Pembuatan Rpg Halo

Game “Halo” is an RPG game that tells a tale of the player as they live their life as a new student at FTI UNTAR. This game is developed using Unity3D game engine and Dialoguer add-on to create RPG-themed dialogues. Player takes the role of a new FTI UNTAR that must fulfill the task of re-registration at UNTAR. In this game, the player have to do sequences of events in order to finish the game. The method of testing that were used are blackbox testing, alpha testing by the advisors and beta testing by using a survey of 34 players. The result of the tests showed that “Halo” already depicted UNTAR situation especially, FTI UNTAR, but it\u27s still lacking on the visual design and user input on character namin

Gravity Wave Drag Parameterizations for Earth’s Atmosphere

Atmospheric gravity waves (GWs), or buoyancy waves, transport momentum and energy through Earth’s atmosphere. GWs are important at nearly all levels of the atmosphere, though, the momentum they transport is particularly important in general circulation of the middle and upper atmosphere. Primary sources of atmospheric GWs are flow over mountains, moist convection, and imbalances in jet/frontal systems. Secondary GWs can also be generated as a result of dissipation of a primary GWs. Gravity waves typically have horizontal wavelengths of 10’s to 100’s of kilometers, though, they can have scales of 1’s to 1000’s of kilometers as well. Current effective resolutions of climate models, and even numerical weather prediction models, do not resolve significant portions of the momentum- and energy-flux-carrying GW spectrum, and so parameterizations are necessary to represent under- and unresolved GWs in most current models. Here, an overview of GWs generated by orography, convection, jet/front systems, primary wave breaking, and secondary wave generation is provided. The basic theory of GW generation, propagation, and dissipation relevant to parameterization is presented. Conventionally used GW parameterizations are then reviewed. Lastly, we describe uncertainties and parameter tuning in current parameterizations and discuss known processes that are currently missing

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host–pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions.The support and funding of Tres Cantos Open Lab Foundation is gratefully acknowledgedPeer reviewe

Author Correction: Limited capacity of tree growth to mitigate the global greenhouse effect under predicted warming.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Phase transition systematics in BiVO4 by means of high-pressure-high-temperature Raman experiments

"We report here high-pressure-high-temperature Raman experiments performed on BiVO4. We characterized the fergusonite and scheelite phases (powder and single crystal samples) and the zircon polymorph (nanopowder). The experimental results are supported by ab initio calculations, which, in addition, provide the vibrational patterns. The temperature and pressure behavior of the fergusonite lattice modes reflects the distortions associated with the ferroelastic instability. The linear coefficients of the zircon phase are in sharp contrast to the behavior observed in the fergusonite phase. The boundary of the fergusonite-to-scheelite second-order phase transition is given by TF-Sch (K) = -166(8)P(GPa) + 528(5). The zircon-to-scheelite, irreversible, first-order phase transition takes place at T-Z-(Sch )(K) = -107(8)P(GPa) + 690(10). We found evidence of additional structural changes around 15.7 GPa, which in the downstroke were found to be not reversible. We analyzed the anharmonic contribution to the wave-number shift in fergusonite using an order parameter. The introduction of a critical temperature depending both on temperature and pressure allows for a description of the results of all the experiments in a unified way.

The spatio-temporal pattern of Argentine shortfin squid (Illex argentinus) abundance in the Spanish bottom-trawl fishery in the southwest Atlantic.

The Argentine shortfin squid (Illex argentinus) is a common neritic species occurring in waters off Brazil, Uruguay, Argentina, and the Falkland/Malvinas Islands in the southwest Atlantic. Illex is the most important cephalopod species in the area and plays a significant role in the ecosystem. It is object of major fisheries using both trawlers (mostly from European countries) and jigging vessels (mainly from Asian countries) and the actual total annual catch could reach up to 700 thousand tons. Fishery and biological information collected by scientific observers aboard commercial trawlers between 1988 and 2003 was analysed in relation to physical and environmental factors to establish the spatio-temporal pattern of the species distribution. The data included 26 168 fishing haul records, of which 11103 were positive. CPUE (Catch Per Unit Effort, kg⋅hr-1) was used as abundance index. The analyses of the general spatio-temporal pattern of fish abundance, and the influence of environmental factors, such as SST, SBT and depth on squid abundance and distribution, was based on correlation, variograms, and time-series maps created using GIS. The areas of the highest densities were found in deep waters of the High Seas between 44.5º S – 47.0º S outside the Argentinean EEZ and to the north-west of the Islands in February–May. The correlations between squid abundance and cloud index at different moon phases were also analyzed

The spatio-temporal pattern of Argentine shortfin squid Illex argentinus abundance in the southwest Atlantic

The Argentine shortfin squid (Illex argentinus) is a common neritic species occurring in waters off Brazil, Uruguay, Argentina, and the Falkland/Malvinas Islands in the southwest Atlantic. Illex argentinus is the most important fished cephalopod species in the area and plays a significant role in the ecosystem. It is object of major fisheries using both trawlers (mostly from European countries) and jigging vessels (mainly from Asian countries) and estimated total annual average catch for the last 15 years (1988-2003) is about 700 000 tons. The present paper aims to develop predictive models of squid abundance in relation to physical and environmental conditions, models that could ultimately be applied to fishery forecasting. Fishery and biological data collected by scientific observers aboard commercial trawlers between 1988 and 2003 were analysed in relation to physical and environmental factors to establish the spatio-temporal pattern of the species’ distribution and quantify the influence of environmental variables (e.g. SST, depth) on local abundance. The data included 26 168 fishing haul records, of which 11 103 were positive for Illex. CPUE (Catch Per Unit Effort, kg h−1) was used as abundance index. The analyses were based on time-series maps created using Geographical Information Systems (GIS). GIS maps showed that highest CPUE values were recorded during the first four months of the year (the Austral summer-autumn), with peak values higher than 5000 kg h−1 mainly located within 42◦ S, 46◦ S and MN (North part of Malvinas/Falkland) areas. Generalised additive models (GAMs) were used to describe variation in Illex argentinus abundance in relation to geographical and environmental variables. The presence/absence (PA) of Illex and its abundance (CPUE) in areas of presence were modelled separately. Predictors retained in the optimal models included SST, latitude, longitude, month, average fishing depth and year. Both models suggest a clear seasonal effect: maximum catchability was found during March (PA model) and the maximum abundances were found during the first quarter of the year (CPUE model). GAM models also demonstrated that higher catches and maturity of squid were related, in general terms, to warmer and deeper water.Abondance spatio-temporelle du calmar Illex argentinus dans l’Atlantique Sud. L’encornet rouge argentin (Illex argentinus) est une espèce néritique commune de l’Atlantique Sud-Ouest présente dans les eaux du Brésil, de l’Uruguay de l’Argentine et des îles Malouines (Falklands). Illex argentinus est la principale espèce de céphalopode exploitée dans cette région où elle joue un rôle majeur dans l’écosystème. L’espèce est pêchée par d’importantes flottilles de chalutiers (principalement de pays européens) et aux turluttes industrielles (de pays asiatiques) pour une production annuelle de 700 000 t en moyenne sur les 15 dernières années (1988-2003). Cet article présente des modèles prédictifs de l’abondance en fonction des facteurs physiques et environnementaux ; modèles qui pourraient à terme être appliqués à la gestion des pêches. Les données de capture et les paramètres biologiques récoltés, grâce à des observateurs embarqués, de 1988 à 2003, ont été analysées en relation avec les facteurs physiques pour préciser les variations spatio-temporelles de répartition et quantifier l’effet de la température et de la profondeur sur l’abondance. Le jeu de données porte sur 26 168 traits de pêche dont 11 103 comportant des captures d’Illex. Les captures par unité d’effort (CPUE en kg h−1) sont utilisées comme indice d’abondance et les analyses utilisent des séries de cartes, créées avec un système d’information géographique (SIG). Les valeurs les plus élevées de CPUE sont enregistrées durant les quatre premiers mois de l’année (l’été et l’automne austral) avec un pic dépassant 5000 kg h−1 localisé entre 42◦ S et 46◦ S dans la partie Nord desMalouines. Les modèles additifs généralisés (GAM) ont servi à décrire les variations d’abondance en fonction des variables géographiques et environnementales. La présence ou l’absence de la ressource est modélisée séparément de l’abondance. Les modèles optimaux retiennent comme variables explicatives la température, la latitude, la longitude, le mois, la profondeur et l’année. Les deux modèles indiquent un effet saisonnier net: la capturabilité est maximale en mars (présence/absence) et l’abondance (CPUE) est la plus élevée durant le premier trimestre. Les modèles additifs généralisés montrent également que les captures les plus élevées d’animaux à maturité sont associées à des eaux plus tièdes et des secteurs plus profonds

Data collection for stock assessment of two Hakes (Merluccius Hubbsi and M. Australis) in international and Falkland Waters of the SW Atlantic

Study Project 99/016 “Data collection for stock assessment of two hakes (Merluccius hubbsi and M. australis) in international and Falkland waters of the SW Atlantic” ran from January 2000 to December 2001. The main objective of the project was the collection and collation of already existing and newly acquired fishery and biological data needed for preliminary assessment of two hake species occurring in the study area. In addition to this basic remit, additional objectives included the creation of a common database, study of spawning seasons and areas, discard pattern and length-frequency composition of target and non-target species, estimation of annual by-catch rates, analysis of trophic relationships, marine mammals by-catch and sightings, morphometric analysis for stock differentiation, and developing GIS applications for analysis of the data collected. Historical fishery and biological data series available from IEO and FIGFD (since 1988 and 1987 respectively) were provided to the project. New fishery and biological data were collected by scientific observers provided by IEO, ANAMER and FIGFD, and placed on board Spanish fishing vessels operating in the study area during the project period. Data on fishing activity included effort, catches and discards of target and non-target species on a haul-by-haul basis. Biological information (size, sex, maturity stage, etc) of target and non-target species was recorded on a daily basis. Data on landings and effort were provided by ANAMER to its subcontractor (MG OTERO) for processing and estimation of total catch and effort of the whole Spanish fishing fleet in the area; MG OTERO was also responsible for organisation of observers in collaboration with ANAMER staff in Vigo and Port Stanley. Ancillary data on location, time of fishing, depth, SST, SBT, sea roughness, wind, etc, was recorded on a haul-by-haul basis. This type of information was essential for development of GIS at AU to relate the species distribution to physical and environmental factors. Other information collected was about by-catches and sightings of small cetaceans and seabirds, and biological samples such as otoliths, stomachs and whole specimens of hakes for subsequent studies on growth (IEO, FIGFD), diet and morphometrics (AU). All the historical and new data collected during the project were collated and integrated into a common database designed by all participants and built at IEO. The information was used for preliminary assessment of two hake populations co-ordinated by RRAG during a workshop held in London in July 2001. All these data will be analysed and written up for future publications. Discard rates of target species were generally low in all areas and seasons with the highest discard rate for Notothen sp. (around 100% of the catch). Illex squid was found to be the major by-catch for hake fishery in the 46 S area. IEO observers reported data on incidental catches of marine mammals and sea birds since 1993 and the analysis of this information was made by AU. The observed mortality in the fishing gears comprised small numbers of black-browed albatross, gentoo penguin and the hourglass dolphin. The species most frequently sighted was the Peale’s dolphin, although this species did not appear in by-catches, followed by the hourglass dolphin. The project provided an opportunity to collect and integrate for the first time at European level the necessary fishery and biological data for the development of partial stock assessment for the future rational management of the fisheries in the area. Such management is needed for the sustainability of the commercial fisheries, the conservation of the onshore and offshore jobs and the supply of fish to the most important markets worldwide.EUROPEAN COMMISSION DIRECTORATE GENERAL FISHERIES – DG XI

Overview of the Spanish fisheries in the Patagonian Shelf

The fishing grounds of the Patagonian Shelf support some of the most important fisheries in the world. The great abundance of marine resources among parallels 35º and 54º South, is associated with the Subtropical Convergence formed by the Brazil and Falkland/Malvinas currents. The mixing of the flow of La Plata River and the western branch of the Falkland/Malvinas Current generates areas of high plankton production on the shelf. Hakes (Merluccius hubbsi and Merluccius australis) and cephalopods (Illex argentinus and Loligo gahi) have been found the main commercial species, with important amounts of accompanying species in the catches such as Patagonian toothfish (Dissostichus eleginoides), Kingclip (Genypterus blacodes), Hoki (Macruronus magellanicus), Red cod (Salilota australis), Southern blue whiting (Micromesistius australis), etc. These fisheries are currently among the most important to the Spanish bottom trawler freezing fleet that has around 40 vessels fishing in this area, besides another 20 that operate in joint ventures sailing Falkland flag. It is estimated that this fleet generates approximately 2,000 direct offshore jobs, and more than 10,000 indirect onshore jobs. This paper presents results from the EC Study Project 99/016 “Data collection for stock assessment of two hakes (Merluccius hubbsi and M. australis) in international and Falkland waters of the SW Atlantic”. Historical fishery and biological data series available from the Instituto Español de Oceanografía (IEO) and the Falkland Islands Fishery Department (FIFD) were used during the project to describe fishing patterns and spatio-temporal changes in the abundance and distribution of target and accompanying species, as well as to give an overview of these important fisheries

Antimicrobial stewardship programs in adult intensive care units in Latin America: Implementation, assessments, and impact on outcomes

OBJECTIVE: To assess the impact of antimicrobial stewardship programs (ASPs) in adult medical-surgical intensive care units (MS-ICUs) in Latin America. DESIGN: Quasi-experimental prospective with continuous time series. SETTING: The study included 77 MS-ICUs in 9 Latin American countries. PATIENTS: Adult patients admitted to an MS-ICU for at least 24 hours were included in the study. METHODS: This multicenter study was conducted over 12 months. To evaluate the ASPs, representatives from all MS-ICUs performed a self-assessment survey (0-100 scale) at the beginning and end of the study. The impact of each ASP was evaluated monthly using the following measures: antimicrobial consumption, appropriateness of antimicrobial treatments, crude mortality, and multidrug-resistant microorganisms in healthcare-associated infections (MDRO-HAIs). Using final stewardship program quality self-assessment scores, MS-ICUs were stratified and compared among 3 groups: ≤25th percentile, \u3e25th to \u3c75th \u3epercentile, and ≥75th percentile. RESULTS: In total, 77 MS-ICU from 9 Latin American countries completed the study. Twenty MS-ICUs reached at least the 75th percentile at the end of the study in comparison with the same number who remain within the 25th percentile (score, 76.1 ± 7.5 vs 28.0 ± 7.3; P \u3c .0001). Several indicators performed better in the MS-ICUs in the 75th versus 25th percentiles: antimicrobial consumption (143.4 vs 159.4 DDD per 100 patient days; P \u3c .0001), adherence to clinical guidelines (92.5% vs 59.3%; P \u3c .0001), validation of prescription by pharmacist (72.0% vs 58.0%; P \u3c .0001), crude mortality (15.9% vs 17.7%; P \u3c .0001), and MDRO-HAIs (9.45 vs 10.96 cases per 1,000 patient days; P = .004). CONCLUSION: MS-ICUs with more comprehensive ASPs showed significant improvement in antimicrobial utilization