162 research outputs found

    A God that could be real in the new scientific universe

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    Business Models for Energy Entrepreneurship in Emerging Markets

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    Access to electricity produces greater levels of economic value and increases the quality of life in emerging markets across the globe. Emerging economies have surpassed developed nations in clean energy investment and deployment1 , but based on our review of the literature, there is a lack of high-level study on the factors that most affect the success of these businesses. The goal of this project is to identify these success factors, and use them to inform entrepreneurs’ strategic decision-making as well as elucidate the environments in which these ventures have a higher probability of success. By better understanding what drives success in the renewable energy industry, both entrepreneurs and key stakeholders such as policy makers, investors, and interested non-governmental organizations (NGOs) can better prioritize their efforts and investments to drive increased levels of clean energy adoption. This project focuses on clean energy business models in two emerging economies: India and Uganda. These countries have significant differences in levels of access to energy and development of their entrepreneurial landscapes, and therefore, provide a broad scope for analysis. This report presents an overview of existing empirical research on factors that hinder or increase success of business models, identifies potential gaps in this research, and presents analysis based on qualitative, in-country interviews conducted by our team. Based on a comparative analysis between the literature review and interview findings, the team drew conclusions about factors that would benefit from better coordination and investment from industry players. The team also identified aspects of the entrepreneurial experience in developing countries that are strong candidates for further academic research. Throughout the project, entrepreneurs and industry experts (such as the stakeholders above) highlighted several of the key topics identified in existing research, including the challenge of attracting private investment, strategies for revenue collection given limited ability to pay among customers, the effect of domestic energy policy, and the industry’s lack of institutional support, whether it be nonexistent or ineffective small business associations, trade associations, lobbying groups, etc. While it was reassuring to see entrepreneur and stakeholder interviews validate what had been uncovered in the literature review, the key value created by this project was largely the nuance the interviews provided regarding the structural issues that were inhibiting growth for the renewable and clean energy industries, and provide context around how some of these issues were overcome in India and Uganda. Our research questions aimed to understand how entrepreneurs can directly improve their prospects for success and where their efforts require coordination with other partners in the renewable energy value chain or key policymakers. The interviews revealed a clear distinction between the factors that entrepreneurs and industry experts found to be most relevant and important to the success of clean energy entrepreneurs. Factors such as positioning/strategy, company structure, ability to collect revenue, and business model flexibility were by far more relevant for entrepreneurs than industry experts. This understanding of which factors are more directly in entrepreneurs’ control can allow them to prioritize which factors to focus their attention and resources on. In contrast, industry experts regularly mentioned factors that were not top of mind for entrepreneurs in interviews such as domestic energy policy, customer financial resources, and distribution and utility infrastructure. Despite the relative dichotomy between entrepreneurs and industry experts, there was some overlap among what factors the two groups found to be the most important. These factors include talent attraction and retention, accessibility of private investment, competitive landscape, consumer education and strategic partnerships. The overlapping factors indicate the significance of these challenges, and highlights the potential areas where strategic partnerships would be the most beneficial to foster a healthier entrepreneurial ecosystem. Overall, the interviews raised new issues that were not discussed as in-depth in the literature. For example, the conclusion that there is a lack of product awareness and trust among most consumers, and that regulatory uncertainty of even the most well-intentioned policies can be extremely detrimental. In India, there were difficulties retaining employees. In Uganda, there appears to be a weak pipeline of educated, local talent. These issues demand comprehensive solutions that can only be realized by greater cooperation and coordination between entrepreneurs, industry experts, and policy makers. In sum, the hope is that this research will inform market players of key factors of entrepreneurial success and act as a catalyst for future research. In particular, what factors do entrepreneurs and industry experts see affecting success, where do they see greater opportunities for coordination, and how are the Indian and Ugandan experiences representative of other emerging markets?Master of ScienceSchool for Environment and SustainabilityUniversity of Michiganhttps://deepblue.lib.umich.edu/bitstream/2027.42/148815/1/Business Models for Energy Entrepreneurship in Emerging Markets_P46.pd

    Aluminum Effects in Infants and Children

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    Aluminum has no known biological function; however, it is a contaminant present in most foods and medications. Aluminum is excreted by the renal system, and patients with renal diseases should avoid aluminum-containing medications. Studies demonstrating long-term toxicity from the aluminum content in parenteral nutrition components led the US Food and Drug Administration to implement rules for these solutions. Large-volume ingredients were required to reduce the aluminum concentration, and small-volume components were required to be labeled with the aluminum concentration. Despite these rules, the total aluminum concentration from some components continues to be above the recommended final concentration. The concerns about toxicity from the aluminum present in infant formulas and antiperspirants have not been substantiated but require more research. Aluminum is one of the most effective adjuvants used in vaccines, and a large number of studies have documented minimal adverse effects from this use. Long-term, high-concentration exposure to aluminum has been linked in meta-analyses with the development of Alzheimer disease

    On Overreaching, or Why Rick Perry May Save the Voting Rights Act but Destroy Affirmative Action

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    Abstract The State of Texas is presently staking out two positions that are not typically pursued by a single litigant. On the one hand, Texas is seeking the invalidation of the Voting Rights Act, and, on the other, the State is now defending the validity of the expansive race-based affirmative action policy it uses at its flagship university. This Essay presses the claim that Texas has increased the chance it will lose in both Texas v. Holder and Fisher v. University of Texas because it has opted to stake out markedly extreme positions in each. I argue that Texas would be more likely to succeed had it chosen to temper both its actions and claims in the pending cases. As it stands, Texas's assertive stance in Fisher promises to bolster the aversion many Justices already feel towards affirmative action. With regard to the VRA, however, Texas's uncompromising approach to the regime may prove to be the VRA's best defense. As recent redistricting and voter ID decisions suggest, Texas's stance may be provide what is arguably better evidence for why the statute remains necessary than anything proffered by the VRA's many supporters. Indeed, the State's aggressively hostile stance towards the VRA has the potential to destabilize judicial misgivings about the statute, and, if not fully reverse them, postpone their implementation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98443/1/elj%2E2012%2E1147.pd

    Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy

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    <p>Abstract</p> <p>Background</p> <p>Antiretroviral treatment (ART) regimens in HIV patients commonly cause significant lipid elevations, including increases in both triglycerides and cholesterol. Standard treatments for hypercholesterolemia include the HMG CoA reductase inhibitors, or "statins." Because many ART agents and statins share a common metabolic pathway that uses the cytochrome P450 enzyme system, coadministration of ART with statins could increase statin plasma levels significantly. The oyster mushroom, <it>Pleurotus ostreatus</it>, has been shown in animal models to decrease lipid levels - a finding that has been supported by preliminary data in a small human trial.</p> <p>Methods</p> <p>To assess the safety and efficacy of <it>P. ostreatus </it>in patients with HIV and ART-induced hyperlipidemia, a single-arm, open-label, proof-of-concept study of 8 weeks' duration with a target enrollment of 20 subjects was conducted. Study patients with ART-induced elevated non-HDL cholesterol levels (> 160 mg/dL) were enrolled. Participants received packets of freeze-dried <it>P. ostreatus </it>(15 gm/day) to be administered orally for the 8 week trial period. Lipid levels were drawn every two weeks to assess efficacy. Safety assessments included self-reported incidence of muscle aches and measurement of liver and muscle enzymes. Mean within-person change in lipid levels were estimated using generalized estimating equations to account for repeated observations on individuals. A 30 mg/dL decrease in non-HDL cholesterol was deemed clinically significant.</p> <p>Results</p> <p>126 patients were screened to enroll 25, of which 20 completed the 8-week study. The mean age was 46.4 years (36-60). Patients had a mean 13.7 yrs of HIV infection. Mean non-HDL cholesterol was 204.5 mg/dL at day 0 and 200.2 mg/dL at day 56 (mean within-person change = -1.70; 95% confidence interval (CI) = -17.4, 14.0). HDL cholesterol levels increased from 37.8 mg/dL at day 0 to 40.4 mg/dL on day 56 (mean within-person change = 2.6; 95% CI = -0.1, 5.2). Triglycerides dropped from 336.4 mg/dL on day 0 to 273.4 mg/dL on day 56 (mean within-person change = -63.0; 95% CI = -120.9, -5.1). Only 3 individuals achieved a sustained clinically significant (30 mg/dL) decline in non-HDL cholesterol after 8 weeks of therapy. There were no adverse experiences reported other than patients' distaste for the preparation. Liver function tests and muscle enzymes were not affected by the 8 weeks of treatment.</p> <p>Conclusions</p> <p><it>Pleurotus ostreatus </it>as administered in this experiment did not lower non-HDL cholesterol in HIV patients with ART-induced hypercholesterolemia. Small changes in HDL and triglycerides were not of a clinical magnitude to warrant further study.</p> <p>Trial Registration</p> <p>clinicaltrials.gov Identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00069524">NCT00069524</a></p

    Technique of anterior colporrhaphy: a Dutch evaluation

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    Contains fulltext : 96395.pdf (publisher's version ) (Closed access)INTRODUCTION AND HYPOTHESIS: To evaluate the variation in techniques of anterior colporrhaphy among members of the Dutch Urogynecologic Society. METHODS: A questionnaire evaluating the technique of anterior colporrhaphy, preoperative and postoperative care, and use of the POP-Q score was sent out by e-mail. RESULTS: One hundred thirty-three completed questionnaires were received. The response rate was 65%. There are large variations in incisions, use of hydrodissection, method of plication, and excision of redundant vaginal epithelium. The urinary catheter was generally removed on day 2 after surgery and the vaginal pack on day 1. Less than half of the respondents used the POP-Q score routinely. CONCLUSIONS: Dutch gynecologists use a variety of surgical techniques to operate on a cystocele. This suggests that there is no widely accepted opinion on the best surgical approach. The lack of differentiation between central and lateral defects is striking and in contrast with the, mostly, American literature

    Be prepared: communism and the politics of scouting in 1950s Britain

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    This article examines the exposure, and in some cases dismissal, of Boy Scouts who belonged or sympathised with the Young Communist League in Britain during the early 1950s. A focus on the rationale and repercussions of the organisation's approach and attitudes towards ‘Red Scouts’ found within their ‘ranks’ extends our understanding of youth movements and their often complex and conflicting ideological foundations. In particular, the post-World War Two period presented significant challenges to these spaces of youth work in terms of broader social and political change in Britain. An analysis of the politics of scouting in relation to Red Scouts questions not only the assertion that British McCarthyism was ‘silent’, but also brings young people firmly into focus as part of a more everyday politics of communism in British society
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