Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways

Funding Information: This work was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project Number (PNURSP2023R3), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.Peer reviewedPublisher PD

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents

Funding Information: The author acknowledge the support by Princess Nourah Bint Abdulrahman University Researchers Supporting Project Number (PNURSP2023R3), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.Peer reviewedPublisher PD

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

Funding Information: This work was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project Number (PNURSP2022R3), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.Peer reviewedPublisher PD

ANALISIS PENYEBAB KURANG BAGASI/ ADVICE HANDLING (AHL) DAN CARA PENANGANANNYA DI BANDAR UDARA ABDULRAHMAN SALEH MALANG

Pelayanan kepada penumpang yang mengatasi masalah bagasi penumpang yang mengalami irregularities, kerusakan bagasi, kehilangan bagasi dan keterlambatan bagasi atau barang bawaan penumpang merupakan tugas dari unit lost and found. Kasus kehilangan bagasi masih terjadi pada PT Avia Citra Dirgantara Bandar Udara Abdulrahman Saleh Malang. Penelitian ini bertujuan untuk mengetahui penyebab kurang bagasi / Advice Handling  (AHL) Di Bandar Udara Abdulrahman Saleh Malang dan cara mengatasinya. Penelitian ini menggunakan metode penelitian kualitatif dengan subjek pada penelitian ini adalah karyawan lost and found sedangkan objek pada penelitian ini adalah penyebab kurang bagasi / Advice Handling (AHL) dan cara penangananya di Bandar Udara Abdulrahman Saleh Malang. Teknik pengumpulan data dilakukan dengan teknik wawancara, observasi, dan dokumentasi. Jenis data pada penelitian ini terdiri dari data primer dan data sekunder. Penelitian ini dilaksanakan di Bandar Udara Abdulrahman Saleh Malang pada April 2023.Hasil dari penelitian ini adalah Penyebab kurang bagasi atau Advice Handling di Bandar Udara Abdulrahman Saleh Malang terdiri dari beberapa faktor, yaitu label tag bagasi yang terlepas,  human eror, banyaknya label pada koper, bagasi yang tertukar dengan penumpang lain, dan adanya penumpang yang lupa mengambil bagasi miliknya dan Petugas akan mencari tahu claim tag bagasi yang mengalami Advice Handling, Petugas Lost and Found melakukan crosscheck ke breakdown checklist untuk memastikan terdapat nomornya atau tidak, jika bagasi sudah ditemukan maka akan diserahkan kepada penumpang dengan syarat sesuai aturan yaitu identitas KTP dan boarding pass harus sesuai dengan claim tag

Determinants of capital structure in listed insurance companies in Nigeria

This study investigates the determinants of capital structure in listed insurance companies in Nigeria for the period of thirteen years, from 2006-2018. Ex-post facto research design was adopted for this study. The population of the study is made up of the 28 insurance companies listed on the floor of the Nigerian Stock Exchange (NSE) as at 2018. Since the population is not too large, this study utilized census sampling technique to take all the population. The data used in this study were secondary data derived from annual reports of insurance companies that are listed on the NSE. The study used panel regression with respect to the use of Hausman specification test to determine the use of fixed or random effect model. The random effect regression result revealed that that firm size has insignificant positive effect on capital structure (CST) of listed insurance companies in Nigeria. The study showed a significant positive effect between age and CST of listed insurance companies in Nigeria. Based on the regression result, asset tangibility has insignificant negative effect on CST, the regression result shows that risk has insignificant positive effect on CST, while the study found that insurance growth has significant positive effect on CST of listed insurance companies in Nigeria. The study concludes that size, age, tangibility of asset, insurance risk and growth are determinants of CST of listed insurance companies in Nigeria. The study recommends that insurance companies should have a high consideration for the value of total asset when determining their capital mix. Also, insurance companies that have been incorporated for long should consider external financing likewise, insurance companies should not give fixed asset priority when considering their capital structure mix. Debt providers should seek for high return in order to hold the risk related to the bankruptcy and financial distress. Lastly, debt holders should require such return to hold the risk of agency conflicts with shareholders and management.peer-reviewe

Who speaks for the Middle East : a new generation of journalists is challenging how their region is covered

This article is an investigation of the changes in fcoverage of the Middle East by the English-speaking press. It looks at how the traditional foreign-correspondent model has shifted since the American invasion of Iraq in 2003, and asks whether hiring reporters who come from the countries they cover will produce more accurate coverage.JournalismMiddle Eastern Studie

Manifold dynamics and periodic orbits in a multiwell potential

In this article, we explore the dynamics as well as the geometry of the invariant manifolds that determine the escapes from a multiwell potential. We also present the network of both symmetric and asymmetric solutions of the system, while at the same time we extract valuable information about the periodic solutions, such as their locations, multiplicity, and linear stability.The present research work was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number PNURSP2022R106, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia