3,211 research outputs found
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Dating the dead: New radiocarbon dates from the lower Ica Valley, south coast Peru
This article presents radiocarbon dates from human bone samples (n = 13) from seven pre-Columbian cemeteries in the Samaca and Ullujaya Basins of the lower Ica Valley, south coast of Peru, spanning from the end of the Early Horizon to the Inca Late Horizon. These contexts have been severely looted. Yet, in all cases, their putative dating by material culture remains is confirmed by these 14C dates. This shows that such disturbed contexts, sadly typical of the Peruvian coast, can nonetheless still yield valuable bioarchaeological and burial practice data. These dates elaborate upon an emerging picture of the absolute dating of the cultural phases of the wider south coast region, in particular casting new light on the poorly understood Middle Horizon to Late Intermediate period transition. A paucity of archaeological data for this 3-century period has been taken as evidence of some sort of environmentally or socially induced lacuna. Instead, the 14C dates presented here suggest that the basins of the lower Ica Valley were continuously occupied over this period.We thank the Ministerio de Cultural del Perú for granting permission for the fieldwork (No. 0028-2010-VMPCIC-MC) and analysis of samples for dating (No. 369-2011-VMPCIC-MC); Alberto Benavides Ganoza and the people of Samaca for facilitating fieldwork; the Arts and Humanities Research Council for LC's doctoral funding; the NERC Radiocarbon Facility for funding radiocarbon dating (grant number NF/2012/1/7 to TCO’C and LC); and Tom Higham, Diane Baker, Ingmar Unkel and Elmo Leon for their help and advice.This is the final version of the article. It first appeared from University of Arizona via http://dx.doi.org/10.2458/azu_rc.57.1834
Effect of Biodiversity Changes in Disease Risk: Exploring Disease Emergence in a Plant-Virus System
The effect of biodiversity on the ability of parasites to infect their host and cause disease (i.e. disease risk) is a major question in pathology, which is central to understand the emergence of infectious diseases, and to develop strategies for their management. Two hypotheses, which can be considered as extremes of a continuum, relate biodiversity to disease risk: One states that biodiversity is positively correlated with disease risk (Amplification Effect), and the second predicts a negative correlation between biodiversity and disease risk (Dilution Effect). Which of them applies better to different host-parasite systems is still a source of debate, due to limited experimental or empirical data. This is especially the case for viral diseases of plants. To address this subject, we have monitored for three years the prevalence of several viruses, and virus-associated symptoms, in populations of wild pepper (chiltepin) under different levels of human management. For each population, we also measured the habitat species diversity, host plant genetic diversity and host plant density. Results indicate that disease and infection risk increased with the level of human management, which was associated with decreased species diversity and host genetic diversity, and with increased host plant density. Importantly, species diversity of the habitat was the primary predictor of disease risk for wild chiltepin populations. This changed in managed populations where host genetic diversity was the primary predictor. Host density was generally a poorer predictor of disease and infection risk. These results support the dilution effect hypothesis, and underline the relevance of different ecological factors in determining disease/infection risk in host plant populations under different levels of anthropic influence. These results are relevant for managing plant diseases and for establishing conservation policies for endangered plant species
Influence of environmental factors in the adherence of an atypical enteropathogenic Escherichia coli strain to epithelial cells
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Doubts about How the Middle Horizon Collapsed (ca. A.D. 1000) and Other Insights from the Looted Cemeteries of the Lower Ica Valley, South Coast of Peru
This paper presents new information from funerary contexts in the lower Ica Valley, south coast of Peru, spanning two millennia from the end of the Early Horizon to the Late Intermediate Period. Although severely looted, these sites can still yield valuable information. We discuss their architecture and material culture in the context of radiocarbon dates. Among other findings, these cast new light on the poorly understood transition from the Middle Horizon to the Late Intermediate Period, for which a paucity of archaeological data from c. A.D. 1000 to 1250 has long been taken as evidence of an environmentally or socially-induced demographic collapse. Yet the data we present here suggests that the basins of the lower Ica Valley were likely occupied continuously over this period, and that the echoes of Wari influence here may have lasted longer than previously thought.We thank the Ministerio de Cultural del Perú for granting permission for the fieldwork (No. 0028-2010-VMPCIC-MC) and analysis of samples for dating (No. 369-2011-VMPCIC-MC); Alberto Benavides Ganoza and the people of Samaca for facilitating fieldwork, all participants of the Proyecto de investigación arqueológica Samaca and Viviana Siveroni and Ruben Garcia for their useful thoughts and suggestions. This work was funded by the Arts and Humanities Research Council
Dynamically Configurable Nonlinear Optical Switching Based on Vertically Aligned Carbon Nanotubes
Enteric dysbiosis and fecal calprotectin expression in premature infants.
BackgroundPremature infants often develop enteric dysbiosis with a preponderance of Gammaproteobacteria, which has been related to adverse clinical outcomes. We investigated the relationship between increasing fecal Gammaproteobacteria and mucosal inflammation, measured by fecal calprotectin (FC).MethodsStool samples were collected from very-low-birth weight (VLBW) infants at ≤2, 3, and 4 weeks' postnatal age. Fecal microbiome was surveyed using polymerase chain reaction amplification of the V4 region of 16S ribosomal RNA, and FC was measured by enzyme immunoassay.ResultsWe enrolled 45 VLBW infants (gestation 27.9 ± 2.2 weeks, birth weight 1126 ± 208 g) and obtained stool samples at 9.9 ± 3, 20.7 ± 4.1, and 29.4 ± 4.9 days. FC was positively correlated with the genus Klebsiella (r = 0.207, p = 0.034) and its dominant amplicon sequence variant (r = 0.290, p = 0.003), but not with the relative abundance of total Gammaproteobacteria. Klebsiella colonized the gut in two distinct patterns: some infants started with low Klebsiella abundance and gained these bacteria over time, whereas others began with very high Klebsiella abundance.ConclusionIn premature infants, FC correlated with relative abundance of a specific pathobiont, Klebsiella, and not with that of the class Gammaproteobacteria. These findings indicate a need to define dysbiosis at genera or higher levels of resolution
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder
The host metabolite D-serine contributes to bacterial niche specificity through gene selection
Escherichia coli comprise a diverse array of both commensals and niche-specific pathotypes. The ability to cause disease results from both carriage of specific virulence factors and regulatory control of these via environmental stimuli. Moreover, host metabolites further refine the response of bacteria to their environment and can dramatically affect the outcome of the host–pathogen interaction. Here, we demonstrate that the host metabolite, D-serine, selectively affects gene expression in E. coli O157:H7. Transcriptomic profiling showed exposure to D-serine results in activation of the SOS response and suppresses expression of the Type 3 Secretion System (T3SS) used to attach to host cells. We also show that concurrent carriage of both the D-serine tolerance locus (dsdCXA) and the locus of enterocyte effacement pathogenicity island encoding a T3SS is extremely rare, a genotype that we attribute to an ‘evolutionary incompatibility’ between the two loci. This study demonstrates the importance of co-operation between both core and pathogenic genetic elements in defining niche specificity
A retrospective comparison of false negative skin test rates in penicillin allergy, using pencilloyl-poly-lysine and minor determinants or Penicillin G, followed by open challenge
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