Unusual presentation in a case of primary hyperparathyroidism

This report describes a case of classic severe primary hyperparathyroidism (PH) with clinical presentation that is very infrequent nowadays, which was osteitis fibrosa cystica. As bone scintigraphy demonstrated multiple areas of increasing uptake associated with hypercalcemia, a thorough investigation was conducted to exclude the neoplasms which most frequently are responsible for bone secondarisms. A fludeoxyglucose (FDG) positron emission tomography/CT demonstrated diffuse and multiple foci of increased FDG uptake and a focal uptake at the left thyroid region. Parathyroid function was studied, revealing unexpectedly high parathyroid hormone (PTH) levels. Further tests confirmed the diagnosis of PH and localized a parathyroid adenoma in the lower left side

Yungas propolis in the scavenging of vitamin B2-photogenerated ROS

This study focused on the scavenging action and antioxidant activity of propolis from Trancas (ProTr) as a promoter and scavenger of Riboflavin (Rf)-photogenerated reactive oxygen species (ROS), widely used in traditional medicine as an antioxidant. A thorough examination of the antioxidant activity of ethanolic extract (EE) was made possible by a kinetic and mechanistic study of the total polyphenol contents in the extract using stationary photolysis and time-resolved photochemical methods.Under aerobic visible-light-irradiation conditions, with Rf as the only light-absorber molecule, a complex frame of competitive interactions takes place, with the triplet excited states of Rf being quenched by ProTr. Rf triplet excited states can interact with ProTr or produce singlet oxygen and superoxide radical anions. The results indicated ProTr to be an efficient ROS scavenger. The antioxidant behavior of ProTr is similar to that of Trolox, a well-known antioxidant. Propolis is slightly photodegraded by interaction with the mentioned ROS, highlighting the crucial role of ProTr and its potential in mitigating oxidative stress-induced damage in biological systems. These findings suggest that ProTr could be a promising natural alternative to synthetic antioxidants for combating oxidative stress.Fil: Tolay, Martin Maximiliano. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Ingeniería en Procesos y Gestión Industrial; ArgentinaFil: Sacchetto, Julieta Lorena. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Massad, Walter Alfredo. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Airaghi, Florencia. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Ingeniería en Procesos y Gestión Industrial; ArgentinaFil: Natera, Jose Eduardo. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Estudios Basicos y Agropecuarios; Argentina. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentin

NAFLD fibrosis score (NFS) can be used in outpatient services to identify chronic vascular complications besides advanced liver fibrosis in type 2 diabetes

We demonstrate in 351 diabetic patients with steatosis that NAFLD fibrosis score (NFS), a rapid and affordable score to diagnose hepatic fibrosis, identifies patients at higher risk of advanced fibrosis and vascular diabetic complications (especially peripheral neuropathy), pointing NFS as a first-line vascular and hepatic screening in diabetic patients