in usu publico

Storia dei dogmi e individualità dei giuristi nell'interpretazione della categoria delle res communes omnium

Il saggio approccia la questione delle possibili interpretazioni della categoria delle res communes omnium alla luce della distinzione tra storia dei dogmi e dei giuristi, giungendo a proporre una soluzione originale al problema

La dottrina degli status e la teoria analitica del reato (rileggendo un saggio di F. Horak)

Il contributo sviluppa un'intuizione di Horak e propone una rilettura della teoria analitica del reato alla luce dell'antica teoria degli status

Commento al testo 29

Commento al testo 29 del volume

C.I. 4.5.10: note a margine di un dibattito giurisprudenziale classico nell'ottica giustinianea

L’articolo intende fare il punto sui rapporti tra C.I. 4.5.10, una delle quinquaginta decisiones con cui Giustiniano intendeva risolvere controversie risalenti alla giurisprudenza precedente, e il pensiero dei giuristi classici in esso nominativamente citati così come restituito dalla lettura dei Digesta, in particolare dei passi D.12.6.26.13 (Ulp. 26 ad ed.), D.31.19 (Cels. 18 dig.) e D.12.6.32.3 (Iul. 10 dig.). Contro un recente tentativo in senso contrario, si intende riaffermare, alla luce dei più recenti studi su finalità e modalità di redazione delle quinquaginta decisiones, la lettura secondo cui questi brani sarebbero effettivamente testimoni del medesimo ius controversum risolto da Giustiniano in C.I. 4.5.10

Remarks on Common Possession Between Law and History

‘Common possession’ can be designated as a distinguishing feature of the legal status of common goods, as opposed to the monopolistic character of real rights and especially property. The paper aims at proving how the study of the Roman legal category of res in usu publico can shed a light on the interpretation of existing legis- lation and ground a legal regulation of the commons based on possessory remedies