康泉方治疗良性前列腺增生的中医思路初探

康泉方是笔者课题组长期临床实践总结的有效治疗良性前列腺增生(benign prostatic hyperplasia,BPH)的自拟中药复方。本文通过阐述康泉方组方特色与中医治疗BPH理论的契合点,并结合康泉方的实验和临床研究成果,总结分析康泉方治疗BPH的中医思路。整体而言,康泉方具有补益肾精、化瘀通络、清热解毒、通利水道的功效,补肾不留邪,驱邪不伤正,希冀能够对临床中医药治疗前列腺增生有所启迪和借鉴。国家自然科学基金面上项目(No.81674041);;厦门市科技局科研项目(No.3502Z20164013);;福建省自然科学基金(No.2018J01395

巴茱合剂治疗老年性痴呆肾虚髓减证36例

目的观察巴茱合剂治疗老年性痴呆肾虚髓减证的临床疗效。方法选取老年性痴呆肾虚髓减证患者74例随机分为治疗组36例和对照组38例。治疗组给予巴茱合剂口服,对照组给予金匮肾气丸配合银杏叶提取物片(金纳多)口服,疗程3个月。运用阿尔茨海默病评价量表-认知部分(ADAS-cog)、简易精神状态量表(MMSE)评价患者的智能,日常生活能力量表(ADL)评价患者的日常生活能力,中医证候疗效积分评价疗效。结果治疗组总有效率为88.9%,优于对照组71.1%,2组ADAS-cog评分、MMSE评分、ADL评分、中医证候疗效积分较治疗前均有所改善(P<0.05),且治疗组ADAS-cog评分、MMSE评分、中医证候疗效积分改善优于对照组(P<0.05)。2组治疗过程中未见不良反应发生。结论巴茱合剂能够改善老年性痴呆肾虚髓减证患者中医证候、智能及日常生活能力,未见不良反应发生。福建省科技重点项目(2012D064);; 厦门市中医药科研项目(wst201208);; 福建省中医科研课题(wzln201312

Effects of mixed-culture densities of Spartina alterniflora on eco-physiological characteristics of Kandelia candel seedling

按照不同密度将互花米草与秋茄进行混种,对比研究胁迫条件下秋茄幼苗生长、光合特性及其渗透调节物质变化规律。结果表明,低密度互花米草促进秋茄的茎长以及各部分生物量,高密度则起抑制作用。随着互花米草密度的增大,秋茄幼苗叶片光合速率、气孔导度、蒸腾速率、水分利用率和蛋白含量均下降;相反,胞间CO2浓度、可溶性糖、淀粉、脯氨酸含量却上升,这些变化有利于对抗互花米草带来的不利影响。 【英文摘要】 Kandelia candel seedlings were mix-cultured with Spartina alterniflora of different densities for 120 days,and their growth,photosynthetic characteristics as well as osmotic adjustment law were studied.The results showed that the stem height and biomass of K.candel seedlings were enhanced with low density S.alterniflora and inhabited with high density ones.With the density of S.alterniflora going up,Pn、Gs、Tr、WUE and protein content in K.candel seedlings decreased respectively.On the contrary,the content of ...国家自然科学基金资助项目(30670317,30271065);; 福建省自然科学基金资助项目(D0210001

糖尿病胃肠病中医诊疗标准

文章所讨论的糖尿病胃肠病中医诊疗标准是在中华中医药学会2007年发布的《糖尿病中医防治指南》的基础上,研究、整合、优化以往中医糖尿病标准方面的研究成果,结合临床实际,研究而形成的能够被学术界普遍认可的诊疗标准。文章对糖尿病胃肠病的临床表现、理化检查、鉴别诊断、处理原则、辨证施治、成药治疗、辅助疗法、西医治疗等分别进行阐述,旨在进一步推广和发挥中医药在治疗糖尿病胃肠病时的特色与优势,规范糖尿病胃肠病的诊疗行为,促进糖尿病胃肠病中医药临床疗效的进一步提升

活心丸(浓缩丸)治疗冠心病稳定性心绞痛的多中心、随机、双盲、安慰剂对照临床研究

目的观察活心丸(浓缩丸)治疗冠心病稳定性心绞痛的临床疗效和安全性。方法本研究采用多中心、随机、双盲、安慰剂对照研究方法,将480例气虚血瘀型冠心病稳定性心绞痛患者以3:1比例随机分为试验组(360例)和对照组(120例)。在西医常规治疗基础上,两组患者分别服用活心丸(浓缩丸)和安慰剂,1次2粒,每日3次;疗程8周。观察两组治疗前后主要指标(心绞痛症状积分)和次要指标(包括硝酸甘油减停率、中医证候积分及生活质量评价)及安全性。结果共454例患者完成试验(试验组336例,对照组118例)。与本组治疗前比较,试验组和对照组心绞痛症状积分和中医证候积分均降低,西雅图心绞痛量表评分改善(P<0.01);与对照组治疗后比较,试验组心绞痛症状积分、中医证候积分、西雅图心绞痛量表评分改善均优于对照组(P<0.01)。试验组心绞痛症状疗效总有效率为80.95%,硝酸甘油停减率为80.70%,中医证候疗效有效率80.65%,均高于对照组[36.44%、45.07%、38.99%(χ~2=58.21、40.94、66.55,P<0.01)]。试验组中既往有心梗史患者心绞痛症状总有效率为83.22%,中医证候有效率83.22%,西雅图心绞痛量表评分为(361.74±62.10)分,均高于无心梗史患者[60.92%、66.89%、(327.95±65.07)分(χ~2=13.89、13.26,P<0.01)]。治疗过程中未发生明显不良反应。结论活心丸(浓缩丸)治疗气虚血瘀型冠心病稳定性心绞痛疗效显著,尤其适用于既往有心梗病史的冠心病稳定性心绞痛患者,无明显不良反应。国家中医药管理局资助课题(No.国中医药科2016ZX04

康精汤治疗精液不液化症的临床观察

厦门市卫生局科技项目WSK052

Clinical Study of Senile Hypertension Treated by the Method of Tonifying Kidney and Activating Blood

探讨补肾活血法治疗老年性高血压病的临床疗效。治疗组30例用补肾活血法联合络活喜,对照组30例单用络活喜,观察降压疗效、症状疗效、内皮素、血栓素B2变化情况。结果显示治疗组疗效明显优于对照组,收缩压、症状积分、内皮素、血栓素B2下降明显优于对照组。提示补肾活血法能有效降低老年性高血压患者的收缩压、内皮素及血栓素B2水平,改善临床症状。To observe the curative effect of the method of tonifying kidney and activating blood in treating senile hypertension,30 patients of treatment group were treated with the prescription of tonifying kidney and activating blood plus Norvasc and 30 patients of control group were treated with Norvasc alone,the changes of blood pressure,clinical symptoms,endothelin,thromboxane B2 were observed.The results showed that the curative effect of treatment group was better,the systolic blood pressure,symptomatic scores,endothelin and thromboxane B2 were lower than that of control group.Conclusion: The method of tonifying kidney and activating blood can effectively lower systolic blood pressure,endothelin,thromboxane B2,and improve clinical symptoms of patients with senile hypertension

超疏水壁面影响下空泡溃灭诱导涡分布规律研究

超疏水固体壁面影响下空泡溃灭诱导的流动规律,在海洋工程、生物医学等领域有重要的应用。文章结合实验和数值模拟,深入研究了单个空泡在超疏水壁面影响下溃灭诱导涡产生机制与分布规律。在实验中,使用NeverWet涂层形成超疏水壁面,通过电火花低压放电生成空泡,溃灭过程和涡分布使用高速摄像机进行捕捉。数值模拟采用OpenFOAM两相可压缩求解器开展模拟,考虑到超疏水壁面的表面滑移现象,数值模拟通过改变壁面滑移边界条件和壁面接触角来模拟超疏水壁面,观察涡的分布规律。结果证实了不同间距下空泡溃灭会产生不同运动状态的涡,包括沿壁面迁移、向上迁移和震荡消失三种,得到了不同间距下的涡种类相图,并讨论了超疏水壁面对涡分布规律的影响。同时,文章重点分析了不同间距下涡的产生机理,认为气泡溃灭过程会产生三种方向射流,不同间距决定了主导射流从而决定涡的种类和分布。最后,文章讨论了超疏水壁面附近空泡溃灭在表面清洁、混合和生物医学等方向的应用

Effect of Kangquan Recipe on Apoptosis Regulatory Genes bax and bcl-2mRNA in Prostate of Rats

目的探讨康泉方对实验性大鼠前列腺组织凋亡调控基因bax mRNA、bcl-2 mRNA的影响。方法采用大鼠去势后注射丙酸睾丸酮致前列腺增生法造模,同时灌胃给药30天后,处死大鼠取前列腺组织并测量湿重,RT-PCR法检测各组前列腺腹叶组织bax mRNA、bcl-2 mRNA的表达。结果与模型组比较,康泉各剂量组前列腺湿重显著下降(P0.05);与模型组比较,康泉各剂量组bax mRNA及bax/bcl-2显著升高(P0.05)。结论康泉方对大鼠良性前列腺增生有明显的治疗作用,其作用机理可能通过调节前列腺组织bax mRNA、bcl-2 mRNA表达,促进前列腺细胞凋亡,并呈明显量效关系。Objective To investigate the effect of Kangquan Recipe (KQR) on apoptosis regulatory genes bax and bcl-2 mRNA in prostate of rats. Methods Benign prostatic hyperplasia model rat was established by injecting testosterone after castration. The model rats were killed and prostate glands were removed for examination after being treated with administration of KQR by gastrogavage for 30 days. The wet weight of prostate was measured and the mRNA expressions of bax and bcl-2 in rats' tissue of abdominal lobe of prostate were determined by RT-PCR. Results Compared with the model group, wet weight of prostate was lower significantly in the groups treated with different dosages of KQR (P0.05). Compared with the model group, the expressions of bax mRNA and ratios of bax/bcl-2 were significantly higher and the expressions of bcl-2 mRNA significantly lower in the KQR treated groups (P0.05). Conclusion KQR shows an obvious treatment effect on rats with benign prostatic hyperplasia, the mechanism might be through effectively regulating the expressions of bax mRNA and bcl-2 mRNA in prostatic tissue to accelerate the cell apoptosis of prostate in obvious dose-effect manner.福建省中医药科研项目(No.wzy0616);; 厦门市医学科研项目(No.WSK0526);; 厦门市卫生青年创新课题(No.WQK0510