The role of copper and the copper-related protein CUTA in mediating APP expression and Aβ generation

阿尔茨海默症(Alzheimer’sdisease，AD)的一个重要病理特征和致病关键原因是大脑中有由β-淀粉样蛋白(Aβ)过度产生和沉积形成的淀粉样斑。Aβ是由β-淀粉样蛋白前体蛋白（β-AmyloidPrecursorProtein，APP）经过β-分泌酶和γ-分泌酶的顺序剪切后所产生。Aβ有多种形式，主要为Aβ40和Aβ42，Aβ42约占Aβ总量的5%，但却是Aβ的主要毒性形式。此外，金属离子铜在AD的病理过程中也发挥着重要的作用。我们实验室前期工作发现的一个铜相关蛋白CUTA能够与β-分泌酶BACE1相互作用，调控APP的-剪切和Aβ的生成。 本论文中我们进一步研究了...One major pathological hallmark and trigger of Alzheimer’s disease (AD) is overeproduction and accumulation of β-amyloid (Aβ), especially the neurotoxic Aβ42 species, in the brain. Aβ is derived from -amyloid precursor protein (APP) through sequential cleavages by - and -secretases. In addition, abnormal copper metabolism may also contribute to the pathogenesis of AD. Recen...学位：理学硕士院系专业：药学院_化学生物学学号：3232011115327

Study Of RMB's Internationalization

随着中国经济的高速发展和综合国力的跃升，人民币国际化问题引起了国内理论界和实务界的关注，成为理论研究的热点和前沿。当今世界，经济一体化趋势进一步加强。在亚太地区，区域一体化呼声也很高，但要建立像“欧盟”和“北美自由贸易区”那样的区域组织很难。亚太地区应寻求自己的发展模式。目前，许多次级区域组织在亚太地区逐渐兴起，大大推动了亚洲经济一体化进程。中国作为亚洲大国，要在亚洲经济一体化进程中发挥应有的作用，人民币国际化问题不容忽视。近年来，中国经济的高速增长，整体经济实力的增强，人民币汇率的持续稳定，特别是中国政府在亚洲金融危机中表现出的高度责任感，使人民币的国际声望大大提高，周边国家和地区居民逐渐认...With the high speed development of China’s economy and synthetic power, close concern of China’s high rank policy makers and domestic theoretic circle are paid to the RMB’s internationalization. And research on RMB’s internationalization has become the frontier science. Now, the tendency of economical combination strengthens in the world. In orient area, the demand for area combination is more....学位：经济学硕士院系专业：经济学院财政金融系_金融学(含保险学)学号：2005130093

Linear Maps Preserving *-Congruence on S(H)

本文讨论了S(H)上保*-同构的线性映射.主要结论为:令H是复的有限维希尔伯特空间.我们记B(H)为H上的所有有界线性算子构成的Banach代数、S(H)为H上的所有自伴算子构成的实线性子空间,则有:为S(H)到S(H)的双边保*-同构的有界线性满射当且仅当存在B(H)上的可逆元A使得对所有T∈S(H)有(T)=ATA*.In this paper,linear maps preserving *-congruence are discussed. The results we obtained are as follows: Let H be a complex infinite dimensional Hilbert space. By B( H),S( H) we denote the Banach algebra of all bounded linear operators on H and the real linear subspace of all self-adjoint operators on H. It is proved that a bounded linear surjection Φ: S( H)→S( H) preserving *-congruence in both directions if and only if there exists invertible element A ∈ B( H) such that Φ( T) = AT A*for all T ∈ S( H)

黄道周年谱考评

黄道周(1585—1646),字幼玄等,号石斋等,福建漳浦人。明天启二年(1622)进士,改庶吉士,授编修。崇祯朝,累官少詹事协理府事兼翰林院侍读学士,刚正不阿,犯颜屡谏,名震天下。弘光朝,官至礼部尚书。隆武朝,以武英殿大学士辅政,自请募师北上江西抗击清军,兵败婺源,不屈而死,是个著名的爱国主义者。他还是明末儒学大师,一生精力主要用于治学授业,有《榕坛问业》、《易象正》、《黄漳浦集》等著述百余种;子弟众多,其中最著者如方以智、彭士望、张履祥等。同时,他又是大书法家,近代以来著名书画家沈增植、潘天寿、来楚生、诸乐三、沙孟海等就是直承其风的

基于有限元与逆向工程的轮-沙耦合沉降试验研究

小型轮式车辆与松软沙地的相互作用会显著地影响车辆的稳定性与安全性,研究二者之间的承压关系对无人地面车辆的设计与应用具有重要意义。利用ABAQUS建立了小型轮式车辆与松软沙地的承压模型,通过自行开发的车轮-土壤相互作用测试系统进行试验,在综合考虑了轮胎和沙地的非线性变形后,建立了5种胎压下轮胎的整合径向静刚度,利用二元线性回归分析法拟合试验数据,确定胎压-负荷-下沉量三者之间的相互关系。针对轮胎在松软地面接地印迹难于提取问题,提出了利用逆向工程技术来完成接地印迹曲面重构设计,进一步验证了耦合模型的准确性,为无人地面车辆性能的改进及新型行走机构的设计制造提供了参考依据。2016年厦门市“十三五”国家海洋沙滩废弃物综合处置成套装备研发与示范应用项目(16CZB033SF14)资

双氨基酸手性五配位氢膦烷化学新进展

本文关注了氨基酸手性五配位磷化学的新进展,结合本实验室对五配位磷的长期研究工作,对一类双氨基酸手性五配位磷化合物的结构进行了系统总结.确定该系列化合物中心磷原子属于三角双锥构型,H原子和两个N原子在平伏键,两个O原子在直立键.在此基础上,借鉴配位化合物的命名规则,对其绝对构型进行命名,并通过固体CD光谱以及1H NMR对该系列化合物的绝对构型进行关联.1H-1H COSY信号的差异表明,此类化合物还存在着特殊的4JH-C-N-P-H耦合相互作用

Noise reduction of excavator cooling fan and wind scooper based on CFD

针对某型挖掘机在工作过程中冷却风扇出口端噪声水平严重超标的问题,对风扇在旋转过程中的气动性能进行了研究。首先,建立了风扇与导风罩所形成的流体域有限元模型。基于Cfd理论,运用fluEnT软件对其流场进行了稳态数值模拟。分别探究了风扇与导风罩相关结构参数对其风量大小与噪声水平的影响。结合厂商提供的散热系统选型软件OPTIMISEr,兼顾风量与噪声要求,得到了最适合该挖掘机的风扇及导风罩型号。优化结果表明,在提供相同风量的前提下,优化后的风扇噪声比原风扇的噪声降低了1.5 d b左右。随后,对该流体域进行了瞬态仿真,分析了风扇噪声的频率特性。仿真结果表明,风扇旋转噪声主要集中在低频段,为企业有针对性地对该频段噪声采取降噪措施提供了指导。Aiming at the problem that the noise level on the outlet side of the cooling fan exceeded the national standard seriously during the working process of an excavator,researches on the aerodynamic performances of revolving fan were carried out.Firstly,the finite element model of the fluid domain which was formed by the fan and the wind scooper was established.Steady-state numerical simulations for the flow field were conducted by using Fluent based on CFD theory.The effects of relevant structural parameters of fan and wind scooper on their blowing rate and noise level were explored respectively.Taking account of both wind and noise requirements,the most suitable type of fan and wind scooper for the excavator were obtained by using Optimiser,a cooling system selection software provided by the manufacturer.The optimization results indicate that the noise of optimized fan reduced 1.5 d B compared to that of original one under the premise that it can provide the same wind as before.Then,transient simulations for the flow field were done to analyze the frequency performances of fan noise.The simulation results indicate that the rotation fan noise concentrates mainly on low frequency stage which guided the company to take noise reduction measures for this frequency band noise specifically.国家科技支撑计划资助项目(2013BAF07B04); 福建省自然科学基金计划资助项目(2014J01210

Studies on Arbuscular Mycorrhiza infection to Mangrove Plants in Fujian

2010年5月和12月,对福建沿海3个红树林生长区(洛阳江、九龙江口、漳江口)的红树林植物丛枝菌根(AM)侵染状况进行研究。结果表明:(1)红树林生长区中6种植物根内均发现AMf侵染结构,其中桐花树、秋茄、鱼藤和芦苇的丛枝为AruM(疆南星)型;(2)6种植物的丛枝菌根侵染率差异较大,老鼠簕的侵染率最高,鱼藤最低;(3)桐花树和秋茄的丛枝菌根侵染率呈显著差异,而其在不同生长区之间无差异;(4)桐花树和秋茄的丛枝菌根侵染率在不同时间呈显著差异,而钝草的丛枝菌根侵染率在不同时间的差异不显著。To study the symbiosis between arbuscular mycorrhizal fungi(AMF) and mangrove plant species,102 root and soil samples from 6 plant species were collected in three main mangroves growth zone in Fujian,in May and December of 2010.The main results showed that:(1)AMF infection structures were mostly found in the form of curled and expanded intracellular hyphae,vesicles,which were commonly associated with all the mangrove species we investigated.'Arum-type' arbuscules were found in Parmentiera cerifera,Kandelia obovata,Derris trifoliata and Phragmites australis;(2)AM infection rate was different in mangrove plant species,with Acanthus ilicifolius the highest and Derris trifoliate the lowest;(3) There were significant differences of AM infection rate existing between Parmentiera cerifera and Kandelia obovata,but no difference among three sampling sites;(4) There were also significant differences of AM infection rate in different period in Parmentiera cerifera and Kandelia obovata,but no significant difference in Stenotaphrum helferi in different period.厦门市科技项目(3502Z20072010、3502Z20102004);厦门市园林植物园园长基金(BG201101)资

渤海南部海底桩尖阻尼系数的试验研究

波动方程沉桩分析已成为桩式海洋石油钻采平台勘测设计与施工的重要组成部分,但分析所用的参数直接影响沉桩能力和承载能力预测的精确性。当前波动方程分析所用参数因纯属经验性系数,且影响因素较多,各方面选用的计算模型及具体参数值均不相同,变化及影响较大的主要参数可归结为桩周土及垫层材料两部分。土的计算模型有(双折)线性及非线

ADVANCES IN CHROMASOME RESEARCH IN MARINE ZOOPLANKTON IN CHINA

国家自然科学基础研究重大项目G1999043708