乌蔹莓化学成分的初步探究

目的:系统性研究福建道地药材乌蔹莓的有效成分。方法:运用大孔树脂,Sephadex LH-20,ODS及正相硅胶柱等色谱手段对乌蔹莓Cayratia japonica的全草进行分离。结果:从中得到13个化合物,通过多种波谱数据分析鉴定化合物结构,确定其分别为木犀草素(1),芹菜素(2),柠檬酸三乙酯(3),吲哚-3-甲醛(4),秦皮乙素(5),邻苯二甲酸二乙基己酯(6),calendin(7),反式咖啡酸乙酯(8),木犀草素7-O-葡萄糖苷(9),5-hydroxy-3,4-dimethyl-5-pentyl-2(5H)-furanone(10),3,4-二羟基苯甲酸乙酯(11),圣草酚(12),胡萝卜苷(13)。结论:其中3～8及10～12均为首次从乌蔹莓中分离得到

刺苋的化学成分研究

目的研究刺苋Amaranthus spinosus的化学成分。方法采用大孔树脂、硅胶、Sephadex LH-20柱色谱、ODS柱色谱等方法进行分离纯化,利用波谱技术鉴定化合物的结构。结果分离得到了16个化合物,分别鉴定为香草醛(1)、丁香醛(2)、邻苯二甲酸二异丁酯(3)、邻苯二甲酸二丁酯(4)、对羟基苯甲醛(5)、2-羟基苯并噻唑(6)、丁香脂素(7)、hydroxydihydrobovolide(8)、黑麦草内酯(9)、蚱蜢酮(10)、棕榈酸甘油酯(11)、反式阿魏酸酰对羟基苯乙胺(12)、菠甾醇-3-O-β-D-葡萄糖苷(13)、齐墩果酸-3-O-β-D-吡喃葡萄糖醛酸甲酯苷(14)、齐墩果酸-3-O-β-D-吡喃葡萄糖醛酸苷(15)、芦丁(16)。结论化合物1～12、14、15均为首次从该植物中分离得到

小槐花的化学成分研究

目的:系统研究中药小槐花中的化学成分。方法:利用大孔树脂,Sephadex LH-20,ODS及正相硅胶柱等色谱手段进行分离,通过多种波谱学数据分析进行化合物的结构鉴定。结果:从小槐花60%乙醇提取物中分离得到15个化合物,经结构鉴定分别为豆甾醇(1),β-谷甾醇(2),柠檬酚(3),黄槿酮A(4),异柠檬酚(5),kenusanone I(6),neophellamuretin(7),清酒缸酚(8),古柯三醇(9),黄槿酮D(10),山柰酚(11),8-prenylquercetin(12),leachianone G(13),5,7,4'-三羟基-二氢黄酮醇(14),4H-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-8-(3-methyl-2-butenyl)-,(2R-trans)-(9CI)(15)。结论:除化合物8外,所有化合物均为从该种植物中首次分离得到

东方肉穗草黄酮类化学成分研究

目的:系统研究东方肉穗草中的黄酮类化学成分。方法:利用大孔吸附树脂、Sephadex LH-20,ODS及正相硅胶柱等色谱手段进行分离,通过多种波谱学数据分析进行黄酮类化合物的结构鉴定。结果:从醋酸乙酯部分分离得到8个黄酮类化合物,经鉴定为异鼠李素(1)、槲皮素(2)、异鼠李素-3-O-β-D-吡喃葡萄糖苷(3)、槲皮素-3-O-β-D-葡萄糖苷(4)、异鼠李素-3-D-(6″-乙酰基)-β-D-吡喃葡萄糖苷(5)、异鼠李素-3-O-(2″-乙酰基)-β-D-吡喃葡萄糖苷(6)、槲皮素-3-O- (6″-乙酰基)-β-D-吡喃葡萄糖苷(7)、槲皮素-3-O-(6″-反式-对香豆酰基)-β-D-吡喃葡萄糖苷(8)。结论:所有化合物均系首次从该属植物中分离鉴定

Experimental study on reperfusion of intraocular lens

作者简介: 祁明信, 男, 1945 年7 月 出生, 教授、主任医师、博士研究生 导师, 主要从事白内障的基础与临 床研究。联系电话: 0591-83570887; E-mail:qihuang@netease. com 通讯作者: 黄秀榕,E-mail:[email protected][中文文摘]目的开展晶状体再灌注的离体和动物实验研究,并对再灌注人工晶状体技术进行评价。方法采用新鲜离体幼兔眼、离体猪眼、新西兰白兔眼,应用自行研制的人工晶状体材料,进行以下实验:(1)体外固化实验;(2)晶状体前囊膜微型撕囊及其稳固性实验;(3)经微型前囊膜开口超声乳化吸出晶状体内容物实验;(4)活的新西兰白兔眼内人工晶状体再灌注实验。结果(1)按硅酮聚合物与固化剂50:1的比例可获得柔软、弹性好、固化时间短(完全固化时间为60min)的注入材料;(2)晶状体前囊膜1.8～2.0mm的连续环形撕囊口具有较好的稳定性,可经该微型开口吸出晶状体内容物并灌注材料;(3)超声能量18%、流量25mL·min-1、负压120mmHg(1kPa=7.5mmHg)为晶状体内容物经微型前囊膜开口吸出的最佳条件;(4)注入灌注材料后可形成由晶状体囊膜包裹的、置换原晶状体皮质和核的、新的再灌注人工晶状体。结论采用再灌注人工晶状体的方法可进行新型人工晶状体再灌注,可为治疗白内障和老视提供参考。[英文文摘]Objective To carry out the experimental study on reperfusion of intraocular lens(IOLs) in vitro or in animal,and to assess the technique of IOLs reperfusion.Methods The following experiments were performed by using self-developed materials in fresh rabbit eyes and pig eyes in vitro,as well as in eyes of alive New-Zea-land rabbits:(1)Solidification study of self-developed material in vitro;(2)Continuous circular capsulorhexis(CCC) in anterior capsule of lens and its stability;(3)Draw of lens contents via phaco through mini-CCC;(4)IOLs ref illing in the eyes of alive New-Zea land rabbits. Results(1) Thematerialwhich was soft, springy and short-term solidification(full solidification time was 60 minutes) were obtained in certain proportion of geland solidified agent(50:1) in vitro; ( 2)The CCC in anterior capsule of lens with 1.8-2.0 mm diameter had very good stability. The lens contents were drawn and the materialwere refilled through themini-CCC; (3) The best conditions of drawing out lens contents through m ini-CCC were phaco energy 18% , flow 25 mL·min- 1, and negative pressure 120 mmH g (1kPa=7.5 mmHg);(4) The new refilled IOLs, which were wrapped by capsule of lens and were replaced original cortex and nucleus of lens, were obtained after thematerial refillied. Conc lusion. New IOLs are refilled through this method, which can prov ide reference for the treatment of cataract and presbyopia.福建省科技三项费用;教育厅重点资助项目基金资助(编号:K98041

Chemical constituents in higher polar substances from Desmodium caudatum

该实验研究了传统中药小槐花大极性部位的化学成分。综合运用硅胶柱色谱,聚酰胺凝胶柱色谱,OdS中低压柱色谱,SEPHAdEX lH-20柱色谱,薄层色谱,重结晶,分析型和制备型HPlC等方法进行分离,利用核磁共振波谱,质谱及化合物的理化性质对化合物的结构进行了鉴定。从小槐花大极性部位中分离得到13个单体化合物,它们的结构经鉴定分别为香草醛(1),黑麦草内酯(2),吲哚-3-甲醛(3),水杨酸(4),当药黄素(5),SACCHAruMOSIdE C(6),ISOSInEnSIn(7),7-O-α-l-吡喃鼠李糖基-山柰酚-3-O-β-d-吡喃葡萄糖苷(8),异牡荆素(9),牡荆素(10),nOTHOfAgIn(11),rESVErATrOlOSIdE(12),2″-α-rHAMnOPyrAnOSyl-7-O-METHylVITEXIn(13)。除化合物5外,其余12个化合物均为小槐花中首次分离得到的化合物,化合物2,3,6~8,11~13等8个化合物为山蚂蝗属植物中首次分离得到的化合物。In this study the chemical constituents of the higher polar substances from Desmodium caudatum were investigated.The compounds were isolated by using column chromatographies over silicagel,polyamide,ODS,Sephadex LH-20,and preparative HPLC.The structures of these compounds were identified on the basis of NMR and MS spectra.Thirteen compounds were obtained and their structures were identified as vanillin( 1),loliolide( 2),indole-3-carboxaldehyde( 3),salicylic acid( 4),swertisin( 5),saccharumoside C( 6),isosinensin( 7),kaempferol 3-O-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside( 8),isovitexin( 9),vitexin( 10),nothofagin( 11),resveratroloside( 12),and 2″-α-rhamnopyranosyl-7-O-methylvitexin( 13).Except for compound 5,the remaining compounds were isolated from D.caudatum for the first time.Compounds 2,3,6-8,11-13 were separated from the genus Desmodium for the first time.福建省区域重大专项(2009Y3004); 厦门市重大科技计划项目(3502Z20100006

Biomass Structure and Energy Distribution of Phyllostachys heterocycla cv. pubescens Population

研究了福建省永春县毛竹种群的生物量结构、能量分布 ,研究结果表明 :(1)永春毛竹种群的现存生物量为6 474.874g/m2 ,其中地上部分为 46 76 .6 39g/m2 ,占 72 .2 3% ;地下部分为 1798.2 35g/m2 ,占 2 7.77% ;其各组分分别为 :杆 3736 .2 0 0 g/m2 、枝 772 .0 6 9g/m2 、叶 16 8.370 g/m2 、竹蔸 10 5 9.115 g/m2 、鞭根 739.12 0 g/m2 ;(2 )毛竹种群生物量在Ⅰ至Ⅳ度的分配为 :5 .12 % ,40 .5 2 % ,39.82 % ,14.5 4% ;(3)毛竹种群的能量现存量为 12 46 89.5 76kJ/m2 ,其中地上部为 912 18.36 1kJ/m2 (占 73.16 % ) ,地下部为 334 71.2 15kJ/m2 (占 2 6 .84% ) ;(4 )能量现存量在Ⅰ至Ⅳ度的分配为 :5 .0 8% ,40 .38% ,39.80 % ,14.74% .Biomass structure and energy distribution of Phyllostachys heterocycla cv. pubescens population in Yongchun county, Fujian were discussed in this paper. The results showed as follows:(1)the standing crop of biomass in the Phyllostachys heterocycla cv. pubescens population was 6 474.874 g/m 2, in which the biomass of above-ground was 4 676.639 g/m 2 (accounting for 72.23%), and that of below-ground was 1 798.235 g/m 2 (27.77%), respectively; the biomass of various components of population was 3 736.200 g/m 2 for stem, 772.069 g/m 2 for branch, 168.370 g/m 2for leaf, 1 059.115 g/m 2 for rhizome and 739.120 g/m 2 for roots, respectively.(2)the biomass components fromⅠto Ⅳ age was 5.12%, 40.52%, 39.82% and 14.54%, respectively.(3)the standing crop of energy was 124 689.576 kJ/m 2 , in which above-ground and below-ground comprised 91 218.361 kJ/m 2 (accounting for 73.16%) and 33 471.215 kJ/m 2 (26.84%), respectively.(4)the standing crop of energy from Ⅰto Ⅳ age was 5.08%, 40.38%, 39.80% and 14.74%, respectively.福建省自然科学基金 (B0 110 0 0 7)资助项

Chemical constituents from Elephantopus tomentosus

目的:系统研究中国传统中药白花地胆草中的化学成分。方法:利用大孔吸附树脂、SEPHAdEX lH-20,OdS及正相硅胶柱等色谱手段进行分离,通过多种波谱学手段对单体化合物进行结构鉴定。结果:从白花地胆草60%乙醇提取物中分离得到18个单体化合物,它们经结构鉴定分别为2-dEETHOXy-2β-HydrOXyPHAnTOMOlIn(1),2β-HydrOXy-2-dEETHOXy-8-O-dEACylPHAnTO-MOlIn-8-O-TIglInATE(2),2β-METHOXy-2-dEETHOXyPHAnTOMOlIn(3),2β-METHOXy-2-dEETHOXy-8-O-dEACylPHAnTOMOlIn-8-O-TIglInATE(4),白花地胆草亭(5),柔毛地胆宁(6),苜蓿素(7),木犀草素(8),槲皮素(9),表无羁萜醇(10),3β-HydrOXyOlEAn-12-En-28-OIC ACId(11),3,5-O-二咖啡酰基奎宁酸(12),3,4-O-二咖啡酰基奎宁酸甲酯(13),丁香脂素-4-O-β-d-葡萄糖苷(14),XylOgrAnATInIn(15),byzAnTIOnOSIdE b(16),邻羟基肉桂醛(17),咖啡酸乙酯(18)。结论:其中化合物9,11,14~18均为从该属植物中首次分离得到。Objective: To study the chemical constituents of Elephantopus tomentosus.Method: The compounds were isolated by repeated HP20 macro porous adsorption resin column combined with Sephadex LH-20,ODS and silica gel chromatographies.The structures were identified on the basis of extensive spectroscopic data analysis and by comparison of their spectral data reported.Result: Eighteen compounds were identified as 2-deethoxy-2β-hydroxyphantomolin(1),2β-hydroxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate(2),2β-methoxy-2-deethoxyphantomolin(3),2β-methoxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate(4),molephantin(5),molephantinin(6),tricin(7),luteolin(8),quercetin(9),3β-friedelinol(10),3β-hydroxyolean-12-en-28-oic acid(11),3,5-di-O-caffeoyl quinic acid(12),3,4-di-O-caffeoyl quinic acid(13),syringaresinol-4-β-D-glucopyranoside(14),xylogranatinin(15),byzantionoside B(16),2′-hydroxycinnamaldehyde(17),and caffeic acid ethyl ester(18).Conclusion: Compounds 9,11,14-18 were separated from Elephantopus for the first time.福建省区域重大专项(2009Y3004); 厦门市重大科技计划项目(3502Z20100006

北方典型海岛高质量发展策略与途径——以长岛为例

海岛是我国国土的重要组成部分,其高质量发展对海岛生态保护和可持续发展具有重要意义。长岛是山东省唯一的海岛型行政区,是国家级重点生态功能区。为实现我国北方海岛以绿色、低碳、循环为核心的高质量发展,本文以长岛为例,分析了其发展现状和存在问题,厘清了其高质量发展的理念和定位。通过实地调研和问卷调查等方法,提出了长岛生态文明综合试验区高质量发展的策略和途径,即以国家公园建设工程进行生态保护和修复,以零碳海岛建设工程旅游海岛建设工程和牧场海岛建设工程进行海岛开发和利用,以智慧海岛建设工程和科技海岛建设工程进行科技引领和支撑。六大工程陆海联动,共同推动长岛高质量发展,为我国北方典型海岛海洋生态文明建设及其高质量发展提供思路

北方典型海岛高质量发展策略与途径——以长岛为例

海岛是我国国土的重要组成部分,其高质量发展对海岛生态保护和可持续发展具有重要意义。长岛是山东省唯一的海岛型行政区,是国家级重点生态功能区。为实现我国北方海岛以绿色、低碳、循环为核心的高质量发展,本文以长岛为例,分析了其发展现状和存在问题,厘清了其高质量发展的理念和定位。通过实地调研和问卷调查等方法,提出了长岛生态文明综合试验区高质量发展的策略和途径,即以国家公园建设工程进行生态保护和修复,以零碳海岛建设工程旅游海岛建设工程和牧场海岛建设工程进行海岛开发和利用,以智慧海岛建设工程和科技海岛建设工程进行科技引领和支撑。六大工程陆海联动,共同推动长岛高质量发展,为我国北方典型海岛海洋生态文明建设及其高质量发展提供思路