Video-assisted Thoracoscopic 3D Mode Operation for Solitary Pulmonary Nodules

目的探讨三维胸腔镜手术(3d VIdEO-ASSISTEd THOrACIC SurgEry,3d-VATS治疗孤立性肺结节(SOlITAry PulMOnAry nOdulE,SPn)的效果。方法回顾性分析2013年3月~2014年3月50例SPn的资料,采用3d-VATS手术模式楔形切除结节,根据快速病理结果决定是否行肺叶切除加淋巴结清扫术。统计手术时间(去除快速冰冻时间)、术后24 H引流量、总引流量、引流管拔除时间、淋巴结清扫数及术后并发症等。结果 3d-VATS模式下,50例均行肺结节楔形切除,其中23例病理为恶性,继续行肺癌根治术,手术顺利。肺癌根治术手术时间(62±12)MIn,术中出血量(35±5)Ml,清扫淋巴结(19±3)个,术后24 H引流量(120±20)Ml,术后胸管引流时间(4±1)d,术后住院时间(7±2)d。并发症3例,其中术后肺炎2例,阵发性心房纤颤1例,均治愈。无围手术期死亡。随访2~12个月,平均6.3月。1例术后3个月脑转移,1例术后5个月肺癌复发。结论胸腔镜3d模式下治疗SPn是一种新的选择方式,安全可行,值得推广应用。Objective To evaluate the effects of surgical treatment for solitary pulmonary nodules under thoracoscopic 3D mode(3D-VATS).Methods A total of 50 cases of solitary pulmonary nodules from March 2013 to March 2014 were retrospectively analyzed.Intraoperative wedge pulmonary resection with 3D-VATS was utilized.According to intraoperative pathological findings,lobectomy plus lymph node dissection was given or not.Intraoperative time( minus fast freezing time),drainage volume for 24 h,total drainage volume,drainage tube removal time,number of lymph node dissected,and postoperative complications were recorded.Results Under 3D-VATS mode,50 cases of solitary pulmonary nodules were treated with wedge resection,including 23 cases of malignant pathology receiving radical resection, which was smoothly.The radical resection time( lung lobectomy plus lymphadenectomy) was(62 ± 12) min,the bleeding volume was(35 ± 5) ml,the lymphadenectomy number was 19 ± 3,the drainage volume for 24 h was(120 ± 20) ml,the postoperative chest tube removal time was(4 ± 1) days,and the postoperative hospital stay was(7 ± 2) days.Postoperative complications occurred in 3 cases,including 2 cases of pneumonia and 1 case of paroxysmal atrial fibrillation.No perioperative deaths were observed.All the cases were followed up for 2- 12 months,with an average of 6.3 months.Brain metastases was found in 1 case at the third postoperative month and recurrence of lung cancer was noted in 1 case at the fifth postoperative month.Conclusion Thoracoscopic 3D mode treatment for solitary pulmonary nodules is a new,safe,and feasible alternative and should be widely applied

Combined Use of Thoracoscopy and Laparoscopy in Total Laryngectomy for Cervical Esophageal Carcinoma

目的探讨胸、腹腔镜联合全喉切除治疗颈段食管的可行性和疗效。方法 2009年1月~2014年7月胸、腹腔镜联合全喉切除治疗33例颈段食管癌。胸腔镜下分离食管、腹腔镜下管胃成形、全喉切除、气管永久造口、胃咽吻合术。结果胸部手术时间40~66 MIn,平均53 MIn;腹部手术时间35~51 MIn,平均44 MIn;颈部手术时间128~150 MIn,平均139 MIn。术中出血量130~270 Ml,平均150 Ml。术后住院时间8~14 d,平均12 d。病理均为鳞状细胞癌,其中高分化2例,中分化19例,中-低分化7例,低分化5例。切缘病理学检查无癌组织残留。31例淋巴结转移。并发症:吻合口漏2例,喉返神经损伤3例,肺部感染6例,胃排空障碍2例,吻合口狭窄1例,无死亡病例。33例随访1个月~5年,术后1、3、5年生存率分别为87.9%、54.5%、45.5%。结论颈段食管癌应采取积极的手术治疗,胃咽吻合术是颈段食管癌切除后较为理想的修复手段。Objective To investigate clinical feasibility and efficacy of combined use of thoracoscopy and laparoscopy in total laryngectomy for cervical esophageal carcinoma.Methods Clinical data of 33 patients with cervical esophageal carcinoma undergoing surgical treatment in our department from January 2009 to July 2014 were analyzed retrospectively.The esophagus was separated under thoracoscopy.And laparoscopic gastroplasty,total laryngectomy,tracheal permanent colostomy,and gastric pharyngeal anastomosis were performed.Results The thoracoscopic operation time was 40- 66 min( mean,53 min),the laparoscopic operation time was 35- 51 min( mean,44 min),and the cervical operation time was 128- 150 min( mean,139 min).The blood loss was 130- 270 ml( mean,150 ml).The postoperative hospital stay was 8- 14 d( mean,12 d).Pathological examinations showed squamous cell carcinoma in all the cases,including 2 cases of highly differentiated carcinoma,19 cases of moderately differentiated carcinoma,7 cases of moderately or lowly differentiated carcinoma,and 5 cases of lowly differentiated carcinoma.No residual cancer was found at cutting edges pathologically.Among the 33 cases,lymph node metastasis was found in 31 cases.Complications included 2 cases of anastomotic fistula,3 cases of recurrent laryngeal nerve injury,6 cases of pulmonary infection,2cases of delayed gastric emptying,and 1 case of anastomotic stenosis.There was no death.All the patients were followed up for 1months to 5 years.The survival rates at 1,3,and 5 postoperative year were 87.9%,54.5%,and 45.5%,respectively.Conclusions Cervical esophageal carcinoma should be surgically treated actively.Gastric pharyngeal anastomosis is an ideal option for the repair of cervical esophageal cancer resection

酸雨胁迫下,稀土元素对菠菜膜保护系统作用

利用盆栽实验，探讨了酸雨胁迫下对菠菜膜保护酶系统的防护效应。实验结果表明：单一酸雨处理会造成超氧化物歧化酶（ Ｓ Ｏ Ｄ）、过氧化酶（ Ｃ Ａ Ｔ）活性总体水平下降，其变化曲线呈“∧”形，并使过氧化物酶（ Ｐ Ｏ Ｄ）活性明显增加。施用稀土元素后酸雨胁迫下的植株叶片中 Ｓ Ｏ Ｄ、 Ｃ Ａ Ｔ 活性总体水平上升，变化曲线的峰值向酸度较大的方向移动， Ｐ Ｏ Ｄ 活性上升幅度减小，３ 种膜保护酶的活性与单一酸雨处理组相比，处在一种相对稳定的状态下，表现出在酸度不大的情况下，稀土元素对酸雨影响菠菜膜保护系统有明显的防护作用

稀土元素对酸雨胁迫小麦活性氧清除系统响应的作用

盆栽条件下,就酸雨胁迫下小麦活性氧清除系统的响应及稀土元素作用进行了研究。结果表明:酸雨导致小麦活性氧酶促系统的SOD、CAT、POD酶活性总体水平发生变化。CAT、SOD活性减弱,POD活性增加,致使体内活性氧清除能力减弱,稀土元素的施用增加了CAT、SOD活性水平,削弱了由于酸雨胁迫所导致的POD活性的增加,从而增强了清除活性氧的能力,减弱了由于酸雨胁迫对小麦活性氧清除系统造成的影响

酸雨胁迫下稀土元素对小麦生理生化响应的作用

运用盆栽实验,对酸雨胁迫下稀土元素(REE)对小麦生理生化响应的作用进行了研究。结果表明:酸雨影响了叶绿素含量及叶绿素a/b值。叶绿素a及叶绿素总量与酸雨pH值呈正相关,POD活性随酸雨pH值减小逐渐增加,间接导致叶绿素a分解速度加快,造成叶绿素总量减少和a/b值减小,加速了叶片的老化,影响植株光能吸收、转换及碳同化。REE施用后,仍在酸雨胁迫下的植株与单一酸雨处理相比,其叶绿素含量、叶绿素a/b值、POD活性均能稳定在一定水平上。在酸雨pH>3.5的情况下REE明显地表现出对小麦体内叶绿素及过氧化物酶有一定的防护作用

50 Gbit/s-EPON中基于预测的多波长带宽分配算法

根据IEEE 802.3ca新标准中对50 Gbit/s-以太网无源光网络（EPON）上行链路的说明，网络上行链路中需要对多波长进行动态带宽分配。文章采用长短时记忆神经网络对网络流量进行预测，旨在提高带宽分配的效率；同时，考虑到网络中不同类型业务对网络时延和带宽要求的差别，分别对不同优先级的业务采取不同的分配方案。仿真实验表明，基于神经网络预测的方法可以有效降低网络的延迟；对不同业务采取不同分配方案时，高优先级业务的延迟降低，并且随着网络负载的提高，延迟变化幅度较小。文章所提算法满足了高优先级业务的需求，虽然低优先级业务延迟与之前方式相比有所增大，但考虑到低优先级业务对延迟要求并不高，因此对于网络整体服务质量影响不大

An Experimental Study on the Therapeutic Effects of Quqianling Formula on the Lead Level in Plasma among Rats with Lead Poisoning

目的观察中药复方驱铅灵降低铅染毒大鼠血铅含量的效果。方法将SD大鼠分成 6组 [正常对照组, 模型对照组, 低、中、高剂量中药驱铅灵组, EDTA(依地酸钙钠 )组], 以醋酸铅灌胃造模, 以中药复方驱铅灵及EDTA进行驱铅治疗, 以石墨炉无火焰原子吸收光谱法检测血铅浓度。结果：驱铅灵组及EDTA组大鼠血铅浓度显著低于模型对照组。结论：中药复方驱铅灵具有驱铅功效

Interfacial behavior of phospholipid monolayers revealed by mesoscopic simulation

A mesoscopic model with molecular resolution is presented for dipalmitoyl phosphatidylcholine (DPPC) and pal-mitoyl oleoyl phosphatidylcholine (POPC) monolayer simulations at the air-water interface using many-body dissipative particle dynamics (MDPD). The parameterization scheme is rigorously based on reproducing the physical properties of water and alkane and the interfacial property of the phospholipid monolayer by comparison with experimental results. Using much less computing cost, these MDPD simulations yield a similar surface pressure-area isotherm as well as similar pressure-related morphologies as all-atom simulations and experiments. Moreover, the compressibility modulus, order parameter of lipid tails, and thickness of the phospholipid monolayer are quantitatively in line with the all-atom simulations and experiments. This model also captures the sensitive changes in the pressure-area isotherms of mixed DPPC/POPC monolayers with altered mixing ratios, indicating that the model is promising for applications with complex natural phospholipid monolayers. These results demonstrate a significant improvement of quantitative phospholipid monolayer simulations over previous coarse-grained models

Machine learning assisted fast prediction of inertial lift in microchannels

Inertial effect has been extensively used in manipulating both engineered particles and biocolloids in microfluidic platforms. The design of inertial microfluidic devices largely relies on precise prediction of particle migration that is determined by the inertial lift acting on the particle. In spite of being the only means to accurately obtain the lift forces, direct numerical simulation (DNS) often consumes high computational cost and even becomes impractical when applied to microchannels with complex geometries. Herein, we proposed a fast numerical algorithm in conjunction with machine learning techniques for the analysis and design of inertial microfluidic devices. A database of inertial lift forces was first generated by conducting DNS over a wide range of operating parameters in straight microchannels with three types of cross-sectional shapes, including rectangular, triangular and semicircular shapes. A machine learning assisted model was then developed to gain the inertial lift distribution, by simply specifying the cross-sectional shape, Reynolds number and particle blockage ratio. The resultant inertial lift was integrated into the Lagrangian tracking method to quickly predict the particle trajectories in two types of microchannels in practical devices and yield good agreement with experimental observations. Our database and the associated codes allow researchers to expedite the development of the inertial microfluidic devices for particle manipulation