The Effect of Obturator Nerve Blockade on Oncological Outcomes of Patients with Lateral Wall Localized Non-Muscle Invasive Bladder Cancer

Objective:To investigate the effect of obturator nerve blockade on oncological outcomes of patients with a diagnosis of lateral wall localized non-muscle invasive bladder cancer.Materials and Methods:One hundred six patients diagnosed with lateral wall localized non-invasive bladder cancer were evaluated between January 2015 and March 2020 in this retrospective, cross-sectional observational study. The patients were divided into two groups: patients receiving only spinal anesthesia and those receiving spinal anesthesia combined with ultrasound-guided obturator nerve blockade. Oncological outcomes of the groups were compared statistically.Results:We observed recurrent tumors in 25 patients (45.5%) in Group 1 and 11 patients (21.6%) in Group 2. Additionally, we observed tumor progression in eight patients (14.5%) in Group 1 and two patients (3.9%) in Group 2. We observed statistical significance in differences between groups regarding tumor size, recurrence rate, adequate muscle tissue sampling, ability for complete resection, and persistent obturator reflex. The efficacy rate of obturator blockade was 92.1% in Group 2. One-year recurrence-free survival (RFS) was 98.0% and 5-year RFS was 23.5% for Group 1, while for Group 2, they were 97.4% and 57.2%, respectively.Conclusion:The obturator reflex is a common and challenging reflex that may cause major complications and result in unintended consequences, such as incomplete resection or tumor recurrence with transurethral resection of bladder tumors. In this study, we demonstrated that combining spinal anesthesia with obturator nerve blockade for lateral wall localized non-muscle invasive bladder cancer may prevent tumor recurrence and reduce peroperative complications

Predictive value of hounsfield unit in urinary system stones applied with eswl

This study claims to examine the relationship between the Housfield unit (HU) value and the success of Electro Shock Wave Lithotripsy (ESWL) treatment. Data of 142 patients were evaluated retrospectively in this cross-sectional observational study. The threshold value for stone density is calculated as 991.20 HU in the ROC analysis. The patients are seperated into two groups with respect to this value, and their demographic characteristics, stone characteristics and success rates after ESWL treatment are statistically compared. For the variables that are statistically crucial in the univariate analysis, logistic regression analysis are used as a multivariate analysis. The mean age of all patients were 45.25±11.72 years and the mean body mass index (BMI) is 28.42±3.98 kg/m2. While our stone-free rate was 66.2% in our study, the mean stone size was 11.25±3.83mm, the Hounsfield unit value was 1007.55±337.75 HU, and the stone-skin distance was 108.02±20.02mm, respectively. We observed a crucial difference in between the Housfield unit value and stone size in univariate and multivariate analyzes between the two groups, and the stone-free rate after ESWL. The Hounsfield unit value, measured by the non-contrast computed tomography method, is a parameter for the prediction in success of patients undergoing Electro Shock Wave Lithotripsy treatment. Also, stone density above 991.20 HU in patients having urinary system stone disease requires the evaluation of alternative treatments as a condition that reduces the success of the treatment

Web-Based Bibliometric Evaluation of Robotic Radical Prostatectomy in Prostate Cancer: Analysis of Turkey Data

Aim: Prostate cancers are the second most commonly diagnosed cancers in men. The developments in robotic surgery brought along a period in which all number of articles were written. This study, we researched the field and contribution of articles written in the world and in Turkey on robot assisted radical prostatectomy with bibliometric analysis in a web-based software. Material and Methods: In our study, 1434 original articles in the world and 57 original articles in Turkey, which met the criteria, were scanned in ISI Web of Knowledge-Science (WoS) data base by using the keywords ‘robot, prostate cancer, radical prostatectomy’. The parameters, country of the article, publication year of the article, WoS category of the article, the name of the journal where the article was published, type of the article (Original), language of the article (English) and WoS index (SCI-E), were evaluated with bibliometric analysis method. Results: Analysis of countries points out that the United States of America ranked the first with 563 (39.2%) articles, while Turkey ranked in the 11th place with 57 (3.9%) articles. According to publication year, it was found that the highest number of articles published in the world was in 2020 with 173 (12.06%) articles, while it was in 2021 with 10 (17.5%) in Turkey. With respect to field categories in WoS data base, the world was found that the field of Urology-Nephrology ranked the first with 1042 (72%) articles, while similarly Urology-Nephrology ranked the first with 35 (61.4%) articles in Turkey. According to journal name, BJU International was the journal in which the highest number of articles were published in the world with 157 (10.9%), while Journal of Endourology was the journal in which the highest number of articles were published in Turkey with 10 (17.5%) articles. In the citations and H-index rates of articles by year, it was 78 in the world and 15 in Turkey which show rising curve over the last two decades. Conclusion: Current developments in robotic surgery have a significant place in world scientific publication performance. Turkey has made valuable contributions to literature since 2014 with increasing number of articles and citations

The role of sperm DNA integrity in couples with recurrent implantation failure following IVF treatment

There is increasing evidence from the literature that indicates the association between impaired sperm DNA integrity and male infertility. However, the data is insufficient regarding recurrent implantation failure (RIF) and sperm DNA damage. This study aimed to investigate the association between sperm DNA fragmentation and RIF cases. Basic semen parameters and sperm DNA fragmentation index (DFI) of men whose partner was suffering from RIF were compared with men whose partner was diagnosed with unexplained infertility (UEI) but had clinical pregnancies following IVF treatment. A retrospective analysis from a large-volume IVF center has been performed, and a total of 197 couples underwent analysis. Two groups were formed, couples with RIF and couples diagnosed with UEI but had clinical pregnancies (controls) following IVF cycles. The mean number of cycles showed significant differences between the groups. However, no statistical difference was observed between RIF and the control group regarding patient characteristics, semen parameters, and sperm DNA fragmentation index (DFI). Also, no statistically significant correlation was found between sperm DFI and clinical pregnancies in the unexplained infertility cohort. Our results show that sperm DNA fragmentation may not be an important contributing factor to RIF cases

ÜRİNER SİSTEM TAŞ HASTALIĞI NEDENİYLE EKSTRAKORPOREAL ŞOK DALGA LİTOTRİPSİ (ESWL) UYGULANAN HASTALARDA AĞRININ TEDAVİ BAŞARISI ÜZERİNE ETKİSİ

Giriş: Çalışmamızda ekstrakorporeal şok dalga litotripsi (ESWL) işlemi sırasında vizüel ağrı skoru (VAS) ile değerlendirilen ağrı skorunun böbrek taşı tanısı alan hastalarda uygulanan ESWL başarısına etkisini değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışma Ocak 2020- Ocak 2022 tarihleri arasında üst üriner sistem taşı tanısı konulan ve bu sebeple ilk defa ESWL tedavisi alan 160 hastanın verileri retrospektif incelenerek gerçekleştirildi. Hastaların demografik özellikleri, radyolojik görüntülemede üriner sistem taşının özellikleri ve işlem esnasında kaydedilen vizüel ağrı skorları kaydedildi. Hastalar ESWL tedavisi sonrası yapılan kontrollerinde taşsızlık sağlanan ve rezidü taş izlenen hastalar olmak üzere iki gruba ayrılarak gruplar istatistiksel olarak karşılaştırıldı. Bulgular: 101 (%63.1) hastada ESWL tedavisi ile taşsızlık sağlandı. ESWL tedavisinin başarı oranı %63.1 olarak hesaplandı. Hastaların sırasıyla ortalama taş boyutu, taş-cilt mesafesi ve taş yoğunluğu; 11.41±3.79 mm, 108.12±19.48 mm ve 1024.51±322.59 Hounsfield Unit (HU) olarak hesaplandı. Ortalama VAS ise 5.22±2.64 idi. Lojistik regresyon analizi sonucunda ESWL başarısında taş boyutu ve ağrı skorunun bağımsız risk faktörleri olduğu görüldü. Sonuç: ESWL üriner sistem taşlarının tedavisinde etkili bir yöntemdir. Taş boyutunun artması ve işlem sırasında izlenen yüksek VAS’nun ESWL başarısında rol oynayan en önemli risk faktörleri olduğunu ortaya koyduk. ESWL esnasında başarılı ağrı kontrolü ile tedavi başarı oranının artacağını düşünmekteyiz

The synergy between endoscopic assistance and extraoral approach in subcondylar fracture repair: a report of 13 cases

ABSTRACT BACKGROUND: We aimed to present the primary experience of one surgeon with a new surgical technique performed on the first 13 cases and to evaluate outcomes following an extraoral endoscopic approach to subcondylar fractures

Role of vaginal brachytherapy boost following adjuvant external beam radiotherapy in cervical cancer: Turkish Society for Radiation Oncology Gynecologic Group Study (TROD 04-002)

Objectiv

Pl8to/swirl_courses: swril_courses (test)

This release was created to demonstrate the process of creating a release for DOI creation and archiving in zenodo as part of an introductory training workshop