Pulse-Echo Harmonic Generation Measurements for Non-destructive Evaluation

Ultrasonic harmonic generation measurements have shown great potential for detecting nonlinear changes in various materials. Despite this, the practical implementation of the technique in non-destructive evaluation (NDE) has typically been limited to the through transmission setup case, with which problems arise in certain situations. Recently, works in the fields of nonlinear fluids and biomedical imaging have reported different application of the harmonic generation theory by making use of reflective boundaries and beam focusing. It is thought that such techniques may be similarly applied in the field of NDE to enable single-sided nonlinear inspection of components. In this paper, we initially describe a numerical model which has been used to determine the effects of attenuation and acoustic beam diffraction on measurements of the nonlinear parameter beta. We then extend the model to incorporate first the effects of multiple reflecting boundaries in the propagation medium, then of focused source excitation. Simulations, supported by experimental data, show that nonlinear pulse-echo measurements have the potential to provide a viable (and practical) alternative to the usual through-transmission type as a means of measuring beta in solids. Furthermore, it is shown that such measurements may be optimised, both by adjusting the excitation frequency, and by focusing the acoustic source at a certain point relative to the specimen boundary.</p

Fusion of multi-view ultrasonic data for increased detection performance in non-destructive evaluation

State-of-the-art ultrasonic non-destructive evaluation (NDE) uses an array to rapidly generate multiple, information-rich views at each test position on a safety-critical component. However, the information for detecting potential defects is dispersed across views, and a typical inspection may involve thousands of test positions. Interpretation requires painstaking analysis by a skilled operator. In this paper, various methods for fusing multi-view data are developed. Compared with any one single view, all methods are shown to yield significant performance gains, which may be related to the general and edge cases for NDE. In the general case, a defect is clearly detectable in at least one individual view, but the view(s) depends on the defect location and orientation. Here, the performance gain from data fusion is mainly the result of the selective use of information from the most appropriate view(s) and fusion provides a means to substantially reduce operator burden. The edge cases are defects that cannot be reliably detected in any one individual view without false alarms. Here, certain fusion methods are shown to enable detection with reduced false alarms. In this context, fusion allows NDE capability to be extended with potential implications for the design and operation of engineering assets

Prevalence of, and risk factors for, HIV, hepatitis B and C infections among men who inject image and performance enhancing drugs: a cross-sectional study

Objective: To describe drug use, sexual risks and the prevalence of blood-borne viral infections among men who inject image and performance enhancing drugs (IPEDs). Design: A voluntary unlinked-anonymous crosssectional biobehavioural survey. Setting: 19 needle and syringe programmes across England and Wales. Participants: 395 men who had injected IPEDs. Results: Of the participants (median age 28 years), 36% had used IPEDs for <5 years. Anabolic steroids (86%), growth hormone (32%) and human chorionic gonadotropin (16%) were most frequently injected, with 88% injecting intramuscularly and 39% subcutaneously. Two-thirds also used IPEDs orally. Recent psychoactive drug use was common (46% cocaine, 12% amphetamine), 5% had ever injected a psychoactive drug and 9% had shared injecting equipment. ‘Viagra/Cialis’ was used by 7%, with 89% reporting anal/vaginal sex in the preceding year (20% had 5+ female-partners, 3% male-partners) and 13% always using condoms. Overall, 1.5% had HIV, 9% had antibodies to the hepatitis B core antigen (anti-HBc) and 5% to hepatitis C (anti-HCV). In multivariate analysis, having HIV was associated with: seeking advice from a sexual health clinic; having had an injection site abscess/wound; and having male partners. After excluding those reporting male partners or injecting psychoactive drugs, 0.8% had HIV, 8% anti-HBc and 5% anti-HCV. Only 23% reported uptake of the hepatitis B vaccine, and diagnostic testing uptake was poor (31% for HIV, 22% for hepatitis C). Conclusions: Previous prevalence studies had not found HIV among IPED injectors. HIV prevalence in this, the largest study of blood-borne viruses among IPED injectors, was similar to that among injectors of psychoactive drugs. Findings indicate a need for targeted interventions

HIV testing strategies outside of health care settings in the European Union (EU)/European Economic Area (EEA): a systematic review to inform European Centre for Disease Prevention and Control guidance

Objectives: In recent years, new technologies and new approaches to scale up HIV testing have emerged. The objective of this paper was to synthesize the body of recent evidence on strategies aimed at increasing the uptake and coverage of HIV testing outside of health care settings in the European Union (EU)/European Economic Area (EEA). Methods: Systematic searches to identify studies describing effective HIV testing interventions and barriers to testing were run in five databases (2010–2017) with no language restrictions; the grey literature was searched for similar unpublished studies (2014–2017). Study selection, data extraction and critical appraisal were performed by two independent reviewers following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Eighty studies on HIV testing in non-health care settings were identified, the majority set in Northern Europe. Testing was implemented in 65 studies, with men who have sex with men the risk group most often targeted. Testing coverage and positivity/reactivity rates varied widely by setting and population group. However, testing in community and outreach settings was effective at reaching people who had never previously been tested and acceptability of HIV testing, particularly rapid testing, outside of health care settings was found to be high. Other interventions aimed to increase HIV testing identified were: campaigns (n&nbsp;=&nbsp;8), communication technologies (n&nbsp;=&nbsp;2), education (n&nbsp;=&nbsp;3) and community networking (n&nbsp;=&nbsp;1). Conclusions: This review has identified several strategies with potential to achieve high HIV testing coverage outside of health care settings. However, the geographical spread of studies was limited, and few intervention studies reported before and after data, making it difficult to evaluate the impact of interventions on test coverage

Electronic health records to capture primary outcome measures: two case studies in HIV prevention research

BACKGROUND: There is increasing interest in the use of electronic health records (EHRs) to improve the efficiency and cost-effectiveness of clinical trials, including the capture of outcome measures. MAIN TEXT: We describe our experience of using EHRs to capture the primary outcome measure - HIV infection or the diagnosis of HIV infection - in two randomised HIV prevention trials conducted in the UK. PROUD was a clinic-based trial evaluating pre-exposure prophylaxis (PrEP), and SELPHI was an internet-based trial evaluating HIV self-testing kits. The EHR was the national database of HIV diagnoses in the UK, curated by the UK Health Security Agency (UKHSA). In PROUD, linkage to the UKHSA database was performed at the end of the trial and identified five primary outcomes in addition to the 30 outcomes diagnosed by the participating clinics. Linkage also produced an additional 345 person-years follow-up, an increase of 27% over clinic-based follow-up. In SELPHI, new HIV diagnoses were primarily identified via UKHSA linkage, complemented by participant self-report through internet surveys. Rates of survey completion were low, and only 14 of the 33 new diagnoses recorded in the UKHSA database were also self-reported. Thus UKHSA linkage was essential for capturing HIV diagnoses and the successful conduct of the trial. CONCLUSIONS: Our experience of using the UKHSA database of HIV diagnoses as a source of primary outcomes in two randomised trials in the field of HIV prevention was highly favourable and encourages the use of a similar approach in future trials in this disease area