Os museus portugueses e a Web 2.0

O presente artigo dá a conhecer um projecto de investigação que teve como objectivo determinar e analisar a partir da observação dos sítios Web dos museus portugueses quais as ferramentas Web 2.0 usadas por estas instituições no desenvolvimento das suas actividades. Neste sentido, foram seleccionados como amostra os 125 museus pertencentes à Rede Portuguesa de Museus. Os resultados obtidospermitem-nos afirmar que utilização das ferramentas Web 2.0 por parte dos museus portugueses analisados está numa fase inicial. A ferramenta mais usada é o blogue. Foram, também, identificados projectos pioneiros ao nível dos wikis, Licenças Creative Commons, Youtube, Flickr e redes sociais on-line. Palavras-chave Ferramentas Web 2.0. Museu. Sítio Web. Portuguese museums and Web 2.0 Abstract This article presents the results of an investigation work that had as main objective the determination and analysis of the Web 2.0 tools used by Portuguese museums in the development of their activities. The selected samples were the 125 museums from the Rede Portuguesa de Museus. The conclusion is that this practice is only at an early stage. The most used tool is the blog. Pioneer projects were also identified namely wikis, Creative Commons Licenses, Youtube, Flickr and online social networks. Keywords Web 2.0 tools. Museum. Web site

Enrichment of IFN- producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite.

Here we report that lean mice infected with the intracellular parasite Neospora caninum show a fast but sustained increase in the frequency of IFN-γ-producing cells noticeable in distinct adipose tissue depots. Moreover, IFN-γ-mediated immune memory could be evoked in vitro in parasite antigen-stimulated adipose tissue stromal vascular fraction cells collected from mice infected one year before. Innate or innate-like cells such as NK, NK T and TCRγδ(+) cells, but also CD4(+) and CD8(+) TCRβ(+) lymphocytes contributed to the IFN-γ production observed since day one of infection. This early cytokine production was largely abrogated in IL-12/IL23 p40-deficient mice. Moreover, production of IFN-γ by stromal vascular fraction cells isolated from these mice was markedly lower than that of wild-type counterparts upon stimulation with parasite antigen. In wild-type mice the increased IFN-γ production was concomitant with up-regulated expression of genes encoding interferon-inducible GTPases and nitric oxide synthase, which are important effector molecules in controlling intracellular parasite growth. This increased gene expression was markedly impaired in the p40-deficient mice. Overall, these results show that NK cells but also diverse T cell populations mediate a prompt and widespread production of IFN-γ in the adipose tissue of N. caninum infected mice

MarinEye - A tool for marine monitoring

This work presents an autonomous system for marine integrated physical-chemical and biological monitoring – the MarinEye system. It comprises a set of sensors providing diverse and relevant information for oceanic environment characterization and marine biology studies. It is constituted by a physicalchemical water properties sensor suite, a water filtration and sampling system for DNA collection, a plankton imaging system and biomass assessment acoustic system. The MarinEye system has onboard computational and logging capabilities allowing it either for autonomous operation or for integration in other marine observing systems (such as Observatories or robotic vehicles. It was designed in order to collect integrated multi-trophic monitoring data. The validation in operational environment on 3 marine observatories: RAIA, BerlengasWatch and Cascais on the coast of Portugal is also discussed.info:eu-repo/semantics/publishedVersio

Phenotyping GABA transaminase deficiency: a case description and literature review

Gamma-aminobutyric acid transaminase (GABA-T) deficiency is an autosomal recessive disorder reported in only three unrelated families. It is caused by mutations in the ABAT gene, which encodes 4-aminobutyrate transaminase, an enzyme of GABA catabolism and mitochondrial nucleoside salvage. We report the case of a boy, deceased at 12 months of age, with early-onset epileptic encephalopathy, severe psychomotor retardation, hypotonia, lower-limb hyporeflexia, central hypoventilation, and rapid increase in weight and, to a lesser rate, length and head circumference. He presented signs of premature pubarche, thermal instability, and water-electrolyte imbalance. Serum total testosterone was elevated (43.3 ng/dl; normal range  T (p.Gln296His),not previously described. In vitro analysis concluded that this variant is pathogenic. The clinical features of this patient are similar to those reported so far in GABA-T deficiency. However, distinct mutations may have a different effect on enzymatic activity, which potentially could lead to a variable clinical outcome. Clinical investigation aiming for a diagnosis should not end with the patient's death, as it may allow a more precise genetic counselling for the family.info:eu-repo/semantics/publishedVersio

EAIR 41st Annual Forum in Leiden, The Netherlands 25 till 28 August 2019

Trabalho apresentado em EAIR 41st Annual Forum, 25-28 agosto 2019, Leiden, Países Baixos.Polytechnic Institutes in Portugal: research on the impact of twelve institutes on the local economy Higher Education Institutions are recognized as important actors in regional development. The Portuguese higher education system comprises both Universities and Polytechnic Institutes, which face an increasing pressure to demonstrate that their presence has an impact on the surrounding communities contributing to their economic development. This paper presents the estimation of the economic impact of twelve Polytechnic Institutes, located in quite diverse regions, based on a shared model so that comparisons have a collective framework of analysis. The main results obtained show that the economic impact ranged from 1.8% to 10.6% of the local GDP and that these Institutes are major local employers.info:eu-repo/semantics/publishedVersio

Hurdles and opportunities in implementing marine biosecurity systems in data-poor regions

Managing marine nonindigenous species (mNIS) is challenging, because marine environments are highly connected, allowing the dispersal of species across large spatial scales, including geopolitical borders. Cross-border inconsistencies in biosecurity management can promote the spread of mNIS across geopolitical borders, and incursions often go unnoticed or unreported. Collaborative surveillance programs can enhance the early detection of mNIS, when response may still be possible, and can foster capacity building around a common threat. Regional or international databases curated for mNIS can inform local monitoring programs and can foster real-time information exchange on mNIS of concern. When combined, local species reference libraries, publicly available mNIS databases, and predictive modeling can facilitate the development of biosecurity programs in regions lacking baseline data. Biosecurity programs should be practical, feasible, cost-effective, mainly focused on prevention and early detection, and be built on the collaboration and coordination of government, nongovernment organizations, stakeholders, and local citizens for a rapid response.This work resulted from a workshop organized at the King Abdul- lah University of Science and Technology and sponsored under the Support for Conferences and Workshops Program. We would like to thank the admin support of the Red Sea Research Cen- ter team, IT, and teachers and students from the KAUST schools who participated in some outreach activities. We thank Ana Bi- gio for the artwork presented in this article (figures 1–4). GS was supported by the European Social Fund, under project no 09.3.3- LMT-K-712, the “Development of Competences of Scientists, other Researchers and Students through Practical Research Activities” measure, grant agreement no. 09.3.3-LMT-K-712–19-0083

INTRAOPERATIVE ANTICOAGULATION MONITORIZATION IN VASCULAR SURGERY – DOES A BLIND DOSIS FITS ALL?

Introduction: Unfractionated heparin (UFH) has been used for decades to prevent thrombotic events during vascular surgery. Although it is known that UFH has a complex and nonlinear pharmacokinetics, with great individual variability, anticoagulation monitorization in vascular surgery is not routine and a standard empirical dose is often used. Activated clotting time (ACT) has been shown to be a simple, reliable and inexpensive way to monitor UFH anticoagulant effect, being routinely used during cardiac surgery. However, heparinisation remains a dilemma in vascular surgery and few studies emphasized the role of anticoagulation monitoring in this setting. Objectives: To investigate whether a fixed heparin dose of 5000 IU in arterial vascular surgery results in adequate and homogeneous heparinisation in all patients. Secondary endpoints: to identify preoperative factors for heparin response, intraoperative events and outcomes. Methods: This observational prospective pilot study included 30 consecutive patients undergoing arterial vascular surgery. ACT monitoring was performed before clamping and at 3, 30 and 60 minutes after 5000 IU UFH bolus. Preoperative and intraoperative data were also accessed. A target ACT of ≥ 200 s was set, taking in account of the lowest ACT value admitted by vascular surgery recommendations. Results: The average ACT value increased to 210.20 ± 28.82 s (1.61 ± 0.25 times vs baseline) 3 minutes after bolus, then declined to 191.60 ± 21.86 s and 173.4 ± 21.37 s after 30 and 60 minutes, respectively. Three minutes after UFH bolus, 53% patients had ACT ≥ 200 s, decreasing to one third and 7% at 30 and 60 minutes, respectively. Even when weight-based, a correlation between heparin dose per kilogram and ACT change was not found (r = 0.187; p = 0.322). There was also no correlation between ACT values and preoperative hemoglobin, platelet count, creatinine clearance or INR. There was a positive correlation between preoperative aPTT and intraoperative ACT measurements (r = 0.432; p = 0.017). There was no difference between ACT values and previous antithrombotic/anticoagulant therapy and between intraoperative ACT and intraoperative blood loss. Conclusions: This study confirms that administrating a fixed or even a weight-based heparinisation is insufficient to provide consistent anticoagulation levels in all patients. Perioperative anticoagulation should be monitored and ACT-based. Larger clinical RCT's are warranted

Ciudades en construcción permanente: ¿Destino de casas para todos?

La presente colección Ciudades de la Gente representa a hombres y mujeres cuya cultura popular, producto de las mezclas de todos aquellos que vivían y otros que han llegado a nuestros territorios, han hecho de lugares declarados como no aptos, lugares donde vivir, y han creado dentro de nuestras ciudades, la extensión de lo distinto. Son hombres y mujeres cuyo trabajo, el que tienen para aportar, junto al de otros y otras de su misma condición, les ha permitido autoproducir interesantes y sin duda bellos espacios donde convivir. Los profesores e investigadores miembros del Grupo de Trabajo Habitat Popular e Inclusión Social de CLACSO, nos unimos a todos aquellos hacedores que, superando los miedos y con deseos de avanzar, se atreven a caminar por lo desconocido y a no conformarse con lo conocido de otras realidades, buscando en conjunto afirmar, como derechos universales, las posibilidades de vidas dignas y de construcciones colectivas dentro de nuestras ciudades. Emprendemos la tarea de describir e interpretar el habitat popular y la inclusión social, abriendo posibilidades para que, experimentados y debutantes líderes populares e investigadores, hablen sobre "las ciudades de la gente" de muy diversos modos

Atualizações sobre a abordagem e o tratamento da depressão bipolar maior em adultos: Update on the approach and treatment of bipolar major depression in adults

Os princípios e questões gerais envolvidos no tratamento da depressão bipolar incluem a avaliação inicial, objetivos do tratamento, cenário, farmacoterapia, duração de um ensaio clínico adequado, monitoramento, psicoterapia adjuvante e comorbidade. O transtorno bipolar é um transtorno de humor caracterizado por períodos de elevação patológica do humor (mania ou hipomania). Os pacientes com transtorno bipolar I apresentam episódios maníacos  e quase sempre apresentam episódios hipomaníacos e episódios depressivos maiores. O transtorno bipolar II é caracterizado por pelo menos um episódio de hipomania e um ou mais episódios depressivos maiores. Além disso, características psicóticas, como delírios e alucinações, frequentemente acompanham episódios depressivos bipolares, particularmente em pacientes com transtorno bipolar I. O termo droga antimaníaca é utilizado para nos referir a medicamentos que podem reduzir os sintomas agudos de mania/hipomania, sem causar uma mudança para a polaridade oposta, exemplos incluem lítio, antiepilépticos, como carbamazepina e valproato, e antipsicóticos de segunda geração, como aripiprazol, cariprazina, lurasidona, olanzapina, quetiapina e risperidona. Os pacientes com depressão bipolar I podem não responder ou tolerar a monoterapia com quetiapina e monoterapia com lurasidona.&nbsp

Temas de investigação em direitos humanos para o século XXI

Edição comemorativa do 10.º aniversário do Mestrado em Direitos Humanos da Universidade do Minho.Este livro é uma celebração do ensino e da investigação em direitos humanos que têm vindo a ser desenvolvidos, na Escola de Direito da Universidade do Minho, há já mais de uma década. A sua publicação num momento em que se avolumam os riscos para valores fundamentais subjacentes à proteção dos direitos humanos – como a igualdade e a não discriminação, a proibição da escravatura e de tratamentos cruéis, desumanos e degradantes, a liberdade de religião ou crença, entre muitos outros –, torna-o especialmente oportuno. Os sinais de aparente retrocesso no consenso das nossas sociedades a respeito desses valores – visíveis no triunfo político de discursos abertamente racistas, xenófobos, sexistas, etc. – recordam-nos que, também no mundo ocidental, os direitos humanos são um work in progress, não um dado adquirido. Os novos riscos para a dignidade da pessoa humana associados aos avanços tecnológicos andam de par com velhas formas de subalternização e de opressão. O campo para a reflexão crítica é muito vasto. Os temas que hoje (pre)ocupam académicos, decisores políticos e ativistas de direitos humanos são também aqueles que estruturam o plano de estudos do Mestrado em Direitos Humanos da Universidade do Minho. Todos estes temas surgem ao longo do presente livro, que reúne contributos de muitos dos membros da comunidade científica e académica que o Mestrado em Direitos Humanos mobilizou e ajudou a dinamizar ao longo da última década, entre docentes do Mestrado, colaboradores em júris de provas públicas e/ou na orientação de mestrandos, oradores convidados e estudantes. Os textos aqui reunidos refletem bem as sinergias interdisciplinares, interinstitucionais e inter-nacionais que o Mestrado em Direitos Humanos foi capaz de criar, não apenas pela variedade de campos disciplinares representados – Direito, Filosofia, Relações Internacionais, Antropologia –, mas também pela participação de autores que são docentes e/ou investigadores em diversas instituições nacionais e estrangeiras, como a Faculdade de Direito da Universidade do Porto, a Faculdade de Economia da Universidade de Coimbra, a Universidade Federal da Paraíba e a Pontifícia Universidade Católica de São Paulo.info:eu-repo/semantics/publishedVersio