Analysis on 6 Cases of Adverse Drug Reactions Induced by Ammonium Chloride and Licoricl Oral Solution

目的：探讨氯化铵甘草口服溶液不良反应的特点,为临床安全用药提供参考。方法：对本院2014年1月-2016年3月上报的6例氯化铵甘草口服溶液不良反应监测报告进行回顾性分析,对6例患者的年龄、性别、原患疾病,药物使用情况,ADR发生时间、临床表现、治疗与转归,ADR的类型与关联性评价等项目进行统计分析。结果：氯化铵甘草口服溶液不良反应多发生于老年患者;发生时间主要在用药8h内;以累及系统呼吸系统和皮肤为主;6例患者均痊愈,未出现后遗症或导致死亡。6例ADR中一般的ADR 2例,新的一般的ADR 2例,新的严重ADR 2例;关联性评价为可能4例,很可能2例。结论：临床上应重视氯化铵甘草口服溶液的不良反应,应密切观察患者,保证用药安全。Objective： To explore the characteristics of the adverse drug reactions （ADRs） induced by ammonium chloride and licoricl oral solution, to provide the reference for clinical safe medication and prevent adverse reaction. Methods：Restrospectively analysis were used on the ADRs reports of 6 cases of ammonium chloride and licoricl oral solution form January 2014 to March 2016 in our hospital. The application of drug, the age and gender distribution of patients ,occurrence time of ADRs, clinical manifestations ; treatment and outcome ; types and relevance evaluation of ADRs were analyzed respectively. Results：ADRs were mostly happened in the senile patients 8h after the medication. The clinical manifestations were respiratory and skins. 6 patients were all recovered, no occurrence sequel or lead to death. There were 4 cases of new ADR ,4 cases of commom ADR and 2 cases of severe ADR, 4 cases of possible relevance and 2 cases of probale relevance. Conclusion：The ADRs caused by ammonium chloride and licoricl oral solution should be pay more attention to, observed the changes closely to ensure clinical safe mediation

从鱿鱼顶骨β-甲壳素合成的丙酰化甲壳素的结晶结构

分别从α 甲壳素 (来源于蟹壳 )和 β 甲壳素 (来源于鱿鱼顶骨 )制备丙酰化甲壳素。丙酰化β 甲壳素的大角X光衍射图出现 2 0个衍射峰 ,而丙酰化α 甲壳素只在 2 0°左右出现弥散峰。发现丙酰化β 甲壳素的结晶属三斜晶系 ,a =7.997,b =1 3.0 67,c =6.31 6(任意单位 ) ,α =98°5 6′ ,β =1 0 4°1 9′,γ =82°2 6′。列表说明了各衍射峰的归属。据分析 ,每个单元晶胞内含一根分子链的 2 .5个葡萄糖残基单元。分子轴为b

Study on Water Environmental Capacity of Reservoired River in Jiulong River Basin

针对九龙江流域湖库化问题,确定湖库化河段判定标准,提出综合电站的概念,基于大量的实测数据进行水质模型的降解系数值k参数率定,以此为基础,提出湖库化河段水环境容量计算方法,对九龙江流域湖库化后的水环境容量核算开展研究,确定了流域河流湖库化对水环境容量计算的影响,湖库化河段的水环境容量,为流域的水环境容量总量控制和管理、决策提供科学的依据.According to the problem of reservoired in Jiulong River basin,the judgment standard of reservoired river was determined,and the concept of integrate hydropower station was presented.Then,the parameter value of degradation coefficient K was calibrated with water quality model based on a large number of measured data of water quality.On this basis,calculation method of water environmental capacity for reservoired river was proposed.Finally,research was carried on water environmental capacity accounting of reservoired river in Jiulong River basin.The results show the effect of reservoired on water environmental capacity calculation,and the water environmental capacity of reservoired river,which provided scientific basis for the total emission control,management and decision-making of water environmental capacity in Jiulong River basin.福建省环保资助项目(ZLT0903); 福建省科技重大专项(2013YZ001-1

Probing nanoscale spatial distribution of plasmonically excited hot carriers

表面等离激元（SP）效应可产生远高于热平衡下费米能级能量的热电子-空穴对（热载流子），从而能够引发和促进相关的光电或者化学过程，为在纳米尺度上高效利用光能实现物质和能量转化提供了极为有效的手段，化学化工学院任斌教授课题组利用前期自主发展的电化学针尖增强拉曼光谱技术，通过调控电位开关SP热载流子催化的反应，实现了有效热载流子催化反应区域的纳米分辨成像，使反应区域在实空间的分布可视化。实验上获得了有效热载流子的输运距离，从而证明了能量越高的热载流子越需要在更短的输运距离范围内收集捕获。 该工作在任斌教授和王翔副教授的共同指导下完成。实验主要由化学化工学院已毕业博士生黄声超完成。理论计算主要由电子科学与技术学院的朱锦峰副教授和已毕业硕士生李察微完成。此外，化学化工学院已毕业硕士生赵庆庆、博后何玉韩和胡树等人也参与了部分研究与课题讨论。【Abstract】Surface plasmons (SPs) of metals enable the tight focusing and strong absorption of light to realize an efficient utilization of photons at nanoscale. In particular, the SP-generated hot carriers have emerged as a promising way to efficiently drive photochemical and photoelectric processes under moderate conditions. In situ measuring of the transport process and spatial distribution of hot carriers in real space is crucial to efficiently capture the hot carriers.Here, we use electrochemical tip-enhanced Raman spectroscopy (EC-TERS) to in situmonitor an SP-driven decarboxylation and resolve the spatial distribution of hot carriers with a nanometer spatial resolution. The transport distance of about 20 nm for the reactive hot carriers is obtained from the TERS imaging result. The hot carriers with a higher energy have a shorter transport distance. These conclusions can be guides for the design and arrangement of reactants and devices to efficiently make use of plasmonic hot carriers.The authors acknowledge the financial supports from MOST of China (2016YFA0200601), NSFC (21633005, 21790354, 21503181, 21711530704, U1830116), Natural Science Foundation of Fujian Province (2016J05046), China Postdoctoral Science Foundation (2017M622062) and the Fundamental Research Funds for the Central Universities (20720190010).本研究工作得到了国家自然科学基金委和科技部等的资助和支持

养正消积胶囊辅助GP方案治疗晚期非小细胞肺癌临床研究

目的观察养正消积胶囊辅助GP方案治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法采用随机数字表法将89例晚期NSCLC患者分为对照组44例及观察组45例。2组均采用GP方案;观察组并予养正消积胶囊,每次4粒,每日3次,口服。2组均21d为1个周期,连续治疗2个周期,随访1年。观察2组治疗前后Ki67、Bax、Bcl-2蛋白表达及肿瘤标志物[血管内皮生长因子(VEGF)、骨桥蛋白(OPN)、癌胚抗原(CEA)、糖类抗原199(CA199)]、中医症状评分、生活质量评分,比较2组客观缓解率(ORR)、疾病控制率(DCR)、无进展生存时间(PFS),监测不良反应。结果观察组ORR、DCR明显优于对照组(P<0.05)。与本组治疗前比较,观察组治疗后、随访1年VEGF、OPN、CEA、CA199水平明显降低(P<0.05);对照组治疗后上述指标明显降低(P<0.05),随访1年CEA水平明显降低(P<0.05)。与本组治疗前比较,2组治疗后Ki67、Bcl-2蛋白表达明显降低,Bax蛋白表达明显升高(P<0.05);2组治疗后比较,观察组Ki67、Bcl-2蛋白表达低于对照组(P<0.05),Bax蛋白表达高于对照组(P<0.05)。与本组治疗前比较,2组治疗后中医症状评分(神疲乏力、胃纳少馨、腰膝无力、夜尿频多、头晕目眩)、生活质量评分(躯体功能、认知功能、社会功能、情绪功能)明显改善(P<0.05);2组治疗后比较,观察组上述评分改善明显优于对照组(P<0.05)。观察组PFS明显长于对照组(P<0.05),不良反应明显低于对照组(P<0.05)。结论养正消积胶囊辅助GP方案治疗晚期NSCLC可有效降低患者肿瘤标志物水平,改善生存质量,减少吉西他滨和顺铂的不良反应,提高疗效。福建省卫生厅中医药科研专项课题(wst201210

Mediating role of basic psychological needs between the level of parents mindful parenting and adolescents physical and mental health

目的:探讨父母正念教养水平与青少年身心健康之间的关系，以及基本心理需求满足在二者之间的中介效应。方法:采用正念养育量表、基本心理需求满意与挫败度量表、90项症状清单对258名中学生及其父母进行问卷调查。结果:(1)相关分析显示，父母对青少年的正念教养水平与青少年健康症状显著负相关(r=-0.187,P</p

Effects of Intermittent Breath Method on Anxiety and Pain: A Randomized Controlled Trial

目的:在前人研究的基础上,对已有的放松方法进行改良,提出了间断式呼吸训练法,并探讨此方法应对焦虑及镇痛效果。方法:共招募在校大学生、研究生93名。随机分成间断式呼吸放松组(简称呼吸放松组)(n=31),音乐放松组(n=31),和对照组(n=31)。被试填写特质焦虑问卷,疼痛灾难化量表,然后分别进行20分钟的呼吸放松、音乐放松或自由等待,之后填写状态焦虑问卷,应激实验、冷压任务,最后填写应对策略问卷。结果:经过20分钟的训练,呼吸放松组和音乐放松组的状态焦虑水平显著低于对照组(28.76±5.08 vs. 36.66±7.44,P <0.001;31.41± 7.94 vs. 36.66±7.44,P <0.01);呼吸放松组的痛阈显著高于音乐放松组和对照组(16.80±13.87 vs. 11.49±9.83,P <0.05; 16.80±13.87 vs.8.46±4.72,P <0.001);冷压任务中,冷压痛恢复阶段,呼吸放松组与音乐放松组的痛苦得分显著低于对照组(1.72±1.67vs. 3.10±2.53,P <0.01;1.93±1.67vs. 3.10±2.53,P <0.05)。结论:经过短期间断式呼吸放松训练的个体能有效应对焦虑,从痛苦中恢复。并且疼痛耐受性优于音乐放松组。间断式呼吸训练是一种有效的放松方法

Effects of Intermittent Breath Method on Anxiety and Pain: A Randomized Controlled Trial

摘要：目的:在前人研究的基础上,对已有的放松方法进行改良,提出了间断式呼吸训练法,并探讨此方法应对焦虑及镇痛效果。方法:共招募在校大学生、研究生93名。随机分成间断式呼吸放松组(简称呼吸放松组)(n=31),音乐放松组(n=31),和对照组(n=31)。被试填写特质焦虑问卷,疼痛灾难化量表,然后分别进行20分钟的呼吸放松、音乐放松或自由等待,之后填写状态焦虑问卷,应激实验、冷压任务,最后填写应对策略问卷。结果:经过20分钟的训练,呼吸放松组和音乐放松组的状态焦虑水平显著低于对照组(28.76&plusmn;5.08 vs.36.66&plusmn;7.44,P&lt;0.001;31.41&plusmn;7.94 vs.36.66&plusmn;7.44,P&lt;0.01);呼吸放松组的痛阈显著高于音乐放松组和对照组(16.80&plusmn;13.87 vs.11.49&plusmn;9.83,P&lt;0.05;16.80&plusmn;13.87 vs.8.46&plusmn;4.72,P&lt;0.001);冷压任务中,冷压痛恢复阶段,呼吸放松组与音乐放松组的痛苦得分显著低于对照组(1.72&plusmn;1.67vs.3.10&plusmn;2.53,P&lt;0.01;1.93&plusmn;1.67vs.3.10&plusmn;2.53,P&lt;0.05)。结论:经过短期间断式呼吸放松训练的个体能有效应对焦虑,从痛苦中恢复。并且疼痛耐受性优于音乐放松组。间断式呼吸训练是一种有效的放松方法。 【Abstract】 Objective: Based on previous researches, we developed a new relaxation method and tested its effects on re⁃ducing anxiety and analgesia. Methods: Ninety-three College students participated in this study, and were randomly divid⁃ed into 3 groups: the intermittent breath relaxation group(n=31), the music relaxation group(n=31), and the control group(n=31). The participants were asked to complete the Trait Anxiety Inventory and Pain Catastrophizing scale, and then received 20 min of intermittent breath training, music relaxation training, and just-waiting period, respectively. After that, all partici⁃pants performed two behavioral tasks: Mental Arithmetic Test and Cold Pressure Test. Mental arithmetic induced stress and cold water induced pain were measured to evaluate the effectiveness of relaxation training. Stress-related questionnaires were also filled in after the behavioral tests. Results: After the training, the state anxiety scores of both relaxation groups were significant lower than that of the control group(28.76&plusmn;5.08 vs. 36.66&plusmn;7.44, P&lt; 0.001; 31.41&plusmn;7.94 vs. 36.66&plusmn;7.44, P&lt;0.01). Pain thresholds of the intermittent breath group were statistically higher than the other two groups(16.80&plusmn;13.87 vs. 11.49&plusmn;9.83, P&lt;0.05; 16.80&plusmn;13.87 vs. 8.46&plusmn;4.72, P&lt;0.001). The distress scores of the two relaxation groups were also lower than that of the control group during the recovery period in the Cold Pressure Test(1.72&plusmn;1.67 vs. 3.10&plusmn;2.53, P&lt;0.01; 1.93&plusmn; 1.67 vs. 3.10&plusmn;2.53, P&lt;0.05). Conclusion: Short-term intermittent breath relaxation training is an effective and reliable method for reducing anxiety and promoting recovery from distress. Overall, it is better than the ordinary music relaxation method.</p

一种含有自折叠结构的聚氨酯及其制备方法

本发明涉及一种含有自折叠结构的聚氨酯，以1，5‑萘二异氰酸酯、均苯四甲酸二酐、二异氰酸酯、羟基胺和低聚物二元醇等为原料，制备得到的自折叠结构的聚氨酯相比于传统的弹性体材料的弹性、模量、强度以及断裂伸长率等机械性能得到大幅提升，在机械和化工等领域有潜在应用。其次，所涉及的制备方法简单，易于实施和控制、且生产效率高

一种含有萘环结构的聚氨酯及其制备方法

本发明涉及一种含有萘环结构的聚氨酯，以1,5‑萘二异氰酸酯、二异氰酸酯、羟基胺和低聚物二元醇等为原料，制备得到的含有萘环结构的聚氨酯相比于传统的弹性体材料的弹性、模量、强度以及断裂伸长率等机械性能得到大幅提升，在机械和化工等领域有潜在应用。本发明还涉及制备方法，具有简单，易于实施和控制、且生产效率高