Phase Segregation of ZnO/ZnMgO Superlattice Affected by Ⅱ-Ⅵ Ratio

在zn1-X Mg X O中,X=0.4~0.6仍为一个岩盐矿和纤锌矿共存的结构,影响了其晶格质量。本文利用等离子体辅助的分子束外延设备在C面蓝宝石衬底上外延生长了znO/znMgO超晶格,并改变其生长过程中的Ⅱ-Ⅵ比,利用原子力显微镜、X射线衍射、透射谱和X射线光电子能谱对样品进行了表征分析。发现在较低氧分压下制备的样品结构以岩盐矿为主导,而在较高氧分压下两相共存并以纤锌矿为主。这种相分离现象与裂解氧原子的密度有关。ZnMgO alloy allows for tunable optoelectronic devices.However,the compositional range between ZnO and MgO is interrupted by a crystalline miscibility gap where the wurtzite crystal structure of ZnO is structurally incompatible with the rocksalt structure of MgO.In this article,ten periods of ZnO / ZnMgO superlattice were produced by plasma-assistant molecular beam epitaxy on cplane sapphire substrate with different oxygen condition.It is found that the sample grown at lower oxygen flow and radio-frenquency( RF) plasma power tends to form rocksalt phase.With the increase of oxygen flow and RF plasma power,wurtzite phase tends to dominate and phase segregation is enhanced.The phase transform affected by the oxygen atoms density is reasoned by the formation enthalpies of ZnO and MgO.国家自然科学基金(61076084)资助项

柴郁地仙方对围绝经期抑郁症模型大鼠行为学及海马BDNF、TrkB蛋白表达的影响

目的观察柴郁地仙方对围绝经期抑郁症(perimenopausal depressive disorder, PDD)模型大鼠行为学及海马脑源性神经营养因子(brain derived neurotrophic factor, BDNF)、酪氨酸激酶B受体(tropomyosin receptor kinase B, TrkB)蛋白表达的影响,探讨其抗围绝经期抑郁症的作用机制。方法 48只3～4月龄雌性SD大鼠随机分为假手术组、模型组、阳性对照组、柴郁地仙方低、中、高剂量组,共6组,每组8只。假手术组行假手术,其余组行卵巢去势术后孤养并予以28天慢性轻度不可预见性应激(chronic unpredictable mild stress, CUMS)建立围绝经期抑郁症模型。CUMS第1天起假手术组、模型组灌服生理盐水,阳性对照组灌服盐酸氟西汀合戊酸雌二醇,中药治疗组灌服柴郁地仙方低、中、高不同浓度的汤药,其浓度分别为:0.38、0.76、1.52 g/mL,每天1次。应激过程中观察大鼠行为学及体重变化,并通过Morris水迷宫实验评价大鼠空间学习和记忆能力,应用免疫印迹法检测大鼠海马BDNF、TrkB蛋白表达情况。结果与假手术组比较,模型组大鼠体重增长缓慢,旷场实验得分及糖水偏好率均明显降低(P0.05)。结论柴郁地仙方可改善PDD模型大鼠行为学、体重水平及水迷宫的空间学习和记忆能力,其作用机制可能是通过提高大鼠海马中BDNF、TrkB蛋白表达量发挥的。福建省计生委中医药科研基金资助项目(No.wzpw201307);;福建省自然科学基金计划项目(No.2017J01147

子宫内膜异位症小鼠腹腔巨噬细胞吞噬功能的变化规律

目的研究子宫内膜异位症发生进程中腹腔巨噬细胞吞噬功能的变化规律。方法构造小鼠子宫内膜异位症模型,用流式细胞术检测造模前后腹腔巨噬细胞吞噬荧光微球数,计算吞噬率和吞噬指数代表巨噬细胞的吞噬能力。结果巨噬细胞吞噬率和吞噬指数分别为:未造模组[(10.1±0.82)%,0.17±0.01]、造模后第1d[(32.78±2.43)%,0.60±0.02]、第2d[(33.82±1.23)%,0.61±0.02]、第3d[(35.93±2.81)%,0.72±0.03]、第4d[(27.92±1.24)%,0.51±0.03]、第5d[(24.34±0.91)%,0.40±0.02]、第6d[(17.91±1.03)%,0.28±0.01]、第9d[(17.56±0.80)%,0.26±0.01]、第12d[(19.42±1.02)%,0.36±0.01]、第15d[(26.78±2.05)%,0.54±0.02]、第18d[(27.46±1.61)%,0.50±0.02]、第21d[(25.99±2.31)%,0.54±0.03]。造模后的小鼠腹腔巨噬细胞吞噬能力均显著高于未造模组,且呈现出三个阶段的改变:第1-5d为第1阶段,第6-12d为第2阶段,第15-21d为第3阶段,第1和第3阶段显著高于第2阶段(P<0.01)。结论子宫内膜异位症小鼠腹腔巨噬细胞的吞噬功能增强,且随时间呈现规律性变化特征,可能与子宫内膜的清除和异位存活有关

Effects of Moxibustion on Gastric Stress Ulcer Rats' Apoptosis Protein Phosphorylation

目的:研究艾灸对应激性胃溃疡大鼠胃黏膜细胞凋亡蛋白质磷酸化的影响,探讨艾灸促进胃黏膜损伤修复的信号转导机制。方法:将大鼠随机分为正常组、模型组、胃经穴组和对照点组,采用束缚冷应激法制作应激性胃溃疡大鼠模型,肉眼观察大鼠胃黏膜损伤程度,APOPTOSIS MICrOArrAy SlIdES芯片检测胃黏膜细胞凋亡蛋白质磷酸化水平。结果:与模型组比较,胃经穴组和对照点组大鼠胃黏膜损伤指数值均显著降低(P<0.05);与对照点组比较,胃经穴组大鼠胃黏膜损伤指数显著降低(P<0.05);APOPTOSIS MICrOArrAy SlIdES芯片检测结果显示:与模型组比较,胃经穴组大鼠胃黏膜细胞10种蛋白质磷酸化水平上调,其中bCl-Xl、MCl-1、bCl-2、IAPS 4种蛋白磷酸化水平差异有统计学意义(P<0.01,P<0.05);18种蛋白质磷酸化水平下调,其中Tnf、fAS、APAf-1、CASPASE-3、CASPASE-9、bAX 6种蛋白质磷酸化水平差异有统计学意义(P<0.01,P<0.05)。结论:艾灸可促进胃黏膜的损伤修复,调节多种凋亡相关信号蛋白质的磷酸化水平,并且存在一定的经脉脏腑相关性。Objective: To study the effects of moxibustion on apoptosis protein phosphorylation in rats with gastric stress ulcer and to explore the signal transduction mechanisms promoting gastric mucosal injury and repairing moxibustion.Methods: The rats were randomly divided into normal group,model group,stomach meridian group and the control point groups and each group had 10 rats.The stress ulcer rat model was established by using restraint cold stress method.We observed the rat gastric mucosa injury degree and Apoptosis Microarray Slides microarray was used to observe the gastric apoptosis protein phosphorylation levels.Results: Compared with the model group,the gastric mucosa injury index values of control point and meridian groups were significantly lower( P < 0.05).Compared with the control point group,a significant reduction in rat gastric mucosa injury index was in meridian group( P < 0.05).Apoptosis Microarray Slides microarray results showed that 10 kinds of protein phosphorylation levels increased,among which Bcl- XL,Mcl- 1,Bcl-2 and IAPs protein phosphorylation levels were statistically significant( P < 0.01,P < 0.05) and 18 kinds of protein phosphorylation levels decreased,among which TNF,Fas,Apaf- 1,Caspase- 3,Caspase- 9 and Bax protein phosphorylation levels were statistically significant( P < 0.01,P < 0.05).Conclusion: Moxibustion can promote gastric mucosal injury and repair and regulate phosphorylation of several proteins related to apoptotic signals and there is a certain correlation between the meridians organs.国家自然科学基金项目(30960484;81260556

长期定位施肥对土壤质量影响的因子分析

自1991至今,在新疆阜康荒漠生态站进行长期定位施肥试验,对灰漠土上9种不同施肥处理后土壤的15项理化指标进行了测试。结果表明,不同处理后土壤的理化性质差异较大,说明不同施肥方式有各自的优缺点;并用SPSS统计软件,采用因子分析的方法对实验结果进行综合分析:由于前三个主分量的累积贡献率达到88.9%,15个评价指标被划分为三个主分量,第一主分量为影响作物产量的有机质(氮)矿化有关的供氮指标,第二主分量为影响钾的容量指标,第三主分量为土壤的磷素指标。并根据因子综合得分得出:施用N2P2K、N1P1K+秸秆、N1P1K+猪粪对改良灰漠土的效果最好,是本区应大力推广的施肥方式

长期定位施肥对灰漠土农田土壤质量的影响

试验研究不同施肥方式下长期定位施肥对灰漠土农田土壤酶活性和土壤理化特性的影响结果表明:经过长期定位施肥试验,灰漠土土壤的生物活性(蛋白酶、脲酶、磷酸酶、蔗糖酶活性)与土壤基本肥力比试验前有所提高;不同施肥处理下土壤酶活性和土壤理化性质存在明显差异,N素和有机质含量是制约灰漠土土壤酶活性和影响作物产量的关键因子