乳化剂OP/水-氯化银体系光散射光谱应用研究

研究了乳化剂ＯＰ／ 水－ 氯化银乳浊体系的共振光散射光谱及其应用， 与其它体系相比， 微乳液体系的增溶能力、增稳效果显著提高． 用共振光散射光谱法测定微量氯离子， 与比浊法等相比， 具有更好的线性关系， 更宽的线性范围， 更高的灵敏度

活心丸(浓缩丸)治疗冠心病稳定性心绞痛的多中心、随机、双盲、安慰剂对照临床研究

目的观察活心丸(浓缩丸)治疗冠心病稳定性心绞痛的临床疗效和安全性。方法本研究采用多中心、随机、双盲、安慰剂对照研究方法,将480例气虚血瘀型冠心病稳定性心绞痛患者以3:1比例随机分为试验组(360例)和对照组(120例)。在西医常规治疗基础上,两组患者分别服用活心丸(浓缩丸)和安慰剂,1次2粒,每日3次;疗程8周。观察两组治疗前后主要指标(心绞痛症状积分)和次要指标(包括硝酸甘油减停率、中医证候积分及生活质量评价)及安全性。结果共454例患者完成试验(试验组336例,对照组118例)。与本组治疗前比较,试验组和对照组心绞痛症状积分和中医证候积分均降低,西雅图心绞痛量表评分改善(P<0.01);与对照组治疗后比较,试验组心绞痛症状积分、中医证候积分、西雅图心绞痛量表评分改善均优于对照组(P<0.01)。试验组心绞痛症状疗效总有效率为80.95%,硝酸甘油停减率为80.70%,中医证候疗效有效率80.65%,均高于对照组[36.44%、45.07%、38.99%(χ~2=58.21、40.94、66.55,P<0.01)]。试验组中既往有心梗史患者心绞痛症状总有效率为83.22%,中医证候有效率83.22%,西雅图心绞痛量表评分为(361.74±62.10)分,均高于无心梗史患者[60.92%、66.89%、(327.95±65.07)分(χ~2=13.89、13.26,P<0.01)]。治疗过程中未发生明显不良反应。结论活心丸(浓缩丸)治疗气虚血瘀型冠心病稳定性心绞痛疗效显著,尤其适用于既往有心梗病史的冠心病稳定性心绞痛患者,无明显不良反应。国家中医药管理局资助课题(No.国中医药科2016ZX04

Separation of 1,1'-Binaphthalene-2,2'-diol Optical Isomers by Derivatization High Performance Liquid Chromatography

以基碳酸酰氯作衍生化试剂 ,采用高效液相色谱拆分 1,1′ 联萘 2 ,2′ 二酚光学异构体。当采用LichrosorbSi 6 0 (4mm× 30 0mm ,5 μm)柱 ,紫外 2 75nm检测 ,正己烷 乙醇 (98.5 1.5 ,V V)为流动相 ,1,1′ 联萘 2 ,2′ 二酚单基碳酸酯的分离因子和分离度分别为 1.36 8、3.0 5 1;用正己烷 乙醚 (98.5 1.5 ,V V)为流动相 ,1,1′ 联萘 2 ,2′ 二酚双基碳酸酯的分离因子和分离度分别为 1.0 5 5、1.347。这一方法可简便、快速地测定联萘二酚单基碳酸酯拆分样品的光学纯度. 　1 ,1′2Binaphthalene22 ,2′2diol2mono2[ (2)2menthyl ] carbonate (3) and 1 ,1′2binaphthalene22 ,2′2diol2 bis2[ (2)2menthyl ] carbonate (4) are intermediates in the chemical resolution of racemic 1 ,1′2binaphthalene22 ,2′2 diols (1) utilizing (2)2( 1R)2menthyl chloroformate ( 2) as the derivating agent . In this paper , the optical separation of compound (3) and (4) has been investigated by high performance liquid chromatography on Lichrosorb Si260 (4 mm i . d. ×300 mm , 5 μm) and YWG2CN (4 mm i . d. ×250 mm , 10 μm) column with hexane2polar regulator mixture as an eluent . The results show that the optical isomers of compound (3) and (4) can be well separated. The optical isomers first eluted are (S , 1R′)23 and (S , 1R′, 1R″)24 respectively. The influence of polar solvents and their ratios in the mobile phase on the resolution is examined. This method has been applied to determine the optical purity of 1 ,1′2binaphthalene22 ,2′2diol2mono2[ (2)2menthyl ] carbonate obtained from a novel resolution process.国家自然科学基金重点资助项目 (No .2 983 2 0 2 0

Liquid Chromatographic Resolution of Enantiomeric 1,1’-Bi-2-naphthol and Phenylsuccinic Acid on a Coated Reversed-phase Column with 2,6-O-Butyled β-Cyclodextrins

利用合成的 2 ,6 O 丁基 β 环糊精动态涂渍反相色谱柱 ,β CD在C18和C8填料表面“永久”吸附形成一手性固定相 ,以联萘二酚和苯基琥珀酸为对象进行高效液相色谱拆分研究。当采用乙腈 水 (体积 33∶6 7)流动相时 ,联萘酚对映体在 2 ,6 O 丁基 β 环糊精涂渍ExsilODS柱上分离的容量因子分别为 14 .2 35和 15 6 2 9,分离选择性为 1.0 98;而采用乙腈 0 .1%三氟乙酸水溶液 (体积比 15∶85 )流动相时 ,苯基琥珀对映体的容量因子分别为 7.0 2 3和 8.14 9,分离选择性为 1.16 0。文中优化了色谱条件 ,探讨了有关的手性色谱拆分机理。该法可用于实际样品的对映体纯度测定。国家自然科学基金资助项目 (No .2 983 2 0 2 0

通信中长周期光纤光栅温度敏感性的补偿方法

为减小环境温度变化对通信中长周期光纤光栅（LPFG）器件谐振波长的影响,文章设计了一种补偿谐振波长漂移的方案,即在光栅表面涂覆一层随温度升高折射率变大的薄膜。计算结果表明,该方案是可行的,实现了谐振波长的零漂移,在通信领域具有广阔的应用前景

Chiral Resolution of 1,1'-binaphthalene-2,2'-diol and its (-)- Menthyl Chloroformate Derivatives by High Performance Liquid Chromatography with Urea Derivative as Chiral Stationary Phase

用高效液相色谱法考察了 1,1’ 联萘 2 ,2’ 二酚及其单和双氯代孟基碳酸衍生物等三对手性化合物在 (S) 特 亮氨酸基 (S) 1 (α 萘基 )乙胺脲型手性色谱柱上的拆分行为 .讨论了三元流动相中 1,2 二氯乙烷和乙醇含量的变化以及不同极性调节剂对分离的影响 ,探讨了这些手性化合物在脲型手性固定相上的可能拆分机理 .该法已用于 ( ) 孟基氯代碳酸酯化学拆分外消旋 1,1’ 联萘 2 ,2’ 二酚过程相关产物的光学纯度测定. The chiral resolution of 1 ,1’2binaphthalene22 ,2’2diol (1) , 1 ,1’2binaphthalene22 ,2’2diol2mono2[ (2)2men2 thyl ] carbonate (2) and 1 ,1’2binaphthalene22 ,2’2diol2bi2[ (2)2menthyl ] carbonate (3) was studied by high performance liquid chromatography using (S)2tert2leucine and (S)212α2NEA as chiral stationary phase. The effect of different content of 1 ,22dichloroethane and ethane , as well as a different polar modifier in mobile phase on the chiral separation was discussed. A baseline separation of optical isomers of compounds 1 and 2 with n2hexane/ 1 ,22 dichloroethane/ ethanol (82∶16∶2 , V/ V/ V) as mobile phase was obtained. The optical isomers first eluted are S22 and R21 , their capacity factors are 0. 159 and 1.196 , separation factors are 1. 779 and 1. 311 ,resolutions are 2. 444 and 4. 266 , respectively. The optical isomers of com2 pound 3 are only partially resolved. The likely role of double hydrogen bonding between 1 ,1’2binaphthalene22 ,2’2diol and (S)2tert2leucine & (S)212α2NEA as well as steric hindrance for the chiral recognition and separation was discussed. This method was applied to identify the optical purity of the samples from the resolution of racemic 1 ,1’2binaphthalene22 ,2’2di2 ol.国家自然科学基金资助项目 (2 9832 0 2 0

EFFECTS OF SOIL DRY-WET CHANGES AND AQUASORB TREATMENT ON PLANT GROWTH AND WATER USE EFFICIENCY

在盆栽玉米、大豆和辣椒的生长阶段进行高水分 (土壤田间持水量FC 10 0 %～ 80 % )、中水分 (FC 70 %～5 5 % )、低水分 (FC 5 0 %～ 40 % )处理 ,后复水至充分供水 .分析 3种植物在干湿变化中的生长和水分利用效应 ,比较土壤施用保水剂的效果 .结果发现 ,水分处理期间 3种植物生长变化与水分供给紧密相关 ,单株干重均表现为 :m (高水分 ) &gt;m(中水分 ) &gt;m(低水分 ) .但水分利用效率 (WUE)效应不一 ,中水分处理下玉米和大豆WUE为 2 0 .2gkg-1和3 .70gkg-1,分别比高水分处理还高 5 9.1%和 2 9.7% .水分处理又复水后 15d ,玉米在中水分处理复水的单株干重增加 39.6 3g ,是一直充分供水处理的 175 .0 % ,WUE达到 13 .3gkg-1,呈现超补偿生长效应和水分利用效率效应 .辣椒在中水分处理后复水 ,其青椒产量较高水分处理增加 6 % ,呈现产量补偿效应 .土壤加入保水剂可明显提高作物在低土壤水分条件下WUE .图 4表 1参 1

Separation of 1,1 '-binaphthalene-2,2 '-diol optical isomers by derivatization high performance liquid chromatography

1, 1'-Binaphthalene-2,2'-diol-mono-[(-)-menthyl] carbonate (3) and 1, 1'-binaphthalene-2, 2'-diol-bis- [(-)-menthyl] carbonate (4) are intermediates in the chemical resolution of racemic 1, 1'-binaphthalene-2,2'-diols (1) utilizing (-)-(1R)-menthyl chloroformate (2) as the derivating agent. In this paper, the optical separation of compound (3) and (4) has been investigated by high performance liquid chromatography on Lichrosorb Si-60(4 mm i. d. x 300 mm, 5 mum) and YWG-CN (4 mm i. d. x 250 mm, 10 mum) column with hexane-polar regulator mixture as an eluent. The results show that the optical isomers of compound (3) and (4) can be wen separated. The optical isomers first eluted are (S, 1R')-3 and (S, 1R', 1R ")-4 respectively. The influence of polar solvents and their ratios in the mobile phase on the resolution is examined. This method has been applied to determine the optical purity of 1, 1'-binaphthalene-2,2'-diol-mono-[(-)-menthyl] carbonate obtained from a novel resolution process