4,433 research outputs found
On the global well-posedness for the Boussinesq system with horizontal dissipation
In this paper, we investigate the Cauchy problem for the tridimensional
Boussinesq equations with horizontal dissipation. Under the assumption that the
initial data is an axisymmetric without swirl, we prove the global
well-posedness for this system. In the absence of vertical dissipation, there
is no smoothing effect on the vertical derivatives. To make up this
shortcoming, we first establish a magic relationship between
and by taking full advantage of the structure of the
axisymmetric fluid without swirl and some tricks in harmonic analysis. This
together with the structure of the coupling of \eqref{eq1.1} entails the
desired regularity.Comment: 32page
In vivo nematicidal potential of camel milk on Heligmosomoides polygyrus gastro-intestinal nematode of rodents
Following our previous fi ndings on the in vitro anthelmintic effect of camel milk on Haemonchus
contortus, the current study aimed at investigating its in vivo effect. Investigations were carried out
using mice infected with Heligmosomoides polygyrus which is a parasite commonly used to test
the effi cacy of anthelmintics. Thirty six Swiss white mice of both sexes aged 5 – 6 weeks old, and
weighing between 20 and 25 g were orally infected with 0.5 ml dose of 100, 1-week-old H. polygyrus
infective larvae (L3
). After the pre-patent period, infected animals were randomly divided into
6 groups of 6 animals each. The nematicidal effi cacy of camel milk was monitored through faecal
egg count reduction (FECR) and total worm count reduction (TWCR). Four doses (8.25; 16.5; 33.0;
66.0 ml/kg body weight (bw)) for fresh camel milk and 22 mg/kg bw for albendazole were studied
using a bioassay. Albendazole and 4 % dimethylsulfoxide were included in the protocol as reference
drug and placebo, respectively. For all tested doses except 8.25 ml/kg bw, camel milk was effective
in vivo against H. polygyrus reducing both faecal egg count and worm count (p < 0.05). The dose
66 ml/kg bw showed the highest nematicidal activity causing a 76.75 % FECR and a 69.62 % TWCR
7 day after initiating the treatment. These results support the possible use of camel milk in the control
of gastro-intestinal helminthiasis
Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene
Background: Golabi, Ito, and Hall reported a family with X linked mental retardation (XLMR), microcephaly, postnatal growth deficiency, and other anomalies, including atrial septal defect, in 1984.Methods: This family was restudied as part of our ongoing study of XLMR, but significant linkage to X chromosome markers could not be found. Extreme short stature and microcephaly as well as other new clinical findings were observed. Mutations in the polyglutamine tract binding protein 1 gene (PQBP1) have recently been reported in four XLMR disorders (Renpenning, Hamel cerebro-palato-cardiac, Sutherland-Haan, and Porteous syndromes) as well as in several other families. The clinical similarity of our family to these patients with mutations in PQBP1, particularly the presence of microcephaly, short stature, and atrial septal defect, prompted examination of this gene.Results: A missense mutation in PQBP1 was identified which changed the conserved tyrosine residue in the WW domain at position 65 to a cysteine (p.Y65C).Conclusions: This is the first missense mutation identified in PQBP1 and the first mutation in the WW domain of the gene. The WW domain has been shown to play an important role in the regulation of transcription by interacting with the PPxY motif found in transcription factors. The p.Y65C mutation may affect the proper functioning of the PQBP1 protein as a transcriptional co-activator
The regularized 3D Boussinesq equations with fractional Laplacian and no diffusion
In this paper, we study the 3D regularized Boussinesq equations. The velocity
equation is regularized \`a la Leray through a smoothing kernel of order
in the nonlinear term and a -fractional Laplacian; we consider
the critical case and we assume . The temperature equation is a pure transport equation, where
the transport velocity is regularized through the same smoothing kernel of
order . We prove global well posedness when the initial velocity is in
and the initial temperature is in for
. This regularity is enough to prove uniqueness of
solutions. We also prove a continuous dependence of the solutions on the
initial conditions.Comment: 28 pages; final version accepted for publication in Journal of
Differential Equation
How Pakistan\u27s media spreads the message about reproductive and sexual health
Abstract, issue, and pagination are not provided by the author/publishe
POEMS Syndrome Presentation with an Abscess within the Plasmacytoma—A Rare Case Report
POEMS Syndrome is a rare cause of demyelinating and axonal mixed neuropathy. Plasmacytomas are usually seen in POEMS syndrome and can be osseous or extramedullary. Plasmacytomas presenting as an abscess has not been noted earlier. Our patient presented with localized hyperpigmented patch on the back and later developed progressive weakness in upper and lower limbs. Initially serum and urine protein electrophoresis were normal. The patient was thought to have Chronic Inflammatory Demyelinating Polyneuropathy and was treated accordingly without any improvement. Repeat serum protein electrophoresis showed monoclonal gammopathy. MRI of the back revealed an abscess in the paravertebral soft tissues reaching up to the skin. Needle biopsy was consistent with plasmacytoma. Later, he developed a purulent fungating lesion in the lower midback. Antibiotics were started and local resection was done followed by radiation. Pathology of the resected mass showed plasmacytoma extensively involving subcutaneous soft tissue and bone. The patient improved with the treatment. Cystic plasmacytomas and abscess within the plasmacytoma has not been reported earlier. Whether abscess formation is part of the disease spectrum due to infiltration of overlying tissue or is secondary to localized immunosuppression is unknown. Local treatment of a single plasmacytoma is useful in ameliorating systemic symptoms
Performance management practices in humanitarian organisations
Purpose – We examine how design and implementation practices for supply chain performance management that have proven successful in commercial organisations apply to Humanitarian Organisations (HOs) to guide the process of designing and implementing performance management in humanitarian organisations.
Design/methodology/approach – We identify from the literature 10 successful practices regarding the design and implementation of supply chain performance management in commercial businesses. We apply these, using action research over a four-year period, at Médecins sans Frontières (MSF) Belgium and draw conclusions from this.
Findings – We find that tools and techniques, such as workshops and technical sheets, are essential in designing and implementing supply chain performance measurement projects at HOs. Furthermore, making a link to an IT project is crucial when implementing performance measurement systems at HOs. Overall, our case study shows that performance management practices used in business can be applied and are relevant for humanitarian supply chains.
Originality/value – Previous research has argued that there are few empirical studies in the domain of performance management at humanitarian organisations. To the best of our knowledge, this paper is the first to provide a longitudinal understanding of the design and implementation of supply chain performance measurement at HOs
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