Unmanned aerial vehicles swarm conflict based on multi-agent system

本文将多agent系统引入到大规模无人机集群对抗决策系统中,给出了基于多agent系统的大规模无人机集群对抗决策方法.将机群中的每个无人机视为一个独立agent,建立了无人机运动模型,为无人机设计了独立的个体行为集,并针对每种行为给出了决策方法.通过每个个体无人机对其邻域环境的作用,涌现出宏观的集群对抗(作战)效果.使用MATLAB仿真软件对所设计的大规模无人机集群对抗方法进行了仿真,验证了所设计的基于多agent系统的大规模无人机集群对抗决策方法的有效性.The multi-agent system theory is employed to build the maneuvering decision-making model for large-scale unmanned aerial vehicle(UAV) swarm conflict. In this model, each UAV in the swarm is regarded as one independent agent. With the establishment of UAV motion equation, individual behavior set and action criterion, each UAV keeps on interacting with its neighboring environment and the UAV swarm conflict outcome emerges eventually from such a process. Simulation experiments are conducted using MATLAB and the results demonstrate the effectiveness of the built decision-making model for UAV swarm conflict.航空科学基金项目(20140168001)资助~

Development of detection kit for T cell infected with Mycobacterium tuberculosis based on fullautomatic chemiluminescence immune analyzer

目的建立基于化学发光平台的人结核感染T细胞检测方法。方法将一株γ-干扰素单抗标记在磁微粒上,另一株γ-干扰素单抗标记在吖啶酯上,然后将检测体系与已有的细胞刺激培养体系相结合。结果本研究成功建立基于化学发光平台的人结核感染T细胞检测方法。以ElISA平台检测试剂的检测结果作为参考,该方法的灵敏度为98.3%,特异性为99.2%,总体符合率达到98.8%。结论该方法具有更高的分析灵敏度(可达0.27 Pg/M l)、更宽的线性范围(1 Pg/M l~5 000 Pg/M l)、更好的重复性(批内与批间变异系数均<6.0%)及更易实现高通量检测,为临床诊断结核感染提供了有力的工具。Objective To develop the detection kit for T cell infected with Mycobacterium tuberculosis based on full-automatic chemiluminescence immune analyzer.Mehtods An anti IFN-γ Mab was coated on the surface of microparticle.Another anti IFN-γ Mab was labelled to acridinium ester.After that, the detection system was combined with the in vitro cell culture system.Results This research developed the detection kit for T cell infected with Mycobacterium tuberculosis based on full-automatic chemiluminescence immune analyzer.Compared with the testing results of the ELISA kit, the sensitivity, specificity and total matching ratio of the CLIA kit was 98.3%, 99.2% and 98.8%, respectively.Conclusion The CLIA kit has better sensitivity(0.27 pg/m L), wilder linear range(1 pg/m L ~ 5 000 pg/m L), and better repeatability(intra and inter coefficient of variation < 6.0%).It makes a high throughput detection available.It will contribute to the clinical diagnosis of Mycobacterium tuberculosis.国家高技术研究发展计划(863计划)(2011AA02A101

戊型肝炎病毒核酸阳性血浆经输血传播感染恒河猴的研究

目的 了解戊型肝炎病毒(HEV)核酸阳性血浆对灵长类动物的感染性和致病性。 方法 对抗-HEV IgM阳性而IgG阴性志愿献血员血浆进行HEV RNA检测,并将存在病毒血症献血员的10ml血浆静脉输入健康恒河猴,观察其对恒河猴的感染性和致病性。 结果 从1份抗-HEV IgM阳性而IgG阴性志愿献血员血浆中分离出HEV基因IV型RNA片段。该份血浆输入恒河猴后,恒河猴出现典型急性肝炎生物化学和病理表现,病毒血症,血清抗-HEV IgM和IgG抗体阳转。 结论 HEV病毒血症献血员血浆输入可以引起灵长类动物的HEV感染以及急性肝炎,提示HEV经输血传播的可能性

厦门地区无偿献血者HEV隐性感染情况及基因型分析

目的了解厦门地区无偿献血者中戊型肝炎的感染情况。方法对2005年3月—2007年4月厦门地区20389人(次)无偿献血者做整群抽样,捕获法ElISA检测IgM抗-HEV、并对IgM抗-HEV阳性样本做HEVrT-PCr检测,经测序后分析其基因型及序列同源性。结果20389份无偿献血者血样本中,IgM抗-HEV阳性率为0.91%(186/20389);186例IgM抗-HEV阳性中有4例经rT-PCr检测为HEV阳性。献血者中病毒血症总阳性率为2/10000(4/20389),4例病毒血症中Ⅰ型与Ⅳ型感染各2例。结论厦门地区无偿献血者中,存在HEV隐性感染者。厦门市卫生局医学科研项目资助课题(编号:WSK0516

戊型肝炎病毒衣壳蛋白中和表位间的构象诱导

重组蛋白NE2包含了戊型肝炎病毒(HEV)衣壳蛋白(pORF2)的aa394～606片段。在NE2上已鉴定出了2个HEV中和表位,并获得了3个识别中和表位的单克隆抗体(MAb)8C11、13D8和8H3。这3个MAb间的交叉阻断ELISA实验发现,8C11和13D8可以彼此完全阻断,8H3对8C11和13D8均不能阻断,而8C11非但不能阻断8H3,反而显著增强了8H3与抗原的结合。用生物传感器进行的抗体与抗原结合的动力学分析也证实了这一现象。这些结果提示,在NE2上8H3表位区域受到抗原上某些结构的掩盖,而8C11与NE2的结合引起了抗原空间结构的改变,导致了掩盖8H3表位的结构的去除和8H3表位的充分暴露。免疫捕获RT PCR发现,8C11同样可以显著增强8H3对天然HEV病毒的捕获能力,提示这种结合诱导的衣壳蛋白空间构象改变在天然HEV病毒颗粒上同样存在

Theoretical Study of Substituent Effects on Bond Dissociation Enthalpies in Lignite Model Compounds

为了探究褐煤热解过程中氧桥键C—O均裂这一重要反应,选取α-O-4和β-O-4类结构单元作为褐煤模型化合物,运用不同密度泛函计算了部分模型化合物中C—O的离解焓,并以CbS-Qb3作为理论基准值进行比较,最后选取M05-2X进行离解焓计算.结果显示,对于选定的α-O-4和β-O-4类模型化合物,其平均离解焓分别为51.0 kCAl/MOl和66.1 kCAl/MOl.周围取代环境能显著影响C—O离解焓,芳环上存在给电子基团(OH,OCH3和CH3)能降低C—O离解焓,而吸电子基团COOH则能增加其离解焓.然后深层次分析了取代基效应对C—O离解焓的影响.此外,分子内氢键的形成对离解焓也有很大的影响.C—O的离解焓与其键长没有特定的相关性,不能简单的通过C—O键长来预测其离解焓.Lignite is an abundant natural resource that is a potential source of clean fuel and value-added chemicals.The mechanisms by which thermal and catalytic treatments deconstruct lignite remain elusive,which is where quantum mechani-cal calculations can offer fundamental insights.In order to investigate the cleavage of C—O bridge bond,which is the critical step in the thermal decomposition of lignite,the α-O-4 and β-O-4 types of structural units are selected as lignite model com-pounds to calculate the C—O bond dissociation enthalpies using several kinds of density functional theory methods(B3PW91,B3P86,PBE1PBE,BMK,M06-2X and M05-2X) at 6-31+G(d,p) level.By the comparison between the results and the theoretical benchmark values provided by CBS-QB3 method,M05-2X functional was applied for the calculations on C—O bond dissociation enthalpies.The present results indicate that the C—O average bond dissociation enthalpies are 51.0 kcal/mol and 66.1 kcal/mol for the α-O-4 and β-O-4 types of model compounds,respectively.Local substituents have a great withdrawing groups such as carboxyl group.Then the substituent effects are deeply analyzed on the basis of the ground-state effect on the C—O bond dissociation enthalpies,the C—O bond dissociation enthalpies will decrease when the adjacent arene rings are substituted by electron donating groups(OH,OCH3 and CH3),while the results are opposite for the electron effect and radical effect.An electron donating group can stabilize the phenoxy radicals(radical effect),however,an electron withdrawing group has the opposite effect.In most cases,the radical effect is more important than the ground-state effect.Furthermore,there is a negligible correlation between the C—O bond distances and strengths,and the C—O bond dissocia-tion enthalpies cannot be predicted so easily.Interestingly,the C—O bond dissociation enthalpies can be significantly influ-enced by the intramolecular hydrogen bond,if the intramolecular hydrogen bond still exists after the cleavage of the C—O bond,the bond dissociation enthalpies will be lower.国家重点基础研究发展计划(No.2012CB214901); 国家自然科学基金(No.51274197)资助~

Theoretical calculation and simulation of shallow dopants in InGaN single junction solar cell

通过氢有效质量理论(HEMT)对In0.65gA0.35n(高In组分,Eg=1.31EV)太阳电池材料进行分析,计算出其浅能级施主和受主的重要性质参数电离能:ΔEd~10.8MEV,ΔEA~90MEV.在此基础上得到了室温条件下In0.65gA0.35n的浅能级施主和受主强电离时的杂质浓度范围:施主9.56x108~4.57x1016CM-3,受主9.56x108~7.84x1016CM-3;并估算了产生杂质能带的最低杂质浓度:施主~1x1018CM-3,受主~5.79x1020CM-3.然后借助AMPS-1d软件对含有部分电离的浅能级施主、受主In0.65gA0.35n单结太阳电池进行模拟,详细讨论了施主能级和受主能级对载流子的俘获对太阳电池效率的影响.本文结果为IngAn单结和多结太阳电池的掺杂(尤其是P型掺杂)和制备提供了理论参考和帮助。Hydrogenic effective-mass theory(HEMT) was adopted to study the photovoltaic property of In0.65Ga0.35N(Eg=1.31 eV).The ionization energy of shallow donors and acceptors in In0.65Ga0.35N was calculated to be ΔED ～10.8 meV and ΔEA～90 meV,respectively.Based on these values,the doping concentration necessary to obtain strong ionization of shallow dopants was estimated to be 9.56×108-4.57×1016 cm-3 for donors and 9.56×108-7.84×1016 cm-3 for acceptors.The lowest doping concentration required to form impurity bands was found to be ～1×1018 cm-3 for donors and ～5.79×1020 cm-3 for acceptors.Using AMPS-1D software,the property of single junction solar cell containing partially ionized shallow dopants,was simulated.The effects of recombination of shallow dopants on the efficiency of the solar cell were analyzed and discussed in detail.The results are useful for doping(especially for p-type doping) and fabrication of InGaN-based single junction and multijunction solar cells.国家高技术研究发展计划(2006AA03Z409);厦门市政府科学和技术部研究项目(2006AA03Z110);广西自然科学基金(0731012);广西大学有色金属和高等材料加工新技术教育部重点实验室开放基金(GXKFZ-04)资

集美大学2002级福建籍新生肝炎感染现状

目的　了解集美大学 2 0 0 2级福建籍新生甲、乙、戊 3型肝炎感染情况。方法　采用血清流行病学调查方法。结果　学生中抗HAV -IgG ,HBsAg和抗HEV -IgG阳性率分别为 77.0 8% ,1 5 .2 3 % ,1 7.1 5 % ,地区差异明显 ;HAV ,HEV无性别差异 ,而HBV以男性为高 ;农村HAV和HBV感染率均高于城镇 ,而HEV感染率无城乡差别。结论　应该加强对本地区大学生的甲、乙肝预防 ,急需研究出一种有效的戊肝疫

两种戊型肝炎IgG抗体检测试剂的比较

目的比较2种国产戊型肝炎IgG抗体诊断试剂(E2-IgG和X-IgG)的特异性与敏感度。方法利用2种试剂对2006年江苏省某市普通人群的流行病调查血清标本460份和经过巢式逆转录聚合酶链式反应(nest-RT-PCR)鉴定为HEV核酸阳性的临床戊型肝炎患者血清标本72份进行平行检测,并以免疫印迹实验(Westernblot,WB)和中和单抗阻断试验进行验证。结果1.460份流行病调查血清标本中WB阳性188份。2.188份WB阳性标本中E2-IgG的检测敏感度为99.5,特异度为99.6,阳性预测值99.5,阴性预测值99.6,准确性99.6;X-IgG的检测敏感度为21.3,特异度为97.4,阳性预测值85.1,阴性预测值64.1,准确性66.3。3.E2-IgG阴、阳性A450/A620值的分布在临界值附近分界明显,小于临界值的A450/A620值取对数后呈正态分布,而阳性血清A450/A620值的高低与其WB的反应强度正相关。4.E2-IgG阳性、X-IgG阴性的血清共148份,中和单抗阻断阳性率为98,WB阳性率99.3。5.经PCR鉴定为HEV核酸阳性的急性戊型肝炎患者血清中E2-IgG敏感度98.6,X-IgG敏感度80.6(χ2=10.7,P<0.01)。结论E2-IgG在不同人群中均能较好的反映体内戊型肝炎抗体存在的真实情况