Effect of relieving fever and reducing plasmas glucose of 3 kinds of Digupi on albino rats

作者简介: 黄小红(1966- ) , 女, 讲师, 硕士. 研究方向: 动物生物化学.用 3种地骨皮 (枸杞根皮、宁夏枸杞根皮、北方枸杞根皮 )原生药总提取物灌喂大、小白鼠 ,测定它们对白鼠的解热和降血糖作用 .结果表明 :枸杞根皮和宁夏枸杞根皮对角叉菜胶致热的大白鼠有明显的解热作用 ;北方枸杞虽也有明显解热作用 ,但其作用强度弱于枸杞和宁夏枸杞 .3种枸杞根皮中仅枸杞根皮对四氧嘧啶小白鼠有明显降血糖作用 ,其余 2种地骨皮降血糖作用不甚明显

Methods on Investigating Properties of Electrode/Electrolyte Interfaces in Lithium-Ion Batteries

Corresponding author e-mail:zhuangquanchao@ 126.com[中文文摘]电极界面特性是影响锂离子电池充放电循环容量与稳定性的重要因素。本文总结了目前对电极界面特性进行研究的方法,主要包括传统的电化学方法、显微方法、谱学方法、电化学石英微晶天平等,重点论述了上述研究方法的原理、优缺点和在研究电极界面特性中的应用,以及这些方法相结合所取得的一些研究进展,并指出在今后的工作中,无论是对新材料的研究还是传统材料的研究,这些方法都仍将发挥重要作用。[英文文摘]The rechargeable lithium-ion battery has been extensively used in mobile communication and portable instruments due to its many advantages,such as high volumetric and gravimetric energy density and low self-discharge rate.In addition,it is the most promising candidate as the power source for(hybrid) electric vehicles and stationary energy storage.The properties of electrode /electrolyte interfaces play an important role in the electrochemical performance of the electrode material and a battery,such as the capacities，irreversible charge “loss”，rate capability and cyclability. In present paper，the methods to investigate the properties of electrode/electrolyte interfaces，for example， traditional electrochemical methods， microscopy methods， spectroscopic methods，electrochemical quartz crystal microgravimetry (EQCM) are summarized. The principles，advantages and disadvantages of these methods and their applications in investigating the properties of electrode/electrolyte interfaces，especially the progress in the combination of these methods to investigate the properties of electrode/electrolyte interfaces，are introduced in detail，and these methods will be considerable to study the new materials or the traditional materials for lithium-ion batteries in the future.中央高校基本科研业务费专项资金项目(No.2010LKHX03,2010QNB04,2010QNB05);中国矿业大学科技攀登计划(No.ON090237),中国矿业大学青年科技基金项目(No.ON080282)资

Effects of Temperature on the Intercalation-Deintercalation Process of Lithium Ion in the Spinel LiMn_2O_4

E-mail: [email protected], [email protected][中文文摘]运用电化学阻抗谱研究了商品化尖晶石LiMn2O4电极在1mol/L LiPF6-EC(碳酸乙烯酯):DEC(碳酸二乙酯)电解液中―10～30℃范围内的阻抗谱特征、固体电解质相界面(SEI)膜阻抗、电子电阻和电荷传递电阻等随温度的变化.研究结果表明,尖晶石LiMn2O4电极的阻抗谱特征与温度有关,随温度的升高,与活性材料电子电导率相关的半圆和与SEI膜相关的半圆会发生重叠而成为一个半圆.通过选取适当的等效电路拟合了实验所得的电化学阻抗谱数据,测得尖晶石LiMn2O4电极在1mol/LLiPF6-EC:DEC电解液中,锂离子迁移通过SEI膜的离子跳跃能垒平均值为15.49kJ/mol;电子电导率的热激活化能平均值为24.21kJ/mol;嵌入反应活化能平均值为53.07kJ/mol。[英文文摘]Variations of impedance spectra,electronic resistance,and the resistances of the solid electrolyte interphase(SEI) film,as well as the charge transfer reaction of commercially spinel LiMn2O4 electrode were investigated by electrochemical impedance spectroscopy(EIS) in 1 mol/L LiPF6-EC(ethylene carbonate):DEC(diethyl carbonate) electrolyte solutions with the temperature in the range of-10～30 ℃.It is found that,the common EIS features of spinel LiMn2O4 electrode are related to the temperature,the semicircles observed in the Nyquist diagram which related to the electronic conductivity of the material and the semicircles related to the SEI film become to overlap each other to form one semicircle at higher temperatures. The experimental EIS data was simulated by a suitable equivalent circuit that includes elements related to the electronic and ionic transport in addition to the charge transfer process. In 1 mol/L LiPF6-EC:DEC electrolyte solutions, the energy barriers for the ion jump relating to migration of lithium ions through the SEI film of the spinel LiMn2O4 electrode were determined to be 15.49 kJ/mol, the thermal active energy of the electronic conductivities to be 24.21 kJ/mol, and the intercalation-deintercalation reaction active energies to be 53.07 kJ/mol, respectively.国家重点基础研究和发展规划(No2009CB220102);中国矿业大学青年科技基金(NoON080282),中国矿业大学人才引进经费(NoZX280),中国矿业大学科技攀登计划(NoON090237)资助项

Diagnosis of Electrochemical Impedance Spectroscopy in Lithium Ion Batteries

Corresponding author e-mail: [email protected]; [email protected][中文文摘]电化学阻抗谱(EIS)是研究电极/电解质界面发生的电化学过程的最有力工具之一,广泛应用于研究锂离子在锂离子电池嵌合物电极活性材料中的嵌入和脱出过程。本文从分析嵌合物电极的EIS谱特征入手,探讨了电化学阻抗谱中各时间常数的归属问题,重点讨论了与锂离子嵌脱过程相关的动力学参数,如电荷传递电阻、活性材料的电子电阻、扩散以及锂离子扩散迁移通过固体电解质相界面膜(SEI膜)的电阻等,对电极极化电位和温度的依赖关系。[英文文摘]Electrochemical impedance spectroscopy(EIS) is one of the most powerful tools to analyze electrochemical processes occurring at electrode/electrolyte interfaces,and has been widely used to analyze the insertion /desertion process of lithium ion in the intercalation electrode for lithium ion battery.In this paper,the ascription of each time constant of EIS spectra is discussed,based on analyzing the common EIS features of intercalation electrode.The kinetic parameters in the lithium ion insertion/desertion,desertion，dependent on temperature and electrode polarization，such as the charge transfer resistance，the electronic resistance of activated material，the resistance of SEI film that lithium ion transferring through，are also discussed based on the theoretical analysis.国家重点基础研究发展计划(973)项目(No.2009CB220102);中国矿业大学青年科技基金项目(No.ON080282)资

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アジル経営時代の生産革新技法の適用 : 「制約条件の理論(TOC)」の解説と実践例

The new technology for manufacturing innovation, TOC is attracting the world\u27s attention. TOC is a theory which focuses on the weakest point (restricted condition) and improves them in a concentrated mannrer. Its most remarkable feature is that results are obtained instantly. Therefore, this is a most suitable innovative technique for the production of short life-cycle products. In this explanation, I would like to provide an outline of this theory and applied examples

Prediction and Analysis of the Human Helical Membrane Proteome with Known Function Annotation

[中文文摘]我们对于两个主要人源基因组数据库(NCBI和UniprotKB/Swissprot)中已知功能的跨膜螺旋膜蛋白进行了系统化的预测和分析。首先应用TMHMM算法预测了每个膜蛋白跨膜螺旋的拓扑结构,应用SignalP预测算法剔除其中的含信号肽的分泌蛋白,并根据蛋白质的已知功能排除信号肽预测中的假阳性结果。同时,在整个跨膜螺旋膜蛋白组中,或者在不同功能类别中,进行了跨膜螺旋数量和分子量分布的分析;并在此基础上,进一步分析了每个跨膜螺旋的氨基酸分布及相对于细胞膜的不同位置上的氨基酸分布。对具有已知功能的人类螺旋膜蛋白的全基因组预测和分析为进一步研究膜蛋白三维结构、功能及蛋白质间的相互作用提供了良好的开端。[英文文摘]Human helical membrane proteins with known function were predicted and analyzed from two human proteome databases: NCBI and UniprotKB/Swissprot.Helical transmembrane topology of each protein was predicted using streamlined TMHMM and SignalP methods.Some false-positive SignalP predictions were verified and rescued based on their function annotation.Distributions of transmembrane helix number and molecular weight were analyzed for either the whole helical membrane proteome or proteins within a specific functional category. Length distribution and amino acids in different locations of each helix were also analyzed. Genome wide prediction and estimation of human helical membrane proteins with known function provide a starting point for further studies of membrane protein structure and function and protein interactions.supported by grants from the"973"Program(2007CB914304); "863"Program(2006AA02A321

ムラ ヨリアイ ノ ハナシアイ ノ ギホウ : ニホン テキ コミュニケーション ブンカ ノ ゲンケイ オ サグル

While argumentation is a decision making mode of the western culture, its counterpart in the Japanese culture is "hanashiai". "Hanashiai" was originally developed in farming villages during the Edo period. Since then, "hanashiai" had been the major communication mode in Japan. In 1970s, "hanashiai" was praised as a significant factor to make incredible Japanese economic growth possible, for it maximizes group cohesion and productivity by forming a consensus. However, in the late 1980s, in accordance with the decline of the Japanese economy and the further westernization of society, the situation reversed itself and "hanashiai" became a target of criticism as an irrational relic of the past. Then, in 1990s, the Ministry of Education introduced "debate" into school curricula with the purpose of changing Japanese communication mode from "hanashiai" to western argumentation. The points I would like to argue in this essay are that "hanashiai" is not such an irrational mode of communication, but it is rather an elaborated and rational mode of communication to form a consensus within a group. For this purpose, this essay will 1) analyze historical and social backgrounds which brought about "hanashiai" as their mode of decision making in traditional Japanese villages; 2) illustrate the process by which "hanashiai" generates a group consensus; and 3) clarify the values behind the "hanashiai" culture in comparison with the western argument culture

ウィーン バイバイ ジョウヤク ノ テキヨウ カイシャク ゲンソク

The United Nations Convention on Contracts for the International Sale of Goods (CISG) has been playing an important legal role in international business transactions since 1980. This paper analyzes how CISG was applied to and construed regarding real business conflicts in the United States, and it is concluded that CISG is not omnipotent. So I recommend that UNIDROIT Principles should be much more widely used as a construction tool of CISG on international business conflicts. Both CISG and UNIDROIT Principles are becoming much more important as a legal framework and instrument

A STUDY ON NANO-HYDROXYAPATITE-CHITOSAN SCAFFOLD FOR BONE TISSUE ENGINEERING

作者单位: 1 中国医学科学院中国协和医科大学生物医学工程研究所天津市生物医学材料重点实验室( 天津, 300192 ) ; 2 厦门大学生物医学工 程研究中心厦门大学医学院厦门市生物医学工程技术研究中心 通讯作者: 张其清, 教授, 博士导师, 研究方向: 组织引导再生, E-mail: zhangqiq@ xmu . edu. cn[中文文摘]目的以一种简单、有效的方法制备多孔的纳米羟基磷灰石(nano hydroxyapatite,nano-HA)-壳聚糖(chitosan,CS)复合支架,并评价其理化性能及与细胞相容性。方法采用原位复合-冷冻干燥方法,制备多孔nano-HA-CS支架。通过扫描电镜、透射电镜、X线衍射和傅立叶红外光谱分析支架的微观形貌及材料的组成。分离初生Wistar大鼠的成骨细胞,取传代培养第3代细胞分别与nano-HA-CS支架和纯CS支架共培养2、4、6、8h,各时间点各取4个样品,测定细胞在支架上的黏附率,并通过组织化学染色、扫描电镜观察细胞形态。结果nano-HA-CS复合支架具有多孔结构,孔径为100~500μm,大多数孔径为400~500μm。具有很高的孔隙率,随CS和HA含量的增加,孔隙率明显降低,密度升高。扫描电镜和透射电镜观察显示合成的HA晶体,晶粒大小为纳米级,在支架孔壁上均匀、连续分布如“铺路石”样。X线衍射和红外光谱分析表明合成的HA是含CO32-弱结晶纳米晶体。细胞相容性实验显示,成骨细胞在支架上黏附、增殖,并分泌纤维状细胞外基质;在复合支架上的黏附率明显高于纯CS支架。结论采用原位复合与冷冻干燥法结合制备的nano-HA-CS复合支架具有良好的理化性质和细胞相容性,有望应用于组织工程骨的构建。[英文文摘] Objective To fabricate a nano-hydroxyapatite-chitosan (nano-HA-CS) scaffold with high porosity by a simple and effective technique and to evaluate the physical and chemical properties and the cytocompatibility of the composite scaffold. Methods The three-dimensional nano-HA-CS scaffolds with high porosity were prepared by the in situ hybridization-freeze-drying method. The microscopic morphology and components of the composite scaffolds were analyzed by the scanning electron microscopy (SEM), the transmission electron microscopy(TEM), the X-ray diffraction(XRD)examination, and the Fourier transformed infrared spectroscopy(FTIR). The calvarial osteoblasts were isolated from the neonatal Wistar rats. The serial subcultured cells (3rd passage) were respectively seeded onto the nano-HA-CS scaffold and the CS scaffold, and then were co-cultured for 2, 4, 6 and 8 hours. At each time point, four specimens from each matrix were taken to determine the cell-adhesion rate. The cell morphology was observed by the histological staining and SEM. Results The macroporous nano-HA-CS scaffolds had a feature of high porosity with a pore diameter from 100 to 500 μm (mostly 400-500 μm). The scaffolds had a high interval porosity; however, the interval porosity was obviously decreased and the scaffold density was increased with an increase in the contents of CS and HA. The SEM and TEM results showed that the nano-sized HA was synthesized and was distributed on the pore walls homogeneously and continuously. The XRD and FTIR results showed that the HA crystals were carbonate-substituded and not well-crystallized. The cytocompatibility test showed that the seeded osteoblasts could adhere the scaffolds, proliferating and producing the extracellular matrix on the scaffolds. The adherence rate for the nano-HA-CS scaffolds was obviously higher than that for the pure CS scaffolds. Conclusion The nano-HA-CS scaffolds fabricated by the in situ hybridization-freeze-drying method have a good physical and chemical properties and a good cytocompatibility; therefore, this kind of scaffolds may be successfully used in the bone tissue engineering.天津市科技攻关项目资助项目(05YFGZGX03800