Preliminary report: Biomedical considerations for future manned space flights

The behavioral, psychological, and sociological aspects of space travel, particularly with emphasis on longer duration missions, are discussed along with the biomedical aspects of space flight. These factors may strongly interact with the various psycho-social factors and as such they stand as an immensely important area of concern in and of themselves. A foundation for understanding weightlessness related medical problems through a discussion of the history of symptoms reported specific details on the major areas of concern and approaches to their investigation are presented. Also, discussion is given to the possibility of various countermeasures. Some indication of the effects of various biomedical changes in performance are also covered

Preliminary Report: Issues in selection and training for long duration space flight

Based on previous experience with crew selection, three important avenues of consideration for future missions are discussed: technical qualifications and expertise; medical fitness and ability to tolerate the various conditions of space; and psychological considerations including personality structure, motivation, intelligence, leadership potential, group compatibility, etc. Primary emphasis was given to the psychological considerations

Performance considerations in long-term spaceflight

Maintenance of skilled performance during extended space flight is of critical importance to both the health and safety of crew members and to the overall success of mission goals. An examination of long term effects and performance requirements is therefore a factor of immense importance to the planning of future missions. Factors that were investigated include: definition of performance categories to be investigated; methods for assessing and predicting performance levels; in-flight factors which can affect performance; and factors pertinent to the maintenance of skilled performance

Living aloft: Human requirements for extended spaceflight

Human psychological and social adjustment to space is investigated. Studies and experiences bearing on human performance capability, psychological well being, and social organization, as they relate to space, were identified and assessed, and suggestions offered as to where further research could ease the Earth/space transition. Special emphasis was given to the variables of crew size, crew diversity, and mission duration, all of which can be expected to increase in future spaceflight. By providing a conceptual framework in which issues and related information can be integrated, the hope is to aid in discovering those conditions under which future space travelers can flourish

The Peanut Genome Consortium and Peanut Genome Sequence: Creating a better future through global food security

The competitiveness of peanuts has been threatened by losses in productivity and quality. The U.S. Peanut Genome Initiative (PGI) was launched in 2004, and expanded to global in 2006 to address these issues beginning with marker development and genetic map improvement. Ultimately, the peanut genome sequencing project was launched in 2012 by Peanut Genome Consortium, a coalition of international scientists and stakeholders that guide and implement research in Peanut Genome Project (PGP) as an integral program of International Peanut Genome Initiative (IPGI). IPGI has over 135 members in 20 countries at 79 institutions and is a committed step by the world-wide peanut research community to meet the needs of the peanut industry. PGP goals are: 1) a high quality tetraploid reference genome sequence, 2) high throughput genome and transcriptome characterization of tetraploid and diploid, 3) phenotypic trait association with genetic haplotypes, 4) interactive bioinformatic resources. The outcome will enable molecular breeding for enhancing peanut genetic improvement. The large size (2.8 Gb) and allotetraploid nature of peanut genome are challenges for peanut assembly. Therefore an integrated approach has been deployed that complements whole genome sequencing with BAC x BAC, GWAS with Recombinant Inbred Lines, and emerging sequencing technologies to bring the assembly together. SNP discovery also will contribute to a high-density genetic map for chromosome level assembly

Mental representation and the subjectivity of consciousness

Many have urged that the biggest obstacles to a physicalistic understanding of consciousness are the problems raised in connection with the subjectivity of consciousness. These problems are most acutely expressed in consideration of the Knowledge Argument against physicalism. I develop a novel account of the subjectivity of consciousness by explicating the ways in which mental representations may be perspectival. Crucial features of my account involve analogies between the representations involved in sensory experience and the ways in which pictorial representations exhibit perspectives or points of view. I argue that the resultant account of subjectivity provides a basis for the strongest response physicalists can give to the Knowledge Argument

Bioreactors as engineering support to treat cardiac muscle and vascular disease

Cardiovascular disease is the leading cause of morbidity and mortality in the Western World. The inability of fully differentiated, load-bearing cardiovascular tissues to in vivo regenerate and the limitations of the current treatment therapies greatly motivate the efforts of cardiovascular tissue engineering to become an effective clinical strategy for injured heart and vessels. For the effective production of organized and functional cardiovascular engineered constructs in vitro, a suitable dynamic environment is essential, and can be achieved and maintained within bioreactors. Bioreactors are technological devices that, while monitoring and controlling the culture environment and stimulating the construct, attempt to mimic the physiological milieu. In this study, a review of the current state of the art of bioreactor solutions for cardiovascular tissue engineering is presented, with emphasis on bioreactors and biophysical stimuli adopted for investigating the mechanisms influencing cardiovascular tissue development, and for eventually generating suitable cardiovascular tissue replacements

Physical activity for people living with dementia: carer outcomes and side effects from the perspectives of professionals and family carers

Adherence to physical activity is challenging for people living with dementia, and largely dependent on carers' involvement. Carers are likely to support physical activity based on their perceived balance between benefits and potential side effects of such intervention for both patients and themselves. Professionals also have a role in terms of optimising such interventions not only for people with dementia but also their carers.publishe

Semantics in active surveillance for men with localized prostate cancer - results of a modified Delphi consensus procedure

Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of terms related to this management option. An iterative three-round sequence of online questionnaires designed to address 61 individual items was completed by each panel member. Consensus was considered to be reached if >= 70% of the experts agreed on a definition. To facilitate a common understanding among all experts involved and resolve potential ambiguities, a face-to-face consensus meeting was held between Delphi survey rounds two and three. Convenience sampling was used to construct the panel of experts. In total, 12 experts from Australia, France, Finland, Italy, the Netherlands, Japan, the UK, Canada and the USA participated. By the end of the Delphi process, formal consensus was achieved for 100% (n = 61) of the terms and a glossary was then developed. Agreement between international experts has been reached on relevant terms and subsequent definitions regarding AS for patients with localized prostate cancer. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.Peer reviewe