AKP'li milletvekillerinden "Nazım Hikmet memlekete dönsün" duası

Taha Toros Arşivi, Dosya Adı: Nazım Hikmetİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

“The Lolelaplap (Marshall Islands) in Us: Sailing West to East (Ralik→Ratak) to These Our Atolls (Aelon Kein Ad) Ad Jolet Jen Anij (Our Blessed Inheritance from God)”

This paper discusses the expansion of Oceania through a Marshallese indigenous lens as a focal point. It explains that decolonizing methodologies allows reclaiming of space for mental liberation and reassurement of constitutional rights. It highlights similar occurrences of decolonization practices meeting resistance in the 21st century all while strengthening the human right argument that no human deserves any less than their fellow human brothers and sisters. It argues that an indigenous imagery can only be viewed through an indigenous lens where the researches’ level of purity is retained and unfiltered. It nevertheless argues that Marshallese ethnolinguistics reveal the same cultural practices in America, Judeo-Christianity, and Oceania thus dictating the reality that “we are the same not withstanding one stays here and one there (Bedbedjin Bedbedjen, Bedbedjinma wot Kwe)”. It further explains the importance in these similarities and how Marshallese spirituality predates introduced American Judeo-Christianity despite the latter attempting to marginalize the former. It concludes by stating that Marshallese contributions on the global stage are rooted in that culture of love (IaKwe) which is echoed by the custom(s) revealing the significance of Marshallese validation academically, spiritually, economically, & socially to prevent institutionalized discrimination. This paper ends stating that the agency to know one’s self and how one should fit in the world, is a human right in itself and Marshallese are entitled to this sense of self worth through knowing thy self by thy self where real thinking takes place in one’s own mind as we all live our own lives

FP'li Akgönenç:Hep kalbimde yaşayacak

Taha Toros Arşivi, Dosya No: 161/A-Ahmet Taner KışlalıUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

Norduz ve Karakas Koçlarında Eseysel Davranıs Özellikleri ve Yasla Değisimi

Bu çalışma, Akkaraman varyetesi Norduz ve Karakaş koçlarında eşeysel davranış özelliklerinin yasa göre değişimini belirlemek amacıyla yapılmıştır. Bu amaçla koçlar, yaslarına göre iki gruba ayrılmış; birinci ve ikinci grubu sırasıyla 3? ve 2 yaslı koçlar oluşturmuştur. Eşeysel davranışların belirlenmesi için birinci (n=7) ve ikinci grup (n=5) koçlar bireysel olarak 2 günde bir 15 dakika süreyle 3-5 kızgın koyunla test edilmiştir. Çalışmada incelenen davranış özelliklerinden flehmensiz genital organları koklama (FSGOK), flehmenli genital organları koklama (FGOK), kuyruk kaldırma (KK), ses çıkarma (SÇ), ejakulasyonsuz (EJSBS) ve ejakulasyonlu binis sayısına (EJBS) ilişkin ortalama değerler sırasıyla; 4.65±0.53, 2.08±0.19, 8.58±0.97, 62.90±6.30, 38.73±3.04 ve 1.29±0.19 bulunmuştur. Biniş süresi (BS), ejakulasyon süresi (ES) ve ejakulasyon etkinliğine (EJET) ilişkin en küçük kareler ortalamaları sırasıyla; 0.65±0.11 dk, 5.16±0.71 dk ve 0.05±0.006 olarak belirlenmiştir. Çalısmada 3? yas grubu koçlar kuyruk kaldırma, ses çıkarma, ejakulasyonlu biniş sayısı, ejakulasyon süresi ve ejakulasyon etkinliği bakımından 2 yas grubu koçlardan üstün bulunmuştur (P<0.05). Eşeysel etkinlik testinin özellikle 2 yaslı koçlarda incelenen özellikler bakımından bir iyileşme sağlamadığı gözlenmiştir

Norduz ve Karakas Koçlarında Eseysel Davranıs Özellikleri ve Yaşla Değisimi

Bu çalışma, Akkaraman varyetesi Norduz ve Karakaş koçlarında eşeysel davranış özelliklerinin yaşa göre değişimini belirlemek amacıyla yapılmıştır. Bu amaçla koçlar, yaşlarına göre iki gruba ayrılmış; birinci ve ikinci grubu sırasıyla 3≥ ve 2 yaşlı koçlar oluşturmuştur. Eşeysel davranışların belirlenmesi için birinci n=7 ve ikinci grup n=5 koçlar bireysel olarak 2 günde bir 15 dakika süreyle 3-5 kızgın koyunla test edilmiştir. Çalışmada incelenen davranış özelliklerinden flehmensiz genital organları koklama FSGOK , flehmenli genital organları koklama FGOK , kuyruk kaldırma KK , ses çıkarma SÇ , ejakulasyonsuz EJSBS ve ejakulasyonlu biniş sayısına EJBS ilişkin ortalama değerler sırasıyla; 4.65±0.53, 2.08±0.19, 8.58±0.97, 62.90±6.30, 38.73±3.04 ve 1.29±0.19 bulunmuştur. Biniş süresi BS , ejakulasyon süresi ES ve ejakulasyon etkinliğine EJET ilişkin en küçük kareler ortalamaları sırasıyla; 0.65±0.11 dk, 5.16±0.71 dk ve 0.05±0.006 olarak belirlenmiştir. Çalışmada 3≥ yaş grubu koçlar kuyruk kaldırma, ses çıkarma, ejakulasyonlu biniş sayısı, ejakulasyon süresi ve ejakulasyon etkinliği bakımından 2 yaş grubu koçlardan üstün bulunmuştur

ISOLATED CENTRAL NERVOUS SYTEM BURKITT'S LYMPHOMA IN ADVANCED AGE: A CASE STUDY

Objective: Burkitt lymphoma is an aggressive type of B-cell lymphoma that is usually seen in the pediatric and young adult population and characteised with myc gene translocation. This disease manifests itself with rapidly growing abdominal mass and systemic sign and symptoms. However, atypical involvements, such as isolated cranial involvements, face both diagnostic and therapeutic challenges, especially in older age groups. Although isolated cranial involvement of Burkitt's lymphoma is rare in older patients, this case report emphasizes the challenges in clinical practice. Case report: A 67-year-old female patient was taken with complaints of headache and vomiting in June 2022. An MRI scan revealed a mass measuring 3.3 × 2.8 × 1.5 cm in the left temporal region. Upon this finding, the patient was referred to the neurosurgery department and the mass was surgically removed. As a result of the pathological examination resulting from the operation, CD10, CD20 were diffusely positive; BCL2 negative; BCL6 positive; C-MYC 70% positive; Kİ67 is 100% positive and confirms Burkitt's Lymphoma. In the PET-CT scan performed for the staging of the patient, reticular dense growths and irregular growth FDG uptakes in ground glass density areas were observed in the medial posterobasal segment of the lower lobe of two lungs and in the anterior segment of the upper lobe of the left lung. In the mediastinal area, increased degrees of FDG uptake were detected in bilateral lower paratracheal and subcarinal lymph nodes. These findings were evaluated as a potential infectious event. While there were no findings in hemogram and biochemical pathological tests, HbsAg positivity was detected but no active disease was found.Prophylactic intrathecal(IT) treatmentwas also recommended for the disease, which started to systemic chemotherapy, but IT chemotherapy was rejected.. In subsequent MRI examinations, the defect formed after craniotomy in the left temporofrontoparietal region and fluid collection in the calvarium were observed, while no residue or recurrence was observed in the operation area.However, a lesion measuring 2 × 3 cm in size was detected in the left parietal at the vertex level, which was primarily considered a fibroma and showed marked hypointenses and heterogeneous contrast enhancement in all sections.In the evaluation PET-CT performed after four cycles of the R-HYPERCVAD regimen, a mild increase in metabolic activity was observed in the mediastinal lymph nodes, but this was consistent with inflammatory processes, and no signs of recurrence or metastasis were found in other parts of the body. Despite these findings, which were accepted as a response to treatment, the planned OKIT treatment was not accepted by the patient and their relatives.After completing the seventh course of treatment, the patient presented to the emergency room with altered consciousness and recurrent headaches. Antieodema treatment was applied to the patient who was diagnosed with brain edema, but the recommended advanced chemotherapy and full cranial radiotherapy were rejected. In December 2023, the patient was re-admitted with symptoms of brain edema and shingles zoster infection was observed, and the patient died after his condition worsened despite symptomatic treatment. Conclusion: This case report highlights the rarity of advanced age Burkitt lymphoma with isolated cranial involvement and the diagnostic and therapeutic difficulties of this condition. Our patient exhibited atypical involvement of an aggressive B-cell lymphoma that usually occurs in childhood and young adults and is characterized by myc gene translocation. The disease, which usually manifests itself with an abdominal mass and systemic symptoms, is rare to show isolated cranial involvement, and this requires us to re-evaluate the diagnosis and treatment strategies in our clinical practice. In this case, although the patient's symptoms and radiological findings initially suggested a typical brain tumor, pathological examination confirmed the diagnosis of Burkitt's lymphoma. During the patient's treatment process, the importance of systemic chemotherapy and prophylactic intrathecal treatment became evident. However, rejection of various treatment options by patients and their relatives may negatively affect the effectiveness of the treatment and patient survival. This case highlights the rarity of Burkitt lymphoma with isolated cranial involvement in older age patients and the challenges and important lessons encountered in the diagnosis and treatment of these atypical presentations

Presentation and management of paroxysmal nocturnal hemoglobinuria: a single-center experience

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder characterized by intravascular hemolysis. Real-world experience of PNH management is largely unreported. A retrospective analysis was undertaken based on medical records from six patients with PNH [two with aplastic anemia (AA)] treated at our center, Dicle University, Turkey. Diagnosis was based on granulocyte PNH clones, ranging from 93% to 66%. All patients had symptoms consistent with PNH. One patient was managed adequately with supportive measures only. Five were treated with the complement inhibitor eculizumab. Follow-up data (&lt;1 year) were available in four cases (the fifth had received only three infusions by final follow-up). Hemoglobin level in these four patients increased from 4.1-7.2 g/dL to 8.3-13.0 g/dL. Lactate dehydrogenase, a marker for hemolysis, decreased profoundly in the two non-AA patients, with more minor improvements in the two AA patients. Weakness and fatigue improved in all eculizumab-treated patients. Four of the five treated patients became transfusion independent, including the patient given only three infusions. In the remaining case, a patient with AA, transfusion requirement decreased, and abdominal pain and dysphagia resolved. No adverse events occurred. PNH can be successfully managed in routine practice

Kemoterapi ya da radyoterapi uygulanan tüberkülin testi olumlu akciğer kanserli olgularda izoniyazit koruyucu tedavisi gerekli mi?

The aim of this study was to determine the efficacy of isoniazid preventive therapy in tuberculin positive lung cancer patients. Tuberculin skin test was performed in 86 patients with lung cancer who were planned to receive chemotherapy and/or radiotherapy during years 1997 and 1998. Of 60 patients with positive tuberculin reaction (10 mm or more), 30 were given isoniazid (300mg/day) for six months and 30 did not receive any preventive therapy. Five patients receiving isoniazid were excluded from the study due to discontinuation of isoniazid and chemotherapy). Total 81 patients were followed until the end of 2000. Fifty-two of the patients were given chemotherapy, 11 radiotherapy, and 18 chemotherapy and radiotherapy. Of these patients, 74 were males and 7 were females; their mean age was 57.8$\pm$8.2 years. During the follow-up period, 74 patients (91.4%) died (mean survival time was 12.5$\pm$10.3 months). None of the patients with positive tuberculin test developed tuberculosis in the follow-up period. Pulmonary tuberculosis occurred in one patient only, who initially had a negative tuberculin test. Although the data is obtained from a relatively small study population, these findings suggest that the tuberculin reactivity is not a good guide :n predicting development of tuberculosis and isoniazid preventive therapy does not seem to provide any benefit because of the short life expectancy of these patients.Kemoterapi ya da radyoterapi uygulanan akciğer kanserli hastalarda izoniyazit (İNH) koruyucu tedavisinin etkinliğini araştırmak amacıyla prospektif, randomize bir çalışma yürütüldü. 1997-1998 yıllarında kemoterapi ve/veya radyoterapi planlanan 86 akciğer kanserli olguya tüberkülin testi yapıldı. Tüberkülin testi 10 mm ve üzeri olan 60 olgunun 30'una altı ay süreyle 300 mg/gün İNH verildi, kalan 30 olguya İNH verilmedi. Tüberkülin testi müspet olup İNH başlanan beş olgu kısa süre içinde koruyucu tedaviyi ve kemoterapiyi bırakmaları ve kontrole gelmemeleri nedeniyle çalışmadan çıkarıldı. Bu nedenle İNH grubundan 25 olgu değerlendirmeye alındı. Tüberkülin testi olumsuz bulunan 26 olguyla birlikte toplam 81 hasta 2000 yılı sonuna kadar izleme alındı. Olguların 52'sine kemoterapi, 11'ine radyoterapi ve 18'ine kemoterapiyle birlikte radyoterapi uygulandı. Yetmiş dördü erkek, yedisi kadın olan olguların yaş ortalaması 57.8 $\pm$ 8.2' idi. İzlem süresi içinde olguların 74'ü (% 91.4) eksitus oldu. Ortalama sağkalım 12.5$\pm$10.3 ay olarak hesaplandı. Tüberkülini pozitif saptanan hiçbir olguda izlem süresince aktif tüberküloz (TB) infeksiyonu gözlenmedi. Ancak tüberkülin testi olumsuz bulunan bir olguda aktif infeksiyon gelişti. Olgu sayısı kısıtlı olmakla birlikte, bu sonuçlar yaşam beklentisi kısa olan ve kemoterapi ya da radyoterapi gören tüberkülini olumlu ileri dönem akciğer kanserli olgularda İNH koruyucu tedavisinin gerekliliği konusunda kuşku yaratmıştır