励起子共振器ポラリトンの実現に向けた空隙／III族窒化物半導体分布ブラッグ反射型微小共振器の作製と評価に関する研究

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 荒川 泰彦, 東京大学教授 志村 努, 東京大学教授 高橋 琢二, 東京大学准教授 岩本 敏, 東京大学准教授 竹中 充, 東京大学准教授 加藤 雄一郎University of Tokyo(東京大学

鱼粉替代——鱼粉高价运行下水产配合饲料研发的技术对策

蛋白质是鱼类生长的主要营养物质,水产饲料配方中蛋白质含量一般是畜禽饲料中的2~4倍,通常占配方的25%~50%,甚至更多。因此,作为水产动物重要的蛋白源的提供者——鱼粉在水产饲料配方中占有重要的作用。然而,一方面由于全球气候变化、环境恶化和过度捕捞等造成渔业生物资源衰退,鱼粉获量越来越少;另一方面,近几年鱼粉的消费结构发生了很大的变化,水产养殖产量的提高,鱼粉市场需求旺盛,导致鱼粉价格不断上涨。鱼粉短缺已成为全球水产饲料工业面临的最大难题之一。鱼粉源于自然资源,在需求总体增长的情况下,鱼粉趋少、趋贵的走势在所难免,要维持以鱼粉为主要蛋白源的水产养殖业稳定的、持续的发展,开辟鱼粉替代品迫在眉睫。大量的研究资料表明,用丰富的动植物蛋白源、单细胞蛋白源和藻粉部分或完全代替鱼粉是可行的。本期我们邀请了厦门大学教授艾春香以“鱼粉替代——鱼粉高价运行下水产配合饲料研发的技术对策“为题,分三个方面就鱼粉替代的必要性及可行性、鱼粉替代的技术方案和鱼粉替代研究与应用存在的问题进行了深入的论述,相信会给行业同仁带来启迪和借鉴。福建省重大项目“基于生态系统水平的海胆海参集约化混养关键技术的集成与示范[2011N3013]”; 福建省星火计划项目“高效环境友好型卵形鲳鲹配合饲料的产业化开发[2012S0005]

Study of Control System of Permanent Magnet Linear Synchronous Motor

介绍了永磁同步直线电机技术、应用范围和直线电机的类型及选型,分析了直线电机伺服控制系统的多种控制方法存在的利弊,为直线电机的高精度控制的实现提供帮助。This paper introduces technology,the application range and the type of the permanent magnet synchronous linear motor, analyzes the advantages and disadvantages of various control methods in linear motor servo control system, offers help for implementation of high precision control of the linear motor.黔科合J字LKS(2013)33

Development and stability test of compound ketoconazole ointment

目的 制备复方酮康唑软膏并考察其稳定性。方法 以酮康唑、莫匹罗星和糠酸莫米松为主药，以聚乙二醇（PEG）为基质制备软膏；利用影响因素试验考察软膏中药物的稳定性。结果 PEG400和PEG3350的比例为2：1时，软膏的黏度最佳，易于涂展。制成软膏后，高温下糠酸莫米松和莫匹罗星稳定性良好；酮康唑有少许分解，加入0.5%的抗坏血酸棕榈酸酯（L-A）后，酮康唑的含量明显提高。加速试验发现，放置6个月后软膏的颜色无变化，3种药物的含量均在98%以上。结论 本实验成功制备了新型复方酮康唑软膏，药物稳定性良好。Objective To prepare compound ketoconazole ointment and perform the stability study.Methods Ketoconazole, mupirocin and mometasone furoate were used as active pharmaceutical ingredients （API）. PEG mixture was used as matrix to prepare the ointment.Stability of the API in the ointment was evaluated by the stress tests.Results The optimal ratio of PEG400 to PEG3350 for the ointment matrix was 2：1. Mometasone furoate and mupirocin in the ointment were stable to the high temperature（40℃）while ketoconazole had some degradation. The stability of the API was improved by addition of 0.5% of L-A. During the accelerate test, the ointment had no color change and the API percentages were above 98%. Conclusion The novel compound ketoconazole ointment was successfully prepared and the formulation stability was excellent.福建省自然科学基金项目（2010J01218

基于多组分评价的雷公藤提取物固体分散体的制备及体外表征

目的制备雷公藤提取物(ETW)固体分散体(ETW-SD),提高其体外溶出度。方法通过溶剂-熔融法,以聚乙二醇6000(PEG 6000)、泊洛沙姆188(F68)为载体制备ETW-SD。以雷公藤甲素、雷公藤内酯酮、雷公藤次碱、雷公藤红素以及雷公藤内酯甲为评价指标,通过体外溶出度、电子扫描电镜(SEM)、差示热量扫描(DSC)和X-射线衍射(XRD)对ETW-SD进行表征。结果 ETW-SD的最优处方为ETW-PEG 6000-F68(1∶2∶1)。与原料药相比,在60 min内雷公藤内酯酮、雷公藤甲素的溶出度分别提高了3.32倍,雷公藤次碱提高了2倍,而雷公藤红素和雷公藤内酯甲的溶出度均达到83%以上。福州总医院院立课题(2016L02);;福建省科技计划重大项目(2012I1001

Advances in preparation of mesoporous silica nanoparticles and its use as different functional drug

近年来,有越来越多的文献报道关于介孔二氧化硅纳米粒（mesoporous silica nanoparticles,MSN）作药物载体的研究。本文结合近几年国内外的相关文献,介绍了由Mobli公司合成的M41S系列,圣巴巴拉大学合成的SBA系列,以及中空介孔二氧化硅纳米粒这3种最常见的MSN的特点及制备方法,并举例介绍了MSN作为药物速释载体的相关研究,同时从p H敏感型、热敏型、光响应型三方面介绍了MSN作为药物控释载体的研究。从相关研究结果可以看出,将MSN作为药物的载体,鉴于其独特的介孔孔径、可调节的纳米孔道结构、易于功能化修饰的表面等特点,可以实现对药物的速释、缓释及控释释放。由此可见,选择将MSN作为药物的载体具有广阔的应用前景。In the past a few years, mesoporous silica nanoparticles (MSN) have attracted more and more attention for their application in drug delivery. The recent relative literature was used for reference to introduce the characteristics and preparation of M41S series MSN (synthesized by Mobil Corporation), the SBA series MSN (synthesized by Santa Barbara University), and hollow mesoporous silica nanoparticles. Examples were presented to introduce the use of MSN as immediate drug delivery carrier. The use of MSN as controlled drug delivery carrier (CDDC) was illustrated via pH-responsive CDDC, temperature-sensitive CDDC, and light-triggered CDDC. MSN showed great properties in immediate/sustained/controlled drug delivery system, in view of their unique mesoporous pore diameter, adjustable nano-channel, and surface easily to be modified. The selection of MSN as drug carrier has a broad application prospect. ? 2017, Chinese Journal of New Drugs Co. Ltd. All right reserved.福建省科技计划重点项目（2013Y0074

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074