The impact of iron metabolism system on a common mechanism of antimicrobial lethality

传统研究认为不同种类的抗生素有其各自不同的杀菌途径，然而近年人们发现了一条抗生素杀菌的共用通路，那就是当细菌细胞受到抗生素致死性刺激时，呼吸链将代谢异常产生大量活性氧簇（ROS），而铁离子对ROS介导的杀菌至关重要。本研究参阅近年来国内外研究结果，通过基因突变、铁离子竞争物等实验方法着重研究了细菌铁代谢系统与抗生素共有杀菌途径之间的关系，重点讨论抗生素刺激下铁离子的调控及其与抗生素介导ROS形成的相互作用关系。对于细菌耐药机制的研究与寻找新型药物作用靶点、开发新药有重要意义。 本研究对铁储存蛋白相关基因（dps、ftnA、ftnB、bfr）及铁调控蛋白相关基因（fur）进行了系统性的敲除，测...Previous work suggested that different antibiotics could kill bacteria via various targets or mechanisms respectively. However, a common mechanism of bactericidal antibiotics was reported recently. When bacteria suffered lethal stress by antibiotics, reactive oxygen species (ROS) was induced by abnormal respiratory chain reaction in which iron plays a key role. By reviewing current research progre...学位：医学硕士院系专业：公共卫生学院_流行病与卫生统计学学号：3272013115053

Advances in bacterial iron homeostasis and antibiotics killing mechanism

传统研究认为不同种类的抗生素有其各自不同的杀菌途径,然而近年人们发现了一条抗生素杀菌的共用通路,那就是当细菌细胞受到抗生素致死性刺激时,呼吸链代谢异常产生大量活性氧簇(ROS),而铁离子对ROS介导的杀菌至关重要。本文参阅近年来国内外研究结果,介绍了铁吸收、储存和利用有关的细菌铁代谢系统及其调控机制,重点讨论铁离子的调控及其与抗生素介导的ROS形成的相互作用关系。对于细菌耐药机制的研究与寻找新型药物作用靶点,探索有效控制手段和开发新药有重要意义。Previous research suggested that different antibiotics kill bacteria via various targets or mechanisms. However, recent study indicated that a common mechanism might be shared by most bactericidal antibiotics. When bacteria suffered lethal stress by antibiotics, reactive oxygen species(ROS) was induced by abnormal respiratory chain reaction in which iron played a key role. By reviewing current research progress regarding antibiotic resistance and iron related proteins in bacteria, including the iron absorbing, storage and consumption system in bacteria, this paper will mainly discuss the possible linkage/interaction between the regulation of ferrous ion and ROS induced by antibiotics. This common bacterial killing mechanism will have a significant impact on the future research for drugresistance, drug target screening, infection controlling and novel drug design.国家自然基金(No.81473251/81301474/31370166);; 福建省自然科学基金(No.2014J01139/2015J01345);; 国家重点基础研究发展计划(973计划)前期研究专项(No.2014CB560710

一种聚乳酸/淀粉全生物基可降解复合材料及其制备方法

本发明公开了一种聚乳酸/淀粉全生物基可降解复合材料，由重量百分比55％～85％的聚乳酸、2％～15％的环氧植物油和5％～36％的酸酐接枝改性淀粉原料制成，该复合材料安全无毒、可生物降解且机械性能优异。本发明还公开了一种聚乳酸/淀粉全生物基可降解复合材料的制备方法，包括：将聚乳酸、环氧植物油和马来酸酐接枝改性淀粉充分混合均匀，再将混合后的物料加入至双螺杆挤出机中熔融共混后拉条、切粒，得到颗粒状混合树脂；干燥处理，得到聚乳酸/淀粉全生物基可降解复合材料。该制备方法简单，易于控制，可操作性强，易于实施，生产成本低廉，易于工业化大规模生产，并且制备的复合材料能够应用于薄膜和一次性餐等领域