662 research outputs found
Growth inhibition of HeLa cell by internalization of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) Tokyo
<p>Abstract</p> <p>Background</p> <p>Intravesical BCG immunotherapy is effective for preventing recurrence and progression in none muscle-invasive bladder cancer but the dosing schedule and duration of treatment remain empirical. The mechanisms by which intravesical BCG treatment mediates antitumor activity are currently poorly understood.</p> <p>Results</p> <p>HeLa cell infected with <it>Mycobacterium bovis </it>Bacillus Calmette-Guérin(BCG) Tokyo which were different multiplicity of infection(MOI). Proliferation of HeLa cell reduced in a dose-dependent manner by live BCG. The cytoplasm of the HeLa cell showed variety lysosomal stages by internalized and interacted BCG.</p> <p>Conclusion</p> <p>Proliferated Live BCG secreted the protein and depressed the growth of tumor. The possibility for clinical introduction of BCG therapy for carcinoma reported with review of literature.</p
Ferromagnetism induced in anisotropic stacked kagome-lattice antiferromagnet CsCuCeF
The magnetic properties of CsCuCeF were investigated through
magnetization and specific heat measurements. CsCuCeF is
composed of a buckled kagome lattice of Cu, which is stacked along the b
axis. The exchange network in the buckled kagome lattice is strongly
anisotropic. Consequently, CsCuCeF can be divided into two
subsystems: alternating Heisenberg chains with strong antiferromagnetic
exchange interactions and dangling spins. The dangling spins couple with one
another via effective exchange interactions, which are mediated by chain spins.
The dangling spins are further divided into two subsystems, DS1 and DS2. The
dangling spins in DS1 undergo three-dimensional ferromagnetic ordering at 3.14
K, while those in DS2 remain paramagnetic down to 0.35 K. The effective
interaction between the DS1 spins is approximately expressed by the
ferromagnetic model with the direction parallel to the
crystallographic c axis. A magnetic phase diagram for was
obtained and was analyzed within the framework of the molecular field
approximation. With increasing magnetic field, the dangling spins are polarized
and the magnetization curve exhibits a wide plateau at one-third of the
saturation magnetization.Comment: 10 pages, 12 figure
Correlation of fasting blood glucose and haemoglobin A1c measured with an automated analyser
A subtype of glycohaemoglobin, haemoglobin (Hb) A1c, in specimens of whole blood was assayed on a new automated analyser that makes use of high-pressure liquid chromatography. The analyser provided precise and reproducible values. The mean of the HbA1c values was lower than that with an older instrument. The mean tended to increase with the age of the subjects, who were undergoing routine health examinations. No sex difference was found. When measurement was made 1 h after the subjects drank 50g of glucose, the value of HbA1c was unaffected. Correlation was strong between the HbA1c value and the fasting blood glucose value, which suggested that fasting blood glucose could be estimated from the HbA1c value
Ground-state properties of a triangular triple quantum dot connected to superconducting leads
We study ground-state properties of a triangular triple quantum dot connected
to two superconducting (SC) leads. In this system orbital motion along the
triangular configuration causes various types of quantum phases, such as the
SU(4) Kondo state and the Nagaoka ferromagnetic mechanism, depending on the
electron filling. The ground state also evolves as the Cooper pairs penetrate
from the SC leads. We describe the phase diagram in a wide range of the
parameter space, varying the gate voltage, the couplings between the dots and
leads, and also the Josephson phase between the SC gaps. The results are
obtained in the limit of large SC gap, carrying out exact diagonalization of an
effective Hamiltonian. We also discuss in detail a classification of the
quantum states according to the fixed point of the Wilson numerical
renormalization group (NRG). Furthermore, we show that the Bogoliubov
zero-energy excitation determines the ground state of a Josephson
junction at small electron fillings.Comment: 6 pages, 7 figure
Development of Liquid Scintillator containing a Zirconium Complex for Neutrinoless Double Beta Decay Experiment
An organic liquid scintillator containing a zirconium complex has been developed for a new neutrinoless double beta decay experiment. In order to produce a detector that has good energy resolution (4% at 2.5 MeV) and low background (0.1 counts/(tonneă»year) and that can monitor tonnes of target isotope, we chose a zirconium ÎČ-diketone complex having high solubility (over 10 wt.%) in anisole. However, the absorption peak of the diketone ligand overlaps with the luminescence of anisole. Therefore, the light yield of the liquid scintillator decreases in proportion to the concentration of the complex. To avoid this problem, we synthesized a ÎČ-keto ester complex introducing -OC3H7 or -OC2H5 substituent groups in the ÎČ-diketone ligand, and a diethyl malonate complex. Those shifted the absorption peak to around 245nm and 210nm, respectively, which are shorter than the emission peak of anisole (275nm). However, the shift of the absorption peak depends on the the scintillation solvent. Therefore we have to choose an adequate solvent for the liquid scintillator. The best performance will be obtained by pure anisole scintillator containing a tetrakis diethyl malonate zirconium. We also synthesized a Zr-ODZ complex, which has a high quantum yield (30%) and good emission wavelength (425nm) with a solubility 5 wt.% in benzonitrile. However, the absorption peak of the Zr-ODZ complex was around 240 nm. Therefore, it is better to use the scintillation solvent which has shorter luminescence wavelength than that of benzonitrile
Reply to "Comment on 'Isotope effect in multi-band and multi-channel attractive systems and inverse isotope effect in iron-based superconductors'"
The Comment insists on the following: in our model it is assumed that the
effective interactions have specific energy ranges within the single band with
a cutoff at \omega_1 for the phononic part and a range from \omega_1 to
\omega_2 in the AF channel. Our reply is that we assume that V_i(k,k')\neq 0 if
|\xi_k|<\omega_i and |\xi_{k'}|<\omega_i, and otherwise V_i(k,k')= 0 (i=1,2),
as stated in our paper. This is the model of BCS type with two attractive
interactions, and this assumption is the characteristic of the BCS
approximation. The claim "the integration limits have been modified such that
the AF channel mediated pairing sets in where the ph-channel pairing terminates
and is limited at an energy given by \omega_j=\omega_{AF}" in the Comment is
wrong. We describe the model and the method to solve the gap equation in more
detail
Removal of Large Whartonâs Duct Salivary Stones Using a CO2 Laser: A Report of Two Cases
Introduction: Salivary stones inside the Whartonâs duct adjacent to the mylohyoid muscle are often removed by a little incision of the mouth floor under local anesthesia. However, in the case of relatively large salivary stones, a large incision is required, which is commonly accompanied by hemorrhage and the need for surgical hemostasis, resulting in prolonged surgery. Furthermore, troublesome sequelae such as ranula and lingual nerve paralysis can occur after surgical procedures.Methods: Two patients who had relatively large salivary stones (>1 cm diameter) in the Whartonâs duct was underwent incision of the mouth floor soft tissues with a CO2 laser.Results: In both patients, the stone was removed in a few minutes without causing abnormal bleeding, nerve injury, or sublingual gland disorders and was completely healed.Conclusion: We report the usefulness and safety of the CO2 laser in two patients with relatively large salivary stones, who underwent successful surgical removal.
DOI: 10.34172/jlms.2021.1
Geographical and seasonal distribution of arenicolous marine fungi along the Pacific coast of the Bousou Peninsula
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