Incidental mucinous adenocarcinoma in situ of renal pelvis presenting as severe hydronephrosis

Background: Mucinous adenocarcinoma of the renal pelvis is a very uncommon tumor, most often secondary to chronic infection and long standing irritation due to conditions such as urolithiasis. Case Presentation: Herein we report our experience with an old age male that presented with flank pain. Mucinous adenocarcinoma in situ has been discovered incidentally in his nephrectomy specimen. Conclusions: Mucinous adenocarcinoma in situ, is extremely rare and to the best of our knowledge only two cases have been reported in the English literature so far

Renal carcinoid tumor

Primary renal carcinoid is a rare tumor, until now less than 50 cases of this tumor has been reported, so very little is known about its presentation clinicopathologic patterns and prognosis. We report a patient with primary carcinoid tumor of kidney in a middle-aged woman treated by nephrectomy and review the literature concerning this kind of neoplasm

Primary Realignment of Posterior Urethral Rupture

Introduction: We report the results of treatment of posterior urethral rupture (PUR) by primary realignment with some modifications of the technique.Materials and Methods: In this prospective study, 25 patients (mean age, 33.5 years; range, 18 to 70 years) in whom PUR had been proved underwent primary urethral realignment. All patients were evaluated postoperatively for urinary incontinence, erectile dysfunction, and urethral stricture. They were followed for a mean of 20 months (range, 9 to 27 months).Results: In 20 of 25 patients (80%), posterior urethral rupture was associated with pelvic fractures and in 2 (8%), bladder rupture also was present. None of the patients had urinary incontinence. Six patients (24%) had evidence of postoperative stricture that required urethral dilatation and/or direct vision internal urethrotomy in 2 or 3 procedures under local anesthesia. Erectile dysfunction (which all responded to sildenafil) was reported by 4 patients (16%) as a decreased quality of erection. Conclusion: We believe that primary realignment of PUR is a simple procedure associated with low morbidity. It is recommended for patients who are stable and have no other significant intra-abdominal and pelvic organ injuries.</p

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

Contains fulltext : 97884.pdf (publisher's version ) (Closed access)Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 x 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC