Distribution of Blood Groups in Different Types of Leukemia Patients in Eskişehir, Turkey

Biochemical and genetic studies by developing technology since the beginning of the 19th&nbsp;century have clarified the functional classification of human blood group antigens, the structures of A, B, H and Lewis determinants and the enzymes that produce them. Moreover, many studies have investigated whether blood group antigens are associated with disease risk. In this retrospective study, we aimed to determine the blood group distribution of patients who had different leukemia diagnoses. Patients were admitted to the Hematology Clinic of Eskişehir Osmangazi University between the years of 2010-2017. ABO and Rh(D) typing of 1055 patients were noted. There were 362 Acute Myeloid Leukemia (AML), 151 Acute Lymphoblastic Leukemia (ALL), 101 Chronic Lymphocytic Leukemia (CLL), 139 Lymphoid Leukemia) and 147 Chronic Myeloid Leukemia (CML) patients. When we examined the data, we showed the blood group distribution of leukemia patients as percentages A, 0 and B, respectively, but not statistically (p&gt;0.05). At the same time, we found that the A Rh(D)+ blood group was more relevant when taken into account in the Rh(D) blood group. In this study, ABO and Rh (D) blood group distribution of different leukemia types (AML, ALL, CLL, CML) was shown for the first time in Eskişehir, Turkey. As a result, when we look at our data, different results are obtained in literature studies. However, we can’t say which blood group is effective in different types of leukemia, so further research is needed.</p

Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disease that may lead to weakness and death of patients, if unrecognized and untreated. Although consensus guidelines were reviewed recently for the diagnostic screening of PNH with multi-parameter flow cytometry (FCM), until now, no study has investigated the efficiency of such clinical indications in older patients