Ecological assessment of a coastal shallow lagoon in Lagos, Nigeria: A bio-indicator approach

Benthic macro-invertebrates of the Northern axis of metropolitan segment of Lagos Lagoon sediments, Nigeria were investigated for six months (April – September, 2010). The study was aimed at using benthic macro-invertebrates to assess the water quality of this part of the Lagoon. A total of ten taxa belonging to three major animal phyla from a total of 2,672 individuals were encountered. The dominant taxa throughoutthe study and stations were Pachymelania aurita, Aloidis trigona, and Neritina glabrata. Station A (Ikorodu port) had seven taxa, station B (Ibese) had five while stations C (Ofin) and D (Oreta) had eight taxa each.Stations A(Ikorodu port), B(Ibese), C(Ofin) and D(Oreta) accounted for 8.19%, 0.94%, 79.83% and 11.04% respectively in all the individuals collected. Gastropoda was highest and accounted for 54.83% of all individuals collected from all stations contributing 2.58% at station A and 0.49%, 48.39% and 3.37% respectively at stations B, C and D, while Polychaeta had the least (0.97%) with station A, B, C and D constituted 0.82%, 0.04%, 0.04% and 0.07% respectively. Sediment type of the study areas was predominantly muddy sand. The presence of more pollution tolerant species (Nereis spp, Capitella capitata and Polydora ciliata) in station A may serve to confirm that the community has been impacted by pollution. The low faunal abundance and diversity observed in station B could be attributed to stress imposed by effluents from industrial sources. The information of this study will be very useful in formulating policies and regulatory framework for sustainable management of Lagos Lagoo

Should Global Burden of Disease Estimates Include Depression as a Risk Factor for Coronary Heart Disease?

The 2010 Global Burden of Disease Study estimates the premature mortality and disability of all major diseases and injuries. In addition it aims to quantify the risk that diseases and other factors play in the aetiology of disease and injuries. Mental disorders and coronary heart disease are both significant public health issues due to their high prevalence and considerable contribution to global disease burden. For the first time the Global Burden of Disease Study will aim to assess mental disorders as risk factors for coronary heart disease. We show here that current evidence satisfies established criteria for considering depression as an independent risk factor in development of coronary heart disease. A dose response relationship appears to exist and plausible biological pathways have been proposed. However, a number of challenges exist when conducting a rigorous assessment of the literature including heterogeneity issues, definition and measurement of depression and coronary heart disease, publication bias and residual confounding. Therefore, despite some limitations in the available data, it is now appropriate to consider major depression as a risk factor for coronary heart disease in the new Global Burden of Disease Study

Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study)

Background: Experimental studies support the anti-neoplastic effect of apo(a), but several clinical studies have reported contradictory results. The purpose of this study was to determine whether a low lipoprotein(a) [Lp(a)] concentration is related to mortality from major causes of death, especially cancer. Methods The subjects were 10,413 participants (4,005 men and 6,408 women) from a multi-center population-based cohort study in Japan (The Jichi Medical School cohort study). The average age at registration was 55.0 years, and the median observation period was 4,559 days. As the estimated hazard ratio was high for both the low and very high Lp(a) levels, we defined two Lp(a) groups: a low Lp(a) group [Lp(a)<80 mg/L] and an intermediate-to-high Lp(a) group [Lp(a)≥80]. Participants who died from malignant neoplasms (n = 316), cardiovascular disease (202), or other causes (312) during the observation period were examined. Results: Cumulative incidence plots showed higher cumulative death rates for the low Lp(a) group than for the intermediate-to-high Lp(a) group for all-cause, cancer, and miscellaneous-cause deaths (p<0.001, p = 0.03, and p = 0.03, respectively). Cox proportional hazards analyses with the sex and age of the participants, body mass index, and smoking and drinking histories as covariates showed that a low Lp(a) level was a significant risk for all-cause, cancer, and miscellaneous-cause deaths (p<0.001, p = 0.003, and p = 0.01, respectively). The hazard ratio (95% CI) [1.48, 1.15–1.92] of a low Lp(a) level for cancer deaths was almost the same as that for a male sex (1.46, 1.00–2.13). Conclusions: This is the first report to describe the association between a low Lp(a) level and all-cause or cancer death, supporting the anti-neoplastic effect of Lp(a). Further epidemiological studies are needed to confirm the present results

The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models

A compelling association has been observed between cardiovascular disease (CVD) and depression, suggesting individuals with depression to be at significantly higher risk for CVD and CVD-related mortality. Systemic immune activation, hypothalamic–pituitary–adrenal (HPA) axis hyperactivity, arterial stiffness and endothelial dysfunction have been frequently implicated in this relationship. Although a differential epidemiological association between CVD and depression subtypes is evident, it has not been determined if this indicates subtype specific biological mechanisms. A comprehensive systematic literature search was conducted using PubMed and PsycINFO databases yielding 147 articles for this review. A complex pattern of systemic immune activation, endothelial dysfunction and HPA axis hyperactivity is suggestive of the biological relationship between CVD and depression subtypes. The findings of this review suggest that diagnostic subtypes rather than a unifying model of depression should be considered when investigating the bidirectional biological relationship between CVD and depression. The suggested model of a subtype-specific biological relationship between depression and CVDs has implications for future research and possibly for diagnostic and therapeutic processes

Distribution of phytoplankton in some parts of Lagos Lagoon, Southwest Nigeria

Investigations were carried out on spatial and seasonal composition and distributions of phytoplankton in some parts of the Lagos Lagoon. Phytoplankton samples were collected from twelve stations during the wet(July, 2008) and dry (March, 2009) seasons. A typical freshwater condition prevailed in the study area during wet season with salinity of 0 parts per thousand (o/oo) at every station, whereas during the dry season, relativelyhigh salinity levels were recorded from all the stations with decreasing trend toward the river mouth. The two seasons had the diatoms (Bacillariophytes) of the Orders Centrales and Pennales as the dominantphytoplankton taxa. A total of 2896 phytoplankton belonging to  twenty-seven species, eight orders and four classes were recorded during wet season while the dry season had a total of 1550 phytoplankton, which cut across sixteen species, three orders and two classes. Wet and dry seasons respectively had Aulacoseira granulata and Coscinodiscus sps. as the dominant phytoplankton taxa. Higher dominance (0.33) and Margalefdiversity (3.26) but lower Shanon-Wiener diversity (1.94) and evenness of distribution (0.26) indices were recorded during the wet than dry seasons. The findings show the influence of seasonality on phytoplanktoncomposition and distributions in the Lagos Lagoon and suggest relatively stress-free environmental conditions within the study area