Moment release rate of Cascadia tremor constrained by GPS

A comparison of GPS and seismic analyses of 23 distinct episodic tremor and slip events, located throughout the Cascadia subduction zone over an 11-year period, yields a highly linear relationship between moment release, as estimated from GPS, and total duration of nonvolcanic tremor, as summed from regional seismic arrays. The events last 1–5 weeks, typically produce ~5 mm of static forearc deformation, and show cumulative totals of tremor that range from 40 to 280 h. Moment released by each event is estimated by inverting GPS-measured deformation, which is sensitive to all rates of tremor-synchronous faulting, including aseismic creep, for total slip along the North American-Juan de Fuca plate interface. Tremor, which is shown to be largely invariant in amplitude and frequency content both between events and with respect to its duration, is quantified using several different parameterizations that agree to within 10%. All known Cascadia events detected since 1997, which collectively span the Cascadia arc from northern California to Vancouver Island, Canada, release moment during tremor at a rate of 5.2 ± 0.4 X 1016 N m per hour of recorded tremor. This relationship enables estimation of moment dissipation, via seismic monitoring of tremor, along the deeper Cascadia subduction zone that poses the greatest threat to its major metropolitan centers

Supercritical CO2-assisted spray drying of strawberry-like gold-coated magnetite nanocomposites in chitosan powders for inhalation

Associate Laboratory Research Unit for Green Chemistry Clean Processes and Technologies-LAQV - (UID/QUI/50006/2013) ; UCIBIO from FCT/MEC - UID/Multi/04378/2013 ; ERDF - POCI-01-0145-FEDER-007265; FCT/MEC - SFRH/BD/51584/2011; SFRH/BPD/93982/2013 ; FCT-Lisbon - IF/00915/2014Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD). The dry powder formulations showed adequate morphology and aerodynamic performances (fine particle fraction 48%-55% and aerodynamic diameter of 2.6-2.8 μm) for deep lung deposition through the pulmonary route. Moreover, the release kinetics of IBP was also investigated showing a faster release of the drug at pH 6.8, the pH of lung cancer. POXylated strawberry-like gold-coated magnetite nanocomposites proved to have suitable sizes for cellular internalization and their fluorescent capabilities enable their future use in in vitro cell based assays. As a proof-of-concept, the reported results show that these nano-in-micro formulations could be potential drug vehicles for pulmonary administration. © 2017 by the authors.publishersversionpublishe

Deep Convolutional Autoencoders as Generic Feature Extractors in Seismological Applications

The idea of using a deep autoencoder to encode seismic waveform features and then use them in different seismological applications is appealing. In this paper, we designed tests to evaluate this idea of using autoencoders as feature extractors for different seismological applications, such as event discrimination (i.e., earthquake vs. noise waveforms, earthquake vs. explosion waveforms, and phase picking). These tests involve training an autoencoder, either undercomplete or overcomplete, on a large amount of earthquake waveforms, and then using the trained encoder as a feature extractor with subsequent application layers (either a fully connected layer, or a convolutional layer plus a fully connected layer) to make the decision. By comparing the performance of these newly designed models against the baseline models trained from scratch, we conclude that the autoencoder feature extractor approach may only perform well under certain conditions such as when the target problems require features to be similar to the autoencoder encoded features, when a relatively small amount of training data is available, and when certain model structures and training strategies are utilized. The model structure that works best in all these tests is an overcomplete autoencoder with a convolutional layer and a fully connected layer to make the estimation

Sulfonic Acid-Functionalized (Bio)Materials as Catalysts for Efficient Amide Bond Synthesis

Funding Information: The authors thank Fundação para a Ciência e Tecnologia (FC&T) for project PTDC/BII‐BIO/30884/2017 and EXPL/BII‐BIO/0436/2021 and also for the researcher contract 2021.03255.CEECIND (M.C.C) and 2020.01614.CEECIND/CP1596/CT0007 (A.F.P.). Authors also thank the support by the Associate Laboratory for Green Chemistry – LAQV, which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020) and i3 N (LA/P/0037/2020, UIDP/50025/2020 and UIDB/50025/2020 . The National NMR Facility is supported by FC&T (ROTEIRO/0031/2013 – PINFRA/22161/2016, co‐financed by FEDER through COMPETE 2020, POCI, and PORL and FC&T through PIDDAC) and CERMAX through project 022162. We thank Prof. Dr. Carlos A. M. Afonso from the Faculty of Pharmacy, ULisboa for the scientific discussions on the experiments carried out with furfuryl alcohol derivatives. Publisher Copyright: © 2023 The Authors. ChemCatChem published by Wiley-VCH GmbH.Sulfonic acid carbon-(bio)based and natural clays-based catalysts were prepared and investigated for the first time as heterogeneous catalysts for amide bond synthesis by a Ritter reaction. The different SO3H-catalysts were screened using benzyl alcohol and acetonitrile as model substrates, and MWCNT-CSP revealed to be an efficient catalyst, affording the amide in 75 % yield. The practical utility of the catalysts was demonstrated by a diverse range of amides, obtained from alcohols and nitriles, in moderate to good yields. Biomass derived platform alcohols, such as 5-HMF and furfuryl alcohol, were also tested as potential building blocks for the synthesis of biopolymers. The SO3H-catalysts revealed to be a highly efficient and environmentally friendly alternative to the conventional acid catalysts commonly used in the Ritter reaction.publishersversionpublishe

Current perspectives

The increasing knowledge of the mechanisms involved in metabolism is shifting the paradigms by which the pathophysiology of many pulmonary diseases is understood. Metabolic dysfunction is recognized in obesity-associated asthma, but other metabolic conditions have been shown to be independently related to asthma. Novel insights have also recently been brought by metabolomics in this filed. The purpose of this review is to discuss current perspectives regarding metabolic dysfunction in asthma, from obesity-related asthma to other metabolic conditions and the role of current pharmacological therapeutic strategies and lifestyle interventions. Obesity is a well-recognized risk factor for asthma across the lifespan, which is generally associated with poorer response to current available treatments, rendering a more severe, refractory disease status. Besides the epidemiological and clinical link, untargeted metabolomics studies have recently supported the obesity-associated asthma phenotype at the molecular level. Not only obesity-related, but also other aspects of metabolic dysregulation can be independently linked to asthma. These include hyperinsulinemia, dyslipidemia and hypertension, which need to be taken into account, even in the non-obese patient. Untargeted metabolomics studies have further highlighted several other metabolic pathways that can be altered in asthma, namely regarding oxidative stress and systemic inflammation, and also suggesting the importance of microbiota in asthma pathogenesis. Considering the reduced response to corticosteroids, other pharmacologic treatments have been shown to be effective regardless of body mass index. Non-pharmacologic treatments (namely weight reduction and dietary changes) may bring substantial benefit to the asthmatic patient. Taken together, this evidence points towards the need to improve our knowledge in this filed and, in particular, to address the influence of environmental factors in metabolic dysfunction and asthma development. Personalized medicine is definitely needed to optimize treatment, including a holistic view of the asthmatic patient in order to set accurate pharmacologic therapy together with dietary, physical exercise and lifestyle interventions.publishersversionpublishe

Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.This research was funded by Fundação para a Ciência e Tecnologia (FCT), Portugal, grants UID/QUI/50006/2019, and PTDC/BTM-SAL/29786/2017.info:eu-repo/semantics/publishedVersio

Conceptual model of the Quenturas hydromineral resource (Furnas volcano, S. Miguel Island): a contribution

RESUMO: O Vulcão das Furnas, na ilha de São Miguel, comporta no seu interior uma grande variabilidade de nascentes, que se podem classificar em 5 tipos distintos, nomeadamente frias lisas, frias gasocarbónicas, termais ácidas, termais básicas e condensado de fumarola, de características marcadas e variadas, originando a designada “Hidrópole” das Furnas. A Concessão Hidromineral das Furnas comporta parte importante destas nascentes, entre elas o Recurso Hidromineral das Quenturas, ou Água Férrea das Quenturas, referida como “3”. Trata-se de uma água termal ácida, com 59 °C de temperatura, pH ácido e mineralização elevada, cuja origem se considera corresponder ao aquecimento de aquíferos mais superficiais por vapor hidrotermal que ascende do aquífero hidrotermal profundo, conferindo a estas águas temperatura e uma importante componente gasocarbónica. Dados isotópicos apontam uma altitude de recarga de cerca de 800 m para esta nascente e uma idade compreendida entre os 23 e os 30 anos.ABSTRACT: Furnas Volcano, located on S. Miguel Island, is home to a large variety of springs, that can be classified in 5 different groups, namely cold waters, cold CO2-rich waters, thermal waters with low pH, thermal waters with high pH and fumaroles, each with distinctive characteristics, originating the “Furnas Hydropolis”. The Furnas Hidromineral Permit includes some of these springs, including the Quenturas spring, also known as Água Férrea das Quenturas, which is referred in the permit by the number “3”. Quenturas is a thermal water with low pH, with a temperature of 59 °C and high mineralization. It has its origin in the shallower aquifers that are heated by the hydrothermal steam provided by the deep-seated hydrothermal aquifers, providing them with temperature and an important gaseous component. Isotopic data estimates a recharge altitude of approximately 800 m for this spring, and 23 to 30 years of age.info:eu-repo/semantics/publishedVersio