FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMOXYCILLIN TRIHYDRATE AND POTASSIUM CLAVULANATE

Objective: The present work is aimed to formulate fast dissolving stable tablet formulation a preferred combination of Amoxycillin trihydrate (Beta-lactum antibiotic) and Potassium clavulanate (Beta-lactum inhibitor) by using various super disintegrants.Methods: Fast dissolving tablets are prepared by direct compression method using super disintegrants i.e. sodium starch glycolate, crospovidone, croscarmellose sodium. Aspartame as a sweetener and trusil mango flavor were used to increase palatability. Reduction in the dose of Amoxycillin trihydrate and Potassium clavulanate tablet was possible by developing fast dissolving tablet. Results: The powder blends were subjected to various pre-formulation evaluations such as, tapped density, bulk density, hausner's ratio, the angle of repose and compressibility index. The prepared Amoxycillin trihydrate and Potassium clavulanate fast dissolving tablets were evaluated for thickness, weight variation, friability, disintegration time, hardness, wetting time and in vitro drug release. All fast dissolving tablet formulations shown uniform weight, hardness and friability data indicates the good mechanical resistance of the fast dissolving tablet. Fast dissolving tablets were disintegrated between 25-50 second and in vitro disintegration time of the best fast disintegrating tablets was found to be 25 second. Conclusion: Amoxycillin trihydrate and Potassium clavulanate fast dissolving tablets were found to be of good quality fulfilling all the needs for fast dissolving tablets. The optimised (F-4) formulation had shown best disintegration time and released profile with a maximum in vitro drug release as compare to marketed preparation at all time intervals of in vitro drug release

Two and three-dimensional shock-shock interactions on the blunt leading edges of the hypersonic inlets

The effect of shock impingement on the blunt leading edges of the top and sidewall compression type inlet of a scramjet engine is studied numerically. The impinging shock is caused by the vehicle forebody. The interaction of this forebody shock with the inlet leading edge shock results in a very complex flowfield containing local regions of high pressure and intense heating. This complex flowfield in calculated by solving the Navier-Stokes equations using a finite volume flux splitting technique due to van Leer. To resolve the finer details of the flow structure as well as to predict the surface heat transfer accurately, adaptive grid technique is used in the analysis. Results of the present numerical study are compared with available experimental results

FAST DISSOLVING TABLETS: A REVIEW

Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson's disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. FDTs formulations contain super disintegrants to enhance the disintegration rate of a tablet in the buccal cavity. FDTs have advantages such as easy portability and manufacturing, accurate dosing, good chemical and physical stability and an ideal alternative for geriatric and pediatric patients. FDTs have disintegrated quickly, absorb faster so, in vitro drug release time improve and this property of drugs (dosage form) enhanced bioavailability. FDT formulations have the advantage of both conventional tablet formulation and liquid dosage form. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs. In this review contain brief information about FDTs including definition, advantages, needs or requirements of FDTs, salient features of FDTs, limitations, challenges to developing FDT, marketed formulations of fast dissolving tablets, etc

Propagating kink waves in the solar corona

The solar atmosphere is known to host various modes of MHD waves. Transverse waves are thought to play an important role in energy transfer in the atmosphere and thus in solar coronal heating and the acceleration of the solar wind. The transverse waves studied so far have predominantly been interpreted as standing kink waves and, via coronal magneto-seismology, they can offer insight into the physical conditions of coronal plasmas. In addition, the excitation of these standing kink waves are associated with low coronal eruptions and thus need special conditions or drivers. Propagating kink waves have been reported recently and have been found to be ubiquitous in the solar corona including in the quiet Sun. It is imperative to understand the mechanisms that enable their energy to be transferred to the plasma. Carrying on the legacy of the standing kink waves, mode conversion via resonant absorption is thought to be one of the main mechanisms for damping of these propagating kink waves, and is considered to play a key role in the process of energy transfer. The propagating kink waves are best observed in the Doppler velocity images of the Coronal Multi-channel Polarimeter (CoMP). The damping is observed using data from this instrument to study the energetics of the propagating kink waves in quiescent coronal loops. A coherence-based method is used to track the Doppler velocity signal of the waves, enabling an investigation into the spatial evolution of velocity perturbations. To enable accurate estimates of these quantities, the first derivation is provided of a likelihood function suitable for fitting models to the ratio of two power spectra obtained from discrete Fourier transforms. Maximum likelihood estimation is used to fit an exponential damping model to the observed variation in power ratio as a function of frequency. This also confirms earlier indications that propagating kink waves are undergoing frequency-dependent damping. Additionally, it is found that the rate of damping decreases, or equivalently the damping length increases, for longer coronal loops that reach higher in the corona. The analysis techniques are used to create a statistical sample of quiescent loops to study the statistical properties of propagating kink waves and compare it to the studies of standing kink waves. It is noted that the damping for the propagating waves appears to be significantly weaker than that found from measurements of standing kink modes. The propagating kink waves also exhibit signatures of power amplification of waves

Newer insights of H1N1: Swine Flu Virus

Swine flu, caused by the H1N1 influenza virus, is a subtype of influenza A that affects both the upper and lower respiratory tracts. It is primarily found in pigs and can be transmitted to humans through genetic variations in the virus. The 1918 Spanish flu pandemic resulted in the deaths of 50 to 100 million individuals. In 2009, the pandemic affected 178 countries, resulting in an estimated 43 to 89 million cases and 1799 deaths. The pathophysiology of H1N1 involves inflammation of the respiratory tract, with an incubation period of 1 to 4 days and a contagious period lasting 5 to 7 days. The signs and symptoms of swine flu include cough, sore throat, fever, myalgia, congestion, headache, rhinorrhoea, dizziness, sneezing, loss of appetite, fatigue, abdominal pain, shortness of breath, and in rare cases, vomiting and diarrhoea. The most common cause of death is respiratory failure, and neurological symptoms can occur due to high fever. To diagnose swine flu, various tests such as haematological, biochemical, and microbiological tests are conducted, including the collection of nasal or oral swabs for reverse transcriptase polymerase chain reaction (RT-PCR). Prevention and control measures include managing swine flu in pigs through herd management, hygiene practices, and vaccination. Treatment options vary based on the severity of the case. Mild to moderate cases can be managed with rest, antipyretics, NSAIDs, antihistamines, and oral rehydration therapy. Severe cases may require intravenous hydration, antibiotics for bacterial infections, antiviral therapy, and respiratory support

Bombax ceiba calyces regulate carbohydrate and lipid digesting enzyme’s actions, display insulin sensitizing and antioxidant activities in vitro: A nutritional and phytochemicals examination

323-331Calyces of Bombax ceiba (Śālmali, शाल्मली) are used as vegetable by traditional Indian folks. However, scientific investigations for this vegetable are not available in literature. This research presents nutritional and phytochemicals composition in raw calyxes’ powder and antihyperglycemic, antihyperlipidemic, insulin-sensitizing and, antioxidant properties in aqueous methanolic extract of calyx applying various in vitro methods. Calyx powder displayed rich source of macro- and micronutrients with energy value 322 Kcal. /100 g. Aqueous methanol extract of calyces exhibited potent antihyperglycemic activities by inhibiting pancreatic α-amylase and intestinal α-glucosidase enzymes, antihyperlipidemic by inhibiting pancreatic lipase and insulin sensitizing property by inhibiting PTP1β. It was found to be potent scavenger of chemical and physiological free radicals and, presented antioxidant activities by preventing H2O2 induced erythrocytes membrane lipid peroxidation and hemolysis. It also prevented H2O2 induced genomic DNA damage. The calyx powder presented 979 μg/100 g total antioxidant value. This report presents original analysis of nutritional and phytochemical composition along with biological activities in B. ceiba calyx

Simulation Study of Microwave Heating of Hematite and Coal Mixture

Temperature distribution in hematite ore mixed with 7.5% coal was predicted by solving a 1-D heat conduction equation using an implicit finite difference approach. In this work, a square slab of 20 cm x 20 cm was considered, which assumed the coal to be uniformly mixed with hematite ore. MATLAB 2018a software was used to solve the equations. Heat transfer effects in this one dimensional slab having convective and the radiative boundary conditions are also considered in this study. Temperature distribution is obtained inside the hematite slab by considering microwave heating time, thermal conductivity, heat capacity, carbon percentage, sample dimensions, and many other factors, such as penetration depth, permittivity, and permeability of coal and hematite ore mixtures. The resulting temperature profile used as a guiding tool for optimizing the microwave-assisted carbothermal reduction process of hematite slab which was extended to other dimensions as well, viz., 1 cm x 1 cm, 5 cm x 5 cm, 10 cm x 10 cm, and 20 cm x 20 cm. The model predictions are in good agreement with experimental results

RNAi-Mediated Downregulation of Inositol Pentakisphosphate Kinase (IPK1) in Wheat Grains Decreases Phytic Acid Levels and Increases Fe and Zn Accumulation

Enhancement of micronutrient bioavailability is crucial to address the malnutrition in the developing countries. Various approaches employed to address the micronutrient bioavailability are showing promising signs, especially in cereal crops. Phytic acid (PA) is considered as a major antinutrient due to its ability to chelate important micronutrients and thereby restricting their bioavailability. Therefore, manipulating PA biosynthesis pathway has largely been explored to overcome the pleiotropic effect in different crop species. Recently, we reported that functional wheat inositol pentakisphosphate kinase (TaIPK1) is involved in PA biosynthesis, however, the functional roles of the IPK1 gene in wheat remains elusive. In this study, RNAi-mediated gene silencing was performed for IPK1 transcripts in hexaploid wheat. Four non-segregating RNAi lines of wheat were selected for detailed study (S3-D-6-1; S6-K-3-3; S6-K-6-10 and S16-D-9-5). Homozygous transgenic RNAi lines at T4 seeds with a decreased transcript of TaIPK1 showed 28–56% reduction of the PA. Silencing of IPK1 also resulted in increased free phosphate in mature grains. Although, no phenotypic changes in the spike was observed but, lowering of grain PA resulted in the reduced number of seeds per spikelet. The lowering of grain PA was also accompanied by a significant increase in iron (Fe) and zinc (Zn) content, thereby enhancing their molar ratios (Zn:PA and Fe:PA). Overall, this work suggests that IPK1 is a promising candidate for employing genome editing tools to address the mineral accumulation in wheat grains

Raphanus sativus (Linn.) fresh juice priming moderates sucrose-induced postprandial glycemia as well as postprandial glycemic excursion in rats

339-345Consumption of sugar sweetened beverages increase individual’s susceptibility towards weight gain, development of Type 2 diabetes mellitus, hypertension, cardiovascular disorders and number of chronic illnesses. Extended postprandial hyperglycemic rise and larger postprandial glycemic spikes following sugar ingestion in diabetic as well as non-diabetic individuals relate with the onset of cardiovascular complications and development of atherosclerosis. Oxidative stress induced due to prolonged postprandial hyperglycemia further aggravates development of diabetic complications. Influence of Raphanus sativus leaf and root juice on sucrose induced postprandial glycemic rise and postprandial glycemic spikes in rats was evaluated in this research. It was observed that priming rats with R. sativus leaf and root juice assuaged sucrose induced postprandial glycemic rise and postprandial glycemic excursions. The juice of R. sativus leaf was found superior than root juice in achieving these results. Similarly, the juice of leaves was more potent (pR. sativus leaf and root was rich source of polyphenol, flavonoid and displayed potent free radical scavenging activity. Additionally, juices also mitigated formation of advance glycation end-products and glycation of hemoglobin under hyperglycemic environment

Urbanization and Green Spaces—A Study on Jnana Bharathi Campus, Bangalore University

Global warming is amongst the most alarming problems of the new era. Carbon emission is evidently the strongest fundamental factor for global warming. So increasing carbon emission is one of today’s major concerns, which is well addressed in the Kyoto Protocol. Trees are amongst the most significant elements of any landscape, because of both biomass and diversity, and their key role in ecosystem dynamics is well known. Trees absorb the atmospheric carbon dioxide and act as a carbon sink, since 50 % of biomass is carbon itself and the importance of carbon sequestration in forest areas is already accepted, and well documented. With this background, a carbon sequestration potential study was carried out in Jnana Bharathi campus, Bangalore University using the Quadrat method. The total geographical area is about 449.74 ha with a rich vegetation sector and the total amount of both above ground carbon (AGC) and below ground carbon (BGC) was estimated as an average of 54.8 t/ha. The total amount of carbon dioxide assimilated into the vegetation in terms of both above ground and below ground biomass was estimated as an average of 200.9 t/ha. Urbanization and habitat fragmentation seem to be increasing worldwide, substantiated by a case study in Bangalore City. The analysis revealed that increase in built-up area at the city level was by about 164.62 km2, while the vegetation and water bodies decreased by about 285.72 and 7.2 km2 respectively. However, Bangalore University, Jnana Bharathi campus attains a good vegetation cover and is seen as one of the ‘green lungs’ of Bangalore city